{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:06:42Z","timestamp":1792710402557,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:00:00Z","timestamp":1794355200000},"content-version":"am","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["CSR&amp;D I01CX002210"],"award-info":[{"award-number":["CSR&amp;D I01CX002210"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6BX006041"],"award-info":[{"award-number":["IK6BX006041"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX005917"],"award-info":[{"award-number":["I01BX005917"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011089","name":"University of Wisconsin Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA261937"],"award-info":[{"award-number":["R01CA261937"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cancer"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.trecan.2025.08.003","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:10:59Z","timestamp":1756465859000},"page":"1037-1040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polo-like kinases as immune modulators: a new frontier in cancer immunotherapy"],"prefix":"10.1016","volume":"11","author":[{"given":"Tanya","family":"Jaiswal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagan","family":"Chhabra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4239-9887","authenticated-orcid":false,"given":"Nihal","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trecan.2025.08.003_bb0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/vaccines11010059","article-title":"Advancements in cancer immunotherapies","volume":"11","author":"Roy","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.trecan.2025.08.003_bb0010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/ajh.24177","article-title":"Polo-like kinase and its inhibitors: ready for the match to start?","volume":"90","author":"Palmisiano","year":"2015","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.trecan.2025.08.003_bb0015","doi-asserted-by":"crossref","first-page":"21797","DOI":"10.1074\/jbc.M109.018275","article-title":"Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS","volume":"284","author":"Vitour","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trecan.2025.08.003_bb0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41467-022-35348-5","article-title":"Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis","volume":"14","author":"Arimoto","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2025.08.003_bb0025","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1182\/blood.2023019782","article-title":"Inhibition of PLK4 remodels histone methylation and activates the immune response via the cGAS-STING pathway in TP53-mutated AML","volume":"142","author":"Man","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2025.08.003_bb0030","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41388-019-1023-z","article-title":"Active PLK1-driven metastasis is amplified by TGF-\u03b2 signaling that forms a positive feedback loop in non-small cell lung cancer","volume":"39","author":"Shin","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.trecan.2025.08.003_bb0035","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s13046-023-02872-1","article-title":"Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1","volume":"42","author":"Xu","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.trecan.2025.08.003_bb0040","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1038\/s41418-021-00781-4","article-title":"PLK1\/vimentin signaling facilitates immune escape by recruiting Smad2\/3 to PD-L1 promoter in metastatic lung adenocarcinoma","volume":"28","author":"Jang","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.trecan.2025.08.003_bb0045","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/cr.2016.78","article-title":"Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8","volume":"26","author":"Helmke","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.trecan.2025.08.003_bb0050","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.molonc.2013.12.013","article-title":"Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis","volume":"8","author":"Matthess","year":"2014","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.trecan.2025.08.003_bb0055","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.7150\/ijms.60135","article-title":"PLK1 Inhibition induces immunogenic cell death and enhances immunity against NSCLC","volume":"18","author":"Zhou","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.trecan.2025.08.003_bb0060","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1158\/0008-5472.CAN-22-0018","article-title":"Targeting Plk1 sensitizes pancreatic cancer to immune checkpoint therapy","volume":"82","author":"Zhang","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.trecan.2025.08.003_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113266","article-title":"Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer","volume":"42","author":"Kandala","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.trecan.2025.08.003_bb0070","doi-asserted-by":"crossref","first-page":"431","DOI":"10.32604\/or.2024.050794","article-title":"Comprehensive analysis reveals PLK3 as a promising immune target and prognostic indicator in glioma","volume":"33","author":"Zhu","year":"2025","journal-title":"Oncol. Res."},{"key":"10.1016\/j.trecan.2025.08.003_bb0075","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6302234","article-title":"PLK4 Is a potential biomarker for abnormal tumor proliferation, immune infiltration, and prognosis in ccRCC","volume":"2022","author":"Hu","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.trecan.2025.08.003_bb0080","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202107134","article-title":"Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells","volume":"221","author":"Weier","year":"2022","journal-title":"J. Cell Biol."}],"container-title":["Trends in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405803325002018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405803325002018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T21:55:03Z","timestamp":1778882103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405803325002018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2405803325002018"],"URL":"https:\/\/doi.org\/10.1016\/j.trecan.2025.08.003","relation":{},"ISSN":["2405-8033"],"issn-type":[{"value":"2405-8033","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polo-like kinases as immune modulators: a new frontier in cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Trends in Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trecan.2025.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}