{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:55:43Z","timestamp":1785700543333,"version":"3.56.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2026R227"],"award-info":[{"award-number":["PNURSP2026R227"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.trim.2026.102411","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:01:11Z","timestamp":1780329671000},"page":"102411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Designing a multi-epitope vaccine against Leishmania major with broad population coverage and innate immune activation through immunoinformatic approaches"],"prefix":"10.1016","volume":"97","author":[{"given":"Rehana","family":"Shaheen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razia","family":"Bibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Aurongzeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Amer","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaz Ali","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Abdullah","family":"Alwaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Al-Hoshani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Alzhrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omniah A.","family":"Mansouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trim.2026.102411_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.702240","article-title":"Advances in understanding leishmania pathobiology: what does rna-seq tell us?","volume":"9","author":"Salloum","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011909","article-title":"The psychosocial burden of cutaneous leishmaniasis in rural Sri Lanka: a multi-method qualitative study","volume":"18","author":"Nuwangi","year":"2024","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.trim.2026.102411_bb0015","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s40257-022-00726-8","article-title":"Cutaneous leishmaniasis: a 2022 updated narrative review into diagnosis and management developments: HJC de Vries, HD Schallig","volume":"23","author":"de Vries","year":"2022","journal-title":"Am. J. Clin. Dermatol."},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/21678707.2024.2335248","article-title":"Current and emerging therapies for the treatment of leishmaniasis","volume":"12","author":"Sundar","year":"2024","journal-title":"Expert Opin. Orphan Drugs"},{"issue":"5","key":"10.1016\/j.trim.2026.102411_bb0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010391","article-title":"Indoor residual spraying for the control of visceral leishmaniasis: a systematic review","volume":"16","author":"Faber","year":"2022","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"4","key":"10.1016\/j.trim.2026.102411_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens11040431","article-title":"The history of live attenuated centrin gene-deleted Leishmania vaccine candidates","volume":"11","author":"Volpedo","year":"2022","journal-title":"Pathogens"},{"issue":"9","key":"10.1016\/j.trim.2026.102411_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens13090812","article-title":"Advances in Leishmania vaccines: current development and future prospects","volume":"13","author":"Ayala","year":"2024","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00430-021-00700-x","article-title":"Identification and selection of immunodominant B and T cell epitopes for dengue multi-epitope-based vaccine","volume":"210","author":"Lim","year":"2021","journal-title":"Med. Microbiol. Immunol."},{"issue":"12","key":"10.1016\/j.trim.2026.102411_bb0045","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.tips.2024.10.013","article-title":"Challenges and considerations in multi-epitope vaccine design surrounding toll-like receptors","volume":"45","author":"Shah","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.trim.2026.102411_bb0050","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1080\/14760584.2020.1811091","article-title":"Designing an efficient multi-epitope vaccine displaying interactions with diverse HLA molecules for an efficient humoral and cellular immune response to prevent COVID-19 infection","volume":"19","author":"Mahapatra","year":"2020","journal-title":"Expert Rev. Vaccines"},{"issue":"10","key":"10.1016\/j.trim.2026.102411_bb0055","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3390\/vaccines9101058","article-title":"A T-cell epitope-based multi-epitope vaccine designed using human HLA specific T cell epitopes induces a near-sterile immunity against experimental visceral leishmaniasis in hamsters","volume":"9","author":"Arya","year":"2021","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0060","doi-asserted-by":"crossref","first-page":"39","DOI":"10.37962\/jbas.v16i1.680","article-title":"Protein subunit and DNA vaccines key research, Development & Future Directions","volume":"16","author":"Shahab","year":"2025","journal-title":"RADS J. Biol. Res. Appl. Sci."},{"issue":"12","key":"10.1016\/j.trim.2026.102411_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0244176","article-title":"Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: immunoinformatics and in silico approaches","volume":"15","author":"Tahir ul Qamar","year":"2020","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.trim.2026.102411_bb0070","article-title":"Development of a vaccine construct against pneumocystis jirovecii pneumonia using computational tools","volume":"7","author":"Mishra","year":"2025","journal-title":"NAR Genom. Bioinform."},{"issue":"17","key":"10.1016\/j.trim.2026.102411_bb0075","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1080\/07391102.2025.2480263","article-title":"Leveraging core proteome data of Kingella kingae for multi-epitope vaccine design against TonB dependent receptor (TDR): an in silico approach","volume":"43","author":"Alshamrani","year":"2025","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.trim.2026.102411_bb0080","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-025-11242-5","article-title":"Immunoinformatics-based development of a multi-epitope vaccine candidate targeting coinfection by Klebsiella pneumoniae and Acinetobacter baumannii","volume":"25","author":"Afshan","year":"2025","journal-title":"BMC Infect. Dis."