{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T21:15:01Z","timestamp":1765055701103,"version":"3.46.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003356","name":"Gazi \u00dcniversitesi","doi-asserted-by":"publisher","award":["02\/2017\\u201314"],"award-info":[{"award-number":["02\/2017\\u201314"]}],"id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.trim.2025.102301","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:08:55Z","timestamp":1758132535000},"page":"102301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Oral cyclosporine a nanosuspension for improved immunosuppressive efficacy: In vivo cytokine profiling in rats"],"prefix":"10.1016","volume":"93","author":[{"given":"\u00c7a\u011fman","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u0131la","family":"G\u00fclba\u011f P\u0131nar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"\u00c7elebi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"author":"U.S. Department of Health & Human Services Health Resources & Services Administration","key":"10.1016\/j.trim.2025.102301_bb0005"},{"first-page":"475","year":"2004","series-title":"Immunology Guidebook","key":"10.1016\/j.trim.2025.102301_bb0010"},{"key":"10.1016\/j.trim.2025.102301_bb0015","article-title":"A novel formulation of cyclosporine a\/phosphatidylserine-containing liposome using remote loading method: potential product for immunosuppressive effects","volume":"77","author":"Nazeri","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"2\u20133","key":"10.1016\/j.trim.2025.102301_bb0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0162-3109(00)00192-2","article-title":"Mechanisms of action of cyclosporine","volume":"47","author":"Matsuda","year":"2000","journal-title":"Immunopharmacology"},{"issue":"3","key":"10.1016\/j.trim.2025.102301_bb0025","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","article-title":"A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.trim.2025.102301_bb0030","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s43094-022-00400-0","article-title":"Pharmaceutical nanotechnology: from the bench to the market","volume":"8","author":"Mazayen","year":"2022","journal-title":"Futur. J. Pharm. Sci."},{"key":"10.1016\/j.trim.2025.102301_bb0035","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3390\/pharmaceutics15051520","article-title":"Formulation strategies of Nanosuspensions for various administration routes","volume":"15","author":"G\u00fclba\u011f P\u0131nar","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.trim.2025.102301_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113583","article-title":"Nanosuspensions as carriers of active ingredients: chemical composition, development methods, and their biological activities","volume":"174","author":"Aguilar-Hern\u00e1ndez","year":"2023","journal-title":"Food Res. Int."},{"issue":"6","key":"10.1016\/j.trim.2025.102301_bb0045","first-page":"1009","article-title":"Optimization and evaluation of cyclosporine a nanosuspension stabilized by combination stabilizers using high pressure homogenization method","volume":"23","author":"G\u00fclba\u011f P\u0131nar","year":"2019","journal-title":"J.Res.Pharm."},{"key":"10.1016\/j.trim.2025.102301_bb0050","article-title":"A new nanosuspension prepared with wet milling method for oral delivery of highly variable drug cyclosporine a: development, optimization and in vivo evaluation","volume":"171","author":"G\u00fclba\u011f P\u0131nar","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.trim.2025.102301_bb0055","article-title":"The application of freeze-drying as a production method of drug nanocrystals and solid dispersions \u2013 a review","volume":"62","author":"Jakubowska","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.trim.2025.102301_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2023.156409","article-title":"Assessing serum cytokine profiles in inflammatory breast cancer patients using Luminex\u00ae technology","volume":"172","author":"Bessaad","year":"2023","journal-title":"Cytokine"},{"key":"10.1016\/j.trim.2025.102301_bb0065","article-title":"Freeze-drying of drug nanosuspension\u2013 study of formulation and processing factors for the optimization and characterization of redispersible cilostazol nanocrystals","volume":"74","author":"Jakubowska","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.trim.2025.102301_bb0070","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.trim.2025.102301_bb0075","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.immunol.22.012703.104622","article-title":"Interleukin-10 and related cytokines and receptors","volume":"22","author":"Pestka","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.trim.2025.102301_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.154987","article-title":"Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis","volume":"127","author":"Duruel","year":"2020","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.trim.2025.102301_bb0085","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","article-title":"Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease","volume":"129","author":"Onishi","year":"2010","journal-title":"Immunol"},{"key":"10.1016\/j.trim.2025.102301_bb0090","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.trim.2025.102301_bb0095","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00784-022-04730-4","article-title":"Evaluation of periodontal status and cytokine response in children with familial Mediterranean fever or systemic juvenile idiopathic arthritis","volume":"27","author":"Acar","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.trim.2025.102301_bb0100","first-page":"S103","article-title":"Evaluation of long-term silicone hydrogel use on ocular surface using impression cytology and tear cytokine analysis","volume":"44","author":"Y\u00fccekul","year":"2018","journal-title":"Eye Contact Lens"},{"issue":"1","key":"10.1016\/j.trim.2025.102301_bb0105","first-page":"1","article-title":"Monocyte chemoattractant protein-1 (MCP-1): an overview","volume":"47","author":"Deshmane","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.trim.2025.102301_bb0110","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s10266-020-00565-1","article-title":"Evaluation of periodontal status and cytokine\/chemokine profile of GCF in patients with severe congenital neutropenia","volume":"109","author":"Acar","year":"2021","journal-title":"Odontology"},{"issue":"7","key":"10.1016\/j.trim.2025.102301_bb0115","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.addr.2007.05.003","article-title":"Nanosizing--oral formulation development and biopharmaceutical evaluation","volume":"59","author":"Kesisoglou","year":"2007","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425001297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327425001297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T21:12:20Z","timestamp":1765055540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327425001297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":23,"alternative-id":["S0966327425001297"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2025.102301","relation":{},"ISSN":["0966-3274"],"issn-type":[{"type":"print","value":"0966-3274"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral cyclosporine a nanosuspension for improved immunosuppressive efficacy: In vivo cytokine profiling in rats","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2025.102301","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102301"}}