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This analysis determined whether mild\u2010to\u2010moderate AD populations could be enriched for cognitive decline based on apolipoprotein (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 genotype, family history of AD, and amyloid abnormalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Modeling estimated the number of randomized patients needed to detect a 2\u2010point treatment difference on the AD Assessment Scale\u2013Cognitive subscale using placebo data from three randomized, double\u2010blind trials (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      Identifiers:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"ctgov:NCT01955161\">NCT01955161<\/jats:ext-link>\n                      ,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"ctgov:NCT02006641\">NCT02006641<\/jats:ext-link>\n                      , and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"ctgov:NCT02006654\">NCT02006654<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An 80% power to detect a 2\u2010point treatment effect required the randomization of 148 amyloid\u2010positive patients; 178 \u03b54 homozygous or amyloid\u2010positive patients; and 231 \u03b54 homozygous, family history\u2010positive, or amyloid\u2010positive patients, compared with 1619 unenriched patients (per\u2009arm).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Enrichment in mild\u2010to\u2010moderate AD clinical trials can be achieved using combinations of biomarkers\/risk factors to increase the likelihood of observing potential treatment effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.trci.2019.04.001","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T23:03:36Z","timestamp":1558307016000},"page":"164-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Enrichment factors for clinical trials in mild\u2010to\u2010moderate Alzheimer's disease"],"prefix":"10.1002","volume":"5","author":[{"given":"Clive","family":"Ballard","sequence":"first","affiliation":[{"name":"University of Exeter Medical School Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Atri","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute Sun City AZ USA"},{"name":"Brigham and Women's Hospital and Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neli","family":"Boneva","sequence":"additional","affiliation":[{"name":"H. 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