{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:34:42Z","timestamp":1781069682056,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.tripleo.2005.07.013","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T15:22:58Z","timestamp":1147447378000},"page":"22-27","source":"Crossref","is-referenced-by-count":45,"title":["Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders"],"prefix":"10.1016","volume":"102","author":[{"given":"Kan","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Takatsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Hatada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyomasa","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuhide","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuuzi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2005.07.013_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1172\/JCI119526","article-title":"Aggrecan degradation in human cartilage","volume":"100","author":"Lark","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tripleo.2005.07.013_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0278-2391(98)90868-0","article-title":"Synovial fluid cytokines and proteinases as markers of temporomandibular joint disease","volume":"56","author":"Kubota","year":"1998","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2005.07.013_bib3","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1054\/bjom.2001.0634","article-title":"Matrix metalloproteinase-2 in synovial lavage fluid of patients with disorders of the temporomandibular joint","volume":"39","author":"Mizui","year":"2001","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2005.07.013_bib4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1067\/moe.2001.115136","article-title":"Matrix metalloproteinases in mild and severe temporomandibular joint internal derangement synovial fluid","volume":"91","author":"Srinivas","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2005.07.013_bib5","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1054\/bjom.2000.0306","article-title":"Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disorders","volume":"38","author":"Ishimaru","year":"2000","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2005.07.013_bib6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1034\/j.1600-0714.2001.300110.x","article-title":"Expression of matrix metalloproteinase-2 and -9 in synovial fluid of the temporomandibular joint accompanied by anterior disk displacement","volume":"30","author":"Tanaka","year":"2001","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2005.07.013_bib7","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1172\/JCI119040","article-title":"Aggrecan is degraded by matrix metalloproteinases in human arthritis","volume":"98","author":"Fosang","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tripleo.2005.07.013_bib8","doi-asserted-by":"crossref","first-page":"20269","DOI":"10.1074\/jbc.272.32.20269","article-title":"Utilization of a recombinant substrate rAgg1 to study the biochemical properties of aggrecanase in cell culture systems","volume":"272","author":"Hughes","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib9","doi-asserted-by":"crossref","first-page":"30576","DOI":"10.1074\/jbc.273.46.30576","article-title":"Differential expression of aggrecanase and matrix metalloproteinase activity in chondrocytes isolated from bovine and porcine articular cartilage","volume":"273","author":"Hughes","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib10","doi-asserted-by":"crossref","first-page":"9294","DOI":"10.1074\/jbc.272.14.9294","article-title":"Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase","volume":"272","author":"Arner","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib11","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1074\/jbc.274.10.6594","article-title":"Generation and characterization of aggrecanase","volume":"274","author":"Arner","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib12","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1053\/joca.2001.0425","article-title":"Distribution of aggrecanase (ADAMTS 4\/5) cleavage products in normal and osteoarthritic human articular cartilage","volume":"9","author":"Bayliss","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.tripleo.2005.07.013_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0945-053X(02)00069-0","article-title":"Characterization of human aggrecanase 2 (ADAM-TS5)","volume":"21","author":"Tortorella","year":"2002","journal-title":"Matrix Bio"},{"key":"10.1016\/j.tripleo.2005.07.013_bib14","doi-asserted-by":"crossref","first-page":"45539","DOI":"10.1074\/jbc.M303737200","article-title":"Aggrecan protects cartilage collagen from proteolytic cleavage","volume":"278","author":"Pratta","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib15","doi-asserted-by":"crossref","first-page":"22201","DOI":"10.1074\/jbc.M200431200","article-title":"Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage","volume":"277","author":"Malfait","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/ar630","article-title":"Aggrecanases and cartilage matrix degradation","volume":"5","author":"Nagase","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.tripleo.2005.07.013_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0945-053X(02)00004-5","article-title":"Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation","volume":"21","author":"Little","year":"2002","journal-title":"Matrix Biol"},{"key":"10.1016\/j.tripleo.2005.07.013_bib18","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1002\/art.1780360906","article-title":"The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis","volume":"36","author":"Lohmander","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.tripleo.2005.07.013_bib19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1042\/bj3260235","article-title":"Aggrecan degradation in human intervertebral disk and articular cartilage","volume":"326","author":"Sztrolovics","year":"1997","journal-title":"Biochem J"},{"key":"10.1016\/j.tripleo.2005.07.013_bib20","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1006\/bbrc.1999.0266","article-title":"Coincubation of bovine synovial or capsular tissue with cartilage generates a soluble \u201caggrecanase\u201d activity","volume":"255","author":"Vankemmelbeke","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.tripleo.2005.07.013_bib21","doi-asserted-by":"crossref","first-page":"38885","DOI":"10.1074\/jbc.M003875200","article-title":"Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different site","volume":"275","author":"Nakamura","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib22","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0003-2697(02)00638-3","article-title":"A microplate assay specific for the enzyme aggrecanase","volume":"314","author":"Miller","year":"2003","journal-title":"Anal Biochem"},{"key":"10.1016\/j.tripleo.2005.07.013_bib23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/bj20030609","article-title":"Variations in aggrecan structure modulate its susceptibility to aggrecanases","volume":"375","author":"Roughley","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.tripleo.2005.07.013_bib24","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/0278-2391(91)90143-A","article-title":"Tissue responses to degenerative changes in the temporomandibular joint","volume":"49","author":"Stegenga","year":"1991","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2005.07.013_bib25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1053\/joms.2001.21001","article-title":"Surgical arthroscopy as the preferred treatment for internal derangements of the temporomandibular joint","volume":"59","author":"Indresano","year":"2001","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2005.07.013_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1053\/joms.2001.21002","article-title":"Arthroscopic lysis and lavage as the preferred treatment for internal derangement of temporomandibular joint","volume":"59","author":"White","year":"2001","journal-title":"J Oral Maxillofac Surg"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210405005925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210405005925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T14:28:10Z","timestamp":1547648890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079210405005925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S1079210405005925"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2005.07.013","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]}}}