{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:26:09Z","timestamp":1783052769954,"version":"3.54.6"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.tripleo.2010.02.030","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T09:01:07Z","timestamp":1276765267000},"page":"e19-e25","source":"Crossref","is-referenced-by-count":58,"title":["Squamous cell carcinoma in a patient with oral lichen planus treated with topical application of tacrolimus"],"prefix":"10.1016","volume":"110","author":[{"given":"Ulf","family":"Mattsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jontell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2010.02.030_bib1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/10454411980090010501","article-title":"Update on oral lichen planus: etiopathogenesis and management","volume":"9","author":"Scully","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.tripleo.2010.02.030_bib2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bjoms.2007.07.199","article-title":"Oral mucosal disease: lichen planus","volume":"46","author":"Scully","year":"2008","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"Suppl 1","key":"10.1016\/j.tripleo.2010.02.030_bib3","doi-asserted-by":"crossref","first-page":"S25.e1","DOI":"10.1016\/j.tripleo.2006.11.001","article-title":"Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations","volume":"103","author":"Al-Hashimi","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.02.030_bib4","doi-asserted-by":"crossref","first-page":"901","DOI":"10.14219\/jada.archive.2001.0302","article-title":"Oral lichen planus: patient profile, disease progression and treatment responses","volume":"132","author":"Chainani-Wu","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.tripleo.2010.02.030_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1358\/dot.2002.38.1.677132","article-title":"Topical tacrolimus Protopic","volume":"38","author":"Lazarus","year":"2002","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.tripleo.2010.02.030_bib6","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1093\/ajhp\/52.14.1521","article-title":"Tacrolimus: a new immunosuppressive agent","volume":"52","author":"Kelly","year":"1995","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.tripleo.2010.02.030_bib7","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/archderm.135.5.574","article-title":"Tacrolimus: the drug for the turn of the millennium?","volume":"135","author":"Ruzicka","year":"1999","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1345\/aph.10261","article-title":"Tacrolimus in dermatologic disorders","volume":"35","author":"Skaehill","year":"2001","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.tripleo.2010.02.030_bib9","first-page":"5","article-title":"US FDA advisory committee recommends approval of tacrolimus ointment","volume":"6","author":"Committee","year":"2000","journal-title":"Skin Therapy Lett"},{"key":"10.1016\/j.tripleo.2010.02.030_bib10","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1468-3083.2006.01953.x","article-title":"The use of topical calcineurin inhibitors in the management of oral lichen planus","volume":"21","author":"Chaudhry","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10227-005-0038-y","article-title":"Refractory erosive oral lichen planus associated with hepatitis C: response to topical tacrolimus ointment","volume":"9","author":"Donovan","year":"2005","journal-title":"J Cutan Med Surg"},{"key":"10.1016\/j.tripleo.2010.02.030_bib12","first-page":"419","article-title":"Successful treatment of erosive lichen planus with topical tacrolimus","volume":"137","author":"Lener","year":"2001","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib13","first-page":"E462","article-title":"Topic tacrolimus, alternative treatment for oral erosive lichen planus resistant to steroids: a case report","volume":"11","author":"Riano Arguelles","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.tripleo.2010.02.030_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1468-3083.2005.01338.x","article-title":"Successful treatment of severe recalcitrant erosive oral lichen planus with topical tacrolimus","volume":"20","author":"Shichinohe","year":"2006","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib15","first-page":"142","article-title":"Topical tacrolimus: a novel therapeutic intervention for recalcitrant labial pemphigus vulgaris","volume":"13","author":"Hodgson","year":"2003","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1067\/mjd.2002.120535","article-title":"Management of recalcitrant ulcerative oral lichen planus with topical tacrolimus","volume":"46","author":"Kaliakatsou","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib17","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.tripleo.2006.02.033","article-title":"Tacrolimus powder in Orabase 0.1% for the treatment of oral lichen planus and oral lichenoid lesions: an open clinical trial","volume":"102","author":"Lozada-Nur","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.02.030_bib18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1067\/mjd.2002.126275","article-title":"An open trial of topical tacrolimus for erosive oral lichen planus","volume":"47","author":"Morrison","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib19","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1001\/archderm.138.10.1335","article-title":"Treatment of chronic erosive oral lichen planus with low concentrations of topical tacrolimus: an open prospective study","volume":"138","author":"Olivier","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijom.2007.06.016","article-title":"Heat-shock protein expression and topical treatment with tacrolimus in oral lichen planus: an immunohistochemical study","volume":"37","author":"Tavassol","year":"2008","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2010.02.030_bib21","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1001\/archderm.140.12.1508","article-title":"Response of oral lichen planus to topical tacrolimus in 37 patients","volume":"140","author":"Byrd","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mjd.2002.119648","article-title":"Topical tacrolimus in the treatment of symptomatic oral lichen planus: a series of 13 patients","volume":"46","author":"Rozycki","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1080\/09546630410018247","article-title":"Treatment of erosive oral lichen planus with topical tacrolimus","volume":"15","author":"Thomson","year":"2004","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.tripleo.2010.02.030_bib24","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2340\/00015555-0070","article-title":"A comparison of treatment of oral lichen planus with topical tacrolimus and triamcinolone acetonide ointment","volume":"86","author":"Laeijendecker","year":"2006","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tripleo.2007.07.029","article-title":"A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus","volume":"105","author":"Radfar","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.02.030_bib26","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-051X.2007.01191.x","article-title":"Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus","volume":"35","author":"Corrocher","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib27","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1365-2133.2003.05735.x","article-title":"Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin","volume":"149","author":"Niwa","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib28","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jaad.2006.01.054","article-title":"The