{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:13:57Z","timestamp":1788383637099,"version":"build-2803163510"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001422","name":"American Society of Hematology Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.trecan.2026.08.002","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:41:56Z","timestamp":1788320516000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["RBM15 in leukemogenesis: an emerging regulator at the interface of RNA biology and hematopoiesis"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8957-0322","authenticated-orcid":false,"given":"Jether Amos","family":"Espinosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-0434","authenticated-orcid":false,"given":"Madeline Y.","family":"Mayday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-1945","authenticated-orcid":false,"given":"Abigail R.","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5567-8054","authenticated-orcid":false,"given":"Gina","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-6947","authenticated-orcid":false,"given":"Diane S.","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trecan.2026.08.002_bb0005","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cell.2012.06.032","article-title":"Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL","volume":"150","author":"Wen","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.08.002_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2017.53","article-title":"Acute lymphoblastic leukemia: a comprehensive review and 2017 update","volume":"7","author":"Terwilliger","year":"2017","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.trecan.2026.08.002_bb0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cbi.2012.01.007","article-title":"Perspectives on the causes of childhood leukemia","volume":"196","author":"Wiemels","year":"2012","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.trecan.2026.08.002_bb0020","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40364-024-00649-y","article-title":"Global, regional, and national burden of acute myeloid leukemia, 1990\u20132021: a systematic analysis for the global burden of disease study 2021","volume":"12","author":"Zhou","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.trecan.2026.08.002_bb0025","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(17)30186-9","article-title":"International incidence of childhood cancer, 2001\u201310: a population-based registry study","volume":"18","author":"Steliarova-Foucher","year":"2017","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0030","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/jcm4010127","article-title":"Pediatric AML: from biology to clinical management","volume":"4","author":"De Rooij","year":"2015","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.trecan.2026.08.002_bb0035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13045-020-00927-w","article-title":"RNA-binding proteins in tumor progression","volume":"13","author":"Qin","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0040","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1038\/s41467-024-47031-y","article-title":"Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma","volume":"15","author":"Zhou","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.08.002_bb0045","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1101\/gad.350314.122","article-title":"SPOC domain proteins in health and disease","volume":"37","author":"Appel","year":"2023","journal-title":"Genes Dev."},{"key":"10.1016\/j.trecan.2026.08.002_bb0050","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1101\/gad.266203","article-title":"A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling","volume":"17","author":"Ariyoshi","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.trecan.2026.08.002_bb0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.08.002_bb0060","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s10020-024-00965-x","article-title":"N6-methyladenosine and its epitranscriptomic effects on hematopoietic stem cell regulation and leukemogenesis","volume":"30","author":"Chang","year":"2024","journal-title":"Mol. Med."},{"key":"10.1016\/j.trecan.2026.08.002_bb0065","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.celrep.2019.07.032","article-title":"m6A RNA methylation maintains hematopoietic stem cell identity and symmetric commitment","volume":"28","author":"Cheng","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.trecan.2026.08.002_bb0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.stem.2020.01.005","article-title":"Post-transcriptional regulation of homeostatic, stressed, and malignant stem cells","volume":"26","author":"Chua","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.trecan.2026.08.002_bb0075","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.trecan.2026.08.002_bb0080","article-title":"RNA m6A modification plays a key role in maintaining stem cell function in normal and malignant hematopoiesis","volume":"9","author":"Wang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0085","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41568-025-00889-6","article-title":"N6-methyladenosine: an RNA modification as a central regulator of cancer","volume":"26","author":"Luo","year":"2026","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.trecan.2026.08.002_bb0090","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/jleuko\/qiad061","article-title":"The role of m6A mRNA modification in normal and malignant hematopoiesis","volume":"115","author":"Ma","year":"2024","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13045-021-01129-8","article-title":"N6-methyladenosine methyltransferases: functions, regulation, and clinical potential","volume":"14","author":"Huang","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0100","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1128\/MCB.01339-06","article-title":"Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation","volume":"27","author":"Ma","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0105","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1182\/blood-2009-01-197921","article-title":"c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development","volume":"114","author":"Niu","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2026.08.002_bb0110","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1073\/pnas.0609041104","article-title":"Ott1(Rbm15) has pleiotropic roles in hematopoietic