{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:12:20Z","timestamp":1782850340335,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.trim.2021.101482","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T22:09:49Z","timestamp":1634335789000},"page":"101482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?"],"prefix":"10.1016","volume":"69","author":[{"given":"Mepur H.","family":"Ravindranath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Filippone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly J.","family":"Amato-Menker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A.","family":"Arosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ballabh","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen J.","family":"Norin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trim.2021.101482_bb0005","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1111\/j.1600-6143.2004.00360.x","article-title":"Predicting kidney graft failure by HLA antibodies: a prospective trial","volume":"4","author":"Terasaki","year":"2004","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2021.101482_bb0010","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.coi.2005.07.018","article-title":"Humoral theory of transplantation: further evidence","volume":"17","author":"Terasaki","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.trim.2021.101482_bb0015","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1600-6143.2006.01644.x","article-title":"Four-year follow-up of a prospective trial of HLA and MICA antibodies on kidney graft survival","volume":"7","author":"Terasaki","year":"2007","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2021.101482_bb0020","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/TP.0b013e31817c4cb8","article-title":"Human leukocyte antigen antibodies and chronic rejection: From association to causation","volume":"86","author":"Terasaki","year":"2008","journal-title":"Transplantation"},{"issue":"5","key":"10.1016\/j.trim.2021.101482_bb0025","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/TP.0b013e3181837626","article-title":"Transplant glomerulopathy: risk and prognosis related to anti-human leukocyte antigen class II antibody level","volume":"86","author":"Issa","year":"2008","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.trim.2021.101482_bb0030","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1097\/TP.0b013e3181a44206","article-title":"Anti-human leukocyte antigen and donor-specific antibodies detected by Luminex post transplant serve as biomarkers for chronic rejection of renal grafts","volume":"87","author":"Lachmann","year":"2009","journal-title":"Transplantation."},{"issue":"1","key":"10.1016\/j.trim.2021.101482_bb0035","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/TP.0000000000000840","article-title":"Evidence to support a contribution of polyreactive antibodies to HLA serum reactivity","volume":"100","author":"Gao","year":"2016","journal-title":"Transplantation."},{"key":"10.1016\/j.trim.2021.101482_bb0040","article-title":"Clinical relevance of HLA antibodies in kidney transplantation: recent data from the Heidelberg transplant center and the collaborative transplant study","volume":"5619402","author":"S\u00fcsal","year":"2017","journal-title":"J Immunol Res"},{"key":"10.1016\/j.trim.2021.101482_bb0045","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/TP.0b013e3182100f77","article-title":"No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing: a collaborative transplant study report","volume":"91","author":"Susal","year":"2011","journal-title":"Transplantation."},{"key":"10.1016\/j.trim.2021.101482_bb0050","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.humimm.2011.08.001","article-title":"Heart transplantation with donor-specific antibodies directed toward denatured HLA a*02:01: a case report","volume":"72","author":"Poli","year":"2011","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.trim.2021.101482_bb0055","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.humimm.2011.02.012","article-title":"Donor-specific antibody against denatured HLA-A1: clinically nonsignificant?","volume":"72","author":"Pereira","year":"2011","journal-title":"Hum. Immunol."},{"issue":"6","key":"10.1016\/j.trim.2021.101482_bb0060","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.humimm.2016.04.010","article-title":"Clinically-relevant threshold of preformed donor-specific anti-HLA antibodies in kidney transplantation","volume":"77","author":"Salvad\u00e9","year":"2016","journal-title":"Hum. Immunol."