{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:15:15Z","timestamp":1786997715281,"version":"build-2736575974"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018531","name":"Major Science and Technology Projects in Yunnan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.trim.2025.102184","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T11:08:34Z","timestamp":1738408114000},"page":"102184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Research on gene editing and immunosuppressants in kidney xenotransplantation"],"prefix":"10.1016","volume":"89","author":[{"given":"JiaJiao","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CongWen","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HanFei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.trim.2025.102184_bb0005","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1097\/TP.0000000000003035","article-title":"Liver retransplantation associated with kidney transplantation for end-stage liver graft disease and renal insufficiency: a morbid procedure on a unique subgroup of patients","volume":"104","author":"Cauchy","year":"2020","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2025.102184_bb0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijsu.2020.02.008","article-title":"Current status of combined liver-kidney transplantation","volume":"82s","author":"Ekser","year":"2020","journal-title":"Int. J. Surg."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0015","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.gtc.2018.01.001","article-title":"Living donor liver transplantation: technical innovations","volume":"47","author":"Tulla","year":"2018","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.trim.2025.102184_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.900594","article-title":"Xenotransplantation: a new era","volume":"13","author":"Carrier","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2025.102184_bb0025","article-title":"Developments in kidney xenotransplantation","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2025.102184_bb0030","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11138","article-title":"Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft","volume":"7","author":"Mohiuddin","year":"2016","journal-title":"Nat. Commun."},{"issue":"7982","key":"10.1016\/j.trim.2025.102184_bb0035","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-023-06594-4","article-title":"Design and testing of a humanized porcine donor for xenotransplantation","volume":"622","author":"Anand","year":"2023","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.trim.2025.102184_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12814","article-title":"Auxiliary liver xenotransplantation technique in a transgenic pig-to-non-human primate model: a surgical approach to prolong survival","volume":"30","author":"Lee","year":"2023","journal-title":"Xenotransplantation"},{"issue":"6","key":"10.1016\/j.trim.2025.102184_bb0045","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/MOT.0000000000000582","article-title":"Progress and challenges in lung xenotransplantation: an update","volume":"23","author":"Burdorf","year":"2018","journal-title":"Curr. Opin. Organ Transplant."},{"issue":"1","key":"10.1016\/j.trim.2025.102184_bb0050","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa2201422","article-title":"Genetically modified porcine-to-human cardiac xenotransplantation","volume":"387","author":"Griffith","year":"2022","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0055","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41587-024-02223-1","article-title":"First gene-edited pig kidney transplant","volume":"42","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0060","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MOT.0b013e328329250d","article-title":"Immune responses to alpha1,3 galactosyltransferase knockout pigs","volume":"14","author":"Puga Yung","year":"2009","journal-title":"Curr. Opin. Organ Transplant."},{"issue":"Suppl. 22","key":"10.1016\/j.trim.2025.102184_bb0065","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1399-0012.2010.01270.x","article-title":"Histopathology of xenografts in pig to non-human primate discordant xenotransplantation","volume":"24","author":"Shimizu","year":"2010","journal-title":"Clin. Transpl."},{"issue":"6","key":"10.1016\/j.trim.2025.102184_bb0070","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/xen.12124","article-title":"Cloning and expression of porcine \u03b21,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen","volume":"21","author":"Byrne","year":"2014","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.trim.2025.102184_bb0075","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.actbio.2016.06.007","article-title":"Physical equivalency of wild type and galactose \u03b1 1,3 galactose free porcine pericardium; a new source material for bioprosthetic heart valves","volume":"41","author":"McGregor","year":"2016","journal-title":"Acta Biomater."