development","volume":"104","author":"Raffel","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.trecan.2026.08.002_bb0115","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1182\/blood-2012-01-403089","article-title":"Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress","volume":"119","author":"Xiao","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2026.08.002_bb0120","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1182\/blood-2014-08-593392","article-title":"Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl","volume":"125","author":"Xiao","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2026.08.002_bb0125","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/90054","article-title":"Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia","volume":"28","author":"Ma","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.trecan.2026.08.002_bb0130","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1073\/pnas.101001498","article-title":"Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia","volume":"98","author":"Mercher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.trecan.2026.08.002_bb0135","doi-asserted-by":"crossref","first-page":"36915","DOI":"10.1074\/jbc.M608745200","article-title":"RNA-binding motif protein 15 binds to the RNA transport element RTE and provides a direct link to the NXF1 export pathway","volume":"281","author":"Lindtner","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0140","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.08.002_bb0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.trecan.2026.08.002_bb0150","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41467-023-35853-1","article-title":"The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators","volume":"14","author":"Appel","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.08.002_bb0155","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature19342","article-title":"m(6)A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.08.002_bb0160","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/s12276-024-01235-w","article-title":"The m6A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism","volume":"56","author":"Park","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.trecan.2026.08.002_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2025.108264","article-title":"Bioinformatic and experimental characterization of the RBM15 RNA binding protein","volume":"218","author":"Bose","year":"2026","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0170","doi-asserted-by":"crossref","first-page":"13109","DOI":"10.1074\/jbc.272.20.13109","article-title":"Two RNA-binding domains determine the RNA-binding specificity of nucleolin","volume":"272","author":"Serin","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1375942","article-title":"Exploring the role of m6A writer RBM15 in cancer: a systematic review","volume":"14","author":"Cao","year":"2024","journal-title":"Front. Oncol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0180","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-cellbio-100913-013325","article-title":"Liquid-liquid phase separation in biology","volume":"30","author":"Hyman","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0185","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1002\/pro.3718","article-title":"Features of molecular recognition of intrinsically disordered proteins via coupled folding and binding","volume":"28","author":"Yang","year":"2019","journal-title":"Protein Sci."},{"key":"10.1016\/j.trecan.2026.08.002_bb0190","doi-asserted-by":"crossref","first-page":"33292","DOI":"10.1074\/jbc.M113.500397","article-title":"Identification of Wilms\u2019 tumor 1-associating protein complex and its role in alternative splicing and the cell cycle","volume":"288","author":"Horiuchi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0195","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259594","article-title":"Nuclear speckles \u2013 a driving force in gene expression","volume":"135","author":"Faber","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.trecan.2026.08.002_bb0200","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq8381","article-title":"Sequence-based prediction of intermolecular interactions driven by disordered regions","volume":"388","author":"Ginell","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.08.002_bb0205","doi-asserted-by":"crossref","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.trecan.2026.08.002_bb0210","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/s41422-022-00725-8","article-title":"Cryo-EM structures of human m6A writer complexes","volume":"32","author":"Su","year":"2022","journal-title":"Cell Res."},{"key":"10.1016\/j.trecan.2026.08.002_bb0215","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbagrm.2018.09.008","article-title":"The m6A-methylase complex and mRNA export","volume":"1862","author":"Lesbirel","year":"2019","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.trecan.2026.08.002_bb0220","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1101\/gad.309146.117","article-title":"Zc3h13\/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15\/Spenito to the m6A machinery component Wtap\/Fl(2)d","volume":"32","author":"Knuckles","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.trecan.2026.08.002_bb0225","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.92537","article-title":"The catalytic mechanism of the RNA methyltransferase METTL3","volume":"12","author":"Corbeski","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.trecan.2026.08.002_bb0230","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature18298","article-title":"Structural basis of N6-adenosine methylation by the METTL3\u2013METTL14 complex","volume":"534","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.08.002_bb0235","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41422-018-0062-2","article-title":"Mettl3\u2013Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells","volume":"28","author":"Yao","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.trecan.2026.08.002_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3003386","article-title":"Why does the m6A writer complex require so many proteins?","volume":"23","author":"Pandey","year":"2025","journal-title":"PLoS Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0245","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1038\/s41467-021-23892-5","article-title":"Hakai is required for stabilization of core components of the m6A mRNA methylation machinery","volume":"12","author":"Bawankar","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.08.002_bb0250","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/s41467-021-22424-5","article-title":"Role of Hakai in m6A modification pathway in Drosophila","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.08.002_bb0255","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1093\/nar\/gkp782","article-title":"Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA","volume":"37","author":"Zolotukhin","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.trecan.2026.08.002_bb0260","doi-asserted-by":"crossref","first-page":"26106","DOI":"10.1074\/jbc.M109.040113","article-title":"The