{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:07:05Z","timestamp":1791662825764,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.trim.2024.101991","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T12:17:40Z","timestamp":1704716260000},"page":"101991","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Investigating the effect of pre-transplant thrombocytopenia and anemia on the engraftment and long-term survival in multiple myeloma patients"],"prefix":"10.1016","volume":"82","author":[{"given":"Dariush","family":"Kadkhoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nikoonezhad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Bonakchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahshid","family":"Mehdizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Hajifathali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Baghestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Jabarinanva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Akbar","family":"Khadem Maboudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trim.2024.101991_bb0005","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrclinonc.2011.63","article-title":"Treatment of multiple myeloma","volume":"8","author":"Rajkumar","year":"2011","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.trim.2024.101991_bb0010","first-page":"1","article-title":"Current status of autologous stem cell transplantation for multiple myeloma, Blood","volume":"9","author":"Al Hamed","year":"2019","journal-title":"Cancer J."},{"key":"10.1016\/j.trim.2024.101991_bb0015","first-page":"1","article-title":"How can imaging help the radiation oncologist in multiple myeloma treatment","volume":"57","author":"Belgioia","year":"2021","journal-title":"Med."},{"key":"10.1016\/j.trim.2024.101991_bb0020","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.soncn.2017.05.004","article-title":"Hematopoietic stem cell transplantation for multiple myeloma","volume":"33","author":"Koniarczyk","year":"2017","journal-title":"Semin. Oncol. Nurs."},{"key":"10.1016\/j.trim.2024.101991_bb0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/jnci\/djy073","article-title":"Association between autologous stem cell transplant and survival among californians with multiple myeloma","volume":"111","author":"Rosenberg","year":"2019","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.trim.2024.101991_bb0030","doi-asserted-by":"crossref","first-page":"730","DOI":"10.4103\/ijmr.IJMR_1593_18","article-title":"High-dose chemotherapy followed by autologous stem cell transplant for multiple myeloma: predictors of long-term outcome","volume":"149","author":"Kumar","year":"2019","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.trim.2024.101991_bb0035","doi-asserted-by":"crossref","first-page":"17046","DOI":"10.1038\/nrdp.2017.46","article-title":"Multiple myeloma","volume":"3","author":"Kumar","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.trim.2024.101991_bb0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/stem.5530140734","article-title":"The problem of thrombocytopenia after hematopoietic stem cell transplantation","volume":"14","author":"Nash","year":"1996","journal-title":"Stem Cells"},{"key":"10.1016\/j.trim.2024.101991_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2020.102810","article-title":"Pre-transplant thrombocytopenia predicts engraftment time and blood products requirement in allogeneic hematopoietic stem cell transplantation patients","volume":"59","author":"Roshandel","year":"2020","journal-title":"Transfus. Apher. Sci."},{"key":"10.1016\/j.trim.2024.101991_bb0050","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1080\/10428194.2016.1233542","article-title":"Autologous stem cell transplantation in elderly patients with multiple myeloma: evaluation of its safety and efficacy","volume":"58","author":"Stettler","year":"2017","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.trim.2024.101991_bb0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3109\/10428194.2011.606942","article-title":"Feasibility of autologous hematopoietic stem cell transplant in patients aged \u226570 years with multiple myeloma","volume":"53","author":"Bashir","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.trim.2024.101991_bb0060","series-title":"Thrombocytopenia, in: StatPearls, Treasure Island (FL)","author":"Jinna","year":"2022"},{"key":"10.1016\/j.trim.2024.101991_bb0065","author":"World Health Organization"},{"key":"10.1016\/j.trim.2024.101991_bb0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mayocp.2015.11.007","article-title":"Multiple Myeloma: Diagnosis and Treatment","volume":"91","author":"Rajkumar","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.trim.2024.101991_bb0075","first-page":"76","article-title":"Pre Transplantation Serum Parathyroid Hormone Influences the Number of Mobilized CD34 + Hematopoietic Stem Cells in Autologous Hematopoietic Stem Cell Transplantation, Reports Biochem","volume":"10","author":"Kian","year":"2021","journal-title":"Mol. Biol."