{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:33:15Z","timestamp":1793745195323,"version":"4.6.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009844","name":"PA Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019992","name":"Australian Academy of Technology and Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001026","name":"National Breast Cancer Foundation","doi-asserted-by":"publisher","award":["#2023\/IIRS0063"],"award-info":[{"award-number":["#2023\/IIRS0063"]}],"id":[{"id":"10.13039\/501100001026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011302","name":"Children's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004176","name":"Miltenyi Biotec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001794","name":"University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018675","name":"Kids' Cancer Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021954","name":"Tour de Cure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cancer"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.trecan.2026.05.004","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:24:19Z","timestamp":1780658659000},"page":"695-698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pseudomyxoma peritonei and the microbiome: Emerging observations and unanswered questions"],"prefix":"10.1016","volume":"12","author":[{"given":"Jessica M.","family":"Grant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate E.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-8946","authenticated-orcid":false,"given":"Fernando","family":"Souza-Fonseca-Guimaraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trecan.2026.05.004_bb0005","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/j.ajpath.2025.08.005","article-title":"From theory to practice: a comprehensive review of pseudomyxoma peritonei research and its implications for future treatment","volume":"195","author":"Gao","year":"2025","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.trecan.2026.05.004_bb0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41568-024-00788-2","article-title":"Defining a \u2018cells to society\u2019 research framework for appendiceal tumours","volume":"25","author":"Holowatyj","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.trecan.2026.05.004_bb0015","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.18632\/oncotarget.3198","article-title":"Global gene expression in pseudomyxoma peritonei, with parallel development of two immortalized cell lines","volume":"6","author":"Roberts","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.trecan.2026.05.004_bb0020","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s13577-023-01015-0","article-title":"Establishment and characterization of NCC-PMP2-C1: a novel patient-derived cell line of pseudomyxoma peritonei with signet ring cells","volume":"37","author":"Noguchi","year":"2024","journal-title":"Hum. Cell"},{"key":"10.1016\/j.trecan.2026.05.004_bb0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1021\/jacs.4c09582","article-title":"Discovery of a chimeric polyketide family as cancer immunogenic chemotherapeutic leads","volume":"147","author":"Xue","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.trecan.2026.05.004_bb0030","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.ajpath.2014.03.004","article-title":"Orthotopic animal model of pseudomyxoma peritonei: an in vivo model to test anti-angiogenic drug effects","volume":"184","author":"Dohan","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.trecan.2026.05.004_bb0035","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41573-025-01211-7","article-title":"The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development","volume":"24","author":"Elkrief","year":"2025","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.trecan.2026.05.004_bb0040","first-page":"493","article-title":"Microbiome dysbiosis, neutrophil recruitment and mesenchymal transition of mesothelial cells promotes peritoneal metastasis of colorectal cancer","volume":"6","author":"Li","year":"2025","journal-title":"Nat. Can."},{"key":"10.1016\/j.trecan.2026.05.004_bb0045","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00366-12","article-title":"Microbial composition of human appendices from patients following appendectomy","volume":"4","author":"Guinane","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.trecan.2026.05.004_bb0050","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.ejso.2019.01.223","article-title":"Pre- and post-operative antibiotics in conjunction with cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC) should be considered for pseudomyxoma peritonei (PMP) treatment","volume":"45","author":"Merrell","year":"2019","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.trecan.2026.05.004_bb0055","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1073\/pnas.1006451107","article-title":"The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions","volume":"108 Suppl 1","author":"Johansson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.trecan.2026.05.004_bb0060","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.tips.2023.08.011","article-title":"Shearing of surface mucin saps tumor cell strength","volume":"44","author":"Greenberg","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.trecan.2026.05.004_bb0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.tips.2023.12.006","article-title":"Leveraging spatial omics for the development of precision sarcoma treatments","volume":"45","author":"Tu","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.trecan.2026.05.004_bb0070","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1038\/s41591-025-03957-4","article-title":"Microbial signals in primary and metastatic brain tumors","volume":"31","author":"Morad","year":"2025","journal-title":"Nat. Med."},{"key":"10.1016\/j.trecan.2026.05.004_bb0075","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1245\/s10434-025-16939-0","article-title":"The transcriptomic landscapes of appendiceal primary and metastatic tumors are distinct","volume":"32","author":"Park","year":"2025","journal-title":"Ann. Surg. Oncol."}],"container-title":["Trends in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240580332600107X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240580332600107X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:11:16Z","timestamp":1787429476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240580332600107X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S240580332600107X"],"URL":"https:\/\/doi.org\/10.1016\/j.trecan.2026.05.004","relation":{},"ISSN":["2405-8033"],"issn-type":[{"value":"2405-8033","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pseudomyxoma peritonei and the microbiome: Emerging observations and unanswered questions","name":"articletitle","label":"Article Title"},{"value":"Trends in Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trecan.2026.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}