{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:47:36Z","timestamp":1778572056364,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.tripleo.2004.10.018","type":"journal-article","created":{"date-parts":[[2005,1,27]],"date-time":"2005-01-27T12:53:44Z","timestamp":1106830424000},"page":"471-478","source":"Crossref","is-referenced-by-count":40,"title":["Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing"],"prefix":"10.1016","volume":"99","author":[{"given":"Jang-Jaer","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark-Yenping","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Jung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Pin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiiang-Huei","family":"Jeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Hueng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Shiung","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Hong","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Heng","family":"Kok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2004.10.018_bib1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/10454411980090010501","article-title":"Update on oral lichen planus: etiopathogenesis and management","volume":"9","author":"Scully","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0030-4220(77)90325-5","article-title":"A follow-up study of sixty-one oral dysplastic precancerous lesions in Indian villagers","volume":"43","author":"Pindborg","year":"1977","journal-title":"Oral Surg"},{"key":"10.1016\/j.tripleo.2004.10.018_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1600-0714.1986.tb00580.x","article-title":"Malignant potential of oral lichen planus: observations in 722 patients from India","volume":"15","author":"Murti","year":"1986","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1600-0714.1993.tb00134.x","article-title":"Oral cancer development in patients with oral lichen planus","volume":"22","author":"Barnard","year":"1993","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib5","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0030-4220(85)90210-5","article-title":"A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association","volume":"60","author":"Silverman","year":"1985","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2004.10.018_bib6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S1368-8375(98)00116-X","article-title":"A retrospective study of oral lichen planus patients with concurrent or subsequent development of malignancy","volume":"35","author":"Hietanen","year":"1999","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0964-1955(97)00005-5","article-title":"Malignant potential of oral lichen planus: a follow-up study of 326 patients","volume":"33","author":"Markopoulos","year":"1997","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1079-2104(99)70033-8","article-title":"A review of the recent literature regarding malignant transformation of oral lichen planus","volume":"88","author":"van der Meij","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2004.10.018_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0714.1978.tb01879.x","article-title":"Oral lichen planus: the evidence regarding potential malignant transformation","volume":"7","author":"Krutchkoff","year":"1978","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib10","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/0030-4220(92)90014-H","article-title":"The controversy of a premalignant potential of lichen planus is over","volume":"73","author":"Holmstrup","year":"1992","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2004.10.018_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1079-2104(00)70085-0","article-title":"Oral lichen planus and oral cancer: is there enough epidemiologic evidence?","volume":"89","author":"Lozada-Nur","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2004.10.018_bib12","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1053\/joms.2000.16629","article-title":"Oral lichen planus: a benign lesion","volume":"58","author":"Eisenberg","year":"2000","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2004.10.018_bib13","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0030-4220(85)90315-9","article-title":"Lichenoid dysplasia: a distinct histopathologic entity","volume":"60","author":"Krutchkoff","year":"1985","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2004.10.018_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/358015a0","article-title":"Cancer. p53, guardian of the genome","volume":"358","author":"Lane","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.tripleo.2004.10.018_bib15","first-page":"4855","article-title":"Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis","volume":"54","author":"Greenblatt","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.tripleo.2004.10.018_bib16","first-page":"1779","article-title":"Archival analysis of p53 genetic and protein alteration in Chinese oesophageal cancer","volume":"6","author":"Bennett","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/j.tripleo.2004.10.018_bib17","first-page":"1217","article-title":"High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early noninvasive lesions","volume":"10","author":"Ahomadegbe","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.tripleo.2004.10.018_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0964-1955(95)00095-X","article-title":"p53 overexpression in head and neck squamous cell carcinoma: review of the literature","volume":"32","author":"Raybaud-Diogene","year":"1996","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib19","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ijc.2910580305","article-title":"Overexpression of p53 protein in betel and tobacco related human oral dysplasia and squamous cell carcinoma in India","volume":"58","author":"Kaur","year":"1994","journal-title":"Int J Cancer"},{"key":"10.1016\/j.tripleo.2004.10.018_bib20","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/path.1711660411","article-title":"Assessment of p53 protein expression in normal, benign, and malignant oral mucosa","volume":"166","author":"Ogden","year":"1992","journal-title":"J Pathol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0714.1995.tb01124.x","article-title":"p53 expression in sequential oral dysplasia and in situ carcinomas","volume":"24","author":"Regezi","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1034\/j.1600-0714.2001.300302.x","article-title":"Sequential immunohistochemical p53 expression in biopsies of oral lichen planus undergoing malignant evolution","volume":"30","author":"Valente","year":"2001","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1128\/MCB.9.1.57","article-title":"Involvement of proliferating cell nuclear antigen (cyclin) in DNA replication in living cells","volume":"9","author":"Zuber","year":"1989","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0046-8177(95)90015-2","article-title":"The proliferative activity in oral epithelial dysplasia analyzed by proliferating cell nuclear antigen immunostaining and argyrophilic nuclear organizer