{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:59:03Z","timestamp":1792479543337,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSII5183550"],"award-info":[{"award-number":["CRSII5183550"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["APP23835"],"award-info":[{"award-number":["APP23835"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["EP\/X033015\/1"],"award-info":[{"award-number":["EP\/X033015\/1"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends Open"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.treopn.2026.05.007","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:55:36Z","timestamp":1782820536000},"page":"215-226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["T cells are blind to the dark mechanics of tumors"],"prefix":"10.1016","volume":"1","author":[{"given":"Marco","family":"Fritzsche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.treopn.2026.05.007_bb0005","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41577-021-00507-0","article-title":"The spatio-temporal control of effector T cell migration","volume":"21","author":"Fowell","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0010","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature16985","article-title":"Visualization of immediate immune responses to pioneer metastatic cells in the lung","volume":"531","author":"Headley","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.treopn.2026.05.007_bb0015","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.trecan.2017.09.006","article-title":"Migrating into the tumor: a roadmap for T cells","volume":"3","author":"Woude","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.treopn.2026.05.007_bb0020","doi-asserted-by":"crossref","first-page":"533A","DOI":"10.1016\/j.bpj.2022.11.2828","article-title":"Mechanoimmunological control of metastatic site selection","volume":"122","author":"Elbanna","year":"2023","journal-title":"Biophys. J."},{"key":"10.1016\/j.treopn.2026.05.007_bb0025","article-title":"Mechanoimmunological control of metastatic site selection","author":"Elbanna","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.treopn.2026.05.007_bb0030","first-page":"311","article-title":"Obstacles posed by the tumor microenvironment to T cell activity: a case for synergistic therapies","volume":"33","author":"Anderson","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.treopn.2026.05.007_bb0035","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nnano.2012.167","article-title":"The nanomechanical signature of breast cancer","volume":"7","author":"Plodinec","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0040","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58688","article-title":"Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment","volume":"10","author":"Nicolas-Boluda","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.treopn.2026.05.007_bb0045","first-page":"469","article-title":"Forces in the tumor microenvironment: insights into stromal mechanics","volume":"21","author":"Chaudhuri","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0050","first-page":"36","article-title":"Discrimination of cancerous cells using viscoelastic properties","volume":"116","author":"Lee","year":"2019","journal-title":"Biophys. J."},{"key":"10.1016\/j.treopn.2026.05.007_bb0055","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/boc.201600078","article-title":"Are cancer cells really softer than normal cells?","volume":"109","author":"Alibert","year":"2017","journal-title":"Biol. Cell"},{"key":"10.1016\/j.treopn.2026.05.007_bb0060","first-page":"192","article-title":"Viscoelastic properties of normal and cancerous human breast cells are affected differently by contact to adjacent cells","volume":"106","author":"Schierbaum","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.treopn.2026.05.007_bb0065","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/s41567-022-01755-0","article-title":"Rigid tumours contain soft cancer cells","volume":"18","author":"Fuhs","year":"2022","journal-title":"Nat. Phys."},{"key":"10.1016\/j.treopn.2026.05.007_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1162880","article-title":"Characterizing viscoelastic properties of human melanoma tissue using Prony series","volume":"11","author":"Park","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.162","article-title":"T-cell exhaustion in the tumor microenvironment","volume":"6","author":"Jiang","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.treopn.2026.05.007_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103941","article-title":"Improving CAR-T immunotherapy: overcoming the challenges of T cell exhaustion","volume":"77","author":"Gumber","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.treopn.2026.05.007_bb0085","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41577-024-01053-1","article-title":"Stiff tumours exhaust T cells","volume":"24","author":"Bird","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0090","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/s41551-021-00826-6","article-title":"Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy","volume":"5","author":"Lei","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.treopn.2026.05.007_bb0095","first-page":"123","article-title":"Mechanoregulation of lymphocyte cytotoxicity","volume":"23","author":"Huse","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0100","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1603032","article-title":"Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation","volume":"3","author":"Fritzsche","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.treopn.2026.05.007_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3118","article-title":"Visualizing dynamic microvillar search and stabilization during ligand detection by T cells","volume":"356","author":"Cai","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.treopn.2026.05.007_bb0110","first-page":"31073","article-title":"The \u03b1\u03b2 T cell receptor is an anisotropic mechanosensor","volume":"287","author":"Kim","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.treopn.2026.05.007_bb0115","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1073\/pnas.1424829112","article-title":"Force-dependent transition in the T-cell receptor \u03b2-subunit allosterically regulates peptide discrimination and pMHC bond lifetime","volume":"112","author":"Das","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.treopn.2026.05.007_bb0120","doi-asserted-by":"crossref","first-page":"E8204","DOI":"10.1073\/pnas.1703559114","article-title":"Mechanosensing drives acuity of \u03b1\u03b2 T-cell recognition","volume":"114","author":"Feng","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.treopn.2026.05.007_bb0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023050118","article-title":"Molecular design of the \u03b3\u03b4 T cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing","volume":"118","author":"Mallis","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.treopn.2026.05.007_bb0130","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1073\/pnas.71.10.4135","article-title":"Kinetic proofreading: a new mechanism for reducing errors in biosynthetic processes requiring high specificity","volume":"71","author":"Hopfield","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.treopn.2026.05.007_bb0135","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1073\/pnas.92.11.5042","article-title":"Kinetic proofreading in T-cell receptor signal transduction","volume":"92","author":"McKeithan","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.treopn.2026.05.007_bb0140","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75263","article-title":"Progressive enhancement of kinetic proofreading in T cell antigen discrimination from receptor activation to DAG generation","volume":"11","author":"Britain","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.treopn.2026.05.007_bb0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tibs.2017.11.008","article-title":"TCR signaling: mechanisms of initiation and propagation","volume":"43","author":"Courtney","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.treopn.2026.05.007_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/science.abl5282","article-title":"Tuning T cell receptor sensitivity through catch bond engineering","volume":"376","author":"Zhao","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.treopn.2026.05.007_bb0155","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.aaa4971","article-title":"Neoantigens in cancer immunotherapy","volume":"348","author":"Schumacher","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.treopn.2026.05.007_bb0160","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.aar7112","article-title":"Personalized vaccines for cancer immunotherapy","volume":"359","author":"Sahin","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.treopn.2026.05.007_bb0165","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41571-024-00860-8","article-title":"Harnessing neoantigen-specific T cells for precision cancer immunotherapy","volume":"21","author":"Donia","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0170","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrc3670","article-title":"Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy","volume":"14","author":"Coulie","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.treopn.2026.05.007_bb0175","first-page":"5513","article-title":"Tumor antigens preferentially derive from unmutated genomic sequences in melanoma and non-small cell lung cancer","volume":"13","author":"Apavaloaei","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.treopn.2026.05.007_bb0180","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41577-023-00970-x","article-title":"Therapeutic induction of antigen-specific immune tolerance","volume":"24","author":"Kenison","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0185","first-page":"351","article-title":"Assumptions of the tumor \u2018escape\u2019 hypothesis","volume":"13","author":"Restifo","year":"2003","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0190","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.treopn.2026.05.007_bb0195","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc2544","article-title":"A tense situation: forcing tumour progression","volume":"9","author":"Butcher","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.treopn.2026.05.007_bb0200","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4049\/jimmunol.1701413","article-title":"Hitting the target: how T cells detect and eliminate tumors","volume":"200","author":"Zamora","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0205","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nrc3080","article-title":"The physics of cancer: the role of physical interactions and mechanical forces in metastasis","volume":"11","author":"Wirtz","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.treopn.2026.05.007_bb0210","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41556-018-0131-2","article-title":"Mechanisms and impact of altered tumour mechanics","volume":"20","author":"Mohammadi","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0215","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.treopn.2026.05.007_bb0220","article-title":"Self organisation of invasive breast cancer driven by the interplay of active and passive nematic dynamics","author":"Gottheil","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.treopn.2026.05.007_bb0225","article-title":"Gliomas organize as liquid crystals: three-dimensional nematic order, disclinations and quasi-long-range order","author":"Argento","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.treopn.2026.05.007_bb0230","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.15252\/embr.201439246","article-title":"The extracellular matrix modulates the hallmarks of cancer","volume":"15","author":"Pickup","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.treopn.2026.05.007_bb0235","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm3902","article-title":"Extracellular matrix assembly: a multiscale deconstruction","volume":"15","author":"Mouw","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0240","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1091\/mbc.E18-05-0319","article-title":"Cancer cells\u2019 ability to mechanically adapt to the matrix stiffness correlates with their invasive potential","volume":"29","author":"Wullkopf","year":"2018","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.treopn.2026.05.007_bb0245","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri.2017.74","article-title":"Mechanical forces in the immune system","volume":"17","author":"Huse","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0250","first-page":"528","article-title":"Mapping the stochastic sequence of individual ligand-receptor binding events to cellular activation: TCR-pMHC binding dynamics in T cell activation","volume":"9","author":"Lin","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.treopn.2026.05.007_bb0255","article-title":"TCR-pMHC kinetics under force in a cell-free system show allosteric regulation by the CD8 co-receptor","volume":"8","author":"Limozin","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.treopn.2026.05.007_bb0260","article-title":"Mechanical forces impair antigen discrimination by reducing differences in T-cell receptor\/peptide\u2013MHC off-rates","volume":"42","author":"Pettmann","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.treopn.2026.05.007_bb0265","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2215694120","article-title":"Harnessing \u03b1\u03b2 T cell receptor mechanobiology to achieve the promise of