},{"issue":"10","key":"10.1016\/j.trim.2021.101482_bb0065","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1093\/ndt\/gfy088","article-title":"The disappointing contribution of antihuman leukocyte antigen donor-specific antibodies characteristics for predicting allograft loss","volume":"33","author":"Courant","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"issue":"9","key":"10.1016\/j.trim.2021.101482_bb0070","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1681\/ASN.2018020205","article-title":"Pretransplant C3d-fixing donor-specific anti-HLA antibodies are not associated with increased risk for kidney graft failure","volume":"29","author":"Kamburova","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.trim.2021.101482_bb0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.21037\/hbsn.2019.01.01","article-title":"Detecting donor-specific antibodies: the importance of sorting the wheat from the chaff","volume":"8","author":"McCaughan","year":"2019","journal-title":"Hepatobiliary Surg Nutr."},{"key":"10.1016\/j.trim.2021.101482_bb0080","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3389\/fimmu.2016.00665","article-title":"Divide, conquer, and sense: CD8+CD28- T cell in perspective","volume":"7","author":"Arosa","year":"2017","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.trim.2021.101482_bb0085","doi-asserted-by":"crossref","first-page":"9738","DOI":"10.3390\/ijms22189738","article-title":"Open MHC class I conformers: a look through the looking glass","volume":"22","author":"Arosa","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.trim.2021.101482_bb0090","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1084\/jem.171.5.1431","article-title":"(1990) activated human T lymphocytes express MHC class I heavy chains not associated with beta 2 microglobulin","volume":"171","author":"Schnabl","year":"1990","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.trim.2021.101482_bb0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0092-8674(90)90020-F","article-title":"Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro","volume":"62","author":"Schumacher","year":"1990","journal-title":"Cell."},{"issue":"6321","key":"10.1016\/j.trim.2021.101482_bb0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/351074a0","article-title":"Peptide binding to empty HLA-B27 molecules of viable human cells","volume":"351","author":"Benjamin","year":"1991","journal-title":"Nature."},{"key":"10.1016\/j.trim.2021.101482_bb0105","series-title":"Leukocyte Typing IV","first-page":"511","article-title":"LA45, an activation-induced human lymphocyte antigen with strong homology to MHC class I molecules","author":"Majdic","year":"1989"},{"issue":"5","key":"10.1016\/j.trim.2021.101482_bb0110","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1084\/jem.174.5.1085","article-title":"Molecular definition of a polymorphic antigen (LA45) of free HLA-A and -B heavy chains found on the surfaces of activated B and T cells","volume":"174","author":"Madrigal","year":"1991","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.trim.2021.101482_bb0115","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/rheumatology\/kel305","article-title":"Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathological roles","volume":"45","author":"Raine","year":"2006","journal-title":"Rheumatology. (Oxford)"},{"issue":"9","key":"10.1016\/j.trim.2021.101482_bb0120","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00277-018-3332-7","article-title":"Distinctive CD8+ T cell and MHC class I signatures in polycythemia vera patients","volume":"97","author":"Cardoso","year":"2018","journal-title":"Ann. Hematol."},{"issue":"51","key":"10.1016\/j.trim.2021.101482_bb0125","doi-asserted-by":"crossref","first-page":"53062","DOI":"10.1074\/jbc.M408794200","article-title":"Misfolding of major histo- compatibility complex class I molecules in activated T cells allows cis-interactions with receptors and signaling molecules and is associated with tyrosine phosphorylation","volume":"279","author":"Santos","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.trim.2021.101482_bb0130","doi-asserted-by":"crossref","first-page":"15050","DOI":"10.1073\/pnas.96.26.15050","article-title":"Abundant empty class II MHC molecules on the surface of immature dendritic cells","volume":"96","author":"Santambrogio","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.trim.2021.101482_bb0135","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.4049\/jimmunol.1300080","article-title":"HLA-F and MHC-I open conformers cooperate in an MHC-I antigen cross-presentation pathway","volume":"191","author":"Goodridge","year":"2013","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.trim.2021.101482_bb0140","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/TP.0b013e3181ac6198","article-title":"Intact HLA not beta2m-free heavy chain-specific HLA class I antibodies are predictive of graft failure","volume":"88","author":"Cai","year":"2009","journal-title":"Transplantation."