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Interestingly, single administration of zerumbone (1 and 10\u2009mg\/kg) reversed the hyperactivity, anxiety\u2010like behaviours, and learning impairment effects of scopolamine in the three experimental model studied respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Our findings demonstrated that the scopolamine\u2010induced impairment of learning and memory was reversed by the administration of zerumbone. As a conclusion, our findings presented the positive effects of zerumbone on dementia\u2010like behaviours in the animal model used and could possibly contribute for future research to manage hyperactivity, anxiety, and learning disabilities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.trci.2019.09.009","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T23:22:08Z","timestamp":1571700128000},"page":"637-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Effect of zerumbone on scopolamine\u2010induced memory impairment and anxiety\u2010like behaviours in rats"],"prefix":"10.1002","volume":"5","author":[{"given":"Sahba","family":"Jafarian","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King\u2010Hwa","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Selangor Malaysia"},{"name":"Department of Genetics Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zurina","family":"Hassan","sequence":"additional","affiliation":[{"name":"Center for Drug Research Universiti Sains Malaysia Gelugor Penang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lua","family":"Perimal\u2010Lewis","sequence":"additional","affiliation":[{"name":"Flinders Digital Health Research Centre College of Nursing and Health Sciences, Flinders University of South Australia Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Roslan","family":"Sulaiman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enoch Kumar","family":"Perimal","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science, Faculty of Medicine and Health Sciences Universiti Putra Malaysia Serdang Selangor Malaysia"},{"name":"Australian Research Council Centre of Excellence for Nanoscale BioPhotonics University of Adelaide Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,1]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.2"},{"key":"e_1_2_8_3_2","first-page":"e47","article-title":"2014 Alzheimer's disease facts and figures","volume":"10","author":"Association, Alzheimer Association","year":"2014","journal-title":"Alzheimers Dement"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.02.001"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt280"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/927804"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.05.017"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.5.795"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC4502_12"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20175"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208845"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.3844\/ajptsp.2008.209.211"},{"key":"e_1_2_8_13_2","article-title":"Use of the Open Field Maze to measure locomotor and anxiety\u2010like behavior in mice","volume":"96","author":"Seibenhener M.L.","year":"2015","journal-title":"J Vis Exp"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9693-9"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1037\/bne0000080"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bfopcu.2013.11.001"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1501672"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2017.1285320"},{"key":"e_1_2_8_19_2","first-page":"17","article-title":"A review on chemical constituents and pharmacological activities of Coriandrum sativum","volume":"6","author":"Al\u2010Snafi A.E.","year":"2016","journal-title":"IOSR J Pharm"}],"container-title":["Alzheimer's &amp; 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