{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:09:29Z","timestamp":1777356569913,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1016\/j.tripleo.2004.08.030","type":"journal-article","created":{"date-parts":[[2006,12,2]],"date-time":"2006-12-02T02:56:07Z","timestamp":1165028167000},"page":"709-716","source":"Crossref","is-referenced-by-count":22,"title":["Papillon-Lef\u00e8vre syndrome with albinism: A review of the literature and report of 2 brothers"],"prefix":"10.1016","volume":"100","author":[{"given":"Faiez N.","family":"Hattab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wala M.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2004.08.030_bib1","first-page":"82","article-title":"Deux cas de keratoderma palmaire et plantaire symmetrique familiale (maladie de Meleda) chez le frere et la soeur: coexistence dans les deux cas d'alterations dentaires graves","volume":"31","author":"Papillon","year":"1924","journal-title":"Bull Soc Fr Dermatol Syph"},{"key":"10.1016\/j.tripleo.2004.08.030_bib2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0022-3476(64)80014-7","article-title":"The syndrome of palmar-plantar hyperkeratosis and premature periodontal destruction of the teeth","volume":"65","author":"Gorlin","year":"1964","journal-title":"J Pediatr"},{"key":"10.1016\/j.tripleo.2004.08.030_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00278288","article-title":"The Papillon-Lef\u00e8vre syndrome: keratosis palmoplantaris with periodontopathy: report of a case and review of the cases in the literature","volume":"51","author":"Haneke","year":"1979","journal-title":"Hum Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib4","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1902\/jop.1995.66.5.413","article-title":"Papillon-Lef\u00e8vre syndrome: a review of the literature and report of 4 cases","volume":"66","author":"Hattab","year":"1995","journal-title":"J Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0757.1994.tb00029.x","article-title":"Papillon-Lef\u00e8vre syndrome","volume":"6","author":"Hart","year":"1994","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.tripleo.2004.08.030_bib6","first-page":"147","article-title":"Papillon-Lef\u00e8vre syndrome: report of four cases","volume":"49","author":"Baghdady","year":"1982","journal-title":"ASDC J Dent Child"},{"key":"10.1016\/j.tripleo.2004.08.030_bib7","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1365-4362.1986.tb04525.x","article-title":"Papillon-Lef\u00e8vre syndrome: a report of six cases in one family","volume":"25","author":"Pareek","year":"1986","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-4362.1988.tb02344.x","article-title":"Papillon-Lef\u00e8vre syndrome: successful treatment with oral retinoids in three patients","volume":"27","author":"El-Darouti","year":"1988","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1365-4362.1989.tb02539.x","article-title":"Papillon-Lef\u00e8vre syndrome in four siblings treated with etretinate: a nine-year evaluation","volume":"28","author":"Kellum","year":"1989","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib10","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S1079-2104(99)70036-3","article-title":"Papillon-Lef\u00e8vre syndrome: neutrophil function in 15 cases from 4 families in Egypt","volume":"88","author":"Ghaffar","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2004.08.030_bib11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1067\/mjd.2003.197","article-title":"Dermatologic and oral findings in a cohort of 47 patients with Papillon-Lef\u00e8vre syndrome","volume":"48","author":"Ullbro","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1542\/peds.111.1.e85","article-title":"Pyogenic liver abscess and Papillon-Lef\u00e8vre syndrome: not a rare association","volume":"111","author":"Almuneef","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.tripleo.2004.08.030_bib13","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ajmg.1320430502","article-title":"Consanguineous marriage in Jordan","volume":"43","author":"Khoury","year":"1992","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1469-1809.1998.6250411.x","article-title":"Major congenital malformations in the United Arab Emirates (UAE): need for genetic counselling","volume":"62","author":"Altalabani","year":"1998","journal-title":"Ann Hum Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib15","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s004390050645","article-title":"Localization of a gene for Papillon-Lef\u00e8vre syndrome to chromosome 11q14-q21 by homozygosity mapping","volume":"101","author":"Laass","year":"1997","journal-title":"Hum Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib16","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1136\/jmg.36.12.881","article-title":"Mutations of the cathepsin C gene are responsible for Papillon-Lef\u00e8vre syndrome","volume":"36","author":"Hart","year":"1999","journal-title":"J Med Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib17","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/70525","article-title":"Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplanter keratosis","volume":"23","author":"Toomes","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/jmg.37.2.81","article-title":"Of palms, soles, and gums","volume":"37","author":"Gorlin","year":"2000","journal-title":"J Med Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1902\/jop.2002.73.3.307","article-title":"A novel mutation of the cathepsin C gene in Papillon- Lef\u00e8vre syndrome","volume":"73","author":"Cury","year":"2002","journal-title":"J Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1600-051X.1986.tb01407.x","article-title":"Treatment of the periodontal component of Papillon-Lef\u00e8vre