},{"issue":"3","key":"10.1016\/j.trim.2021.101482_bb0145","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/cei.12127","article-title":"The significance of pretransplant donor-specific antibodies reactive with intact or denatured human leucocyte antigen in kidney transplantation","volume":"173","author":"Otten","year":"2013","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.trim.2021.101482_bb0150","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.humimm.2015.09.012","article-title":"Evaluation of the iBeads assay as a tool for identifying class I HLA antibodies","volume":"76","author":"Visentin","year":"2015","journal-title":"Hum. Immunol."},{"issue":"7","key":"10.1016\/j.trim.2021.101482_bb0155","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1002\/eji.201445340","article-title":"Deciphering allogeneic antibody response against native and denatured HLA epitopes in organ transplantation","volume":"45","author":"Visentin","year":"2015","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.trim.2021.101482_bb0160","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/TP.0000000000001420","article-title":"Conformational variants of the individual HLA-I antigens on Luminex single antigen beads used in monitoring HLA antibodies: problems and solutions","volume":"101","author":"Jucaud","year":"2017","journal-title":"Transplantation."},{"issue":"3","key":"10.1016\/j.trim.2021.101482_bb0165","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1423-0410.2010.01420.x","article-title":"Prevalence of leucocyte antibodies in the Dutch donor population","volume":"100","author":"Middelburg","year":"2011","journal-title":"Vox Sang."},{"issue":"1","key":"10.1016\/j.trim.2021.101482_bb0170","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.transproceed.2011.12.049","article-title":"Effects of different sensitization events on HLA alloimmunization in solid organ transplantation patients","volume":"44","author":"Hyun","year":"2012","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.trim.2021.101482_bb0175","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/tan.12095","article-title":"Direct binding to antigen-coated beads refines the specificity and cross-reactivity of four monoclonal antibodies that recognize polymorphic epitopes of HLA class I molecules","volume":"81","author":"Hilton","year":"2013","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.trim.2021.101482_bb0180","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3343\/alm.2015.35.3.321","article-title":"Inter laboratory comparison of the results of Lifecodes a class I and class II single antigen kits for human leukocyte antigen antibody detection","volume":"35","author":"Oh","year":"2015","journal-title":"Ann Lab Med."},{"issue":"6","key":"10.1016\/j.trim.2021.101482_bb0185","first-page":"636","article-title":"Anti-HLA antibodies testing on solid phase: comparative evaluation of different kit vendors T\\through luminex technology","volume":"15","author":"Minucci","year":"2017","journal-title":"Exp. Clin. Transplant."},{"issue":"9","key":"10.1016\/j.trim.2021.101482_bb0190","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/ajt.14709","article-title":"Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant","volume":"18","author":"Kamburova","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2021.101482_bb0195","first-page":"390","article-title":"Cytotoxic antibodies\u2014valuable prognostic factor for long term kidney allograft survival","volume":"3","author":"Moise","year":"2010","journal-title":"J Med Life."},{"key":"10.1016\/j.trim.2021.101482_bb0200","first-page":"473","article-title":"Comparative evaluation of ELISA and Luminex panel reactive antibody assays for HLA alloantibody screening","volume":"29","author":"Jung","year":"2009","journal-title":"Korean J Lab Med."},{"key":"10.1016\/j.trim.2021.101482_bb0205","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/ajt.14201","article-title":"Prozone effect can be specific to single antigen bead kit manufacturers","volume":"17","author":"Battle","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2021.101482_bb0210","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1097\/TXD.0000000000000734","article-title":"Comparative assessment of anti- HLA antibodies using two commercially available luminex-based assays","volume":"3","author":"Clerkin","year":"2017","journal-title":"Transplant Direct"},{"issue":"3","key":"10.1016\/j.trim.2021.101482_bb0215","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/TP.0000000000002351","article-title":"Comparison of two Luminex single-antigen bead flow Cytometry assays for detection of donor-specific antibodies after renal transplantation","volume":"103","author":"Bertrand","year":"2019","journal-title":"Transplantation."},{"key":"10.1016\/j.trim.2021.101482_bb0220","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jim.2018.07.008","volume":"460","author":"Ravindranath","year":"2018","journal-title":"J Immunol Methods."