{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:14:35Z","timestamp":1788621275746,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.trim.2026.102433","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:22:24Z","timestamp":1787181744000},"page":"102433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Platelet based regimen in desensitization of highly sensitized patients with kidney transplantation. A novel therapy"],"prefix":"10.1016","volume":"98","author":[{"given":"Sara","family":"Hasibi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eghlim","family":"Nemati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Javanbakht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Einollahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trim.2026.102433_bb0005","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.kint.2019.07.012","article-title":"A single number for advocacy and communication-worldwide more than 850 million individuals have kidney diseases","volume":"96","author":"Jager","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.trim.2026.102433_bb0010","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/S0140-6736(17)32152-9","article-title":"Global, regional, and national agesex specific mortality for 264 causes of death, 1980-2016: a systematic analysis for the global burden of disease study 2016","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.trim.2026.102433_bb0015","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.trim.2026.102433_bb0020","unstructured":"The Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD). Available at: https:\/\/ kdigo.org\/wp-content\/uploads\/2017\/02\/KDIGO_2012_CKD_GL.pdf. Accessed December 15, 2020."},{"key":"10.1016\/j.trim.2026.102433_bb0025","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1681\/ASN.2008080860","article-title":"Prediction, progression, and outcomes of chronic kidney disease in older adults","volume":"20","author":"Anderson","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.trim.2026.102433_bb0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ndt\/gfy174","article-title":"Cardiovascular disease in dialysis patients","volume":"33","author":"Cozzolino","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.trim.2026.102433_bb0035","author":"Xu"},{"key":"10.1016\/j.trim.2026.102433_bb0040","series-title":"2020 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States, Volume 2","article-title":"Chapter 5. End stage renal disease: mortality","author":"US Renal Data System","year":"2020"},{"issue":"2","key":"10.1016\/j.trim.2026.102433_bb0045","first-page":"95","article-title":"Perspective of 20 years hemodialysis registry in Iran, on the road to progress","volume":"14","author":"Nafar","year":"2020","journal-title":"Iran. J. Kidney Dis."},{"issue":"1","key":"10.1016\/j.trim.2026.102433_bb0050","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/j.semvascsurg.2021.02.010","article-title":"Epidemiology of end-stage kidney disease","volume":"34","author":"Gupta","year":"2021","journal-title":"Semin. Vasc. Surg."},{"issue":"6","key":"10.1016\/j.trim.2026.102433_bb0055","first-page":"89","article-title":"Quality of life of chronic kidney disease patients on renal replacement therapy","volume":"90","author":"Milovanov","year":"2018","journal-title":"Ter. Arkh."},{"key":"10.1016\/j.trim.2026.102433_bb0060","author":"Health Resources and Services Administration"},{"key":"10.1016\/j.trim.2026.102433_bb0065","doi-asserted-by":"crossref","first-page":"922","DOI":"10.2215\/CJN.08140910","article-title":"Desensitization protocols and their outcome","volume":"6","author":"Marfo","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"10","key":"10.1016\/j.trim.2026.102433_bb0070","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.ekir.2021.07.024","article-title":"Immortal time-Bias-corrected survival of highly sensitized patients and HLA-desensitized kidney transplant recipients","volume":"6","author":"Noble","year":"2021","journal-title":"Kidney Int Rep."},{"key":"10.1016\/j.trim.2026.102433_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.696467","article-title":"New perspectives on desensitization in the current era - an overview","volume":"12","author":"Kumar","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2026.102433_bb0080","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1056\/NEJMoa1012376","article-title":"Desensitization in HLA-incompatible kidney recipients and survival","volume":"365","author":"Montgomery","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.trim.2026.102433_bb0085","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.humimm.2023.02.005","article-title":"COVID-19 infection and vaccination rarely impact HLA antibody profile in waitlisted renal transplant candidates- a multicenter cohort","volume":"84","author":"Roll","year":"2023","journal-title":"Hum. Immunol."},{"issue":"9","key":"10.1016\/j.trim.2026.102433_bb0090","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1111\/j.1600-6143.2011.03705.x","article-title":"Blood transfusions in organ transplant patients: mechanisms of sensitization and implications for prevention","volume":"11","author":"Scornik","year":"2011","journal-title":"Am. J. Transplant."},{"issue":"9","key":"10.1016\/j.trim.2026.102433_bb0095","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/j.1537-2995.2009.02206.x","article-title":"The effect of previous pregnancy and transfusion on HLA alloimmunization in blood donors: implications for a transfusion-related acute lung injury risk reduction strategy","volume":"49","author":"Triulzi","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.trim.2026.102433_bb0100","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1056\/NEJM196904032801401","article-title":"Significance of the positive crossmatch test in kidney transplantation","volume":"280","author":"Patel","year":"1969","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.trim.2026.102433_bb0105","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/01.TP.0000112934.12622.2B","article-title":"Rituximab for reduction of anti-HLA antibodies in patients awaiting renal transplantation: 1. Safety, pharmacodynamics, and pharmacokinetics","volume":"77","author":"Vieira","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2026.102433_bb0110","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1681\/ASN.V12122807","article-title":"Flow cytometric crossmatching in primary renal transplant recipients with a negative anti-human globulin enhanced cytotoxicity crossmatch","volume":"12","author":"Karpinski","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.trim.2026.102433_bb0115","series-title":"ASHI Laboratory Manual","first-page":"41","article-title":"Flow Cytometric T and B Cell Crossmatching","author":"Hamrick","year":"2000"},{"key":"10.1016\/j.trim.2026.102433_bb0120","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000351459","article-title":"Luminex(\u00ae ) and its applications for solid organ transplantation, hematopoietic stem cell transplantation, and transfusion","volume":"40","author":"Lachmann","year":"2013","journal-title":"Transfus. Med. Hemother."