{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:48:02Z","timestamp":1768484882641,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.tripleo.2009.09.028","type":"journal-article","created":{"date-parts":[[2010,1,18]],"date-time":"2010-01-18T09:11:13Z","timestamp":1263805873000},"page":"244-251","source":"Crossref","is-referenced-by-count":35,"title":["Occurrence and regional distribution of TRAIL and DR5 on temporomandibular joint discs: comparison of disc derangement with and without reduction"],"prefix":"10.1016","volume":"109","author":[{"given":"Rosalia","family":"Leonardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Eduardo","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula C.","family":"Trevilatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Loreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2009.09.028_bib1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ijom.2005.12.005","article-title":"Magnetic resonance imaging in the evaluation of temporomandibular joint disc displacement\u2014a review of 144 cases","volume":"35","author":"Whyte","year":"2006","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib2","first-page":"454","article-title":"Prevalence of TMJ disc displacement in a pre-orthodontic adolescent sample","volume":"70","author":"Nebbe","year":"2000","journal-title":"Angle Orthod"},{"key":"10.1016\/j.tripleo.2009.09.028_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0278-2391(96)90435-8","article-title":"Anatomic disorders of the temporomandibular joint disc in asymptomatic subjects","volume":"54","author":"Katzberg","year":"1996","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib4","first-page":"315","article-title":"The natural course of nonreducing disc displacement of the TMJ: relationship of clinical findings at initial visit to outcome after 12 months without treatment","volume":"11","author":"Sato","year":"1997","journal-title":"J Orofac Pain"},{"key":"10.1016\/j.tripleo.2009.09.028_bib5","first-page":"382","article-title":"Pathophysiology and epidemiology of TMJ","volume":"3","author":"Milam","year":"2003","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.tripleo.2009.09.028_bib6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0278-2391(00)90060-0","article-title":"Iron-dependent generation of free radicals: plausible mechanisms in the progressive deterioration of the temporomandibular joint","volume":"58","author":"Zardeneta","year":"2000","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib7","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/ejo\/22.5.489","article-title":"Functional magnetic resonance imaging of temporomandibular joint disorders","volume":"22","author":"Eberhard","year":"2000","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.tripleo.2009.09.028_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.acthis.2007.11.010","article-title":"MMP-13 (collagenase 3) localization in human temporomandibular joint discs with internal derangement","volume":"110","author":"Leonardi","year":"2008","journal-title":"Acta Histochem"},{"key":"10.1016\/j.tripleo.2009.09.028_bib9","first-page":"1485","article-title":"Expression of ADAMTS-5 in deformed human temporomandibular joint discs","volume":"23","author":"Matsumoto","year":"2008","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.tripleo.2009.09.028_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/08869634.1986.11678147","article-title":"Histologic grading of TMJ tissues in internal derangement","volume":"4","author":"McCoy","year":"1986","journal-title":"Cranio"},{"key":"10.1016\/j.tripleo.2009.09.028_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1601-0825.2000.tb00125.x","article-title":"Cytokines in temporomandibular joint arthritis","volume":"6","author":"Alstergren","year":"2000","journal-title":"Oral Dis"},{"key":"10.1016\/j.tripleo.2009.09.028_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/00007632-200101150-00006","article-title":"Expression of Fas receptor on disc cells in herniated lumbar disc tissue","volume":"26","author":"Park","year":"2001","journal-title":"Spine"},{"key":"10.1016\/j.tripleo.2009.09.028_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1023\/A:1025319031417","article-title":"Receptor-mediated choreography of life and death","volume":"23","author":"Bhardwaj","year":"2003","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.tripleo.2009.09.028_bib14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/modpathol.2009.39","article-title":"Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks","volume":"22","author":"Bertram","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.tripleo.2009.09.028_bib15","first-page":"421","article-title":"Expression of Bax and caspase-3 and apoptosis in human lumbar intervertebral disc degeneration","volume":"22","author":"Wang","year":"2008","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"10.1016\/j.tripleo.2009.09.028_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/1074-7613(95)90057-8","article-title":"Identification and characterization of a new member of the TNF family that induces apoptosis","volume":"3","author":"Wiley","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.tripleo.2009.09.028_bib17","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1074\/jbc.271.22.12687","article-title":"Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family","volume":"271","author":"Pitti","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tripleo.2009.09.028_bib18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.277.5327.818","article-title":"Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors","volume":"277","author":"Sheridan","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.tripleo.2009.09.028_bib19","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.277.5327.815","article-title":"An antagonist decoy receptor and a death domain\u2013containing receptor for TRAIL","volume":"277","author":"Pan","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.tripleo.2009.09.028_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1126\/science.276.5309.111","article-title":"The receptor for the cytotoxic ligand TRAIL","volume":"276","author":"Pan","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.tripleo.2009.09.028_bib21","first-page":"293","article-title":"Chondrocyte-like apoptosis in temporomandibular joint disc internal derangement as a repair-limiting mechanism","volume":"24","author":"Loreto","year":"2009","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.tripleo.2009.09.028_bib22","first-page":"681","article-title":"The expression of TRAIL and its receptors in gastric cancer and the apoptotic effect of rh-TRAIL on SGC7901 cells","volume":"21","author":"Hu","year":"2009","journal-title":"Oncol Rep"},{"key":"10.1016\/j.tripleo.2009.09.028_bib23","first-page":"434","article-title":"Clinical findings in temporomandibular joint osteoarthrosis","volume":"85","author":"Kopp","year":"1977","journal-title":"Scand J Dent Res"},{"key":"10.1016\/j.tripleo.2009.09.028_bib24","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/scs.0b013e31814fb72a","article-title":"A histochemical survey of the human temporomandibular joint disc of