},{"issue":"10","key":"10.1016\/j.trim.2021.101482_bb0225","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.humimm.2013.06.035","article-title":"Antibodies against denatured HLA class II molecules detected in Luminex-single antigen assay","volume":"74","author":"Grenzi","year":"2013","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.trim.2021.101482_bb0230","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/tan.12775","article-title":"Many de novo donor specific antibodies recognize \u03b22 -microglobulin-free, but not intact HLA heterodimers","volume":"87","author":"Michel","year":"2016","journal-title":"HLA."},{"issue":"8","key":"10.1016\/j.trim.2021.101482_bb0235","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1111\/ajt.12332","article-title":"Influence of test technique on sensitization status of patients on the kidney transplant waiting list","volume":"13","author":"Gombos","year":"2013","journal-title":"Am. J. Transplant."},{"issue":"11","key":"10.1016\/j.trim.2021.101482_bb0240","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.4049\/jimmunol.1700050","volume":"198","author":"Ravindranath","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.trim.2021.101482_bb0245","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1084\/jem.132.2.211","article-title":"An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for antibody complementarity","volume":"132","author":"Wu","year":"1970","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.trim.2021.101482_bb0250","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/ajt.12287","article-title":"Comprehensive assessment and standardization of solid phase multiplex-bead arrays for the detection of antibodies to HLA","volume":"13","author":"Reed","year":"2013","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2021.101482_bb0255","first-page":"413","article-title":"Immunoglobulin G subclass analysis of HLA donor specific antibodies in heart and renal transplant recipients","volume":"2013","author":"Cicciarelli","year":"2013","journal-title":"Clin. Transpl."},{"issue":"10","key":"10.1016\/j.trim.2021.101482_bb0260","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.humimm.2013.06.027","article-title":"Poor kidney allograft survival associated with positive B cell - only flow cytometry cross matches: a ten year single center study","volume":"74","author":"Norin","year":"2013","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.trim.2021.101482_bb0265","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s12026-018-9027-2","article-title":"Significance of the intra-individual variability of HLA IgG antibodies in renal disease patients observed with different SABs monitored with two different secondary antibodies on a Luminex platform","volume":"66","author":"Ravindranath","year":"2018","journal-title":"Immunol. Res."},{"issue":"3","key":"10.1016\/j.trim.2021.101482_bb0270","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1089\/mab.2014.0096","article-title":"The mono specificity of novel anti-HLA-E monoclonal antibodies enables reliable Immunodiagnosis, immunomodulation of HLA-E, and Upregulation of CD8+ T lymphocytes","volume":"34","author":"Ravindranath","year":"2015","journal-title":"Monoclonal Antibody Immunodiagn Immunother."},{"issue":"5","key":"10.1016\/j.trim.2021.101482_bb0275","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/ajt.15766","article-title":"Reassessment of the clinical impact of preformed donor-specific anti-HLA-Cw antibodies in kidney transplantation","volume":"20","author":"Visentin","year":"2020","journal-title":"Am. J. Transplant."},{"issue":"1","key":"10.1016\/j.trim.2021.101482_bb0280","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/ajt.16127","article-title":"Optimizing the assessment of pathogenic anti-HLA antibodies","volume":"21","author":"Filippone","year":"2021","journal-title":"Am. J. Transplant."},{"issue":"2","key":"10.1016\/j.trim.2021.101482_bb0285","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.humimm.2018.11.007","article-title":"Second update of the International Registry of HLA Epitopes. I. The HLA-ABC epitope database","volume":"80","author":"Duquesnoy","year":"2019","journal-title":"Hum. Immunol."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327421001222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327421001222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T18:02:26Z","timestamp":1760810546000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327421001222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":57,"alternative-id":["S0966327421001222"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2021.101482","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibodies to cryptic epitopes on HLA class I and class II heavy chains bound to single antigen beads: Clinically relevant?","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2021.101482","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101482"}}