},{"issue":"7","key":"10.1016\/j.trim.2025.102184_bb0080","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/TP.0b013e3182472850","article-title":"Human CD55 expression blocks hyperacute rejection and restricts complement activation in Gal knockout cardiac xenografts","volume":"93","author":"McGregor","year":"2012","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0085","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1600-6143.2011.03846.x","article-title":"B-cell depletion extends the survival of GTKO.hCD46Tgpig heart xenografts in baboons for up to 8 months","volume":"12","author":"Mohiuddin","year":"2012","journal-title":"Am. J. Transplant."},{"issue":"12","key":"10.1016\/j.trim.2025.102184_bb0090","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nm1330","article-title":"Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys","volume":"11","author":"Chen","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.trim.2025.102184_bb0095","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.3389\/fimmu.2019.02396","article-title":"N-glycolylneuraminic acid (Neu5Gc) null large animals by targeting the CMP-Neu5Gc hydroxylase (CMAH)","volume":"10","author":"Perota","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2025.102184_bb0100","article-title":"Peptidomes and structures illustrate how SLA-I micropolymorphism influences the preference of binding peptide length","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0105","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/TP.0000000000003303","article-title":"The role of SLAs in xenotransplantation","volume":"105","author":"Ladowski","year":"2021","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0110","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1099\/jgv.0.001232","article-title":"Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous retrovirus (PERV) in non-dividing cells","volume":"100","author":"Al-Shehabi","year":"2019","journal-title":"J. Gen. Virol."},{"issue":"6357","key":"10.1016\/j.trim.2025.102184_bb0115","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aan4187","article-title":"Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9","volume":"357","author":"Niu","year":"2017","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.trim.2025.102184_bb0120","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1161\/CIRCULATIONAHA.116.023301","article-title":"Ischemic cerebroprotection conferred by myeloid lineage-restricted or global CD39 transgene expression","volume":"135","author":"Baek","year":"2017","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.trim.2025.102184_bb0125","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/ATVBAHA.116.307374","article-title":"Role of the CD39\/CD73 purinergic pathway in modulating arterial thrombosis in mice","volume":"36","author":"Covarrubias","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.trim.2025.102184_bb0130","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1111\/j.1600-6143.2010.03257.x","article-title":"Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury","volume":"10","author":"Crikis","year":"2010","journal-title":"Am. J. Transplant."},{"issue":"7","key":"10.1016\/j.trim.2025.102184_bb0135","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1097\/TP.0000000000001679","article-title":"The differential effect of apyrase treatment and hCD39 overexpression on chronic renal fibrosis after ischemia-reperfusion injury","volume":"101","author":"Roberts","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2025.102184_bb0140","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.lfs.2016.10.016","article-title":"Impact of cardiac-specific expression of CD39 on myocardial infarct size in mice","volume":"179","author":"Smith","year":"2017","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.trim.2025.102184_bb0145","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.yjmcc.2012.01.002","article-title":"Transgenic swine: expression of human CD39 protects against myocardial injury","volume":"52","author":"Wheeler","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"10","key":"10.1016\/j.trim.2025.102184_bb0150","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1172\/JCI19560","article-title":"Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation","volume":"113","author":"Dwyer","year":"2004","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0155","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/xen.12085","article-title":"The role of platelets in coagulation dysfunction in xenotransplantation, and therapeutic options","volume":"21","author":"Iwase","year":"2014","journal-title":"Xenotransplantation"},{"issue":"8","key":"10.1016\/j.trim.2025.102184_bb0160","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1007\/s10875-023-01547-y","article-title":"Immunologic and genetic contributors to CD46-dependent immune dysregulation","volume":"43","author":"Meyer","year":"2023","journal-title":"J. Clin. Immunol."