{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:13:04Z","timestamp":1778793184073,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006256","name":"Universit\u00e0 degli Studi dell&apos;Aquila","doi-asserted-by":"publisher","award":["code07_DG_2023_13"],"award-info":[{"award-number":["code07_DG_2023_13"]}],"id":[{"id":"10.13039\/501100006256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.trim.2025.102250","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T20:20:53Z","timestamp":1749154853000},"page":"102250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Serum PD-L1 and CTLA-4 levels as biomarkers of acute rejection and renal dysfunction in kidney transplant recipients"],"prefix":"10.1016","volume":"92","author":[{"given":"Angelica","family":"Canossi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Vistoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Colanardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Del Beato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Panarese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.trim.2025.102250_bb0005","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/00007890-200010150-00018","article-title":"Increased impact of acute rejection on chronic allograft failure in recent era","volume":"70","author":"Meier-Kriesche","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2025.102250_bb0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev.pathmechdis.3.121806.151508","article-title":"Kidney transplantation: mechanisms of rejection and acceptance","volume":"3","author":"Cornell","year":"2008","journal-title":"Annu. Rev. Pathol."},{"issue":"7","key":"10.1016\/j.trim.2025.102250_bb0015","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J. Exp. Med."},{"issue":"18","key":"10.1016\/j.trim.2025.102250_bb0020","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1073\/pnas.1718217115","article-title":"Role of PD-1 during effector CD8 T cell differentiation","volume":"115","author":"Ahn","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.trim.2025.102250_bb0025","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13203","article-title":"Novel immunosuppressive effect of FK506 by upregulation of PD-L1 via FKBP51 in heart transplantation","volume":"96","author":"Luo","year":"2022","journal-title":"Scand. J. Immunol."},{"issue":"1","key":"10.1016\/j.trim.2025.102250_bb0030","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/ki.2010.97","article-title":"Renal tubular PD-L1 (CD274) suppresses alloreactive human T-cell responses","volume":"78","author":"Starke","year":"2010","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.trim.2025.102250_bb0035","first-page":"104","article-title":"Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications","volume":"26","author":"Zheng","year":"2014","journal-title":"Chin. J. Cancer Res."},{"issue":"12","key":"10.1016\/j.trim.2025.102250_bb0040","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.3390\/cancers13123034","article-title":"Soluble programmed death Ligand-1 (sPD-L1): a Pool of circulating proteins implicated in health and diseases","volume":"13","author":"Bailly","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.trim.2025.102250_bb0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.192.2.303","article-title":"Immunologic self-tolerance maintained by CD25(+) CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4","volume":"192","author":"Takahashi","year":"2000","journal-title":"J. Exp. Med."},{"issue":"12","key":"10.1016\/j.trim.2025.102250_bb0050","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nri3108","article-title":"The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses","volume":"11","author":"Walker","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.trim.2025.102250_bb0055","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.it.2011.06.002","article-title":"Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation","volume":"32","author":"Wing","year":"2011","journal-title":"Trends Immunol."},{"issue":"6029","key":"10.1016\/j.trim.2025.102250_bb0060","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.1202947","article-title":"Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4","volume":"332","author":"Qureshi","year":"2011","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.trim.2025.102250_bb0065","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ni846","article-title":"CTLA-4-Ig regulates tryptophan catabolism in vivo","volume":"3","author":"Grohmann","year":"2002","journal-title":"Nat. Immunol."},{"issue":"12","key":"10.1016\/j.trim.2025.102250_bb0070","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/ni1003","article-title":"Modulation of tryptophan catabolism by regulatory T cells","volume":"4","author":"Fallarino","year":"2003","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.trim.2025.102250_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12882-021-02608-3","article-title":"Longitudinal monitoring of mRNA levels of regulatory T cell biomarkers by using non-invasive strategies to predict outcome in renal transplantation","volume":"23","author":"Canossi","year":"2022","journal-title":"BMC Nephrol."