{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:09:54Z","timestamp":1791839394077,"version":"4.3.4"},"reference-count":102,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007380","name":"Fondation de l&apos;Avenir pour la Recherche M\u00e9dicale Appliqu\u00e9e","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["19CE18000201"],"award-info":[{"award-number":["19CE18000201"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016037","name":"Fondation Gustave Roussy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cancer"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.trecan.2026.03.002","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:33:08Z","timestamp":1775781188000},"page":"621-633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Epigenetic, epitranscriptomic, and metabolic control of T cell exhaustion"],"prefix":"10.1016","volume":"12","author":[{"given":"Chloe J.","family":"Slater","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albane","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite","family":"Laprie-Sentenac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-6607","authenticated-orcid":false,"given":"Laurie","family":"Menger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trecan.2026.03.002_bb0005","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41590-023-01578-y","article-title":"Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division","volume":"24","author":"Rudloff","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0010","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41571-022-00689-z","article-title":"Clinical implications of T cell exhaustion for cancer immunotherapy","volume":"19","author":"Chow","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0015","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ccell.2024.05.025","article-title":"Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors","volume":"42","author":"Espinosa-Carrasco","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trecan.2026.03.002_bb0020","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s41590-021-00979-1","article-title":"Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans","volume":"22","author":"Yates","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature19330","article-title":"Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy","volume":"537","author":"Im","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-023-06733-x","article-title":"Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer","volume":"624","author":"Zhou","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0035","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/s41590-025-02219-2","article-title":"Lymph-node-derived stem-like but not tumor-tissue-resident CD8+ T cells fuel anticancer immunity","volume":"26","author":"Wijesinghe","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0040","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/s41586-024-07762-w","article-title":"Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission","volume":"634","author":"Bai","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0045","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature22367","article-title":"Chromatin states define tumour-specific T cell dysfunction and reprogramming","volume":"545","author":"Philip","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0050","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/s41591-023-02415-3","article-title":"Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia","volume":"29","author":"Anderson","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0055","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/s42255-020-00285-4","article-title":"Nuclear metabolism and the regulation of the epigenome","volume":"2","author":"Boon","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.trecan.2026.03.002_bb0060","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.cell.2017.06.007","article-title":"De novo epigenetic programs inhibit PD-1 blockade-mediated T cell rejuvenation","volume":"170","author":"Ghoneim","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.03.002_bb0065","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1016\/j.immuni.2025.09.004","article-title":"Eomesodermin+ CD4+ T cells are critical for curative immunotherapy outcomes","volume":"58","author":"Zhang","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.trecan.2026.03.002_bb0070","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41587-023-02060-8","article-title":"IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases","volume":"42","author":"Zhao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0075","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41590-021-00940-2","article-title":"Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity","volume":"22","author":"Guo","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0080","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/s41586-024-07962-4","article-title":"The type 2 cytokine Fc\u2013IL-4 revitalizes exhausted CD8+ T cells against cancer","volume":"634","author":"Feng","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0085","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41586-023-06797-9","article-title":"An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis","volume":"625","author":"LaMarche","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0090","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa2408771","article-title":"Enhanced CAR T-cell therapy for lymphoma after previous failure","volume":"392","author":"Svoboda","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0095","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1038\/s41588-023-01554-0","article-title":"Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens","volume":"55","author":"McCutcheon","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.trecan.2026.03.002_bb0100","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.1038\/s41586-024-07450-9","article-title":"Publisher correction: FOXO1 is a master regulator of memory programming in CAR T cells","volume":"629","author":"Doan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/s41586-024-07242-1","article-title":"FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy","volume":"629","author":"Chan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0110","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41590-018-0311-z","article-title":"The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity","volume":"20","author":"Gautam","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0115","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/ni.3441","article-title":"BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers","volume":"17","author":"Roychoudhuri","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0120","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41590-021-00868-7","article-title":"BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells","volume":"22","author":"Yao","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0125","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41586-024-07300-8","article-title":"FOXO1 