},{"key":"10.1016\/j.trim.2026.102433_bb0125","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1111\/ajt.12287","article-title":"Comprehensive assessment and standardization of solid phase multiplex-bead arrays for the detection of antibodies to HLA","volume":"13","author":"Reed","year":"2013","journal-title":"Am. J. Transplant."},{"issue":"7","key":"10.1016\/j.trim.2026.102433_bb0130","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1681\/ASN.2014080837","article-title":"Utility of HLA antibody testing in kidney transplantation","volume":"26","author":"Konvalinka","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.trim.2026.102433_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.694763","article-title":"Emerging new approaches in desensitization: targeted therapies for HLA sensitization","volume":"12","author":"Choi","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2026.102433_bb0140","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/TP.0b013e3182612967","article-title":"High transplant rates of highly sensitized recipients with virtual crossmatching in kidney paired donation","volume":"94","author":"Ferrari","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2026.102433_bb0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.23950\/jcmk\/11423","article-title":"Desensitization in kidney transplantation: review","volume":"18","author":"Saparbay","year":"2021","journal-title":"J. Clin. Med. Kazakhstan"},{"key":"10.1016\/j.trim.2026.102433_bb0150","series-title":"Bridging the Gap and Saving Lives - A Comprehensive Guide to Organ Donation [Working Title]","article-title":"Desensitization strategies in kidney transplantation","author":"Nafar","year":"2024"},{"key":"10.1016\/j.trim.2026.102433_bb0155","first-page":"127","article-title":"Comparing plasmapheresis plus IVIg with plasmapheresis plus IVIg plus rituximab on the management of suspicious antibody-mediated acute rejection in kidney transplant recipients","volume":"10","author":"Ahmadi","year":"2019","journal-title":"Int. J. Organ Transplant. Med."},{"key":"10.1016\/j.trim.2026.102433_bb0160","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000002635","article-title":"Desensitization using Bortezomib and high-dose immunoglobulin increases rate of deceased donor kidney transplantation","volume":"95","author":"Jeong","year":"2016","journal-title":"Medicine"},{"issue":"2","key":"10.1016\/j.trim.2026.102433_bb0165","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/TP.0000000000004689","article-title":"Imlifidase desensitization in HLA-incompatible kidney transplantation: finding the sweet spot","volume":"108","author":"de Weerd","year":"2024","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.trim.2026.102433_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.transci.2023.103844","article-title":"Therapeutic apheresis in renal transplantation: an update","volume":"63","author":"Melexopoulou","year":"2024","journal-title":"Transfus. Apher. Sci."},{"issue":"2","key":"10.1016\/j.trim.2026.102433_bb0175","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1097\/TXD.0000000000000570","article-title":"Early and sustained reduction in donor-specific antibodies in desensitized living donor kidney transplant recipients: a 3-year prospective study","volume":"2","author":"Shaffer","year":"2016","journal-title":"Transplant. Direct"},{"key":"10.1016\/j.trim.2026.102433_bb0180","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41409-018-0220-7","article-title":"Depletion of donor-specific anti-HLA A2 alloantibodies in a hematopoietic cell transplant recipient using directed mismatched platelet transfusions","volume":"53","author":"Spriewald","year":"2018","journal-title":"Bone Marrow Transplant."},{"issue":"5","key":"10.1016\/j.trim.2026.102433_bb0185","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/bmt.2017.10","article-title":"Effective desensitization of donor-specific HLA antibodies using platelet transfusion bearing targeted HLA in a case of HLA-mismatched allogeneic stem cell transplantation","volume":"52","author":"Yamashita","year":"2017","journal-title":"Bone Marrow Transplant."},{"issue":"3","key":"10.1016\/j.trim.2026.102433_bb0190","doi-asserted-by":"crossref","first-page":"355","DOI":"10.23876\/j.krcp.21.012","article-title":"Kidney transplantation in highly sensitized recipients","volume":"40","author":"Park","year":"2021","journal-title":"Kidney Res Clin Pract."},{"key":"10.1016\/j.trim.2026.102433_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-54397-3","article-title":"Effect of simultaneous presence of anti-blood group a\/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study","volume":"9","author":"Kwon","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.trim.2026.102433_bb0200","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/TP.0b013e3181919a16","article-title":"Living donor kidney transplantation across positive crossmatch: the University of Illinois at Chicago experience","volume":"87","author":"Thielke","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2026.102433_bb0205","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/ajt.13050","article-title":"Prospective iterative trial of proteasome inhibitor-based desensitization","volume":"15","author":"Woodle","year":"2015","journal-title":"Am. J. Transplant."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426000912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426000912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:55:35Z","timestamp":1788620135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327426000912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":41,"alternative-id":["S0966327426000912"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2026.102433","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet based regimen in desensitization of highly sensitized patients with kidney transplantation. A novel therapy","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2026.102433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102433"}}