{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:37:17Z","timestamp":1792816637823,"version":"4.5.0"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Cancer"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.trecan.2026.10.004","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:48:01Z","timestamp":1792813681000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide human T cell screens: barriers and design"],"prefix":"10.1016","author":[{"given":"Jie","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9448-7718","authenticated-orcid":false,"given":"Lianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trecan.2026.10.004_bb0005","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2024.19462","article-title":"CAR T cells and T-cell therapies for cancer: a translational science review","volume":"332","author":"Brudno","year":"2024","journal-title":"Jama"},{"key":"10.1016\/j.trecan.2026.10.004_bb0010","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.trecan.2024.11.011","article-title":"Turning cold into hot: emerging strategies to fire up the tumor microenvironment","volume":"11","author":"Ma","year":"2025","journal-title":"Trends Cancer"},{"key":"10.1016\/j.trecan.2026.10.004_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adz0348","article-title":"Citraconate preserves T cell stemness and antitumor immunity","volume":"11","author":"Li","year":"2026","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.trecan.2026.10.004_bb0020","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-026-10906-9","article-title":"In vivo genome-wide CRISPR screens of human T cells in solid tumours","author":"Liu","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.10.004_bb0025","article-title":"CRISPR screens identify targets to rescue age-related T cell dysfunction in cancer","author":"Chen","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.10.004_bb0030","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s42255-025-01233-w","article-title":"A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours","volume":"7","author":"Pretto","year":"2025","journal-title":"Nat. Metab."},{"key":"10.1016\/j.trecan.2026.10.004_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2026.08.002","article-title":"Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits","author":"Zhu","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.10.004_bb0040","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41586-025-09926-8","article-title":"The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction","volume":"651","author":"Cheng","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.trecan.2026.10.004_bb0045","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.cell.2025.12.049","article-title":"Hallmarks of cancer\u2014then and now, and beyond","volume":"189","author":"Hanahan","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.trecan.2026.10.004_bb0050","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/s41590-025-02389-z","article-title":"Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy","volume":"27","author":"Conti","year":"2026","journal-title":"Nat. Immunol."}],"container-title":["Trends in Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405803326002384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2405803326002384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:48:03Z","timestamp":1792813683000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2405803326002384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"alternative-id":["S2405803326002384"],"URL":"https:\/\/doi.org\/10.1016\/j.trecan.2026.10.004","relation":{},"ISSN":["2405-8033"],"issn-type":[{"value":"2405-8033","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide human T cell screens: barriers and design","name":"articletitle","label":"Article Title"},{"value":"Trends in Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trecan.2026.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}