},{"issue":"10","key":"10.1016\/j.trim.2025.102184_bb0165","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1097\/TP.0000000000000746","article-title":"Transgenic expression of human CD46 on porcine endothelium: effect on coagulation and fibrinolytic cascades during ex vivo human-to-pig limb xenoperfusions","volume":"99","author":"Bongoni","year":"2015","journal-title":"Transplantation"},{"issue":"12","key":"10.1016\/j.trim.2025.102184_bb0170","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1111\/ajt.12918","article-title":"Transgenic expression of human CD47 markedly increases engraftment in a murine model of pig-to-human hematopoietic cell transplantation","volume":"14","author":"Tena","year":"2014","journal-title":"Am. J. Transplant."},{"issue":"8","key":"10.1016\/j.trim.2025.102184_bb0175","article-title":"Profiling human CD55 transgene performance assist in selecting best suited specimens and tissues for swine organ xenotransplantation","volume":"10","author":"Mart\u00ednez-Alarc\u00f3n","year":"2021","journal-title":"Biology (Basel)"},{"issue":"1","key":"10.1016\/j.trim.2025.102184_bb0180","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1056\/NEJMoa1615887","article-title":"CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis","volume":"377","author":"Ozen","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.trim.2025.102184_bb0185","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1002\/j.1460-2075.1994.tb06836.x","article-title":"Decay-accelerating factor CD55 is identified as the receptor for echovirus 7 using CELICS, a rapid immuno-focal cloning method","volume":"13","author":"Ward","year":"1994","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0190","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00007890-200001270-00013","article-title":"Liver allotransplantation after extracorporeal hepatic support with transgenic (hCD55\/hCD59) porcine livers: clinical results and lack of pig-to-human transmission of the porcine endogenous retrovirus","volume":"69","author":"Levy","year":"2000","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0195","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1073\/pnas.96.2.628","article-title":"Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting","volume":"96","author":"Sun","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.trim.2025.102184_bb0200","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1111\/j.1600-6143.2012.04122.x","article-title":"Protective effects of transgenic human endothelial protein C receptor expression in murine models of transplantation","volume":"12","author":"Lee","year":"2012","journal-title":"Am. J. Transplant."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12557","article-title":"Pig endothelial protein C receptor is functionally compatible with the human protein C pathway","volume":"27","author":"Salvaris","year":"2020","journal-title":"Xenotransplantation"},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0210","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/01.CIR.101.3.289","article-title":"Thromboresistance of balloon-injured porcine carotid arteries after local gene transfer of human tissue factor pathway inhibitor","volume":"101","author":"Zoldhelyi","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0215","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1600-6143.2009.02939.x","article-title":"Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice","volume":"10","author":"Crikis","year":"2010","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2025.102184_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.108073","article-title":"HO-1 overexpression and underexpression: clinical implications","volume":"673","author":"Drummond","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.trim.2025.102184_bb0225","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1007\/s10753-014-9908-z","article-title":"Therapeutic potential of HO-1 in autoimmune diseases","volume":"37","author":"Li","year":"2014","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0230","article-title":"Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders","volume":"11","author":"Ryter","year":"2022","journal-title":"Antioxidants (Basel)"},{"issue":"15","key":"10.1016\/j.trim.2025.102184_bb0235","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.18632\/aging.102136","article-title":"HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress","volume":"11","author":"Wang","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"10","key":"10.1016\/j.trim.2025.102184_bb0240","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1093\/ndt\/gfn247","article-title":"HO-1 induction ameliorates experimental murine membranous nephropathy: anti-oxidative, anti-apoptotic and immunomodulatory effects","volume":"23","author":"Wu","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"issue":"6","key":"10.1016\/j.trim.2025.102184_bb0245","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1399-3089.2011.00674.x","article-title":"Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys","volume":"18","author":"Petersen","year":"2011","journal-title":"Xenotransplantation"},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0250","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1021\/bi00804a016","article-title":"Reduced nicotinamide-adenine dinucleotide phosphate dependent biliverdin reductase: partial purification and characterization","volume":"9","author":"Tenhunen","year":"1970","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0255","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3904\/kjim.2013.28.2.123","article-title":"Carbon monoxide: present and future indications for a medical gas","volume":"28","author":"Ryter","year":"2013","journal-title":"Korean J. Intern. Med."