RNA-binding motif protein 15B (RBM15B\/OTT3) acts as cofactor of the nuclear export receptor NXF1","volume":"284","author":"Uranishi","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0265","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2018.07.020","article-title":"Structure and conformational dynamics of a COMPASS histone H3K4 methyltransferase complex","volume":"174","author":"Qu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.08.002_bb0270","article-title":"Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation","volume":"7","author":"Lee","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.trecan.2026.08.002_bb0275","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07938","article-title":"Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing","volume":"4","author":"Zhang","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.trecan.2026.08.002_bb0280","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500020RR","article-title":"Lactylation increases the stability of RBM15 to drives m6A modification in non-small-cell lung cancer cells","volume":"39","author":"Zhao","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.trecan.2026.08.002_bb0285","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s13238-019-0633-0","article-title":"New paradigms on hematopoietic stem cell differentiation","volume":"11","author":"Cheng","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.trecan.2026.08.002_bb0290","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.semcancer.2017.09.008","article-title":"Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis","volume":"51","author":"Langstein","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0295","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41590-024-01782-4","article-title":"An immunophenotype-coupled transcriptomic atlas of human hematopoietic progenitors","volume":"25","author":"Zhang","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0300","first-page":"2563","article-title":"PRMT1-RBM15 axis regulates megakaryocytic differentiation of human umbilical cord blood CD34+ cells","volume":"15","author":"Jin","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.trecan.2026.08.002_bb0305","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41556-019-0318-1","article-title":"Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation","volume":"21","author":"Lee","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0310","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1038\/s41467-019-12518-6","article-title":"N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis","volume":"10","author":"Kuppers","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.08.002_bb0315","article-title":"m6A modification: a double-edged sword in tumor development","volume":"11","author":"Gao","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0320","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1158\/2159-8290.CD-18-0959","article-title":"The biology of m6A RNA methylation in normal and malignant hematopoiesis","volume":"9","author":"Vu","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.trecan.2026.08.002_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100543","article-title":"MRTFA: a critical protein in normal and malignant hematopoiesis and beyond","volume":"296","author":"Reed","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0330","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1182\/blood-2008-09-180596","article-title":"Role for MKL1 in megakaryocytic maturation","volume":"113","author":"Cheng","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2026.08.002_bb0335","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1182\/blood-2012-04-420828","article-title":"MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation","volume":"120","author":"Smith","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2026.08.002_bb0340","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1182\/blood.2024027712","article-title":"RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and Wnt pathway activation","volume":"146","author":"Mayday","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.trecan.2026.08.002_bb0345","first-page":"852","article-title":"The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model","volume":"119","author":"Mercher","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.trecan.2026.08.002_bb0350","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.105318.3","article-title":"PRMT1-mediated metabolic reprogramming promotes leukemogenesis","volume":"14","author":"Su","year":"2025","journal-title":"Elife"},{"key":"10.1016\/j.trecan.2026.08.002_bb0355","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/s41467-019-09636-6","article-title":"MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation","volume":"10","author":"Hu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.08.002_bb0360","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature24678","article-title":"Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control","volume":"552","author":"Barbieri","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.08.002_bb0365","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.4416","article-title":"The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells","volume":"23","author":"Vu","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.trecan.2026.08.002_bb0370","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2017.11.016","article-title":"METTL14 inhibits hematopoietic stem\/progenitor differentiation and promotes leukemogenesis via mRNA m6A modification","volume":"22","author":"Weng","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.trecan.2026.08.002_bb0375","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41568-024-00763-x","article-title":"The present and future of the Cancer Dependency Map","volume":"25","author":"Arafeh","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.trecan.2026.08.002_bb0380","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ccell.2018.08.007","article-title":"Identification of chemotherapy-induced leukemic-regenerating cells reveals a transient vulnerability of human AML recurrence","volume":"34","author":"Boyd","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.trecan.2026.08.002_bb0385","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.3109\/10428194.2012.684350","article-title":"Biological effects of decreasing RBM15 on chronic myelogenous leukemia