{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:44:08Z","timestamp":1773798248071,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.tripleo.2010.03.034","type":"journal-article","created":{"date-parts":[[2010,7,25]],"date-time":"2010-07-25T08:58:51Z","timestamp":1280048331000},"page":"188-195","source":"Crossref","is-referenced-by-count":62,"title":["A randomized double-blind, positive-control trial of topical thalidomide in erosive oral lichen planus"],"prefix":"10.1016","volume":"110","author":[{"given":"Yun","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-rong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-mei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2010.03.034_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0278-2391(82)90321-4","article-title":"Lichen planus: oral manifestations and suggested treatments","volume":"40","author":"Dusek","year":"1982","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2010.03.034_bib2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1600-0714.1985.tb00516.x","article-title":"Lichen planus: review and update on pathogenesis","volume":"14","author":"Scully","year":"1985","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0030-4220(68)90194-1","article-title":"Oral lichen planus. 1. A clinical evaluation of 115 cases","volume":"25","author":"Andreasen","year":"1968","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.03.034_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1054\/bjom.2000.0335","article-title":"Oral lichen planus: a review","volume":"38","author":"Mollaoglu","year":"2000","journal-title":"Br J Oral Maxillofac Surg"},{"key":"10.1016\/j.tripleo.2010.03.034_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1601-0825.2008.01441.x","article-title":"Oral lichen planus: controversies surrounding malignant transformation","volume":"14","author":"Gonzalez-Moles","year":"2008","journal-title":"Oral Dis"},{"key":"10.1016\/j.tripleo.2010.03.034_bib6","first-page":"235","article-title":"Malignant transformation of oral lichen planus: a retrospective study of 23 cases","volume":"40","author":"Fang","year":"2009","journal-title":"Quintissence Int"},{"key":"10.1016\/j.tripleo.2010.03.034_bib7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tripleo.2004.06.076","article-title":"Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation","volume":"100","author":"Lodi","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.03.034_bib8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0030-4220(91)90007-Y","article-title":"A prospective study of findings and management in 214 patients with oral lichen planus","volume":"72","author":"Silverman","year":"1991","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.03.034_bib9","doi-asserted-by":"crossref","first-page":"901","DOI":"10.14219\/jada.archive.2001.0302","article-title":"Oral lichen planus: patient profile, disease progression and treatment responses","volume":"132","author":"Chainani-Wu","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.tripleo.2010.03.034_bib10","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1378\/chest.08-0440","article-title":"Molecular mechanisms of corticosteroid resistance","volume":"134","author":"Ian","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.tripleo.2010.03.034_bib11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1749-6632.2009.05013.x","article-title":"Clinical features associated with glucocorticoid receptor polymorphisms","volume":"1179","author":"Manenschijn","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.tripleo.2010.03.034_bib12","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1210\/jc.2008-0040","article-title":"Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder","volume":"93","author":"Charmandari","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.tripleo.2010.03.034_bib13","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1365-2133.2003.05735.x","article-title":"Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin","volume":"149","author":"Niwa","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib14","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2133.2004.06315.x","article-title":"Topical use of tacrolimus and squamous cell carcinoma on the penis","volume":"152","author":"Langeland","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2407-6-7","article-title":"The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report","volume":"6","author":"Becker","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.tripleo.2010.03.034_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/000163501750266774","article-title":"Immune mechanisms in oral lichen planus","volume":"59","author":"Thornhill","year":"2001","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.tripleo.2010.03.034_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tripleo.2004.06.077","article-title":"Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis","volume":"100","author":"Lodi","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.03.034_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-0714.1996.tb01375.x","article-title":"Is there a role for tumor necrosis factor alpha (TNF-\u03b1) in oral lichen planus?","volume":"25","author":"Sugerman","year":"1996","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2010.03.034_bib20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1034\/j.1600-0714.2000.290802.x","article-title":"TNF-\u03b1 expression and apoptosis-regulation proteins in oral lichen planus: a comparative immunohistochemical evaluation","volume":"29","author":"Sklavounou","year":"2000","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.tripleo.2010.03.034_bib21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0003-9969(99)00013-8","article-title":"Distribution