},{"key":"10.1016\/j.trim.2024.101991_bb0080","first-page":"16","article-title":"Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Pluripotent Stem Cells, in: Thomas\u2019 Hematop","author":"Dah\u00e9ron","year":"2015","journal-title":"Cell Transplant"},{"key":"10.1016\/j.trim.2024.101991_bb0085","series-title":"Survival analysis: A Self-Learning Text","author":"Kleinbaum","year":"2012"},{"key":"10.1016\/j.trim.2024.101991_bb0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0047-259X(78)90063-5","article-title":"A class of bivariate distributions including the bivariate logistic","volume":"8","author":"Ali","year":"1978","journal-title":"J. Multivar. Anal."},{"key":"10.1016\/j.trim.2024.101991_bb0095","first-page":"657","article-title":"Probability distributions and estimation of Ali-Mikhail-Haq copula","volume":"4","author":"Kumar","year":"2010","journal-title":"Appl. Math. Sci."},{"key":"10.1016\/j.trim.2024.101991_bb0100","article-title":"An Introduction to Copulas, Springer","author":"Nelsen","year":"2006","journal-title":"N. Y."},{"key":"10.1016\/j.trim.2024.101991_bb0105","doi-asserted-by":"crossref","first-page":"266","DOI":"10.32614\/RJ-2020-025","article-title":"CopulaCenR: Copula based Regression Models for Bivariate Censored Data in R","volume":"12","author":"Sun","year":"2020","journal-title":"R J."},{"key":"10.1016\/j.trim.2024.101991_bb0110","doi-asserted-by":"crossref","unstructured":"D.W. Hosmer, S. Lemeshow, S. May, Applied Survival Analysis: Regression Modeling of Time to Event Data: Second Edition, Appl. Surviv. Anal. Regres. Model. Time to Event Data Second Ed. (2011) 1\u2013401. doi:10.1002\/9780470258019.","DOI":"10.1002\/9780470258019"},{"key":"10.1016\/j.trim.2024.101991_bb0115","doi-asserted-by":"crossref","unstructured":"R. Rocha, S. Nadarajah, V. Tomazella, F. Louzada, A new class of defective models based on the Marshall\u2013Olkin family of distributions for cure rate modeling, Comput. Stat. Data Anal. 107 (2017) 48\u201363. doi:https:\/\/doi.org\/10.1016\/j.csda.2016.10.001.","DOI":"10.1016\/j.csda.2016.10.001"},{"key":"10.1016\/j.trim.2024.101991_bb0120","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev-statistics-031017-100101","article-title":"Cure Models in Survival Analysis","volume":"5","author":"Amico","year":"2018","journal-title":"Annu. Rev. Stat. Its Appl."},{"key":"10.1016\/j.trim.2024.101991_bb0125","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1158\/1078-0432.CCR-11-2859","article-title":"Cure models as a useful statistical tool for analyzing survival","volume":"18","author":"Othus","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.trim.2024.101991_bb0130","series-title":"Cure Models\u00a0: Methods, Applications, and Implementation","author":"Peng","year":"2021"},{"key":"10.1016\/j.trim.2024.101991_bb0135","author":"R Core Team"},{"key":"10.1016\/j.trim.2024.101991_bb0140","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/nm.3155","article-title":"Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration","volume":"19","author":"Lucas","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.trim.2024.101991_bb0145","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1177\/1078155218804042","article-title":"Evaluating the adverse effects of melphalan formulations","volume":"25","author":"Xiang","year":"2019","journal-title":"J. Oncol. Pharm. Pract."},{"key":"10.1016\/j.trim.2024.101991_bb0150","series-title":"Blood and bone marrow toxicity, in: Vet","first-page":"277","author":"Ramaiah","year":"2007"},{"key":"10.1016\/j.trim.2024.101991_bb0155","first-page":"665","article-title":"Chemotherapy: Managing side effects and safe handling","volume":"50","author":"Macdonald","year":"2009","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.trim.2024.101991_bb0160","doi-asserted-by":"crossref","first-page":"863","DOI":"10.3109\/10428190109097705","article-title":"Bone Marrow Stromal Damage after Chemo\/Radiotherapy: Occurrence, Consequences and Possibilities of Treatment","volume":"42","author":"Banfi","year":"2001","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.trim.2024.101991_bb0165","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1016\/j.bbmt.2012.11.048","article-title":"Platelet Engraftment Failure Leads to Poor Overall Survival Even After Neutrophil Engraftment without Relapse","volume":"19","author":"Kimura","year":"2013","journal-title":"Biol. Blood Marrow Transpl."},{"key":"10.1016\/j.trim.2024.101991_bb0170","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.exphem.2009.10.004","article-title":"Platelet recovery and transfusion needs after reduced intensity conditioning allogeneic peripheral blood stem cell transplantation","volume":"38","author":"Pr\u00e9bet","year":"2010","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.trim.2024.101991_bb0175","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1182\/blood.V85.2.588.588","article-title":"Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients","volume":"85","author":"Tricot","year":"1995","journal-title":"Blood."