{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:33:18Z","timestamp":1768440798976,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"am","delay-in-days":389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["2022"],"award-info":[{"award-number":["2022"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K09104"],"award-info":[{"award-number":["JP20K09104"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16534"],"award-info":[{"award-number":["22K16534"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H02981"],"award-info":[{"award-number":["JP23H02981"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16535"],"award-info":[{"award-number":["22K16535"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23fk0210108"],"award-info":[{"award-number":["23fk0210108"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.transproceed.2024.02.002","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T21:07:32Z","timestamp":1709586452000},"page":"634-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunotherapy Using Activated Natural Killer Cells Improves Postoperative Neutrophil-to-Lymphocyte Ratio and Long-Term Prognosis of Living Donor Liver Transplant Recipients With Hepatocellular Carcinoma"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8972-5777","authenticated-orcid":false,"given":"Kouki","family":"Imaoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5433-5303","authenticated-orcid":false,"given":"Masahiro","family":"Ohira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiya","family":"Chogahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuna","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Bekki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Imaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Ide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohdan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2024.02.002_bib0001","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s00268-008-9552-6","article-title":"Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma","volume":"32","author":"Gomez","year":"2008","journal-title":"World J Surg"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0002","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2407-13-78","article-title":"Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma","volume":"13","author":"Oh","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0003","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/SLA.0b013e3181a77e59","article-title":"Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma","volume":"250","author":"Halazun","year":"2009","journal-title":"Ann Surg"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0004","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jhep.2012.08.017","article-title":"Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment","volume":"58","author":"Motomura","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0005","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/s41416-020-01189-6","article-title":"Postoperative, but not preoperative, inflammation-based prognostic markers are prognostic factors in stage III colorectal cancer patients","volume":"124","author":"Yasui","year":"2021","journal-title":"Br J Cancer"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0006","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jss.2014.05.078","article-title":"Neutrophil to lymphocyte ratio changes predict small hepatocellular carcinoma survival","volume":"192","author":"Peng","year":"2014","journal-title":"J Surg Res"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0007","doi-asserted-by":"crossref","first-page":"e58184","DOI":"10.1371\/journal.pone.0058184","article-title":"Postoperative neutrophil-to-lymphocyte ratio change predicts survival of patients with small hepatocellular carcinoma undergoing radiofrequency ablation","volume":"8","author":"Dan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0008","doi-asserted-by":"crossref","first-page":"e22640","DOI":"10.1002\/jcla.22640","article-title":"Association of neutrophil-to-lymphocyte ratio and natural killer cell activity revealed by measurement of interferon-gamma levels in a healthy population","volume":"33","author":"Kim","year":"2019","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0009","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00262-021-03005-3","article-title":"Pilot study to determine the safety and feasibility of deceased donor liver natural killer cell infusion to liver transplant recipients with hepatocellular carcinoma","volume":"71","author":"Ohira","year":"2022","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-065X.2006.00457.x","article-title":"Activation, coactivation, and costimulation of resting human natural killer cells","volume":"214","author":"Bryceson","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0011","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/mi.2012.140","article-title":"Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor","volume":"6","author":"Hall","year":"2013","journal-title":"Mucosal Immunol"},{"issue":"45","key":"10.1016\/j.transproceed.2024.02.002_bib0012","doi-asserted-by":"crossref","first-page":"8398","DOI":"10.3748\/wjg.v19.i45.8398","article-title":"Neutrophil-lymphocyte ratio predicts the prognosis of patients with hepatocellular carcinoma after liver transplantation","volume":"19","author":"Xiao","year":"2013","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0013","doi-asserted-by":"crossref","first-page":"12561","DOI":"10.1038\/s41598-018-30906-8","article-title":"Geriatric nutritional risk index predicts prognosis after hepatectomy in elderly patients with hepatitis B virus-related hepatocellular carcinoma","volume":"8","author":"Li","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0014","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.asjsur.2017.02.004","article-title":"Postoperative changes in neutrophil-to-lymphocyte ratio and platelet count: a simple prognostic predictor for adult-to-adult living donor liver transplantation","volume":"41","author":"Hayashi","year":"2018","journal-title":"Asian J Surg"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0015","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1038\/sj.onc.1207232","article-title":"TRAIL and apoptosis induction by TNF-family death receptors","volume":"22","author":"Wang","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0016","first-page":"3226","article-title":"Adoptive immunotherapy with liver allograft-derived lymphocytes induces anti-HCV activity after liver transplantation in humans and humanized mice","volume":"119","author":"Ohira","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0017","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.transproceed.2023.03.066","article-title":"Arteriosclerosis decreases tumor necrosis factor-related apoptosis-inducing ligand expression on liver natural killer cells in living donor liver transplantation","volume":"55","author":"Imaoka","year":"2023","journal-title":"Transplant Proc"},{"issue":"12","key":"10.1016\/j.transproceed.2024.02.002_bib0018","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1111\/tri.13748","article-title":"Impact on biliary complications of donor abdominal aortic calcification among living donor liver transplantation: a retrospective study","volume":"33","author":"Imaoka","year":"2020","journal-title":"Transpl Int"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0019","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s00595-017-1587-6","article-title":"Combined analysis of the pre- and postoperative neutrophil-lymphocyte ratio predicts the outcomes of patients with gastric cancer","volume":"48","author":"Miyatani","year":"2018","journal-title":"Surg Today"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0020","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3892\/ol.2020.12238","article-title":"Preoperative plus postoperative neutrophil-lymphocyte ratio for predicting overall survival following partial hepatectomy for hepatocellular carcinoma","volume":"20","author":"Wu","year":"2020","journal-title":"Oncol Lett"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0021","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3389\/fimmu.2019.00946","article-title":"Hepatic natural killer cells: organ-specific sentinels of liver immune homeostasis and physiopathology","volume":"10","author":"Mikulak","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0022","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3727\/096368911X627589","article-title":"Clinical-scale isolation of interleukin-2-stimulated liver natural killer cells for treatment of liver transplantation with hepatocellular carcinoma","volume":"21","author":"Ohira","year":"2012","journal-title":"Cell Transplant"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0023","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1158\/2159-8290.CD-15-1157","article-title":"Neutrophils suppress intraluminal NK cell-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells","volume":"6","author":"Spiegel","year":"2016","journal-title":"Cancer Discov"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0024","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4049\/jimmunol.179.2.781","article-title":"The CD16-\/CD56bright subset of NK cells is resistant to oxidant-induced cell death","volume":"179","author":"Thor\u00e9n","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1365-2141.2005.05842.x","article-title":"NKp46 and NKG2D receptor expression in NK cells with CD56dim and CD56bright phenotype: regulation by histamine and reactive oxygen species","volume":"132","author":"Romero","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0026","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.4049\/jimmunol.1102002","article-title":"Human NK cells induce neutrophil apoptosis via an NKp46- and Fas-dependent mechanism","volume":"188","author":"Thor\u00e9n","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.transproceed.2024.02.002_bib0027","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.3389\/fimmu.2019.02444","article-title":"Downregulation of HLA class I renders inflammatory neutrophils more susceptible to NK cell-induced apoptosis","volume":"10","author":"Bernson","year":"2019","journal-title":"Front Immunol"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134524001295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134524001295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T23:22:13Z","timestamp":1717197733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134524001295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S0041134524001295"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2024.02.002","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunotherapy Using Activated Natural Killer Cells Improves Postoperative Neutrophil-to-Lymphocyte Ratio and Long-Term Prognosis of Living Donor Liver Transplant Recipients With Hepatocellular Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2024.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}