{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:40:55Z","timestamp":1790696455751,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.trim.2023.101806","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T04:03:17Z","timestamp":1678852997000},"page":"101806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["miR-27a-3p alleviates lung transplantation-induced bronchiolitis obliterans syndrome (BOS) via suppressing Smad-mediated myofibroblast differentiation and TLR4-induced dendritic cells maturation"],"prefix":"10.1016","volume":"78","author":[{"given":"Ming","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqing","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trim.2023.101806_bb0005","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.healun.2019.08.004","article-title":"The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; Focus theme: donor and recipient size match","volume":"38","author":"Khush","year":"2019","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0010","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.healun.2012.08.002","article-title":"The Registry of the International Society for Heart and Lung Transplantation: 29th official adult heart transplant report--2012","volume":"31","author":"Stehlik","year":"2012","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0015","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.healun.2016.09.001","article-title":"The registry of the International Society for Heart and Lung Transplantation: thirty-third adult lung and heart-lung transplant Report-2016; focus theme: primary diagnostic indications for transplant","volume":"35","author":"Yusen","year":"2016","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0020","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1053-2498(99)00115-1","article-title":"Apoptosis and formation of peroxynitrite in the lungs of patients with obliterative bronchiolitis","volume":"19","author":"Hansen","year":"2000","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0025","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.healun.2017.05.030","article-title":"Therapy options for chronic lung allograft dysfunction-bronchiolitis obliterans syndrome following first-line immunosuppressive strategies: a systematic review","volume":"36","author":"Benden","year":"2017","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41577-018-0088-1","article-title":"Dendritic cell subsets in T cell programming: location dictates function","volume":"19","author":"Eisenbarth","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.trim.2023.101806_bb0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000350328","article-title":"Tolerogenic dendritic cells: key regulators of peripheral tolerance in health and disease","volume":"161","author":"Saei","year":"2013","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.trim.2023.101806_bb0040","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3389\/fimmu.2017.01279","article-title":"Clinical Tolerogenic dendritic cells: exploring therapeutic impact on human autoimmune disease","volume":"8","author":"Phillips","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2023.101806_bb0045","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.molimm.2016.03.014","article-title":"Inhibition of RelA expression via RNA interference induces immune tolerance in a rat keratoplasty model","volume":"73","author":"Yang","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.trim.2023.101806_bb0050","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.552988","article-title":"Tolerogenic dendritic cells: the pearl of immunotherapy in organ transplantation","volume":"11","author":"Zhuang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2023.101806_bb0055","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-coding RNAs in human disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.trim.2023.101806_bb0060","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nature07511","article-title":"MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts","volume":"456","author":"Thum","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.trim.2023.101806_bb0065","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"Rooij","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.trim.2023.101806_bb0070","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1681\/ASN.2010020134","article-title":"miR-192 mediates TGF-\u03b2\/Smad3-driven renal fibrosis","volume":"21","author":"Chung","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.trim.2023.101806_bb0075","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1172\/JCI36870","article-title":"A role for microRNA in cystic liver and kidney diseases","volume":"118","author":"Chu","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.trim.2023.101806_bb0080","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.7150\/jca.31361","article-title":"MiR-27a: a novel biomarker and potential therapeutic target in tumors","volume":"10","author":"Li","year":"2019","journal-title":"J. Cancer"},{"key":"10.1016\/j.trim.2023.101806_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/jcmm.15814","article-title":"Cardiac fibroblast miR-27a may function as an endogenous anti-fibrotic by negatively regulating early growth response protein 3 (EGR3)","volume":"25","author":"Teng","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.trim.2023.101806_bb0090","doi-asserted-by":"crossref","first-page":"492","DOI":"10.21037\/atm-21-869","article-title":"Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a)","volume":"9","author":"Liu","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.trim.2023.101806_bb0095","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/gene.2012.45","article-title":"TGF-\u03b2-associated miR-27a inhibits dendritic cell-mediated differentiation of Th1 and Th17 cells by TAB3, p38 MAPK, MAP2K4 and MAP2K7","volume":"13","author":"Min","year":"2012","journal-title":"Genes Immun."