{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:07:48Z","timestamp":1780304868922,"version":"3.54.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"am","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002129","name":"Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005348","name":"American Association for Thoracic Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R41 HL169059"],"award-info":[{"award-number":["R41 HL169059"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009671","name":"Arkansas Children's Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009364","name":"Saving Tiny Hearts Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Proceedings"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.transproceed.2025.07.030","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T21:02:51Z","timestamp":1758056571000},"page":"1652-1658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intramuscular Tacrolimus Pharmacokinetics in a Pediatric Porcine Model for Partial Heart Transplantation"],"prefix":"10.1016","volume":"57","author":[{"given":"Louis","family":"Steen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herra","family":"Javed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Contorno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Irby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lowery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly Paige","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Reemsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Konrad","family":"Rajab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.transproceed.2025.07.030_bib0001","unstructured":"UNOS Data and Transplant Statistics | Organ Donation Data. UNOS https:\/\/unos.org\/data\/."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0002","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/1471-2164-14-332","article-title":"Structural and functional annotation of the porcine immunome","volume":"14","author":"Dawson","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2021.637682","article-title":"Diversity of the swine leukocyte antigen class I and II in commercial pig populations","volume":"8","author":"Techakriengkrai","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0004","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/transplantology2040039","article-title":"Animal Models in Allogenic Solid Organ Transplantation","volume":"2","author":"Wenzel","year":"2021","journal-title":"Transplantology"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2165\/00148581-200709050-00005","article-title":"Induction therapy in pediatric renal transplant recipients: an overview","volume":"9","author":"Moudgil","year":"2007","journal-title":"Paediatr. Drugs"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0006","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/TP.0b013e318277e378","article-title":"Ten-year results of a randomized trial comparing tacrolimus versus cyclosporine a in combination with mycophenolate mofetil after heart transplantation","volume":"95","author":"Guethoff","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0007","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1111\/ajt.13309","article-title":"Pharmacokinetics and toxicity of tacrolimus early after heart and lung transplantation","volume":"15","author":"Sikma","year":"2015","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0008","unstructured":"The registry of the international society for heart and lung transplantation: twenty-eighth adult heart transplant report\u20142011 - ClinicalKey.https:\/\/www-clinicalkey-com.libproxy.uams.edu\/#!\/content\/playContent\/1-s2.0-S1053249811010862?returnurl=null&referrer=null."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0009","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/TP.0000000000003350","article-title":"Thirty years of tacrolimus in clinical practice","volume":"105","author":"Ong","year":"2021","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0010","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1006\/clin.1996.0140","article-title":"the mechanism of action of cyclosporin a and FK506","volume":"80","author":"Ho","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0011","unstructured":"Tacrolimus-associated diffuse gastrointestinal ulcerations and pathergy: a case report-ClinicalKey.https:\/\/www-clinicalkeycom.libproxy.uams.edu\/#!\/content\/playContent\/1-s2.0-S004113451630687X?returnurl=null&referrer=null."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0012","doi-asserted-by":"crossref","first-page":"116597","DOI":"10.1016\/j.taap.2023.116597","article-title":"Pathway-level multi-omics analysis of the molecular mechanisms underlying the toxicity of long-term tacrolimus exposure","volume":"473","author":"Yen","year":"2023","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0013","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13318-019-00591-7","article-title":"High variability of whole-blood tacrolimus pharmacokinetics early after thoracic organ transplantation","volume":"45","author":"Sikma","year":"2020","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0014","first-page":"23","article-title":"CYP3A5 polymorphisms in renal transplant recipients: influence on tacrolimus treatment","volume":"11","author":"Chen","year":"2018","journal-title":"Pharmacogenomics Pers. Med."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0015","unstructured":"Tacrolimus - pharmacokinetic considerations for clinicians: ingenta connect. https:\/\/www-ingentaconnect-com.libproxy.uams.edu\/content\/ben\/cdm\/2018\/00000019\/00000004\/art00007#."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0016","first-page":"2736","article-title":"Pharmacokinetics of FK 506 in transplant patients","volume":"23","author":"Venkataramanan","year":"1991","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0017","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ijpharm.2017.05.040","article-title":"Evaluation of tacrolimus sorption to PVC- and non-PVC-based tubes in administration sets: Pump method vs. drip method","volume":"528","author":"Jin","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0018","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.24958","article-title":"Determination of tacrolimus in human whole blood in kidney transplant recipients using a rapid and specific LC\u2013MS\/MS method","volume":"37","author":"Hieu","year":"2023","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0019","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2146\/ajhp140322","article-title":"Sublingual tacrolimus as an alternative to oral administration for solid organ transplant recipients","volume":"72","author":"Pennington","year":"2015","journal-title":"Am. J. Health. Syst. Pharm."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/03602530902843483","article-title":"Polymorphism of human cytochrome P450 enzymes and its clinical impact","volume":"41","author":"Zhou","year":"2009","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0021","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/00007890-200203150-00021","article-title":"A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: evidence for improved allograft survival at five years","volume":"73","author":"Vincenti","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0022","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.surg.2020.07.051","article-title":"Evidence-based surgical hypothesis: Partial heart transplantation can deliver growing valve implants for congenital cardiac surgery","volume":"169","author":"Rajab","year":"2021","journal-title":"Surgery"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0023","doi-asserted-by":"crossref","DOI":"10.1177\/21501351241245115","article-title":"Surgical protocol for partial heart transplantation in growing piglets","author":"Medina","year":"2024","journal-title":"World J. Pediatr. Congenit. Heart Surg."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0024","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-63072-1","article-title":"Survival after partial heart transplantation in a piglet model","volume":"14","author":"Medina","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.transproceed.2025.07.030_bib0025","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/aor.14664","article-title":"Partial heart transplantation: Growing heart valve implants for children","volume":"48","author":"Rajab","year":"2024","journal-title":"Artif. Organs"},{"key":"10.1016\/j.transproceed.2025.07.030_bib0026","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1001\/jama.2023.23823","article-title":"Partial heart transplant in a neonate with irreparable truncal valve dysfunction","volume":"331","author":"Turek","year":"2024","journal-title":"JAMA"}],"container-title":["Transplantation Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134525004233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041134525004233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:36:10Z","timestamp":1780302970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041134525004233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0041134525004233"],"URL":"https:\/\/doi.org\/10.1016\/j.transproceed.2025.07.030","relation":{},"ISSN":["0041-1345"],"issn-type":[{"value":"0041-1345","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intramuscular Tacrolimus Pharmacokinetics in a Pediatric Porcine Model for Partial Heart Transplantation","name":"articletitle","label":"Article Title"},{"value":"Transplantation Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.transproceed.2025.07.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}