is a master regulator of memory programming in CAR T cells","volume":"629","author":"Doan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0130","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s41586-022-05105-1","article-title":"MYB orchestrates T cell exhaustion and response to checkpoint inhibition","volume":"609","author":"Tsui","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0135","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41586-022-04494-7","article-title":"A genome-scale screen for synthetic drivers of T cell proliferation","volume":"603","author":"Legut","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0140","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cmet.2022.02.009","article-title":"A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy","volume":"34","author":"Ye","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.trecan.2026.03.002_bb0145","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41586-019-1805-z","article-title":"c-Jun overexpression in CAR T cells induces exhaustion resistance","volume":"576","author":"Lynn","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0150","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41590-021-00964-8","article-title":"BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells","volume":"22","author":"Seo","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0155","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/s41591-022-01959-0","article-title":"Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma","volume":"28","author":"Haradhvala","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0160","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/s41586-024-08314-y","article-title":"Central control of dynamic gene circuits governs T cell rest and activation","volume":"637","author":"Arce","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0165","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/j.ccell.2025.07.021","article-title":"Genome-wide CRISPR screens identify critical targets to enhance CAR-NK cell antitumor potency","volume":"43","author":"Biederst\u00e4dt","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trecan.2026.03.002_bb0170","doi-asserted-by":"crossref","DOI":"10.1126\/science.abn5647","article-title":"Enhanced T cell effector activity by targeting the Mediator kinase module","volume":"378","author":"Freitas","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.03.002_bb0175","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41392-024-01777-5","article-title":"RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.trecan.2026.03.002_bb0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41586-019-1821-z","article-title":"Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy","volume":"576","author":"Wei","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0185","doi-asserted-by":"crossref","DOI":"10.1101\/2021.04.12.439455","article-title":"In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4+ TH1 cell response","volume":"6","author":"Galy","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0190","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/s41586-025-09489-8","article-title":"In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma","volume":"646","author":"Knudsen","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0195","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1470-2045(25)00083-X","article-title":"Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial","volume":"26","author":"Lou","year":"2025","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0200","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.scib.2023.11.029","article-title":"Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells","volume":"69","author":"Guo","year":"2024","journal-title":"Sci. Bull."},{"key":"10.1016\/j.trecan.2026.03.002_bb0205","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1158\/0008-5472.CAN-25-0065","article-title":"METTL14 enhances antitumor immunity through m6A-dependent loss of PD-1","volume":"85","author":"Huang","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.trecan.2026.03.002_bb0210","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/s41590-022-01268-1","article-title":"The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells","volume":"23","author":"Ito-Kureha","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0215","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41419-025-07606-z","article-title":"FTO controls CD8+ T cell survival and effector response by modulating m6A methylation of Fas","volume":"16","author":"Sun","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.trecan.2026.03.002_bb0220","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1038\/s41590-025-02235-2","article-title":"Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy","volume":"26","author":"Xiao","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0225","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav0080","article-title":"Cap-specific terminal N6-methylation of RNA by an RNA polymerase II\u2013associated methyltransferase","volume":"363","author":"Akichika","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.03.002_bb0230","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1038\/s41467-021-25105-5","article-title":"m6Am-seq reveals the dynamic m6Am methylation in the human transcriptome","volume":"12","author":"Sun","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.03.002_bb0235","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41590-024-02047-w","article-title":"The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity","volume":"26","author":"Xiang","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0240","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/s41467-023-36595-w","article-title":"Nsun2 coupling with RoR\u03b3t shapes the fate of Th17 cells and promotes colitis","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.03.002_bb0245","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2218324120","article-title":"Tet2 deletion in CD4+ T cells disrupts Th1 lineage commitment in memory cells and enhances T follicular helper cell recall responses to viral rechallenge","volume":"120","author":"Baessler","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.trecan.2026.03.002_bb0250","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/s42003-024-07312-0","article-title":"Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice","volume":"7","author":"Gioulbasani","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0255","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/s41586-024-07969-x","article-title":"RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis","volume":"634","author":"Zou","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0260","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41590-025-02100-2","article-title":"A