},{"key":"10.1016\/j.trim.2024.101991_bb0180","first-page":"544","article-title":"The association of disease type, pre-transplant hemoglobin level and platelet count with transfusion requirement after autologous hematopoietic stem cell transplantation","volume":"12","author":"Tabasi","year":"2021","journal-title":"Casp. J. Intern. Med."},{"key":"10.1016\/j.trim.2024.101991_bb0185","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0301-472X(99)00076-4","article-title":"Stromal damage as consequence of high-dose chemo\/radiotherapy in bone marrow transplant recipients","volume":"27","author":"Galotto","year":"1999","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.trim.2024.101991_bb0190","article-title":"Primitive and definitive erythropoiesis in mammals","volume":"5 JAN","author":"Palis","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.trim.2024.101991_bb0195","article-title":"Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.trim.2024.101991_bb0200","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/bmt.2014.39","article-title":"Autologous haematopoietic stem cell mobilisation in multiple myeloma and lymphoma patients: a position statement from the European Group for Blood and Marrow Transplantation","volume":"49","author":"Mohty","year":"2014","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.trim.2024.101991_bb0205","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2141.2003.04107.x","article-title":"Mobilization of CD34+ cells in elderly patients (\u2265 70 years) with multiple myeloma: Influence of age, prior therapy, platelet count and mobilization regimen","volume":"120","author":"Morris","year":"2003","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.trim.2024.101991_bb0210","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3906\/sag-2001-173","article-title":"Cd34+ hematopoietic progenitor cell dose as a predictor of engraftment and survival in multiple myeloma patients undergoing autologous stem cell transplantation","volume":"50","author":"Alada\u011f","year":"2020","journal-title":"Turkish J. Med. Sci."},{"key":"10.1016\/j.trim.2024.101991_bb0215","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/leu.2013.313","article-title":"Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients","volume":"28","author":"Kumar","year":"2014","journal-title":"Leukemia."},{"key":"10.1016\/j.trim.2024.101991_bb0220","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1200\/JCO.2014.55.1028","article-title":"Multiple myeloma in the older adult: better prospects, more challenges","volume":"32","author":"Wildes","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.trim.2024.101991_bb0225","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3324\/haematol.2013.098608","article-title":"Age is a prognostic factor even among patients with multiple myeloma younger than 66 years treated with high-dose melphalan: the IFM experience on 2316 patients","volume":"99","author":"Chretien","year":"2014","journal-title":"Haematologica."},{"key":"10.1016\/j.trim.2024.101991_bb0230","doi-asserted-by":"crossref","first-page":"980","DOI":"10.3324\/haematol.2012.075051","article-title":"Age and organ damage correlate with poor survival in myeloma patients: meta-analysis of 1435 individual patient data from 4 randomized trials","volume":"98","author":"Bringhen","year":"2013","journal-title":"Haematologica."},{"key":"10.1016\/j.trim.2024.101991_bb0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41408-018-0065-8","article-title":"Defining cure in multiple myeloma: A comparative study of outcomes of young individuals with myeloma and curable hematologic malignancies","volume":"8","author":"Ravi","year":"2018","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.trim.2024.101991_bb0240","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2307\/2532041","article-title":"Modelling paired survival data with covariates","volume":"45","author":"Huster","year":"1989","journal-title":"Biometrics."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327424000078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327424000078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T18:05:16Z","timestamp":1760810716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327424000078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"alternative-id":["S0966327424000078"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2024.101991","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the effect of pre-transplant thrombocytopenia and anemia on the engraftment and long-term survival in multiple myeloma patients","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2024.101991","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101991"}}