{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:03:43Z","timestamp":1780297423666,"version":"3.54.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.trim.2026.102395","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T19:34:07Z","timestamp":1777577647000},"page":"102395","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The impact of rabbit anti-thymocyte globulin (thymoglobulin) timing and dosing on pediatric stem cell transplantation outcomes: Time to move forward"],"prefix":"10.1016","volume":"96","author":[{"given":"Mohammad","family":"Jahanpanah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Behfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Farajifard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atieh","family":"Karimzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soudeh","family":"Ramezani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Mokaram Doost Delkhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Ali","family":"Hamidieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.trim.2026.102395_bb0005","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13287-024-04126-z","article-title":"Hematopoietic stem cells: understanding the mechanisms to unleash the therapeutic potential of hematopoietic stem cell transplantation","volume":"16","author":"Aljagthmi","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"9","key":"10.1016\/j.trim.2026.102395_bb0010","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1182\/bloodadvances.2024014836","article-title":"Improved survival with model-based dosing of antithymocyte globulin in pediatric hematopoietic cell transplantation","volume":"9","author":"Admiraal","year":"2025","journal-title":"Blood Adv."},{"issue":"7","key":"10.1016\/j.trim.2026.102395_bb0015","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/sj.bmt.1703680","article-title":"Immune reconstitution after haematopoietic transplantation with two different doses of pre-graft antithymocyte globulin","volume":"30","author":"Duval","year":"2002","journal-title":"Bone Marrow Transplant."},{"issue":"2","key":"10.1016\/j.trim.2026.102395_bb0020","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/S2352-3026(21)00375-6","article-title":"Individualised dosing of anti-thymocyte globulin in paediatric unrelated allogeneic haematopoietic stem-cell transplantation (PARACHUTE): a single-arm, phase 2 clinical trial","volume":"9","author":"Admiraal","year":"2022","journal-title":"Lancet Haematol."},{"issue":"4","key":"10.1016\/j.trim.2026.102395_bb0025","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1016\/S2352-3026(17)30029-7","article-title":"Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a multicentre, retrospective, pharmacodynamic cohort analysis","volume":"4","author":"Admiraal","year":"2017","journal-title":"Lancet Haematol."},{"issue":"12","key":"10.1016\/j.trim.2026.102395_bb0030","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.bbmt.2017.08.027","article-title":"Comparison of different rabbit anti-thymocyte globulin formulations in allogeneic stem cell transplantation: systematic literature review and network Meta-analysis","volume":"23","author":"Gagelmann","year":"2017","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"3","key":"10.1016\/j.trim.2026.102395_bb0035","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s00277-025-06267-4","article-title":"Comparison of ATG-thymoglobulin with atg-fresenius in patients with hematological malignancies who undergo allogeneic hematopoietic stem cell transplantation: a propensity score-matched analysis","volume":"104","author":"Zhang","year":"2025","journal-title":"Ann. Hematol."},{"issue":"5","key":"10.1016\/j.trim.2026.102395_bb0040","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1016\/S2352-3026(15)00045-9","article-title":"Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis","volume":"2","author":"Admiraal","year":"2015","journal-title":"Lancet Haematol."},{"issue":"1","key":"10.1016\/j.trim.2026.102395_bb0045","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbmt.2017.08.029","article-title":"Optimizing antithymocyte globulin dosing for unrelated donor allogeneic hematopoietic cell transplantation based on recipient absolute lymphocyte count","volume":"24","author":"Kennedy","year":"2018","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"4","key":"10.1016\/j.trim.2026.102395_bb0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41409-024-02206-5","article-title":"Individualized dose of anti-thymocyte globulin based on weight and pre-transplantation lymphocyte counts in pediatric patients: a single center experience","volume":"59","author":"Barriga","year":"2024","journal-title":"Bone Marrow Transplant."},{"issue":"4","key":"10.1016\/j.trim.2026.102395_bb0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s40262-014-0214-6","article-title":"Population pharmacokinetic modeling of thymoglobulin(\u00ae) in children receiving allogeneic-hematopoietic cell transplantation: towards improved survival through individualized dosing","volume":"54","author":"Admiraal","year":"2015","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.trim.2026.102395_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.828094","article-title":"Therapeutic drug monitoring of anti-Thymocyte globulin in allogeneic stem cell transplantation: proof of concept","volume":"13","author":"Meesters-Ensing","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.trim.2026.102395_bb0065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fimmu.2019.00315","article-title":"Differential elimination of anti-thymocyte globulin of Fresenius and Genzyme impacts T-cell reconstitution after hematopoietic stem cell transplantation","volume":"10","author":"Oostenbrink","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.trim.2026.102395_bb0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbmt.2012.10.010","article-title":"Immune reconstitution kinetics as an early predictor for mortality using various hematopoietic stem cell sources in children","volume":"19","author":"Bartelink","year":"2013","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"2","key":"10.1016\/j.trim.2026.102395_bb0075","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1182\/blood.V93.2.467","article-title":"Comparison of immune reconstitution after unrelated and related T-cell\u2013depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions","volume":"93","author":"Small","year":"1999","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.trim.2026.102395_bb0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1182\/blood-2013-05-502385","article-title":"Impact of thymoglobulin prior to pediatric unrelated umbilical cord blood transplantation on immune reconstitution and clinical outcome","volume":"123","author":"Lindemans","year":"2014","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.trim.2026.102395_bb0085","doi-asserted-by":"crossref","first-page":"263.e1","DOI":"10.1016\/j.jtct.2025.01.893","article-title":"Bodyweight and absolute lymphocyte count-based dosing of rabbit anti-thymocyte globulin results in early CD4(+) immune reconstitution in patients with inborn errors of metabolism undergoing umbilical cord blood transplantation","volume":"31","author":"Drozdov","year":"2025","journal-title":"Transplant. Cell Ther."},{"issue":"23","key":"10.1016\/j.trim.2026.102395_bb0090","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1182\/bloodadvances.2024012670","article-title":"Effect of rabbit ATG PK on outcomes after TCR-\u03b1\u03b2\/CD19-depleted pediatric haploidentical HCT for hematologic malignancy","volume":"8","author":"Dvorak","year":"2024","journal-title":"Blood Adv."},{"issue":"8","key":"10.1016\/j.trim.2026.102395_bb0095","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jcyt.2025.04.069","article-title":"Immune monitoring after cell therapy and hematopoietic cell transplantation: guidelines by the ISCT stem cell engineering committee","volume":"27","author":"Oppizzi","year":"2025","journal-title":"Cytotherapy"}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426000535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426000535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T06:49:46Z","timestamp":1780296586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327426000535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":19,"alternative-id":["S0966327426000535"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2026.102395","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of rabbit anti-thymocyte globulin (thymoglobulin) timing and dosing on pediatric stem cell transplantation outcomes: Time to move forward","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2026.102395","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102395"}}