syndrome","volume":"13","author":"Tinanoff","year":"1986","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1600-051X.1988.tb02266.x","article-title":"Treatment of rapidly destructive periodontitis in Papillon-Lef\u00e8vre syndrome: laboratory and clinical observations","volume":"15","author":"Preus","year":"1988","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1034\/j.1600-051X.1999.260910.x","article-title":"Microbiological features of Papillon-Lef\u00e8vre syndrome periodontitis","volume":"26","author":"Velazco","year":"1999","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib23","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1600-051X.1993.tb00712.x","article-title":"Late onset of Papillon-Lef\u00e8vre syndrome: a chromosomic, neutrophil function and microbiological study","volume":"20","author":"Bullon","year":"1993","journal-title":"J Clin Periodontal"},{"key":"10.1016\/j.tripleo.2004.08.030_bib24","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1902\/jop.1996.67.11.1210","article-title":"Clinical and immunological findings in 2 siblings with Papillon-Lef\u00e8vre syndrome","volume":"67","author":"Firatli","year":"1996","journal-title":"J Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib25","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0090-1229(84)90094-1","article-title":"The Papillon-Lef\u00e8vre syndrome: neutrophil dyfunction with severe periodontal disease","volume":"31","author":"Van Dyke","year":"1984","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1902\/jop.1990.61.6.373","article-title":"Periodontitis associated with Papillon-Lef\u00e8vre syndrome","volume":"61","author":"Bimstein","year":"1990","journal-title":"J Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib27","first-page":"59","article-title":"In vitro studies of monocyte function in two siblings with Papillon-Lef\u00e8vre syndrome","volume":"95","author":"Preus","year":"1987","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.tripleo.2004.08.030_bib28","first-page":"407","article-title":"Immunological study of patients with the Papillon-Lef\u00e8vre syndrome","volume":"40","author":"Levo","year":"1980","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-051X.1988.tb01550.x","article-title":"Ultrastructure of the periodontal lesion in a case of Papillon-Lef\u00e8vre syndrome (PLS)","volume":"15","author":"Vrahopoulous","year":"1988","journal-title":"J Clin Periodontal"},{"key":"10.1016\/j.tripleo.2004.08.030_bib30","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1902\/jop.1987.58.11.789","article-title":"Treatment of a patient with Papillon-Lef\u00e8vre syndrome: a case report","volume":"58","author":"Lu","year":"1987","journal-title":"J Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib31","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1600-051X.1992.tb00668.x","article-title":"Papillon-Lef\u00e8vre syndrome: characterization of peripheral blood and gingival lymphocytes with monoclonal antibodies","volume":"19","author":"Celenligil","year":"1992","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib32","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1902\/jop.1984.55.8.482","article-title":"Histopathological and ultrastructural findings in a case of Papillon-Lef\u00e8vre syndrome","volume":"55","author":"Sloan","year":"1984","journal-title":"J Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib33","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1600-051X.1983.tb01300.x","article-title":"Behavoir of neutrophilic granulocytes in a case of Papillon-Lef\u00e8vre syndrome","volume":"10","author":"Schroeder","year":"1983","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib34","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0765.1970.tb00725.x","article-title":"The electrophoretic pattern of gingival collagen isolated from a patient with palmoplantar hyperkeratosis","volume":"5","author":"Shoshan","year":"1970","journal-title":"J Clin Periodont Res"},{"key":"10.1016\/j.tripleo.2004.08.030_bib35","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1177\/00220345820610020101","article-title":"Increased collagen synthesis by gingivalfibroblasts derived from a Papillon-Lef\u00e8vre syndrome","volume":"61","author":"Cheung","year":"1982","journal-title":"J Dent Res"},{"key":"10.1016\/j.tripleo.2004.08.030_bib36","first-page":"43","article-title":"Papillon-Lef\u00e8vre: report of a case","volume":"40","author":"Willett","year":"1985","journal-title":"J Oral Med"},{"key":"10.1016\/j.tripleo.2004.08.030_bib37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1902\/jop.1993.64.5.379","article-title":"A possible late onset variation of Papillon-Lef\u00e8vre syndrome: report of 3 cases","volume":"64","author":"Brown","year":"1993","journal-title":"J Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1600-051X.1998.tb02425.x","article-title":"Palmar plantar keratosis and unusual periodontal findings: observations from a family of 4 members","volume":"25","author":"Fardal","year":"1998","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib39","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1600-051X.1996.tb00607.x","article-title":"Partial expression of the Papillon-Lef\u00e8vre syndrome in 2 unrelated families","volume":"23","author":"Soskolne","year":"1996","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib40","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1365-2133.2004.06237.x","article-title":"Co-inheritance of two rare genodermatoses (Papillon-Lef\u00e8vre syndrome and oculocutaneous albinism type 1) in two families: a genetic study","volume":"151","author":"Hewitt","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib41","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/0006-291X(89)91767-1","article-title":"Human