{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:12:54Z","timestamp":1763536374695,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003716","name":"Korea Basic Science Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003716","name":"the Korea Basic Science Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003716","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Ministry of Health and Welfare, Republic of Korea"},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2022-KH129441"],"award-info":[{"award-number":["RS-2022-KH129441"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2020R1A6C101A191"],"award-info":[{"award-number":["2020R1A6C101A191"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.trim.2025.102247","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T02:46:59Z","timestamp":1748918819000},"page":"102247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Identification of allogeneic and xenogeneic neural stem cells' immunogenicity in the brain and strategies to alleviate transplantation rejection"],"prefix":"10.1016","volume":"92","author":[{"given":"Xiangyu","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Oh.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Do","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geun-Hyoung","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Kwon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je Young","family":"Yeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyunghoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun-Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyeung Min","family":"Joo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.trim.2025.102247_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093103","article-title":"Neural stem cell transplantation for neurodegenerative diseases","volume":"21","author":"De Gioia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.trim.2025.102247_bb0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/2052-8426-2-31","article-title":"Neural stem cells: ready for therapeutic applications?","volume":"2","author":"Casarosa","year":"2014","journal-title":"Mol. Cell. Ther."},{"key":"10.1016\/j.trim.2025.102247_bb0015","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuint.2017.02.006","article-title":"Neural stem cell therapy for neurodegenerative disorders: the role of neurotrophic support","volume":"106","author":"Marsh","year":"2017","journal-title":"Neurochem. Int."},{"issue":"3","key":"10.1016\/j.trim.2025.102247_bb0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.trsl.2010.07.002","article-title":"Translation of stem cell therapy for neurological diseases","volume":"156","author":"Schwarz","year":"2010","journal-title":"Transl. Res."},{"key":"10.1016\/j.trim.2025.102247_bb0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-3-030-31206-0_4","article-title":"Neural stem cells","volume":"1201","author":"Tuazon","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.trim.2025.102247_bb0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13287-018-0913-2","article-title":"Neural stem cell therapy for subacute and chronic ischemic stroke","volume":"9","author":"Boese","year":"2018","journal-title":"Stem Cell Res Ther"},{"issue":"22","key":"10.1016\/j.trim.2025.102247_bb0035","doi-asserted-by":"crossref","first-page":"8944","DOI":"10.18632\/aging.204410","article-title":"JAK2\/STAT3 pathway mediates neuroprotective and pro-angiogenic treatment effects of adult human neural stem cells in middle cerebral artery occlusion stroke animal models","volume":"14","author":"Ha","year":"2022","journal-title":"Aging"},{"issue":"8","key":"10.1016\/j.trim.2025.102247_bb0040","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4252\/wjsc.v12.i8.787","article-title":"Stem cell therapy for Alzheimer's disease","volume":"12","author":"Liu","year":"2020","journal-title":"World J. Stem Cells"},{"issue":"8","key":"10.1016\/j.trim.2025.102247_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202307","article-title":"In vivo distribution of U87MG cells injected into the lateral ventricle of rats with spinal cord injury","volume":"13","author":"Won","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.trim.2025.102247_bb0050","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00281-011-0272-x","article-title":"To be or not to be accepted: the role of immunogenicity of neural stem cells following transplantation into the brain in animal and human studies","volume":"33","author":"Capetian","year":"2011","journal-title":"Semin. Immunopathol."},{"issue":"5","key":"10.1016\/j.trim.2025.102247_bb0055","doi-asserted-by":"crossref","first-page":"353","DOI":"10.5966\/sctm.2012-0018","article-title":"Translation of stem cell research: points to consider in designing preclinical animal studies","volume":"1","author":"Frey-Vasconcells","year":"2012","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.trim.2025.102247_bb0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.scr.2018.07.006","article-title":"Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury","volume":"31","author":"Lee","year":"2018","journal-title":"Stem Cell Res."