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Med."},{"key":"10.1016\/j.trecan.2026.04.009_bb0340","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1182\/blood-2005-11-4745","article-title":"Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML","volume":"107","author":"Falini","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2026.04.009_bb0345","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1158\/2159-8290.CD-22-0424","article-title":"Mutant NPM1 hijacks transcriptional hubs to maintain pathogenic gene programs in acute myeloid leukemia","volume":"13","author":"Wang","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.trecan.2026.04.009_bb0350","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1158\/2159-8290.CD-22-0366","article-title":"Mutant NPM1 directly regulates oncogenic transcription in acute myeloid leukemia","volume":"13","author":"Uckelmann","year":"2023","journal-title":"Cancer Discov."},{"key":"10.1016\/j.trecan.2026.04.009_bb0355","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1016\/j.cell.2025.10.010","article-title":"Disparate leukemia mutations converge on nuclear phase-separated condensates","volume":"188","author":"Datar","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.04.009_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112884","article-title":"Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1\/CRM1 and rearrangement of 3D genome structure","volume":"42","author":"Oka","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.trecan.2026.04.009_bb0365","article-title":"Phase separation of PML\/RAR\u03b1 and BRD4 coassembled microspeckles governs transcriptional dysregulation in acute promyelocytic leukemia","volume":"121","author":"Zhang","year":"2024","journal-title":"Proc. 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