},{"issue":"25","key":"10.1016\/j.trim.2025.102184_bb0260","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1016\/S0021-9258(19)37165-0","article-title":"Ferritin: a cytoprotective antioxidant strategem of endothelium","volume":"267","author":"Balla","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.trim.2025.102184_bb0265","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.811525","article-title":"TNFAIP3 reduction-of-function drives female infertility and CNS inflammation","volume":"13","author":"Zammit","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0270","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/SLA.0000000000004996","article-title":"Anti-C5 antibody tesidolumab reduces early antibody-mediated rejection and prolongs survival in renal xenotransplantation","volume":"274","author":"Adams","year":"2021","journal-title":"Ann. Surg."},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0275","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1600-6143.2004.00407.x","article-title":"Ureteral stenosis in HDAF pig-to-primate renal xenotransplantation: a phenomenon related to immunological events?","volume":"4","author":"Baldan","year":"2004","journal-title":"Am. J. Transplant."},{"issue":"10","key":"10.1016\/j.trim.2025.102184_bb0280","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1097\/01.TP.0000178377.55615.8B","article-title":"Effects of long-term administration of high-dose recombinant human antithrombin in immunosuppressed primate recipients of porcine xenografts","volume":"80","author":"Cozzi","year":"2005","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.trim.2025.102184_bb0285","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/TP.0b013e318199c34f","article-title":"The innate immune response and activation of coagulation in alpha1,3-galactosyltransferase gene-knockout xenograft recipients","volume":"87","author":"Ezzelarab","year":"2009","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0290","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ajt.2022.11.022","article-title":"Renin-angiotensin-aldosterone system function in the pig-to-baboon kidney xenotransplantation model","volume":"23","author":"Hansen-Estruch","year":"2023","journal-title":"Am. J. Transplant."},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0295","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.transproceed.2023.03.060","article-title":"Current status of genetically engineered pig to monkey kidney xenotransplantation in Korea","volume":"55","author":"Hwang","year":"2023","journal-title":"Transplant. Proc."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0300","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12293","article-title":"Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts","volume":"24","author":"Iwase","year":"2017","journal-title":"Xenotransplantation"},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0305","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12700","article-title":"Evidence suggesting that deletion of expression of N-glycolylneuraminic acid (Neu5Gc) in the organ-source pig is associated with increased antibody-mediated rejection of kidney transplants in baboons","volume":"28","author":"Iwase","year":"2021","journal-title":"Xenotransplantation"},{"issue":"8","key":"10.1016\/j.trim.2025.102184_bb0310","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1111\/ajt.15329","article-title":"Long-term survival of pig-to-rhesus macaque renal xenografts is dependent on CD4 T cell depletion","volume":"19","author":"Kim","year":"2019","journal-title":"Am. J. Transplant."},{"issue":"9","key":"10.1016\/j.trim.2025.102184_bb0315","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.transproceed.2011.09.024","article-title":"Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons","volume":"43","author":"Le Bas-Bernardet","year":"2011","journal-title":"Transplant. Proc."},{"issue":"1","key":"10.1016\/j.trim.2025.102184_bb0320","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/ajt.16780","article-title":"Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques","volume":"22","author":"Ma","year":"2022","journal-title":"Am. J. Transplant."},{"issue":"7","key":"10.1016\/j.trim.2025.102184_bb0325","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/01.TP.0000152662.55720.83","article-title":"Lack of cross-species transmission of porcine endogenous retrovirus in pig-to-baboon xenotransplantation with sustained depletion of anti-alphagal antibodies","volume":"79","author":"Moscoso","year":"2005","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.trim.2025.102184_bb0330","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/TP.0b013e31822b92a5","article-title":"First experience with the use of a recombinant CD3 immunotoxin as induction therapy in pig-to-primate xenotransplantation: the effect of T-cell depletion on outcome","volume":"92","author":"Nishimura","year":"2011","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.trim.2025.102184_bb0335","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1111\/tri.13273","article-title":"Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study","volume":"31","author":"Rivard","year":"2018","journal-title":"Transpl. Int."