},{"issue":"1","key":"10.1016\/j.trim.2025.102247_bb0065","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2015.11.005","article-title":"Understanding stem cell immunogenicity in therapeutic applications","volume":"37","author":"Wood","year":"2016","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.trim.2025.102247_bb0070","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/archsurg.1993.01420150033006","article-title":"Transplant rejection. Mechanisms and treatment","volume":"128","author":"Chandler","year":"1993","journal-title":"Arch. Surg."},{"key":"10.1016\/j.trim.2025.102247_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.661643","article-title":"Tackling chronic kidney transplant rejection: challenges and promises","volume":"12","author":"Lai","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2025.102247_bb0080","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.3389\/ti.2023.10955","article-title":"Tolerance induction in vascularized composite Allotransplantation-a brief review of preclinical models","volume":"36","author":"Huelsboemer","year":"2023","journal-title":"Transpl. Int."},{"key":"10.1016\/j.trim.2025.102247_bb0085","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211019025","article-title":"Immunosuppressant drugs mitigate immune responses generated by human mesenchymal stem cells transplanted into the mouse parenchyma","volume":"30","author":"Hwang","year":"2021","journal-title":"Cell Transplant."},{"issue":"4","key":"10.1016\/j.trim.2025.102247_bb0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2174\/1874467208666150928153511","article-title":"Stem cell therapy and immunological rejection in animal models","volume":"9","author":"Jin","year":"2016","journal-title":"Curr. Mol. Pharmacol."},{"key":"10.1016\/j.trim.2025.102247_bb0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.scr.2018.07.006","article-title":"Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury","volume":"31","author":"Lee","year":"2018","journal-title":"Stem Cell Res."},{"issue":"11","key":"10.1016\/j.trim.2025.102247_bb0100","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1111\/j.0953-816X.2004.03402.x","article-title":"The therapeutic window after spinal cord injury can accommodate T cell-based vaccination and methylprednisolone in rats","volume":"19","author":"Ibarra","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"7","key":"10.1016\/j.trim.2025.102247_bb0105","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1345\/aph.1K628","article-title":"Corticosteroid interactions with cyclosporine, tacrolimus, mycophenolate, and sirolimus: fact or fiction?","volume":"42","author":"Lam","year":"2008","journal-title":"Ann. Pharmacother."},{"issue":"3","key":"10.1016\/j.trim.2025.102247_bb0110","doi-asserted-by":"crossref","first-page":"F672","DOI":"10.1152\/ajprenal.00199.2009","article-title":"Sirolimus and cyclosporine a alter barrier function in renal proximal tubular cells through stimulation of ERK1\/2 signaling and claudin-1 expression","volume":"298","author":"Martin-Martin","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.trim.2025.102247_bb0115","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/164_2019_331","article-title":"Immunosuppressants in organ transplantation","volume":"261","author":"T\u00f6nshoff","year":"2020","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.trim.2025.102247_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146615","article-title":"The neural stem cell secretome and its role in brain repair","volume":"1729","author":"Willis","year":"2020","journal-title":"Brain Res."},{"issue":"17","key":"10.1016\/j.trim.2025.102247_bb0125","article-title":"Local immunomodulatory strategies to prevent Allo-rejection in transplantation of insulin-producing cells","volume":"8","author":"Wang","year":"2021","journal-title":"Adv. Sci. (Weinh)"},{"issue":"9","key":"10.1016\/j.trim.2025.102247_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093052","article-title":"A comparison of immune responses exerted following syngeneic, allogeneic, and xenogeneic transplantation of mesenchymal stem cells into the mouse brain","volume":"21","author":"Hwang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.trim.2025.102247_bb0135","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13287-020-01602-0","article-title":"Transplantation of human induced pluripotent stem cell-derived cardiomyocytes improves myocardial function and reverses ventricular remodeling in infarcted rat hearts","volume":"11","author":"Guan","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.trim.2025.102247_bb0140","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin-cyclosporin a and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.trim.2025.102247_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014787","article-title":"MHC mismatch inhibits neurogenesis and neuron maturation in stem cell allografts","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"17","key":"10.1016\/j.trim.2025.102247_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20174272","article-title":"Neurodegeneration and Neuro-Regeneration-Alzheimer\u2019s disease and stem cell therapy","volume":"20","author":"Vasic","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.trim.2025.102247_bb0155","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.expneurol.2005.12.035","article-title":"Sustained survival of xenografted human neural stem\/progenitor cells in experimental brain trauma despite discontinuation of immunosuppression","volume":"199","author":"Wennersten","year":"2006","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.trim.2025.102247_bb0160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s12015-009-9104-y","article-title":"Long-term fate of allogeneic neural stem cells following transplantation into injured spinal cord","volume":"6","author":"Xu","year":"2010","journal-title":"Stem Cell Rev. Rep."