critical role of N4-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity","volume":"26","author":"Sun","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0265","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.trecan.2024.03.010","article-title":"Immunometabolism of CD8+ T cell differentiation in cancer","volume":"10","author":"Shi","year":"2024","journal-title":"Trends Cancer"},{"key":"10.1016\/j.trecan.2026.03.002_bb0270","article-title":"CD8+ T cell stressors converge on shared metabolic\u2013epigenetic networks","author":"Shangguan","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.trecan.2026.03.002_bb0275","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","article-title":"Cancer SLC43A2 alters T cell methionine metabolism and histone methylation","volume":"585","author":"Bian","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0280","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/s41590-025-02223-6","article-title":"Early methionine availability attenuates T cell exhaustion","volume":"26","author":"Sharma","year":"2025","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0285","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20231820","article-title":"ACLY and ACSS2 link nutrient-dependent chromatin accessibility to CD8 T cell effector responses","volume":"221","author":"Kaymak","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0290","article-title":"Nutrient-driven histone code determines exhausted CD8+ T cell fates","volume":"387","author":"Ma","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.03.002_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113013","article-title":"The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function","volume":"42","author":"Foskolou","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.trecan.2026.03.002_bb0300","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.abj5104","article-title":"Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function","volume":"377","author":"Notarangelo","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.03.002_bb0305","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/s41591-018-0095-6","article-title":"Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate","volume":"24","author":"Bunse","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0310","doi-asserted-by":"crossref","DOI":"10.1126\/science.adl6173","article-title":"Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity","volume":"385","author":"Wu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.03.002_bb0315","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12929-025-01186-y","article-title":"TCA cycle-derived oncometabolites in cancer and the immune microenvironment","volume":"32","author":"Sarkar","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.trecan.2026.03.002_bb0320","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.immuni.2025.07.017","article-title":"Succinate preserves CD8+ T cell fitness to augment antitumor immunity","volume":"58","author":"Ma","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.trecan.2026.03.002_bb0325","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/s42255-023-00855-2","article-title":"Glutarate regulates T cell metabolism and anti-tumour immunity","volume":"5","author":"Minogue","year":"2023","journal-title":"Nat. Metab."},{"key":"10.1016\/j.trecan.2026.03.002_bb0330","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41556-024-01351-9","article-title":"ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis","volume":"26","author":"Yang","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0335","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1038\/s42255-022-00676-9","article-title":"Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth","volume":"4","author":"Zhao","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.trecan.2026.03.002_bb0340","doi-asserted-by":"crossref","first-page":"8154","DOI":"10.1038\/s41467-023-43988-4","article-title":"Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion","volume":"14","author":"Gu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.03.002_bb0345","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.cmet.2024.11.012","article-title":"Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1","volume":"37","author":"Fan","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.trecan.2026.03.002_bb0350","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-006287","article-title":"Inhibition of lactate transport by MCT-1 blockade improves chimeric antigen receptor T-cell therapy against B-cell malignancies","volume":"11","author":"Lopez","year":"2023","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.trecan.2026.03.002_bb0355","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1038\/s41590-024-01985-9","article-title":"Histone lactylation drives CD8+ T cell metabolism and function","volume":"25","author":"Raychaudhuri","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0360","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1038\/s41590-024-01991-x","article-title":"Metabolic\u2013epigenetic rewiring in CD8+ T cells via lactate-dependent histone lactylation","volume":"25","author":"Sun","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0365","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1073\/pnas.1920413117","article-title":"Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity","volume":"117","author":"Hermans","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.trecan.2026.03.002_bb0370","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm8161","article-title":"Succinate dehydrogenase\/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation","volume":"7","author":"Chen","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0375","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cmet.2023.12.010","article-title":"Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation","volume":"36","author":"Si","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.trecan.2026.03.002_bb0380","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/s41586-023-06546-y","article-title":"Reductive carboxylation epigenetically instructs T cell differentiation","volume":"621","author":"Jaccard","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0385","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adp9371","article-title":"TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function","volume":"10","author":"Dimitri","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.trecan.2026.03.002_bb0390","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cell.2021.02.021","article-title":"In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions","volume":"184","author":"Huang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.03.002_bb0395","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abh0272","article-title":"Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity","volume":"13","author":"Prinzing","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0400","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1158\/2159-8290.CD-22-1319","article-title":"Disruption