},{"issue":"8","key":"10.1016\/j.trim.2026.102411_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines9080818","article-title":"Towards an ensemble vaccine against the pegivirus using computational modelling approaches and its validation through in silico cloning and immune simulation","volume":"9","author":"Zheng","year":"2021","journal-title":"Vaccines"},{"issue":"D1","key":"10.1016\/j.trim.2026.102411_bb0090","doi-asserted-by":"crossref","first-page":"D339","DOI":"10.1093\/nar\/gky1006","article-title":"The immune epitope database (IEDB): 2018 update","volume":"47","author":"Vita","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0095","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.trim.2026.102411_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.565730","article-title":"Class I HLA allele predicted restricted antigenic coverages for spike and nucleocapsid proteins are associated with deaths related to COVID-19","volume":"11","author":"Pretti","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-025-06756-5","article-title":"Screening helper T lymphocyte epitopes based on IFN-\u03b3\/IL-10 ratio for developing a novel multi-epitope vaccine candidate using Wolbachia surface protein as an adjuvant against visceral leishmaniasis","volume":"18","author":"Zhang","year":"2025","journal-title":"Parasit. Vectors"},{"issue":"W1","key":"10.1016\/j.trim.2026.102411_bb0110","doi-asserted-by":"crossref","first-page":"W36","DOI":"10.1093\/nar\/gkac446","article-title":"AllerCatPro 2.0: a web server for predicting protein allergenicity potential","volume":"50","author":"Nguyen","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.trim.2026.102411_bb0115","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3390\/pharmaceutics15020431","article-title":"CSM-toxin: a web-server for predicting protein toxicity","volume":"15","author":"Morozov","year":"2023","journal-title":"Pharmaceutics"},{"issue":"19","key":"10.1016\/j.trim.2026.102411_bb0120","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1093\/bioinformatics\/btx345","article-title":"Protein\u2013sol: a web tool for predicting protein solubility from sequence","volume":"33","author":"Hebditch","year":"2017","journal-title":"Bioinformatics"},{"issue":"7873","key":"10.1016\/j.trim.2026.102411_bb0125","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"nature"},{"issue":"W1","key":"10.1016\/j.trim.2026.102411_bb0130","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gkz288","article-title":"GalaxyRefine2: simultaneous refinement of inaccurate local regions and overall protein structure","volume":"47","author":"Lee","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.trim.2026.102411_bb0135","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nprot.2016.169","article-title":"The ClusPro web server for protein\u2013protein docking","volume":"12","author":"Kozakov","year":"2017","journal-title":"Nat. Protoc."},{"issue":"8","key":"10.1016\/j.trim.2026.102411_bb0140","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1016\/j.bpj.2015.08.015","article-title":"MDTraj: a modern open library for the analysis of molecular dynamics trajectories","volume":"109","author":"McGibbon","year":"2015","journal-title":"Biophys. J."},{"issue":"18","key":"10.1016\/j.trim.2026.102411_bb0145","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/bioinformatics\/btz062","article-title":"Calculation of accurate interatomic contact surface areas for the quantitative analysis of non-bonded molecular interactions","volume":"35","author":"Ribeiro","year":"2019","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.trim.2026.102411_bb0150","doi-asserted-by":"crossref","first-page":"W24","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","volume":"45","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0155","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko","year":"2008","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.trim.2026.102411_bb0160","unstructured":"Castiglione, F. and M. Bernaschi. C-immsim: playing with the immune response. In Proceedings of the Sixteenth International Symposium on Mathematical Theory of Networks and Systems (MTNS2004). 2004. Katholieke Universiteit Leuven Belgium."},{"issue":"suppl_2","key":"10.1016\/j.trim.2026.102411_bb0165","doi-asserted-by":"crossref","first-page":"W526","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.trim.2026.102411_bb0170","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1016\/j.apsb.2021.04.019","article-title":"Salmonella flagella confer anti-tumor immunological effect via activating flagellin\/TLR5 signalling within tumor microenvironment","volume":"11","author":"Chen","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0175","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2217\/fmb.09.104","article-title":"Defensins as anti-inflammatory compounds and mucosal adjuvants","volume":"5","author":"Kohlgraf","year":"2010","journal-title":"Future Microbiol."