patients with internal derangement without reduction","volume":"18","author":"Leonardi","year":"2007","journal-title":"J Craniofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib25","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/rheumatology\/40.3.336","article-title":"The role of hyaluronic acid in protecting surface-active phospholipids from lysis by exogenous phospholipase A(2)","volume":"40","author":"Nitzan","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.tripleo.2009.09.028_bib26","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/00016357109026526","article-title":"The temporomandibular joint","volume":"29","author":"Oberg","year":"1971","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.tripleo.2009.09.028_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0030-4220(85)90051-9","article-title":"Internal derangement of the temporomandibular joint: morphologic description with correlation to joint function","volume":"59","author":"Westesson","year":"1985","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2009.09.028_bib28","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1053\/joms.2001.25015","article-title":"Magnetic resonance imaging evaluation of temporomandibular joint disc deformities in relation to type of disc displacement","volume":"59","author":"Taskaya-Yilmaz","year":"2001","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib29","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.tripleo.2009.02.006","article-title":"Proinflammatory cytokines in temporomandibular joint synovial fluid before and after arthrocentesis","volume":"107","author":"Gulen","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2009.09.028_bib30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tripleo.2007.12.041","article-title":"Severity of arthroscopically observed pathology and levels of inflammatory cytokines in the synovial fluid before and after visually guided temporomandibular joint irrigation correlated with the clinical outcome in patients with chronic closed lock","volume":"106","author":"Hamada","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2009.09.028_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.joms.2007.06.627","article-title":"Cytokine and clinical predictors for treatment outcome of visually guided temporomandibular joint irrigation in patients with chronic closed lock","volume":"66","author":"Hamada","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib32","doi-asserted-by":"crossref","first-page":"59425","DOI":"10.1155\/MI\/2006\/59425","article-title":"Tumor necrosis factor-alpha in temporomandibular joint synovial fluid predicts treatment effects on pain by intra-articular glucocorticoid treatment","volume":"2006","author":"Fredriksson","year":"2006","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.tripleo.2009.09.028_bib33","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1259\/dmfr\/77288976","article-title":"Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study","volume":"35","author":"Matsumoto","year":"2006","journal-title":"Dentomaxillofac Radiol"},{"key":"10.1016\/j.tripleo.2009.09.028_bib34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1600-0714.2005.00302.x","article-title":"Tumor necrosis factor-alpha increases chemokine gene expression and production in synovial fibroblasts from human temporomandibular joint","volume":"34","author":"Ogura","year":"2005","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2009.09.028_bib35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tripleo.2004.06.074","volume":"99","author":"Kaneyama","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2009.09.028_bib36","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0266-4356(02)00215-2","article-title":"Importance of proinflammatory cytokines in synovial fluid from 121 joints with temporomandibular disorders","volume":"40","author":"Kaneyama","year":"2002","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib37","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0278-2391(95)90717-3","article-title":"Tumor necrosis factor in synovial fluid of patients with temporomandibular disorders","volume":"53","author":"Fu","year":"1995","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib38","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/0278-2391(94)90217-8","article-title":"Tumor necrosis factor-alpha as a biochemical marker of pain and outcome in temporomandibular joints with internal derangements","volume":"52","author":"Shafer","year":"1994","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2009.09.028_bib39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00586-007-0509-5","article-title":"Vertebral endplate trauma induces disc cell apoptosis and promotes organ degeneration in vitro","volume":"17","author":"Haschtmann","year":"2008","journal-title":"Eur Spine J"},{"key":"10.1016\/j.tripleo.2009.09.028_bib40","first-page":"283","article-title":"Intervertebral disc cell apoptosis by nitric oxide: biological understanding of intervertebral disc degeneration","volume":"46","author":"Kohyama","year":"2000","journal-title":"Kobe J Med Sci"},{"key":"10.1016\/j.tripleo.2009.09.028_bib41","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.2106\/JBJS.D.02527","article-title":"Mitochondrial involvement in Fas-mediated apoptosis of human lumbar disc cells","volume":"87","author":"Park","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.tripleo.2009.09.028_bib42","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/BRS.0b013e318163e036","article-title":"The occurrence and regional distribution of DR4 on herniated disc cells: a potential apoptosis pathway in lumbar intervertebral disc","volume":"33","author":"Zhang","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.tripleo.2009.09.028_bib43","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/BRS.0b013e318163e036","article-title":"The occurrence and regional distribution of DR4 on herniated disc cells: a potential apoptosis pathway in lumbar intervertebral disc","volume":"33","author":"Zhang","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.tripleo.2009.09.028_bib44","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tripleo.2005.04.004","article-title":"Comparison of altered signal intensity, position, and morphology of the TMJ disc in MR images corrected for variations in surface coil sensitivity","volume":"101","author":"Orhan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2009.09.028_bib45","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.medengphy.2006.02.009","article-title":"An accurate simulation model of anteriorly displaced TMJ discs with and without reduction","volume":"29","author":"Perez del Palomar","year":"2007","journal-title":"Med Eng Phys"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210409007458?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210409007458?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T05:53:04Z","timestamp":1558763584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079210409007458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S1079210409007458"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2009.09.028","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}