},{"issue":"1","key":"10.1016\/j.trim.2025.102184_bb0340","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nm1172","article-title":"Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue","volume":"11","author":"Yamada","year":"2005","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.trim.2025.102184_bb0345","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1097\/TP.0000000000002796","article-title":"Life-supporting kidney xenotransplantation from genetically engineered pigs in baboons: a comparison of two immunosuppressive regimens","volume":"103","author":"Yamamoto","year":"2019","journal-title":"Transplantation"},{"issue":"2\u20133","key":"10.1016\/j.trim.2025.102184_bb0350","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.molimm.2004.03.011","article-title":"Recombinant cobra venom factor","volume":"41","author":"Vogel","year":"2004","journal-title":"Mol. Immunol."},{"issue":"20","key":"10.1016\/j.trim.2025.102184_bb0355","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1182\/bloodadvances.2023010817","article-title":"Complement and platelets: prothrombotic cell activation requires membrane attack complex-induced release of danger signals","volume":"7","author":"Mannes","year":"2023","journal-title":"Blood Adv."},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0360","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1182\/bloodadvances.2021005584","article-title":"Antithymocyte globulin exposure in CD34+ T-cell-depleted allogeneic hematopoietic cell transplantation","volume":"6","author":"Lakkaraja","year":"2022","journal-title":"Blood Adv."},{"issue":"27","key":"10.1016\/j.trim.2025.102184_bb0365","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2404661121","article-title":"Post-immunotherapy CTLA-4 Ig treatment improves antitumor efficacy","volume":"121","author":"Mok","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.trim.2025.102184_bb0370","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.hbpd.2022.10.004","article-title":"A mixed blessing for liver transplantation patients - rapamycin","volume":"22","author":"Fan","year":"2023","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"9","key":"10.1016\/j.trim.2025.102184_bb0375","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1097\/TP.0000000000002717","article-title":"Update on C1 esterase inhibitor in human solid organ transplantation","volume":"103","author":"Berger","year":"2019","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0380","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/120347540100500409","article-title":"Tacrolimus in dermatology","volume":"5","author":"QH, D.T","year":"2001","journal-title":"J. Cutan. Med. Surg."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0385","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1172\/JCI118116","article-title":"FK506 augments activation-induced programmed cell death of T lymphocytes in vivo","volume":"96","author":"Migita","year":"1995","journal-title":"J. Clin. Invest."},{"issue":"8005","key":"10.1016\/j.trim.2025.102184_bb0390","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/d41586-024-00853-8","article-title":"First pig liver transplanted into a person lasts for 10 days","volume":"627","author":"Mallapaty","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.trim.2025.102184_bb0395","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1276566","article-title":"Editorial: liver transplantation for liver cancer in the era of transplant oncology: accurate diagnosis and treatment","volume":"14","author":"Xiang","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.trim.2025.102184_bb0400","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/humrep\/dez047","article-title":"Impact of cancer chemotherapy before ovarian cortex cryopreservation on ovarian tissue transplantation","volume":"34","author":"Poirot","year":"2019","journal-title":"Hum. Reprod."},{"issue":"2s1","key":"10.1016\/j.trim.2025.102184_bb0405","doi-asserted-by":"crossref","first-page":"S457","DOI":"10.1016\/j.ajt.2024.01.018","article-title":"OPTN\/SRTR 2022 annual data report: deceased organ donation","volume":"24","author":"Israni","year":"2024","journal-title":"Am. J. Transplant."},{"issue":"3","key":"10.1016\/j.trim.2025.102184_bb0410","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11248-022-00306-w","article-title":"Xenotransplantation becoming reality","volume":"31","author":"Fischer","year":"2022","journal-title":"Transgenic Res."