{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:25:23Z","timestamp":1759587923436},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1016\/j.tripleo.2005.10.054","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T03:42:40Z","timestamp":1145936560000},"page":"404-409","source":"Crossref","is-referenced-by-count":52,"title":["Receptor activator NF\u03baB-ligand and osteoprotegerin protein expression in human periapical cysts and granulomas"],"prefix":"10.1016","volume":"102","author":[{"given":"Renato","family":"Menezes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00f3vis Monteiro","family":"Bramante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kati\u00facia Batista","family":"da Silva Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadne","family":"Letra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everdan","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willian","family":"Fernando Zambuzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mauro","family":"Granjeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2005.10.054_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-302x.2000.150301.x","article-title":"Protective and destructive immune reactions in apical periodontitis","volume":"15","author":"Marton","year":"2000","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.tripleo.2005.10.054_bib2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/10454411980090040701","article-title":"Periapical inflammatory responses and their modulation","volume":"9","author":"Stashenko","year":"1998","journal-title":"Crit Rev Oral Biol Med."},{"key":"10.1016\/j.tripleo.2005.10.054_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1600-0714.1988.tb01512.x","article-title":"Immunocytochemical examination of immune cells in periapical granulomata and odontogenic cysts","volume":"17","author":"Gao","year":"1988","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.tripleo.2005.10.054_bib4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0099-2399(87)80033-X","article-title":"Identification of inflammatory cells in developing rat periapical lesions","volume":"13","author":"Yu","year":"1987","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib5","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.1365-2591.2003.00627.x","article-title":"Inflammatory infiltrate of chronic periradicular lesions","volume":"36","author":"Liapatas","year":"2003","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2005.10.054_bib6","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.tripleo.2005.10.054_bib7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/416686a","article-title":"Interfering with bone remodelling","volume":"416","author":"Alliston","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.tripleo.2005.10.054_bib8","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1146\/annurev.immunol.20.100301.064753","article-title":"RANK-L and RANK","volume":"20","author":"Theill","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.tripleo.2005.10.054_bib9","first-page":"49","article-title":"RANKL\/RANK\/OPG","volume":"1704","author":"Wittrant","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.tripleo.2005.10.054_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1067\/moe.2001.116813","article-title":"Study of the expression of CD68+ macrophages and CD8+ T cells in human granulomas and periapical cysts","volume":"92","author":"Rodini","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00003086-198806000-00033","article-title":"Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts","volume":"231","author":"Vaes","year":"1988","journal-title":"Clin Orthop"},{"key":"10.1016\/j.tripleo.2005.10.054_bib12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1034\/j.1600-0765.2003.00615.x","article-title":"Receptor activator NF\u03baB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis","volume":"38","author":"Crotti","year":"2003","journal-title":"J Periodontol Res"},{"key":"10.1016\/j.tripleo.2005.10.054_bib13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jmicro\/50.4.365","article-title":"Localization of receptor activator of NF\u03baB ligand, RANK L, in periodontal tissues during experimental movement of rat molars","volume":"50","author":"Shiotani","year":"2001","journal-title":"J Electron Microsc"},{"key":"10.1016\/j.tripleo.2005.10.054_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00774-003-0481-z","article-title":"Osteoclastogenesis during mouse tooth germ development is mediated by receptor activator of NF\u03ba-B ligand (RANKL)","volume":"22","author":"Suzuki","year":"2004","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.tripleo.2005.10.054_bib15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/154405910408300415","article-title":"Identification of RANKL in osteolytic lesions of the facial skeleton","volume":"83","author":"Tay","year":"2004","journal-title":"J Dent Res"},{"key":"10.1016\/j.tripleo.2005.10.054_bib16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S8756-3282(01)00404-5","article-title":"Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone","volume":"28","author":"Atkins","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.tripleo.2005.10.054_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0757.1997.tb00098.x","article-title":"Apical periodontitis","volume":"13","author":"Nair","year":"1997","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.tripleo.2005.10.054_bib18","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1128\/IAI.68.8.4681-4687.2000","article-title":"Toll-like receptor 4\u2013deficient mice have reduced bone destruction following mixed anaerobic infection","volume":"68","author":"Hou","year":"2000","journal-title":"Infect Immun"},{"key":"10.1016\/j.tripleo.2005.10.054_bib19","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/IAI.64.7.2371-2380.1996","article-title":"Bacterially induced bone