region staining","volume":"26","author":"Kobayashi","year":"1995","journal-title":"Human Pathol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF01600508","article-title":"Proliferating cell nuclear antigen in malignant and pre-malignant lesions of epithelial origin in the oral cavity and the skin: an immunohistochemical study","volume":"420","author":"Tsuji","year":"1992","journal-title":"Virchows Archiv-A Pathol Anat Histopathol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib26","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/jnci\/85.12.971","article-title":"Sequential increase in proliferating cell nuclear antigen in head and neck tumorigenesis: a potential marker","volume":"85","author":"Shin","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.tripleo.2004.10.018_bib27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1034\/j.1600-0714.2002.310403.x","article-title":"Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus","volume":"31","author":"Hirota","year":"2002","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib28","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0964-1955(94)90023-X","article-title":"P53 and PCNA expression in carcinogenesis of the oropharyngeal mucosa","volume":"30","author":"Girod","year":"1994","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib29","first-page":"1453","article-title":"Detection of p53 and MDM2 protein expression in head and neck carcinogenesis","volume":"15","author":"Girod","year":"1995","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tripleo.2004.10.018_bib30","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-0714.1998.tb01963.x","article-title":"Epithelial p53 gene expression and mutational analysis, combined with growth fraction assessment, in oral lichen planus","volume":"27","author":"Schifter","year":"1998","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0964-1955(95)00049-6","article-title":"The relationship between vascularity and cell proliferation in human normal and pathological lesions of the oral cheek epithelium","volume":"32","author":"Tipoe","year":"1996","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib32","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0266-4356(98)90708-2","article-title":"Proliferative activity and loss of function of tumour suppressor genes as \u2018biomarkers\u2019 in diagnosis and prognosis of benign and preneoplastic oral lesions and oral squamous cell carcinoma","volume":"36","author":"Girod","year":"1998","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2004.10.018_bib33","first-page":"3527","article-title":"The p53 and nm23-H1 genes are not deleted in oral benign epithelial lesions","volume":"18","author":"Pavelic","year":"1998","journal-title":"Anticancer Res"},{"key":"10.1016\/j.tripleo.2004.10.018_bib34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1034\/j.1600-0447.2002.21235.x","article-title":"Oral lichen planus has a high rate of TP53 mutations. A study of oral mucosa in Iceland","volume":"110","author":"Ogmundsdottir","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.tripleo.2004.10.018_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-0714.1997.tb00453.x","article-title":"Apoptosis-associated markers in oral lichen planus","volume":"26","author":"Dekker","year":"1997","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0030-4220(68)90194-1","article-title":"Oral lichen planus: 1. A clinical evaluation of 115 cases","volume":"25","author":"Andreasen","year":"1968","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2004.10.018_bib37","first-page":"229","article-title":"Expression of p53 protein in oral submucous fibrosis, oral epithelial hyperkeratosis, and oral epithelial dysplasia","volume":"99","author":"Chiang","year":"2000","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.tripleo.2004.10.018_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.1711720103","article-title":"p53 in tumor pathology: can we trust immunohistochemistry? Revisited!","volume":"172","author":"Hall","year":"1994","journal-title":"J Pathol"},{"key":"10.1016\/j.tripleo.2004.10.018_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1600-0714.1992.tb01007.x","article-title":"Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors","volume":"21","author":"Ko","year":"1992","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib40","first-page":"141","article-title":"Betel-quid and areca-nut chewing. Lyon: International Agency for Research on Cancer","volume":"37","author":"IARC","year":"1986","journal-title":"Monographs"},{"key":"10.1016\/j.tripleo.2004.10.018_bib41","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1177\/00220345940730050501","article-title":"Genotoxic and nongenotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro","volume":"73","author":"Jeng","year":"1994","journal-title":"J Dent Res"},{"key":"10.1016\/j.tripleo.2004.10.018_bib42","first-page":"5294","article-title":"Cytotoxic and genotoxic effect of areca nut-related compounds in cultured human buccal epithelial cells","volume":"49","author":"Sundqvist","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.tripleo.2004.10.018_bib43","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1600-0714.1996.tb00193.x","article-title":"The use of antigen retrieval for immunohistochemical detection of p53 over-expression in malignant and benign oral mucosa: a cautionary note","volume":"25","author":"Dowell","year":"1996","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib44","doi-asserted-by":"crossref","first-page":"7555","DOI":"10.1073\/pnas.87.19.7555","article-title":"p53 mutations in colorectal cancer","volume":"87","author":"Rodrigues","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tripleo.2004.10.018_bib45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1034\/j.1600-0714.2003.00134.x","article-title":"Erythematous and reticular forms of oral lichen planus and oral lichenoid reactions differ in pathological features related to disease activity","volume":"32","author":"Karatsaidis","year":"2003","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2004.10.018_bib46","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1046\/j.1365-2184.35.s1.11.x","article-title":"Epithelial cell proliferation in oral lichen planus","volume":"35","author":"Taniguchi","year":"2002","journal-title":"Cell Prolif"},{"key":"10.1016\/j.tripleo.2004.10.018_bib47","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-0714.1995.tb01132.x","article-title":"Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan","volume":"24","author":"Ko","year":"1995","journal-title":"J Oral Pathol Med"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107921040400695X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107921040400695X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T02:59:53Z","timestamp":1548817193000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107921040400695X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S107921040400695X"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2004.10.018","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}