immuno-oncology","volume":"120","author":"Reinherz","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.treopn.2026.05.007_bb0270","doi-asserted-by":"crossref","first-page":"L5","DOI":"10.1016\/j.bpj.2011.12.011","article-title":"Mechanosensing in T lymphocyte activation","volume":"102","author":"Judokusumo","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.treopn.2026.05.007_bb0275","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2404748121","article-title":"Mechanical force matters in early T cell activation","volume":"121","author":"Fritzsche","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.treopn.2026.05.007_bb0280","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41423-019-0273-6","article-title":"TCR\u2013pMHC bond conformation controls TCR ligand discrimination","volume":"17","author":"Sasmal","year":"2020","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0285","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cell.2014.02.053","article-title":"Antigen-specific TCR\u2013pMHC catch bonds trigger signaling by fast accumulation of force-prolonged bond lifetimes","volume":"157","author":"Liu","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.treopn.2026.05.007_bb0290","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nature08746","article-title":"TCR\u2013peptide\u2013MHC interactions in situ show accelerated kinetics and increased affinity","volume":"463","author":"Huppa","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.treopn.2026.05.007_bb0295","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.immuni.2013.08.036","article-title":"A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+ T cells","volume":"39","author":"Huang","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.treopn.2026.05.007_bb0300","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1126\/science.347575","article-title":"Models for the specific adhesion of cells to cells","volume":"200","author":"Bell","year":"1978","journal-title":"Science"},{"key":"10.1016\/j.treopn.2026.05.007_bb0305","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1126\/science.1137592","article-title":"Forces and bond dynamics in cell adhesion","volume":"316","author":"Evans","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.treopn.2026.05.007_bb0315","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.molcel.2018.12.018","article-title":"Mechano-regulation of peptide-MHC class I conformations determines TCR antigen recognition","volume":"73","author":"Wu","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.treopn.2026.05.007_bb0320","first-page":"1311","article-title":"Actin kinetics shapes cortical network structure and mechanics","volume":"18","author":"Fritzsche","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0325","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.67092","article-title":"The discriminatory power of the T cell receptor","volume":"10","author":"Pettmann","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.treopn.2026.05.007_bb0330","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1074\/jbc.M009580200","article-title":"T cell receptor binding to a pMHCII ligand is kinetically distinct from and independent of CD4","volume":"276","author":"Xiong","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.treopn.2026.05.007_bb0335","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s42254-024-00707-2","article-title":"Mechanical properties of human tumour tissues and their implications for cancer development","volume":"4","author":"Massey","year":"2024","journal-title":"Nat. Rev. Phys."},{"key":"10.1016\/j.treopn.2026.05.007_bb0340","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s44341-024-00007-x","article-title":"Mechanical signatures in cancer metastasis","volume":"2","author":"Agrawal","year":"2025","journal-title":"NPJ Biol. Phys. Mech."},{"key":"10.1016\/j.treopn.2026.05.007_bb0345","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1039\/D4NA00003J","article-title":"Cytoplasmic viscosity is a potential biomarker for metastatic breast cancer cells","volume":"6","author":"Dessard","year":"2024","journal-title":"Nanoscale Adv."},{"key":"10.1016\/j.treopn.2026.05.007_bb0350","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1039\/D4TB02334J","article-title":"The effect of microenvironmental viscosity on the emergence of colon cancer cell resistance to doxorubicin","volume":"13","author":"Zeng","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.treopn.2026.05.007_bb0355","first-page":"165","article-title":"The immunological synapse","volume":"9","author":"Dustin","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0365","first-page":"2160","article-title":"Astigmatic traction force microscopy (aTFM)","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.treopn.2026.05.007_bb0370","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1038\/s41467-021-22377-9","article-title":"Two-dimensional TIRF-SIM\u2013tractionforce microscopy (2D TIRF-SIM-TFM)","volume":"12","author":"Barbieri","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.treopn.2026.05.007_bb0375","doi-asserted-by":"crossref","first-page":"7577","DOI":"10.1038\/s41467-025-62104-2","article-title":"CD4+T-cells create a stable mechanical environment for force-sensitive TCR:pMHC interactions","volume":"16","author":"Schrangl","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.treopn.2026.05.007_bb0380","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.bpj.2022.04.039","article-title":"Cancer as a biophysical disease: targeting the mechanical-adaptability program","volume":"121","author":"Nguyen","year":"2022","journal-title":"Biophys. J."},{"key":"10.1016\/j.treopn.2026.05.007_bb0385","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4049\/jimmunol.2300141","article-title":"What\u2019s the catch? the significance of catch bonds in T cell activation","volume":"211","author":"Faust","year":"2023","journal-title":"J. Immunol."},{"key":"10.1016\/j.treopn.2026.05.007_bb0390","doi-asserted-by":"crossref","DOI":"10.1126\/science.adx3162","article-title":"Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering","volume":"391","author":"Chen","year":"2026","journal-title":"Science"}],"container-title":["Trends Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3117347026000295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3117347026000295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:14:10Z","timestamp":1789053250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3117347026000295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S3117347026000295"],"URL":"https:\/\/doi.org\/10.1016\/j.treopn.2026.05.007","relation":{},"ISSN":["3117-3470"],"issn-type":[{"value":"3117-3470","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T cells are blind to the dark mechanics of tumors","name":"articletitle","label":"Article Title"},{"value":"Trends Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.treopn.2026.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}