{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:55:54Z","timestamp":1791413754964,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["Transformational Project Award"],"award-info":[{"award-number":["Transformational Project Award"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["Catalyst Award"],"award-info":[{"award-number":["Catalyst Award"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplant Immunology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.trim.2026.102460","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:19:09Z","timestamp":1790291949000},"page":"102460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CD43 is a checkpoint against KLRG-1+CD49dhi effector CD8+ T cell formation"],"prefix":"10.1016","volume":"99","author":[{"given":"Yukai","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Freibaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory S.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley P.","family":"Leathem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M.","family":"Krummey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trim.2026.102460_bb0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/01.TP.0000438196.30790.66","article-title":"Intermediate-term graft loss after renal transplantation is associated with both donor-specific antibody and acute rejection","volume":"97","author":"DeVos","year":"2014","journal-title":"Transplantation"},{"key":"10.1016\/j.trim.2026.102460_bb0010","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe4929","article-title":"Transitional B cell cytokines predict renal allograft outcomes","volume":"13","author":"Cherukuri","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.trim.2026.102460_bb0015","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1600-6143.2011.03539.x","article-title":"Solid organ allograft survival improvement in the United States: the long-term does not mirror the dramatic short-term success","volume":"11","author":"Lodhi","year":"2011","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2026.102460_bb0020","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-6143.2010.03283.x","article-title":"Long-term renal allograft survival in the United States: a critical reappraisal","volume":"11","author":"Lamb","year":"2011","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2026.102460_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2016.04.012","article-title":"T cell cosignaling molecules in transplantation","volume":"44","author":"Ford","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.trim.2026.102460_bb0030","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.4049\/jimmunol.1601135","article-title":"Costimulation blockade in autoimmunity and transplantation: the CD28 pathway","volume":"197","author":"Adams","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0035","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.trim.2026.102460_bb0040","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41577-020-0306-5","article-title":"A guide to cancer immunotherapy: from T cell basic science to clinical practice","volume":"20","author":"Waldman","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1617773","article-title":"Leveraging innate immune signals in CD8+ T cells to boost antitumor immunity","volume":"16","author":"Albert","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/ni.2849","article-title":"Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells","volume":"15","author":"Mahmud","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0055","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1084\/jem.182.1.139","article-title":"CD43 is a murine T cell costimulatory receptor that functions independently of CD28","volume":"182","author":"Sperling","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.trim.2026.102460_bb0060","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nri3405","article-title":"Molecular mechanisms of T cell co-stimulation and co-inhibition","volume":"13","author":"Chen","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0065","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.4049\/jimmunol.162.7.4109","article-title":"Structural requirements for CD43 function","volume":"162","author":"Walker","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0070","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0167-5699(98)01343-7","article-title":"The Roman god Janus: a paradigm for the function of CD43","volume":"19","author":"Ostberg","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/j.trim.2026.102460_bb0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cellimm.2006.06.007","article-title":"Modulation of MOG 37\u201350-specific CD8+ T cell activation and expansion by CD43","volume":"240","author":"Ford","year":"2006","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0080","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.4049\/jimmunol.171.12.6527","article-title":"CD43 modulates severity and onset of experimental autoimmune encephalomyelitis","volume":"171","author":"Ford","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0085","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.4049\/jimmunol.168.12.6022","article-title":"Dynamic regulation of T cell immunity by CD43","volume":"168","author":"Onami","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202656","article-title":"Increased mortality in CD43-deficient mice during sepsis","volume":"13","author":"Fay","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.trim.2026.102460_bb0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/354233a0","article-title":"CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1","volume":"354","author":"Rosenstein","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.trim.2026.102460_bb0100","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/377535a0","article-title":"Negative regulation of T-cell adhesion and activation by CD43","volume":"377","author":"Manjunath","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.trim.2026.102460_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajt.2026.02.020","article-title":"Identification of a highly functional effector CD8+ T cell program after transplantation in mice and humans","author":"Leathem","year":"2026","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.trim.2026.102460_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112993","article-title":"Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors","volume":"42","author":"Cohen","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.trim.2026.102460_bb0115","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adz8096","article-title":"An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function","volume":"11","author":"Jame-Chenarboo","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.trim.2026.102460_bb0120","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1182\/blood-2007-01-065276","article-title":"Signaling through CD43 regulates CD4 T-cell trafficking","volume":"110","author":"Mody","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.trim.2026.102460_bb0125","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1172\/JCI8082","article-title":"Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade\u2013resistant allograft rejection","volume":"104","author":"Trambley","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.trim.2026.102460_bb0130","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.4049\/jimmunol.180.11.7385","article-title":"CD43 regulates Th2 differentiation and inflammation","volume":"180","author":"Cannon","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0135","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1084\/jem.20021602","article-title":"CD43 regulation of T cell activation is not through steric inhibition of T cell\u2013APC interactions but through an intracellular mechanism","volume":"199","author":"Tong","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.trim.2026.102460_bb0140","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.4049\/jimmunol.141.9.2912","article-title":"Induction of aggregation and enhancement of proliferation and IL-2 secretion in human T cells by antibodies to CD43","volume":"141","author":"Axelsson","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.trim.2026.102460_bb0145","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1091\/mbc.e10-07-0586","article-title":"CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation","volume":"22","author":"Cannon","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.trim.2026.102460_bb0150","doi-asserted-by":"crossref","first-page":"8042","DOI":"10.4049\/jimmunol.175.12.8042","article-title":"CD43 functions as a ligand for E-selectin on activated T cells","volume":"175","author":"Matsumoto","year":"2005","journal-title":"J. Immunol."}],"container-title":["Transplant Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426001188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0966327426001188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:39:32Z","timestamp":1791412772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0966327426001188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":30,"alternative-id":["S0966327426001188"],"URL":"https:\/\/doi.org\/10.1016\/j.trim.2026.102460","relation":{},"ISSN":["0966-3274"],"issn-type":[{"value":"0966-3274","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD43 is a checkpoint against KLRG-1+CD49dhi effector CD8+ T cell formation","name":"articletitle","label":"Article Title"},{"value":"Transplant Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trim.2026.102460","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"102460"}}