},{"issue":"2","key":"10.1016\/j.trim.2026.102411_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030839","article-title":"Synthetic toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants","volume":"7","author":"Shanmugam","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.trim.2026.102411_bb0185","series-title":"Molecular and Cellular Biology of Pathogenic Trypanosomatids","first-page":"291","article-title":"Virulence Factors and Immune Evasion in Leishmania Spp","author":"Requena","year":"2017"},{"issue":"8","key":"10.1016\/j.trim.2026.102411_bb0190","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s11010-023-04825-w","article-title":"A review of immune modulators and immunotherapy in infectious diseases","volume":"479","author":"Sangeetha Vijayan","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.trim.2026.102411_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02529","article-title":"Macrophage polarization in leishmaniasis: broadening horizons","volume":"9","author":"Tomiotto-Pellissier","year":"2018","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.trim.2026.102411_bb0200","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri.2016.72","article-title":"Cutaneous leishmaniasis: immune responses in protection and pathogenesis","volume":"16","author":"Scott","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.trim.2026.102411_bb0205","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrmicro2608","article-title":"Leishmaniasis: complexity at the host\u2013pathogen interface","volume":"9","author":"Kaye","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"issue":"28","key":"10.1016\/j.trim.2026.102411_bb0210","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.2174\/138161209789105171","article-title":"HLA-DR: molecular insights and vaccine design","volume":"15","author":"Stern","year":"2009","journal-title":"Curr. Pharm. Des."},{"issue":"3","key":"10.1016\/j.trim.2026.102411_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230381","article-title":"The immunogenicity and protective immunity of multi-epitopes DNA prime-protein boost vaccines encoding amastin-Kmp-11, Kmp11-Gp63 and amastin-Gp63 against visceral leishmaniasis","volume":"15","author":"Zhang","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.jgeb.2024.100355","article-title":"Multi-epitope vaccine design against leishmaniasis using IFN-\u03b3 inducing epitopes from immunodominant gp46 and gp63 proteins","volume":"22","author":"Dehghani","year":"2024","journal-title":"J. Genetic Eng. Biotechnol."},{"issue":"11","key":"10.1016\/j.trim.2026.102411_bb0225","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00018-022-04583-w","article-title":"Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization","volume":"79","author":"Kumar","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0230","doi-asserted-by":"crossref","DOI":"10.16966\/2470-9948.109","article-title":"Plasmodium sexual stage parasites present distinct targets for malaria transmission-blocking vaccine design","volume":"2","author":"Peymanfar","year":"2016","journal-title":"Intern. J. Vaccine Immuniz."},{"issue":"2","key":"10.1016\/j.trim.2026.102411_bb0235","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/14760584.2021.1878028","article-title":"Transmission-blocking vaccines: harnessing herd immunity for malaria elimination","volume":"20","author":"Duffy","year":"2021","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.trim.2026.102411_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.02351","article-title":"The diverse functional roles of elongation factor Tu (EF-Tu) in microbial pathogenesis","volume":"10","author":"Harvey","year":"2019","journal-title":"Front. Microbiol."},{"issue":"20","key":"10.1016\/j.trim.2026.102411_bb0245","doi-asserted-by":"crossref","first-page":"7856","DOI":"10.1073\/pnas.87.20.7856","article-title":"Evolutionary conservation of antigen recognition: the chicken T-cell receptor beta chain","volume":"87","author":"Tjoelker","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.trim.2026.102411_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines7040156","article-title":"Anti-leishmanial vaccines: assumptions, approaches, and annulments","volume":"7","author":"Zutshi","year":"2019","journal-title":"Vaccines"},{"issue":"1","key":"10.1016\/j.trim.2026.102411_bb0255","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.0105-2896.2004.00144.x","article-title":"Modulating vaccine responses with dendritic cells and toll-like receptors","volume":"199","author":"Pulendran","year":"2004","journal-title":"Immunol. Rev."},{"issue":"8","key":"10.1016\/j.trim.2026.102411_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14081671","article-title":"Protein-based adjuvants for vaccines as immunomodulators of the innate and adaptive immune response: current knowledge, challenges, and future opportunities","volume":"14","author":"D\u00edaz-Dinamarca","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.trim.2026.102411_bb0265","doi-asserted-by":"crossref","first-page":"1711088","DOI":"10.3389\/fmicb.2025.1711088","article-title":"Innate immune sensing and vaccine strategies against West Nile virus: role of toll-like receptors and viral evasion mechanisms","volume":"16","author":"Kayesh","year":"2025","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.trim.2026.102411_bb0270","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.immuni.2022.10.014","article-title":"Innate immune mechanisms of mRNA vaccines","volume":"55","author":"Verbeke","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.trim.2026.102411_bb0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.660183","article-title":"Host-directed therapies for cutaneous leishmaniasis","volume":"12","author":"Novais","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426000699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426000699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:39:12Z","timestamp":1785699552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327426000699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":55,"alternative-id":["S0966327426000699"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2026.102411","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Designing a multi-epitope vaccine against Leishmania major with broad population coverage and innate immune activation through immunoinformatic approaches","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2026.102411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102411"}}