oculocutaneous albinism caused by single base insertion in tyrosinase gene","volume":"164","author":"Tomita","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.tripleo.2004.08.030_bib42","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1006\/mgme.2002.3304","article-title":"Demonstration of altered splicing with the IVS3-1G-> a mutation of cathepsin C","volume":"75","author":"Nusier","year":"2002","journal-title":"Med Genet Metab"},{"key":"10.1016\/j.tripleo.2004.08.030_bib43","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/jmg.37.2.88","article-title":"Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic mutations in cathepsin C","volume":"37","author":"Hart","year":"2000","journal-title":"J Med Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/jmg.37.2.95","article-title":"Localization of a gene for prepubertal periodontitis to chromosome 11q14 and identification of cathepsin C gene mutation","volume":"37","author":"Hart","year":"2000","journal-title":"J Med Genet"},{"key":"10.1016\/j.tripleo.2004.08.030_bib45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/humu.10314","article-title":"The role of cathepsin C in Papillon-Lef\u00e8vre syndrome, prepubertal periodontitis, and aggressive periodontitis","volume":"23","author":"Hewitt","year":"2004","journal-title":"Hum Mutat"},{"key":"10.1016\/j.tripleo.2004.08.030_bib46","doi-asserted-by":"crossref","first-page":"S240","DOI":"10.1016\/S0190-9622(03)01558-5","article-title":"Late-onset Papillon-Lef\u00e8vre syndrome without alteration of the cathepsin C gene","volume":"49","author":"Pilger","year":"2003","journal-title":"Am Acad Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib47","series-title":"Pediatric dermatology","first-page":"417","year":"1998"},{"key":"10.1016\/j.tripleo.2004.08.030_bib48","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000249846","article-title":"Papillon-Lef\u00e8vre syndrome: report of a case treated with oral retinoid RO 10-9359","volume":"166","author":"Bravo-Piris","year":"1983","journal-title":"Dermatologica"},{"key":"10.1016\/j.tripleo.2004.08.030_bib49","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1001\/archderm.1988.01670040035018","article-title":"Papillon-Lef\u00e8vre syndrome: ultrastructural study and successful treatment with acitretin","volume":"124","author":"Nazzaro","year":"1988","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib50","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1525-1470.1989.tb00822.x","article-title":"Long-term preservation of permanent teeth in a patient with Papillon-Lef\u00e8vre syndrome treated with etretinate","volume":"6","author":"Gelmetti","year":"1989","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.bdj.4807059","article-title":"Papillon-Lef\u00e8vre syndrome: a case discussion of aetiology and a case report","volume":"168","author":"Glenwright","year":"1990","journal-title":"Br Dent J"},{"key":"10.1016\/j.tripleo.2004.08.030_bib52","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1034\/j.1600-051x.2000.027005354.x","article-title":"Periodontal treatment of rapid progressive periodontitis in 2 siblings with Papillon-Lef\u00e8vre syndrome: 15-year follow-up","volume":"27","author":"De Vree","year":"2000","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib53","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1600-051X.1987.tb00959.x","article-title":"Clinical management of prepubertal periodontitis in 2 siblings with Papillon-Lef\u00e8vre syndrome","volume":"14","author":"Preus","year":"1987","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib54","first-page":"99","article-title":"Papillon-Lef\u00e8vre syndrome: treatment of two cases with a clinical microbiological and histopathological investigation","volume":"17","author":"Eronat","year":"1993","journal-title":"J Clin Pediatr Dent"},{"key":"10.1016\/j.tripleo.2004.08.030_bib55","first-page":"847","article-title":"Combined systemic and local antimicrobial therapy of periodontal disease in Papillon-Lef\u00e8vre syndrome. A report of 4 cases","volume":"26","author":"Rudiger","year":"1999","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib56","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1034\/j.1600-051X.2002.290414.x","article-title":"Treatment of Papillon-Lef\u00e8vre syndrome periodontitis","volume":"29","author":"Pacheco","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib57","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1600-051X.2004.00591.x","article-title":"Periodontal treatment of patients with Papillon-Lef\u00e8vre syndrome: a 3-year follow-up","volume":"31","author":"Lundgren","year":"2004","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib58","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1034\/j.1600-051x.2000.027012951.x","article-title":"Osseointegrated implants in a patient with Papillon-Lef\u00e8vre syndrome: a 4\u00bd-year follow-up","volume":"27","author":"Ullbro","year":"2000","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2004.08.030_bib59","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/01.ID.0000041223.08656.A7","article-title":"Dental implants in a young patients with Papillon-Lef\u00e8vre syndrome: a case report","volume":"12","author":"Woo","year":"2003","journal-title":"Implant Dent"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210404006237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210404006237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T17:43:06Z","timestamp":1707414186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079210404006237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["S1079210404006237"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2004.08.030","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}