},{"key":"10.1016\/j.trim.2023.101806_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.140","article-title":"Mir-27a-3p attenuates bronchiolitis obliterans in vivo via the regulation of dendritic cells' maturation and the suppression of myofibroblasts' differentiation","volume":"10","author":"Dong","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.trim.2023.101806_bb0105","doi-asserted-by":"crossref","unstructured":"R.D. Yusen, L.B. Edwards, A.I. Dipchand, S.B. Goldfarb, A.Y. Kucheryavaya, B.J. Levvey, L.H. Lund, B. Meiser, J.W. Rossano, J. Stehlik, H. International Society for, and T. Lung, The Registry of the International Society for Heart and Lung Transplan tation: Thirty-third Adult Lung and Heart-Lung Transplant Report-2016; Focus Theme: Primary Diagnostic Indications for Transplant. J. Heart Lung Transpl.: Off. Publ. Intern. Soc. Heart Transpl. 35 1170\u20131184.","DOI":"10.1016\/j.healun.2016.09.001"},{"key":"10.1016\/j.trim.2023.101806_bb0110","doi-asserted-by":"crossref","unstructured":"G. Thabut, J.D. Christie, W.K. Kremers, M. Fournier, and S.D. Halpern, Survival differences following lung transplantation among US transplant centers. JAMA 304 53\u201360.","DOI":"10.1001\/jama.2010.885"},{"key":"10.1016\/j.trim.2023.101806_bb0115","doi-asserted-by":"crossref","unstructured":"S. Stewart, M.C. Fishbein, G.I. Snell, G.J. Berry, A. Boehler, M.M. Burke, A. Glanville, F.K. Gould, C. Magro, C.C. Marboe, K.D. McNeil, E.F. Reed, N.L. Reinsmoen, J.P. Scott, S.M. Studer, H.D. Tazelaar, J.L. Wallwork, G. Westall, M.R. Zamora, A. Zeevi, and S.A. Yousem, Revision of the 1996 working formulation for the standardization of no menclature in the diagnosis of lung rejection. J. Heart Lung Transpl.: Off. Publ. Intern. Soc. Heart Transpl. 26 1229\u201342.","DOI":"10.1016\/j.healun.2007.10.017"},{"key":"10.1016\/j.trim.2023.101806_bb0120","doi-asserted-by":"crossref","unstructured":"T. Martinu, D.N. Howell, R.D. Davis, M.P. Steele, and S.M. Palmer, Pathologic correlates of bronchiolitis obliterans syndrome in pulmonar y retransplant recipients. Chest 129 1016\u201323.","DOI":"10.1378\/chest.129.4.1016"},{"key":"10.1016\/j.trim.2023.101806_bb0125","doi-asserted-by":"crossref","unstructured":"F. D'Ovidio, M. Mura, R. Ridsdale, H. Takahashi, T.K. Waddell, M. Hutcheon, D. Hadjiliadis, L.G. Singer, A. Pierre, C. Chaparro, C. Gutierrez, L. Miller, G. Darling, M. Liu, M. Post, and S. Keshavjee, The effect of reflux and bile acid aspiration on the lung allograft an d its surfactant and innate immunity molecules SP-A and SP-D. Am. J. Transplant. 6 1930\u20138.","DOI":"10.1111\/j.1600-6143.2006.01357.x"},{"key":"10.1016\/j.trim.2023.101806_bb0130","doi-asserted-by":"crossref","unstructured":"R.A. Vilchez, J. Dauber, and S. Kusne, Infectious etiology of bronchiolitis obliterans: the respiratory virus es connection - myth or reality? Am. J. Transplant. 3 245\u20139.","DOI":"10.1034\/j.1600-6143.2003.00056.x"},{"key":"10.1016\/j.trim.2023.101806_bb0135","doi-asserted-by":"crossref","unstructured":"S.A. Daud, R.D. Yusen, B.F. Meyers, M.M. Chakinala, M.J. Walter, A.A. Aloush, G.A. Patterson, E.P. Trulock, and R.R. Hachem, Impact of immediate primary lung allograft dysfunction on bronchioliti s obliterans syndrome. Am. J. Respir. Crit. Care Med. 175 507\u201313.","DOI":"10.1164\/rccm.200608-1079OC"},{"key":"10.1016\/j.trim.2023.101806_bb0140","doi-asserted-by":"crossref","unstructured":"A. Takahagi, M. Sato, T.F. Chen-Yoshikawa, E. Miyamoto, M. Saito, F. Gochi, M. Hamaji, A. Yoshizawa, Y. Terasaki, H. Urushiyama, A. Aoyama, M. Sonobe, and H. Date, LPS-induced airway-centered inflammation leading to BOS-like airway re modeling distinct from RAS-like fibrosis in rat lung transplantation. Transplantation 104 1150\u20131158.","DOI":"10.1097\/TP.0000000000003097"},{"key":"10.1016\/j.trim.2023.101806_bb0145","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1183\/09031936.00107514","article-title":"An international ISHLT\/ATS\/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome","volume":"44","author":"Meyer","year":"2014","journal-title":"Eur. Respiratory Soc."},{"key":"10.1016\/j.trim.2023.101806_bb0150","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/thoraxjnl-2014-205998","article-title":"A randomised controlled trial of azithromycin therapy in bronchiolitis obliterans syndrome (BOS) post lung transplantation","volume":"70","author":"Corris","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.trim.2023.101806_bb0155","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/ajt.13417","article-title":"Prophylactic azithromycin therapy after lung transplantation: post hoc analysis of a randomized controlled trial","volume":"16","author":"Ruttens","year":"2016","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0160","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.healun.2015.08.012","article-title":"ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients","volume":"35","author":"Gottlieb","year":"2016","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0165","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.healun.2014.08.004","article-title":"The registry of the International Society for Heart and Lung Transplantation: thirty-first adult lung and heart\u2013lung transplant report\u20142014; focus theme: retransplantation","volume":"33","author":"Yusen","year":"2014","journal-title":"J. Heart Lung Transplant."},{"key":"10.1016\/j.trim.2023.101806_bb0170","doi-asserted-by":"crossref","unstructured":"W. Zhang, T. Zhou, S.