{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:11:05Z","timestamp":1790223065638,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Brain distribution of synaptic vesicle protein 2A was measured with fluorine\u201018 UCB\u2010H ([\n                      <jats:sup>18<\/jats:sup>\n                      F]UCB\u2010H) and positron emission tomography (PET).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image\u2010derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]UCB\u2010H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image\u2010derived input function provided regional distribution volume with a high linear relationship.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      The cerebral distribution of [\n                      <jats:sup>18<\/jats:sup>\n                      F]UCB\u2010H is similar to that recently observed with carbon\u201011 UCB\u2010J ([\n                      <jats:sup>11<\/jats:sup>\n                      C]UCB\u2010J). An accurate [\n                      <jats:sup>18<\/jats:sup>\n                      F]UCB\u2010H quantification can be performed without invasive arterial blood sampling when no suitable reference region is available, using dynamic PET carotid activity. Brain synaptic density can be studied in\u00a0vivo in normal and pathological aging.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.trci.2017.08.004","type":"journal-article","created":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T17:00:20Z","timestamp":1504112420000},"page":"481-486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Measuring brain synaptic vesicle protein 2A with positron emission tomography and [\n                    <sup>18<\/sup>\n                    F]UCB\u2010H"],"prefix":"10.1002","volume":"3","author":[{"given":"Mohamed Ali","family":"Bahri","sequence":"first","affiliation":[{"name":"GIGA\u2010Cyclotron Research Center, University of Li\u00e8ge Liege Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Plenevaux","sequence":"additional","affiliation":[{"name":"GIGA\u2010Cyclotron Research Center, University of 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