cells","volume":"53","author":"Yang","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.trecan.2026.08.002_bb0390","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1186\/s12887-024-05053-x","article-title":"TARGET based m6A methylation-related genes predict prognosis relapsed B-cell acute lymphoblastic leukemia","volume":"24","author":"Qiu","year":"2024","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.trecan.2026.08.002_bb0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175523","article-title":"Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1","volume":"12","author":"Jin","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.trecan.2026.08.002_bb0400","doi-asserted-by":"crossref","DOI":"10.1080\/15592294.2022.2160134","article-title":"m6A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia","volume":"18","author":"Liao","year":"2023","journal-title":"Epigenetics"},{"key":"10.1016\/j.trecan.2026.08.002_bb0405","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41556-023-01213-w","article-title":"RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation","volume":"25","author":"Dou","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0410","doi-asserted-by":"crossref","first-page":"26820","DOI":"10.1074\/jbc.M802315200","article-title":"Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity","volume":"283","author":"Sawada","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0415","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41420-021-00703-w","article-title":"RBM15 promotes hepatocellular carcinoma progression by regulating N6-methyladenosine modification of YES1 mRNA in an IGF2BP1-dependent manner","volume":"7","author":"Cai","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.trecan.2026.08.002_bb0420","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s41065-025-00534-0","article-title":"RBM15 enhances paclitaxel resistance in triple-negative breast cancer by targeting m6A methylation of TNFSF9 and inducing polarization of tumor-associated macrophages to M2 phenotype","volume":"162","author":"Fu","year":"2025","journal-title":"Hereditas"},{"key":"10.1016\/j.trecan.2026.08.002_bb0425","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1021\/acs.jmedchem.2c01601","article-title":"METTL3 from target validation to the first small-molecule inhibitors: a medicinal chemistry journey","volume":"66","author":"Fiorentino","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0430","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/s41586-021-03536-w","article-title":"Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia","volume":"593","author":"Yankova","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.08.002_bb0435","article-title":"Targeting METTL3 protein by proteolysis-targeting chimeras: a novel therapeutic approach for acute myeloid leukemia","volume":"12","author":"Nar","year":"2025","journal-title":"Genes Dis."},{"key":"10.1016\/j.trecan.2026.08.002_bb0440","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.1c00773","article-title":"1,4,9-Triazaspiro[5.5]undecan-2-one derivatives as potent and selective METTL3 Inhibitors","volume":"64","author":"Dolbois","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.trecan.2026.08.002_bb0445","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.chembiol.2023.12.009","article-title":"Discovery of a PROTAC degrader for METTL3-METTL14 complex","volume":"31","author":"Du","year":"2024","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.trecan.2026.08.002_bb0450","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41392-020-00361-x","article-title":"Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy","volume":"5","author":"Carter","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.trecan.2026.08.002_bb0455","doi-asserted-by":"crossref","first-page":"20224","DOI":"10.1073\/pnas.1314239110","article-title":"Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974","volume":"110","author":"Liu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.trecan.2026.08.002_bb0460","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s10637-019-00824-1","article-title":"A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer","volume":"38","author":"Davis","year":"2020","journal-title":"Investig. New Drugs"},{"key":"10.1016\/j.trecan.2026.08.002_bb0465","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10549-020-05817-w","article-title":"Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer","volume":"184","author":"Diamond","year":"2020","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.trecan.2026.08.002_bb0470","doi-asserted-by":"crossref","first-page":"11717","DOI":"10.1073\/pnas.1120068109","article-title":"Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors","volume":"109","author":"Gurney","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.trecan.2026.08.002_bb0475","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.08.002_bb0480","doi-asserted-by":"crossref","DOI":"10.1021\/jacsau.4c00040","article-title":"Proteolysis targeting chimera degraders of the METTL3-14 m6A-RNA methyltransferase","volume":"4","author":"Errani","year":"2024","journal-title":"JACS Au"},{"key":"10.1016\/j.trecan.2026.08.002_bb0485","doi-asserted-by":"crossref","DOI":"10.1126\/science.adr8063","article-title":"Design of intrinsically disordered region binding proteins","volume":"389","author":"Wu","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.trecan.2026.08.002_bb0490","doi-asserted-by":"crossref","first-page":"7917","DOI":"10.1038\/s41467-024-52146-3","article-title":"Comprehensive detection and characterization of human druggable pockets through binding site descriptors","volume":"15","author":"Comajuncosa-Creus","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trecan.2026.08.002_bb0495","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev-pharmtox-010611-134525","article-title":"Drugs for allosteric sites on receptors","volume":"54","author":"Wenthur","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["Trends in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240580332600186X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S240580332600186X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:15:30Z","timestamp":1788380130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S240580332600186X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":99,"alternative-id":["S240580332600186X"],"URL":"https:\/\/doi.org\/10.1016\/j.trecan.2026.08.002","relation":{},"ISSN":["2405-8033"],"issn-type":[{"value":"2405-8033","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RBM15 in leukemogenesis: an emerging regulator at the interface of RNA biology and hematopoiesis","name":"articletitle","label":"Article Title"},{"value":"Trends in Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trecan.2026.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}