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IPL and outer nuclear layer also showed significant thinning in two (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.025) and one location (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.010), respectively. No significant differences were found when optic nerve measurements BMO\u2010MRW and LC were compared (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.131 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u2009.721, respectively). Temporal sector GCL, average RNFL, and temporal sector RNFL also exhibited significant thinning when MCI and control eyes were compared (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.015,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.005 and\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.050, respectively), and also the greatest area under the curve values (0.689, 0.647, and 0.659, respectively). GCL, IPL, and RNFL tend to be thinner in the AD group compared with healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our study suggests that RNFL and GCL are useful for potential screening in the early diagnosis of AD. LC and BMO\u2010MRW appear not to be affected by AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.trci.2019.08.008","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T05:55:38Z","timestamp":1570600538000},"page":"570-578","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid PET"],"prefix":"10.1002","volume":"5","author":[{"given":"Alicia","family":"L\u00f3pez\u2010de\u2010Eguileta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology \u2018Marqu\u00e9s de Valdecilla\u2019 University Hospital, University of Cantabria, Institute for Research \u2018Marqu\u00e9s de Valdecilla\u2019 (IDIVAL) Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Lage","sequence":"additional","affiliation":[{"name":"Neurology Department and Centro de 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