},{"issue":"3","key":"10.1016\/j.trim.2025.102247_bb0165","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/cmi.2011.64","article-title":"Human allograft rejection in humanized mice: a historical perspective","volume":"9","author":"Brehm","year":"2012","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.trim.2025.102247_bb0170","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00221-006-0689-y","article-title":"Time of transplantation and cell preparation determine neural stem cell survival in a mouse model of Huntington\u2019s disease","volume":"177","author":"Johann","year":"2007","journal-title":"Exp. Brain Res."},{"issue":"2","key":"10.1016\/j.trim.2025.102247_bb0175","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mehy.2012.05.010","article-title":"Improve the viability of transplanted neural cells with appropriate sized neurospheres coated with mesenchymal stem cells","volume":"79","author":"Li","year":"2012","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.trim.2025.102247_bb0180","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fnmol.2018.00136","article-title":"Brain region-dependent rejection of neural precursor cell transplants","volume":"11","author":"Fainstein","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.trim.2025.102247_bb0185","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3727\/096020198389933","article-title":"Fibronectin promotes survival and migration of primary neural stem cells transplanted into the traumatically injured mouse brain","volume":"11","author":"Tate","year":"2002","journal-title":"Cell Transplant."},{"issue":"1","key":"10.1016\/j.trim.2025.102247_bb0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/jcbfm.2010.81","article-title":"Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain","volume":"31","author":"Darsalia","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"6","key":"10.1016\/j.trim.2025.102247_bb0195","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/STROKEAHA.111.637884","article-title":"Timing of intra-arterial neural stem cell transplantation after hypoxia-ischemia influences cell engraftment, survival, and differentiation","volume":"43","author":"Rosenblum","year":"2012","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.trim.2025.102247_bb0200","first-page":"215","article-title":"Stem cell survival and functional outcome after traumatic brain injury is dependent on transplant timing and location","volume":"29","author":"Shear","year":"2011","journal-title":"Restor. Neurol. Neurosci."},{"issue":"9","key":"10.1016\/j.trim.2025.102247_bb0205","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.3727\/096368912X636920","article-title":"Cell type-associated differences in migration, survival, and immunogenicity following grafting in CNS tissue","volume":"21","author":"Praet","year":"2012","journal-title":"Cell Transplant."},{"issue":"2","key":"10.1016\/j.trim.2025.102247_bb0210","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.expneurol.2005.12.004","article-title":"The high integration and differentiation potential of autologous neural stem cell transplantation compared with allogeneic transplantation in adult rat hippocampus","volume":"199","author":"Muraoka","year":"2006","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.trim.2025.102247_bb0215","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/mrm.22613","article-title":"Long-term MR cell tracking of neural stem cells grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live and dead cells","volume":"65","author":"Berman","year":"2011","journal-title":"Magn. Reson. Med."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425000759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425000759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:45:57Z","timestamp":1762346757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327425000759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":43,"alternative-id":["S0966327425000759"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2025.102247","relation":{},"ISSN":["0966-3274"],"issn-type":[{"type":"print","value":"0966-3274"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of allogeneic and xenogeneic neural stem cells' immunogenicity in the brain and strategies to alleviate transplantation rejection","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2025.102247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102247"}}