},{"issue":"18","key":"10.1016\/j.trim.2025.102184_bb0415","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/cvr\/cvac180","article-title":"Cardiac xenotransplantation: from concept to clinic","volume":"118","author":"Reichart","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.trim.2025.102184_bb0420","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fmed.2019.00276","article-title":"The first case of ischemia-free kidney transplantation in humans","volume":"6","author":"He","year":"2019","journal-title":"Front. Med. (Lausanne)"},{"issue":"7","key":"10.1016\/j.trim.2025.102184_bb0425","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/tri.13828","article-title":"Application of ischaemia-free liver transplantation improves prognosis of patients with steatotic donor livers - a retrospective study","volume":"34","author":"Chen","year":"2021","journal-title":"Transpl. Int."},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0430","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/MOT.0000000000000998","article-title":"Ischemia-free organ transplantation - a review","volume":"27","author":"Guo","year":"2022","journal-title":"Curr. Opin. Organ Transplant."},{"issue":"4","key":"10.1016\/j.trim.2025.102184_bb0435","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.546","article-title":"Abrogation of graft ischemia-reperfusion injury in ischemia-free liver transplantation","volume":"12","author":"Guo","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"5","key":"10.1016\/j.trim.2025.102184_bb0440","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1097\/TP.0000000000004529","article-title":"Metabolomics differences of the donor livers between in situ and ex situ conditions during ischemia-free liver transplantation","volume":"107","author":"Guo","year":"2023","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2025.102184_bb0445","article-title":"Ischaemia-free liver transplantation in humans: a first-in-human trial","volume":"16","author":"Guo","year":"2021","journal-title":"Lancet Reg. Health West. Pac."},{"issue":"2","key":"10.1016\/j.trim.2025.102184_bb0450","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jhep.2023.04.010","article-title":"A randomized-controlled trial of ischemia-free liver transplantation for end-stage liver disease","volume":"79","author":"Guo","year":"2023","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.trim.2025.102184_bb0455","doi-asserted-by":"crossref","first-page":"425","DOI":"10.21037\/atm-20-6296","article-title":"A marginal liver graft with hyperbilirubinemia transplanted successfully by ischemia-free liver transplantation","volume":"9","author":"Huang","year":"2021","journal-title":"Ann. Transl. Med."},{"issue":"5","key":"10.1016\/j.trim.2025.102184_bb0460","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-035374","article-title":"Prospective, single-centre, randomised controlled trial to evaluate the efficacy and safety of ischaemia-free liver transplantation (IFLT) in the treatment of end-stage liver disease","volume":"10","author":"Huang","year":"2020","journal-title":"BMJ Open"},{"issue":"21","key":"10.1016\/j.trim.2025.102184_bb0465","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.21037\/atm-20-2774","article-title":"Non-re-cooling implantation of marginal liver graft after machine perfusion: report of a case","volume":"8","author":"Ju","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"5","key":"10.1016\/j.trim.2025.102184_bb0470","first-page":"2855","article-title":"Substantial decline of organ preservation fluid contamination following adoption of ischemia-free liver transplantation:a post-hoc analysis","volume":"110","author":"Lin","year":"2024","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.trim.2025.102184_bb0475","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1092182","article-title":"Performance assessment of medical service for organ transplant department based on diagnosis-related groups: a programme incorporating ischemia-free liver transplantation in China","volume":"11","author":"Lu","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.trim.2025.102184_bb0480","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.773535","article-title":"Ischemic-free liver transplantation reduces the recurrence of hepatocellular carcinoma after liver transplantation","volume":"11","author":"Tang","year":"2021","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.trim.2025.102184_bb0485","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/lt.25825","article-title":"Association of perfusion characteristics and posttransplant liver function in ischemia-free liver transplantation","volume":"26","author":"Zhang","year":"2020","journal-title":"Liver Transpl."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425000127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425000127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T13:24:03Z","timestamp":1740576243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327425000127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":97,"alternative-id":["S0966327425000127"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2025.102184","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research on gene editing and immunosuppressants in kidney xenotransplantation","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2025.102184","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102184"}}