use of topical calcineurin inhibitors in dermatology: safety concerns","volume":"54","author":"Berger","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib29","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.oraloncology.2006.09.006","article-title":"The possible premalignant character of oral lichen planus and oral lichenoid lesions: a prospective five-year follow-up study of 192 patients","volume":"43","author":"van der Meij","year":"2007","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib30","first-page":"77","article-title":"Erythroplakic lesions in relation to oral lichen planus","volume":"59","author":"Holmstrup","year":"1979","journal-title":"Acta Derm Venereol Suppl"},{"key":"10.1016\/j.tripleo.2010.02.030_bib31","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0030-4220(85)90210-5","article-title":"A prospective follow-up study of 570 patients with oral lichen planus: persistence, remission, and malignant association","volume":"60","author":"Silverman","year":"1985","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib32","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-0714.1988.tb01528.x","article-title":"Malignant development of lichen planus-affected oral mucosa","volume":"17","author":"Holmstrup","year":"1988","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib33","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1600-0528.1989.tb00647.x","article-title":"Oral lichen planus among 4277 patients from Gizan, Saudi Arabia","volume":"17","author":"Salem","year":"1989","journal-title":"Community Dent Oral Epidemiol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0030-4220(91)90007-Y","article-title":"A prospective study of findings and management in 214 patients with oral lichen planus","volume":"72","author":"Silverman","year":"1991","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib35","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1600-0714.1993.tb00134.x","article-title":"Oral cancer development in patients with oral lichen planus","volume":"22","author":"Barnard","year":"1993","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2010.02.030_bib36","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00005537-199603000-00022","article-title":"Oral lichen planus and its association with squamous cell carcinoma: an update on pathogenesis and treatment implications","volume":"106","author":"Duffey","year":"1996","journal-title":"Laryngoscope"},{"key":"10.1016\/j.tripleo.2010.02.030_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0964-1955(97)00005-5","article-title":"Malignant potential of oral lichen planus: a follow-up study of 326 patients","volume":"33","author":"Markopoulos","year":"1997","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib38","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1368-8375(98)80001-8","article-title":"The possible association between oral lichen planus and oral squamous cell carcinoma: a clinical evaluation on 14 cases and a review of the literature","volume":"34","author":"Lo Muzio","year":"1998","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib39","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1053\/ejso.1999.0689","article-title":"Malignant transformation of oral lichen planus","volume":"25","author":"Rajentheran","year":"1999","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib40","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1368-8375(00)00096-8","article-title":"Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: a 5-year experience","volume":"37","author":"Mignogna","year":"2001","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1368-8375(03)00139-8","article-title":"Risk of oral squamous cell carcinoma in 402 patients with oral lichen planus: a follow-up study in an Italian population","volume":"40","author":"Gandolfo","year":"2004","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1601-0825.2005.01221.x","article-title":"Oral lichen planus: a retrospective study of 690 British patients","volume":"12","author":"Ingafou","year":"2006","journal-title":"Oral Dis"},{"key":"10.1016\/j.tripleo.2010.02.030_bib43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0714.2006.00491.x","article-title":"Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital","volume":"36","author":"Hsue","year":"2007","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2010.02.030_bib44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1601-0825.2009.01516.x","article-title":"Course of oral lichen planus: a retrospective study of 808 northern Italian patients","volume":"15","author":"Carbone","year":"2009","journal-title":"Oral Dis"},{"key":"10.1016\/j.tripleo.2010.02.030_bib45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.oraloncology.2008.05.016","article-title":"Potentially malignant disorders of the oral and oropharyngeal mucosa: terminology, classification and present concepts of management","volume":"45","author":"van der Waal","year":"2009","journal-title":"Oral Oncol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib46","first-page":"466","article-title":"Long-term efficacy and safety of topical tacrolimus in the management of ulcerative\/erosive oral lichen planus","volume":"13","author":"Hodgson","year":"2003","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib47","first-page":"2","article-title":"Black box warning for topical calcineurin inhibitors and the death of common sense","volume":"12","author":"Fleischer","year":"2006","journal-title":"Dermatol Online J"},{"key":"10.1016\/j.tripleo.2010.02.030_bib48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11882-006-0059-7","article-title":"Safety of topical calcineurin inhibitors in atopic dermatitis: evaluation of the evidence","volume":"6","author":"Spergel","year":"2006","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.tripleo.2010.02.030_bib49","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/archderm.142.9.1233","article-title":"Topical calcineurin inhibitors labeling: putting the \u201cbox\u201d in perspective","volume":"142","author":"Stern","year":"2006","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.tripleo.2010.02.030_bib50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2407-6-7","article-title":"The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report","volume":"6","author":"Becker","year":"2006","journal-title":"BMC Cancer"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210410001381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210410001381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T01:37:35Z","timestamp":1740188255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079210410001381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1079210410001381"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2010.02.030","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}