-F. Ma, R.F. Machado, S.M. Bhorade, and J.G.N. Garcia, MicroRNAs implicated in dysregulation of gene expression following hum an lung transplantation. Transl. Respir. Med. 1 12.","DOI":"10.1186\/2213-0802-1-12"},{"key":"10.1016\/j.trim.2023.101806_bb0175","doi-asserted-by":"crossref","unstructured":"K.V. Pandit, J. Milosevic, and N. Kaminski, MicroRNAs in idiopathic pulmonary fibrosis. Transl. Res. 157 191\u2013199.","DOI":"10.1016\/j.trsl.2011.01.012"},{"key":"10.1016\/j.trim.2023.101806_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12623","article-title":"Graft-infiltrating host dendritic cells play a key role in organ transplant rejection","volume":"7","author":"Zhuang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trim.2023.101806_bb0185","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s12192-019-01026-7","article-title":"MiR-27a-3p downregulation contributes to the development of occlusive bronchiolitis","volume":"24","author":"Dong","year":"2019","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.trim.2023.101806_bb0190","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.trre.2019.05.001","article-title":"Regulatory dendritic cells for human organ transplantation","volume":"33","author":"Thomson","year":"2019","journal-title":"Transpl. Rev. (Orlando)"},{"key":"10.1016\/j.trim.2023.101806_bb0195","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/s41467-019-09101-4","article-title":"Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma","volume":"10","author":"Park","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.trim.2023.101806_bb0200","doi-asserted-by":"crossref","first-page":"11636","DOI":"10.18632\/aging.103330","article-title":"PLK1 inhibition alleviates transplant-associated obliterative bronchiolitis by suppressing myofibroblast differentiation","volume":"12","author":"Yu","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.trim.2023.101806_bb0205","doi-asserted-by":"crossref","unstructured":"L. Wu, Q. Wang, F. Guo, X. Ma, J. Wang, Y. Zhao, Y. Yan, and G. Qin, Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress. J. Cell. Physiol. 236 1454\u20131468.","DOI":"10.1002\/jcp.29951"},{"key":"10.1016\/j.trim.2023.101806_bb0210","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.18632\/oncotarget.23262","article-title":"MiR-27a as a predictor for the activation of hepatic stellate cells and hepatitis B virus-induced liver cirrhosis","volume":"9","author":"Zhang","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.trim.2023.101806_bb0215","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0002-9440(10)63847-3","article-title":"Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching","volume":"162","author":"Chambers","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.trim.2023.101806_bb0220","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1083\/jcb.122.1.103","article-title":"Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts","volume":"122","author":"Desmouli\u00e8re","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.trim.2023.101806_bb0225","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.trim.2023.101806_bb0230","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1164\/rccm.201101-0134CI","article-title":"Lung transplantation","volume":"184","author":"Kotloff","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.trim.2023.101806_bb0235","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3389\/fimmu.2018.00274","article-title":"Tolerogenic dendritic cells in solid organ transplantation: where do we stand?","volume":"9","author":"Mar\u00edn","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2023.101806_bb0240","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nri1845","article-title":"Dendritic cells in a mature age","volume":"6","author":"Reis e\u00a0Sousa","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.trim.2023.101806_bb0245","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/tri.13504","article-title":"Tolerogenic dendritic cells in organ transplantation","volume":"33","author":"Ochando","year":"2020","journal-title":"Transpl. Int."},{"key":"10.1016\/j.trim.2023.101806_bb0250","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.vetimm.2013.06.014","article-title":"The stimulatory effect of TLRs ligands on maturation of chicken bone marrow-derived dendritic cells","volume":"155","author":"Liang","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.trim.2023.101806_bb0255","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.intimp.2014.05.010","article-title":"Enhanced dendritic cell maturation by the B-chain of Korean mistletoe lectin (KML-B), a novel TLR4 agonist","volume":"21","author":"Kim","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.trim.2023.101806_bb0260","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1084\/jem.190.2.229","article-title":"Freshly isolated Peyer\u2019s patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells","volume":"190","author":"Iwasaki","year":"1999","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.trim.2023.101806_bb0265","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.trim.2023.101806_bb0270","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/PPO.0b013e318258b75b","article-title":"The duality of oncomiR addiction in the maintenance and treatment of cancer","volume":"18","author":"Cheng","year":"2012","journal-title":"Cancer J."},{"key":"10.1016\/j.trim.2023.101806_bb0275","doi-asserted-by":"crossref","first-page":"368","DOI":"10.5732\/cjc.011.10186","article-title":"MicroRNA therapeutics: principles, expectations, and challenges","volume":"30","author":"Rupaimoole","year":"2011","journal-title":"Chin. J. Cancer"}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327423000230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327423000230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T18:02:59Z","timestamp":1760810579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327423000230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":55,"alternative-id":["S0966327423000230"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2023.101806","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-27a-3p alleviates lung transplantation-induced bronchiolitis obliterans syndrome (BOS) via suppressing Smad-mediated myofibroblast differentiation and TLR4-induced dendritic cells maturation","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2023.101806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101806"}}