of SUV39H1-mediated H3K9 methylation sustains CAR T-cell function","volume":"14","author":"Jain","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.trecan.2026.03.002_bb0405","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1158\/2159-8290.CD-22-1350","article-title":"SUV39H1 ablation enhances long-term CAR T function in solid tumors","volume":"14","author":"L\u00f3pez-Cobo","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.trecan.2026.03.002_bb0410","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ccell.2022.06.001","article-title":"Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence","volume":"40","author":"Belk","year":"2022","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trecan.2026.03.002_bb0415","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.immuni.2023.05.008","article-title":"The SWI\/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells","volume":"56","author":"Baxter","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.trecan.2026.03.002_bb0420","doi-asserted-by":"crossref","DOI":"10.1126\/science.adl4492","article-title":"Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy","volume":"386","author":"Kang","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.03.002_bb0425","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1158\/2326-6066.CIR-14-0186","article-title":"Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells","volume":"3","author":"Frigault","year":"2015","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.trecan.2026.03.002_bb0430","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba1786","article-title":"Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling","volume":"372","author":"Weber","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.03.002_bb0435","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ccell.2024.11.006","article-title":"EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function","volume":"43","author":"Isshiki","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trecan.2026.03.002_bb0440","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ccell.2025.01.013","article-title":"EZH1\/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models","volume":"43","author":"Porazzi","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trecan.2026.03.002_bb0445","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1158\/2326-6066.CIR-24-0089","article-title":"Transient EZH2 suppression by tazemetostat during in vitro expansion maintains T-cell stemness and improves adoptive T-cell therapy","volume":"13","author":"Hou","year":"2024","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.trecan.2026.03.002_bb0450","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1038\/s41467-017-02187-8","article-title":"Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity","volume":"8","author":"He","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.03.002_bb0455","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1038\/s41467-019-09882-8","article-title":"miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8+ T cell fate","volume":"10","author":"Ji","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.03.002_bb0460","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1038\/s41467-024-50485-9","article-title":"C-JUN overexpressing CAR-T cells in acute myeloid leukemia: preclinical characterization and phase I trial","volume":"15","author":"Zuo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.03.002_bb0465","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12988","article-title":"In vivo discovery of immunotherapy targets in the tumour microenvironment","volume":"506","author":"Zhou","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0470","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nature23450","article-title":"m6A mRNA methylation controls T cell homeostasis by targeting IL-7\/STAT5\/SOCS pathway","volume":"548","author":"Li","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0475","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41586-022-05692-z","article-title":"TET2 guards against unchecked BATF3-induced CAR T cell expansion","volume":"615","author":"Jain","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0480","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1056\/NEJMoa2401361","article-title":"Risk of second tumors and T-cell lymphoma after CAR T-cell therapy","volume":"390","author":"Hamilton","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0485","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1056\/NEJMoa2309728","article-title":"CAR+ T-cell lymphoma after cilta-cel therapy for relapsed or refractory myeloma","volume":"392","author":"Harrison","year":"2025","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.trecan.2026.03.002_bb0490","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41586-025-09212-7","article-title":"Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery","volume":"644","author":"Chen","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.03.002_bb0495","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1038\/s41467-022-29665-y","article-title":"Inducible and reversible RNA N6-methyladenosine editing","volume":"13","author":"Shi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.03.002_bb0500","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1093\/nar\/gkae110","article-title":"Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase","volume":"52","author":"Zhang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.trecan.2026.03.002_bb0505","article-title":"Programmable RNA acetylation with CRISPR\u2013Cas13","author":"Yu","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.trecan.2026.03.002_bb0510","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-025-02856-w","article-title":"Integrated epigenetic and genetic programming of primary human T cells","author":"Goudy","year":"2025","journal-title":"Nat. Biotechnol."}],"container-title":["Trends in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405803326000579?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405803326000579?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:08:57Z","timestamp":1785967737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405803326000579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":102,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2405803326000579"],"URL":"https:\/\/doi.org\/10.1016\/j.trecan.2026.03.002","relation":{},"ISSN":["2405-8033"],"issn-type":[{"value":"2405-8033","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic, epitranscriptomic, and metabolic control of T cell exhaustion","name":"articletitle","label":"Article Title"},{"value":"Trends in Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trecan.2026.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}