destruction","volume":"64","author":"Nair","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.tripleo.2005.10.054_bib20","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.tripleo.2003.08.006","article-title":"The synergistic effect of peptidoglycan and lipopolysaccaride on osteoclast formation","volume":"96","author":"Jiang","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1079-2104(96)80156-9","article-title":"Types and incidence of human periapical lesions obtained with extracted teeth","volume":"81","author":"Ramachandran Nair","year":"1996","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2591.1993.tb00563.x","article-title":"Radicular cyst affecting a root filled human tooth","volume":"26","author":"Nair","year":"1993","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2005.10.054_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1046\/j.1365-2591.1998.00171.x","article-title":"Microbiological, pathological, inflammatory, immunological and molecular biological aspects of periradicular disease","volume":"31","author":"Takahashi","year":"1998","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2005.10.054_bib24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0099-2399(06)80435-8","article-title":"Detection of interleukin-1 beta mRNA in rat periapical lesions","volume":"21","author":"Hamachi","year":"1995","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0099-2399(96)80266-4","article-title":"Kinetics of macrophages and lymphoid cells during the development of experimentally induced periapical lesions in rat molars","volume":"22","author":"Kawashima","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-302X.1997.tb00619.x","article-title":"Bone-resorptive cytokine gene expression in periapical lesions in the rat","volume":"12","author":"Wang","year":"1997","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.tripleo.2005.10.054_bib27","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1067\/moe.2003.18","article-title":"Calcium hydroxide reduces lipopolysaccharide-stimulated osteoclast formation","volume":"95","author":"Jiang","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.tripleo.2005.10.054_bib29","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tripleo.2005.10.054_bib30","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tripleo.2005.10.054_bib31","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/1529-0131(200002)43:2<259::AID-ANR4>3.0.CO;2-W","article-title":"Involvement of receptor activator of nuclear factor kappa B ligand\/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis","volume":"43","author":"Takayanagi","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.tripleo.2005.10.054_bib32","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1359\/jbmr.2000.15.8.1459","article-title":"Fibroblastic stromal cells express receptor activador of NF-kappa B ligand and support osteoclast differentiation","volume":"15","author":"Quinn","year":"2000","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.tripleo.2005.10.054_bib33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/bbrc.1999.1623","article-title":"Activated T lymphocytes support osteoclast formation in vitro","volume":"265","author":"Horwood","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.tripleo.2005.10.054_bib34","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/1529-0131(200105)44:5<1003::AID-ANR179>3.3.CO;2-R","article-title":"Activated human T cells directly induce osteoclastogenesis from human monocytes","volume":"44","author":"Kotake","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.tripleo.2005.10.054_bib35","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1172\/JCI10763","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","volume":"106","author":"Teng","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tripleo.2005.10.054_bib36","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1359\/jbmr.1999.14.9.1486","article-title":"Expression of osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human dental mesenchymal cells and epithelial cells","volume":"14","author":"Sakata","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.tripleo.2005.10.054_bib37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1359\/jbmr.2002.17.2.210","article-title":"Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activador of nuclear factor \u03baB ligand upregulation via prostaglandin E2 synthesis","volume":"17","author":"Kanzaki","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.tripleo.2005.10.054_bib38","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1177\/154405910408301206","article-title":"Local OPG gene transfer to periodontal tissue inhibits orthodontic tooth movement","volume":"83","author":"Kanzaki","year":"2004","journal-title":"J Dent Res"},{"key":"10.1016\/j.tripleo.2005.10.054_bib39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.DON.0000134210.95473.A7","article-title":"Detection of receptor activator of NF-\u03baB ligand in apical periodontitis","volume":"31","author":"Sabeti","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2005.10.054_bib40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0142-9612(03)00556-8","article-title":"Factors regulating osteoclast formation in human tissues adjacent to peri-implant bone loss","volume":"25","author":"Crotti","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.tripleo.2005.10.054_bib41","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1302\/0301-620X.83B6.10905","article-title":"The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis","volume":"83","author":"Haynes","year":"2001","journal-title":"J Bone Joint Surg Br"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210405009431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210405009431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T23:02:13Z","timestamp":1707001333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079210405009431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["S1079210405009431"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2005.10.054","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}