{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:24:24Z","timestamp":1775244264239,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Health and Medical Research Council Dementia Research Development Fellowship","award":["GNT1097105"],"award-info":[{"award-number":["GNT1097105"]}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["A&amp;amp;D Transl Res &amp;amp; Clin Interv"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inconsistent results from previous studies of exercise and cognitive function suggest that rigorously designed randomized controlled trials are urgently needed. Here, we describe the design of the Intense Physical Activity and Cognition (IPAC) study, which will assess the impact of a 6\u2010month high\u2010intensity exercise intervention on cognitive function and biomarkers of dementia risk, compared with a 6\u2010month moderate\u2010intensity exercise intervention and control group (no study\u2010related exercise).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One\u2010hundred and five cognitively healthy men and women aged between 60 and 80\u00a0years are randomized into a high\u2010intensity exercise, moderate\u2010intensity exercise, or control group. Individuals randomized to an exercise intervention undertake 6 months of cycle\u2010based exercise twice a week, at 50\u00a0minutes per session. All participants undergo comprehensive neuropsychological testing, blood sampling, brain magnetic resonance imaging, fitness testing, and a body composition scan at baseline, 6\u00a0months (immediately after intervention), and 18\u00a0months (12\u00a0months after intervention).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The IPAC study takes a multidisciplinary approach to investigating the role of exercise in maintaining a healthy brain throughout aging. Rigorous monitoring of exertion and adherence throughout the intervention, combined with repeated measures of fitness, is vital in ensuring an optimum exercise dose is reached. Results from the IPAC study will be used to inform a large\u2010scale multicentre randomized controlled trial, with the ultimate aim of pinpointing the frequency, duration, and intensity of exercise that provides the most benefit to the brain, in terms of enhancing cognitive function and reducing dementia risk in older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.trci.2017.09.003","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T11:15:55Z","timestamp":1508411755000},"page":"562-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Study protocol of the Intense Physical Activity and Cognition study: The effect of high\u2010intensity exercise training on cognitive function in older adults"],"prefix":"10.1002","volume":"3","author":[{"given":"Belinda M.","family":"Brown","sequence":"first","affiliation":[{"name":"School of Psychology and Exercise Science, Murdoch University Murdoch Western Australia Australia"},{"name":"Sir James McCusker Alzheimer's Disease Research Unit Hollywood Private Hospital Nedlands Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie R.","family":"Rainey\u2010Smith","sequence":"additional","affiliation":[{"name":"Sir James McCusker Alzheimer's Disease Research Unit Hollywood Private Hospital Nedlands Western Australia Australia"},{"name":"School of Medical and Health Sciences, Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Castalanelli","sequence":"additional","affiliation":[{"name":"Sir James McCusker Alzheimer's Disease Research Unit Hollywood Private Hospital Nedlands Western Australia Australia"},{"name":"School of Psychological Science, University of Western Australia Crawley Western Australia 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