{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:42:25Z","timestamp":1758588145420,"version":"3.44.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.transproceed.2023.08.004","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T08:34:53Z","timestamp":1700210093000},"page":"2121-2125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0584-905X","authenticated-orcid":false,"given":"Michele","family":"Luglio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana de Carvalho Silva","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda Badue","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur Figueiredo","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werther Brunow","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Aoun","family":"Tannuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natascha Silva","family":"Sandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Litvinov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Sanson Yoshino","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane Guissi","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina dos Santos","family":"Lazari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele Soares Gomes","family":"Gouvea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Vicente","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Regina Tozetto","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan Yukimatsu","family":"Tanigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Roberto","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Bubna","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Gusson Galdino","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Renato Rebello","family":"Pinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ester Cerdeira","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cassia","family":"Mendes-Correah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venancio Avancini Ferreira","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heloisa Helena de Sousa","family":"Marques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2023.08.004_bib0001","unstructured":"United Kingdom Health Security Agency (UKHSA). Increase in acute hepatitis cases of unknown aetiology in children, <http:\/\/www.gov.uk\/government\/publications\/hepatitis-increase-in-acute-cases-of-unknown-aetiology-in-children-\/increase-in-acute-hepatitis-cases-of-unknown-aetiologys-in-children>; 2022 [accessed 18.01.23]."},{"year":"2022","series-title":"Recommendations for adenovirus testing and reporting of children with acute hepatitis of unknown etiology","key":"10.1016\/j.transproceed.2023.08.004_bib0002"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0003","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S2468-1253(22)00166-2","article-title":"Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens","volume":"7","author":"Brodin","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0004","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1056\/NEJMra1208937","article-title":"Acute liver failure","volume":"369","author":"Bernal","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0005","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1002\/lt.24435","article-title":"Pediatric acute liver failure in Brazil: is living donor liver transplantation the best choice for treatment?","volume":"22","author":"Tannuri","year":"2016","journal-title":"Liver Transpl"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0006","unstructured":"World Health Organization (WHO). Disease Outbreak news; acute hepatitis of unknown aetiology in children \u2013 multi-country, <https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON389>; 2022 [accessed 18.01.23]."},{"key":"10.1016\/j.transproceed.2023.08.004_bib0007","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/13651820500465741","article-title":"Liver transplantation for acute hepatic failure","volume":"8","author":"Castaldo","year":"2006","journal-title":"HPB (Oxford)"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0008","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jpeds.2009.06.005","article-title":"Pediatric Acute Liver Failure Study Group \u2013 patterns of diagnosis and evaluation for the causes of pediatric acute liver failure: an opportunity for quality improvement","volume":"555","author":"Narkewicz","year":"2009","journal-title":"J Pediatr"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0009","first-page":"S44","article-title":"Acute liver failure in children and adolescents","volume":"25","author":"Alberto","year":"2015","journal-title":"Rev Med Minas Gerais"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.5009\/gnl15352","article-title":"Diagnosis and management of autoimmune hepatitis: current status and future directions","volume":"10","author":"Czaja","year":"2016","journal-title":"Gut Liver"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0011","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s00134-022-06765-3","article-title":"Letter: outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit","volume":"48","author":"Deep","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0012","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1590\/1806-9282.65.6.914","article-title":"Fulminant acute hepatitis in pediatrics in Latin America and the Caribbean","volume":"65","author":"Junior","year":"2019","journal-title":"Rev Associ Med Bras"},{"key":"10.1016\/j.transproceed.2023.08.004_bib0013","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJMoa2206294","article-title":"A case series of children with acute hepatitis and human adenovirus infection","volume":"387","author":"Sanchez","year":"2022","journal-title":"N Engl J Med"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134523005523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134523005523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T21:45:58Z","timestamp":1758577558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134523005523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0041134523005523"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2023.08.004","relation":{},"ISSN":["0041-1345"],"issn-type":[{"type":"print","value":"0041-1345"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2023.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}