},{"issue":"9","key":"10.1016\/j.trim.2025.102250_bb0080","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"Feldman HI et al a new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.trim.2025.102250_bb0085","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ajt.2023.10.016","article-title":"The Banff 2022 kidney meeting report: reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics","volume":"24","author":"Naesens","year":"2024","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2025.102250_bb0090","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4049\/jimmunol.1100056","article-title":"The novel costimulatory programmed death ligand 1\/B7.1 pathway is functional in inhibiting alloimmune responses in vivo","volume":"187","author":"Yang","year":"2011","journal-title":"J. Immunol."},{"issue":"416","key":"10.1016\/j.trim.2025.102250_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam7543","article-title":"PD-L1 genetic overexpression or pharmacological restoration in hematopoietic stem and progenitor cells reverses autoimmune diabetes","volume":"9","author":"Ben Nasr","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.trim.2025.102250_bb0100","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41423-019-0245-x","article-title":"IFN-\u03b3 upregulates membranous and soluble PD-L1 in mesothelioma cells: potential implications for the clinical response to PD-1\/PD-L1 blockade","volume":"17","author":"Pistillo","year":"2020","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.trim.2025.102250_bb0105","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/10799893.2020.1734820","article-title":"The role of programed death-ligand 1 in renal diseases","volume":"40","author":"Wei","year":"2020","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.trim.2025.102250_bb0110","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50256","article-title":"Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist","volume":"8","author":"Ng","year":"2019","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.trim.2025.102250_bb0115","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000449242","article-title":"The influence of hemodialysis on T regulatory cells: a Meta-analysis and systematic review","volume":"42","author":"Caprara","year":"2016","journal-title":"Blood Purif."},{"issue":"3","key":"10.1016\/j.trim.2025.102250_bb0120","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000000871","article-title":"Regulatory T-cell number in peripheral blood at 1 year Posttransplant as predictor of Long-term kidney graft survival","volume":"5","author":"San Segundo","year":"2019","journal-title":"Transplant. Direct"},{"issue":"12","key":"10.1016\/j.trim.2025.102250_bb0125","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1515\/cclm-2023-0232","article-title":"Serum sPD-L1 levels are elevated in patients with viral diseases, bacterial sepsis or in patients with impaired renal function compared to healthy blood donors","volume":"61","author":"Loacker","year":"2023","journal-title":"Clin. Chem. Lab. Med."},{"issue":"7","key":"10.1016\/j.trim.2025.102250_bb0130","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1016\/j.transproceed.2013.07.008","article-title":"Influence of cytotoxic T-lymphocyte antigen-4 polymorphisms on acute rejection onset of cadaveric renal transplants","volume":"45","author":"Canossi","year":"2013","journal-title":"Transplant. Proc."},{"issue":"10","key":"10.1016\/j.trim.2025.102250_bb0135","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.it.2018.08.004","article-title":"Hiding in plain sight: soluble immunomodulatory receptors","volume":"39","author":"Dahal","year":"2018","journal-title":"Trends Immunol."},{"issue":"11","key":"10.1016\/j.trim.2025.102250_bb0140","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3596::AID-IMMU3596>3.0.CO;2-Y","article-title":"A soluble form of CTLA-4 generated by alternative splicing is expressed by non-stimulated human T cells","volume":"29","author":"Magistrelli","year":"1999","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.trim.2025.102250_bb0145","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1002\/eji.201242529","article-title":"The soluble isoform of CTLA-4 as a regulator of T-cell responses","volume":"43","author":"Ward","year":"2013","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.trim.2025.102250_bb0150","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2567.2011.03470.x","article-title":"CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease","volume":"134","author":"Strioga","year":"2011","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.trim.2025.102250_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114768","article-title":"Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80\/PD-L1 interaction","volume":"43","author":"Robinson","year":"2024","journal-title":"Cell Rep."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425000784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425000784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:39:29Z","timestamp":1778791169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327425000784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":31,"alternative-id":["S0966327425000784"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2025.102250","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum PD-L1 and CTLA-4 levels as biomarkers of acute rejection and renal dysfunction in kidney transplant recipients","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2025.102250","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102250"}}