of interleukin-2, -4, -10, tumor necrosis factor-\u03b1 and transforming growth factor-\u03b2 mRNAs in oral lichen planus","volume":"44","author":"Simark-Mattsson","year":"1999","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.clim.2004.12.003","article-title":"A comparison of the pro-inflammatory, NF-\u03baB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients","volume":"114","author":"Rhodus","year":"2005","journal-title":"Clin Immunol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib23","first-page":"5","article-title":"Regulation of BCG-polysaccharide nucleic acid on Thl\/Th2 cytokines from peripheral blood mononuclear cells in oral lichen planus","volume":"7","author":"Zhou","year":"2004","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.tripleo.2010.03.034_bib24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0149-2918(03)80085-1","article-title":"Thalidomide: a review of approved and investigational uses","volume":"25","author":"Matthews","year":"2003","journal-title":"Clin Ther"},{"key":"10.1016\/j.tripleo.2010.03.034_bib25","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/S0140-6736(04)16308-3","article-title":"Thalidomide","volume":"363","author":"Michael","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.tripleo.2010.03.034_bib26","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1001\/archderm.136.12.1442","article-title":"Effective treatment of oral erosive lichen planus with thalidomide","volume":"136","author":"Camisa","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib27","first-page":"1109","article-title":"Treatment of erosive oral lichen planus with thalidomide","volume":"130","author":"Macario-Barrel","year":"2003","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0954-6111(97)90134-7","article-title":"Thalidomide reduces tumor necrosis factor-alpha production by human alveolar macrophages","volume":"91","author":"Tavares","year":"1997","journal-title":"Respir Med"},{"key":"10.1016\/j.tripleo.2010.03.034_bib29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2249.1995.tb05527.x","article-title":"The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Thl cytokine production in mitogen and antigen-stimulated human peripheral blood mononuclear cell cultures","volume":"99","author":"McHugh","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib30","first-page":"306","article-title":"Topical thalidomide having good effect on refractory chronic discoid lupus erythematosus: a case report","volume":"7","author":"Ni","year":"2007","journal-title":"West China Journal of Stomatology"},{"key":"10.1016\/j.tripleo.2010.03.034_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tripleo.2006.11.001","article-title":"Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations","volume":"103","author":"Al-Hashimi","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.tripleo.2010.03.034_bib33","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0149-2918(00)88289-2","article-title":"S.T.E.P.S.: a comprehensive program for controlling and monitoring access to thalidomide","volume":"12","author":"Zeldis","year":"1999","journal-title":"Clin Ther"},{"key":"10.1016\/j.tripleo.2010.03.034_bib34","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1212\/WNL.62.12.2291","article-title":"Thalidomide sensory neurotoxicity: a clinical and neurophysiologic study","volume":"62","author":"Cavaletti","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.tripleo.2010.03.034_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00192350","article-title":"Thalidomide-induced neuropathy and genetic differences in drug metabolism","volume":"49","author":"Harland","year":"1995","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib36","first-page":"88","article-title":"Erosive lichen planus","volume":"29","author":"Randell","year":"1974","journal-title":"J Oral Med"},{"key":"10.1016\/j.tripleo.2010.03.034_bib37","first-page":"1399","article-title":"[A double-blind study on clinical effects of dexaltin ointment]","volume":"26","author":"Ueno","year":"1980","journal-title":"Japanese Journal of Oral Surgery"},{"key":"10.1016\/j.tripleo.2010.03.034_bib38","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1601-0825.2005.01165.x","article-title":"Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone","volume":"12","author":"Rhodus","year":"2006","journal-title":"Oral Dis"},{"key":"10.1016\/j.tripleo.2010.03.034_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0162-3109(98)00010-1","article-title":"Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells","volume":"40","author":"Rowland","year":"1998","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.tripleo.2010.03.034_bib40","first-page":"98","article-title":"Effects of glucocorticoids on T helper cell balance in oral lichen planus","volume":"40","author":"Zhou","year":"2005","journal-title":"Chin J Stomatol"},{"key":"10.1016\/j.tripleo.2010.03.034_bib41","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1067\/mjd.2001.119559","article-title":"Lichen planopilaris treated with thalidomide","volume":"45","author":"George","year":"2001","journal-title":"J Am Acad Dermatol"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210410002118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210410002118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T07:20:15Z","timestamp":1544340015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079210410002118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S1079210410002118"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2010.03.034","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}