{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:14:26Z","timestamp":1790486066124,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.tripleo.2011.05.042","type":"journal-article","created":{"date-parts":[[2011,8,30]],"date-time":"2011-08-30T06:03:43Z","timestamp":1314684223000},"page":"e137-e142","source":"Crossref","is-referenced-by-count":62,"title":["Cytocompatibility of new bioceramic-based materials on human fibroblast cells (MRC-5)"],"prefix":"10.1016","volume":"112","author":[{"given":"Dalia","family":"Mukhtar-Fayyad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tripleo.2011.05.042_bib1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1365-2591.2006.01096.x","article-title":"MTA versus Portland cement as repair material for furcal perforations: a laboratory study using a polymicrobial leakage model","volume":"39","author":"De-Deus","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2011.05.042_bib2","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1023\/B:JMSM.0000032816.45489.54","article-title":"Root canal sealers induce cytotoxicity and necrosis","volume":"15","author":"Huang","year":"2004","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.tripleo.2011.05.042_bib3","series-title":"Definitions in biomaterials","author":"Willians","year":"1986"},{"key":"10.1016\/j.tripleo.2011.05.042_bib4","first-page":"319","article-title":"Carcinogenicity and metallic implants","volume":"24","author":"Valey","year":"1995","journal-title":"Am J Orthod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/(SICI)1097-4636(199701)34:1<29::AID-JBM5>3.0.CO;2-P","article-title":"Effects of metal ions on osteoblast-like cell metabolism and differentiation","volume":"34","author":"Sun","year":"1997","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.tripleo.2011.05.042_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0300-5712(94)90032-9","article-title":"Use of cell cultures for toxicity testing of dental materials\u2014advantages and limitations","volume":"22","author":"Schmalz","year":"1994","journal-title":"J Dent"},{"key":"10.1016\/j.tripleo.2011.05.042_bib7","first-page":"17","article-title":"Cytotoxic effect of a new endodontic cement and mineral trioxide aggregate on L929 line culture","volume":"3","author":"Ghoddusi","year":"2008","journal-title":"Ir Endod J"},{"key":"10.1016\/j.tripleo.2011.05.042_bib8","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.joen.2009.06.022","article-title":"Optimal cytocompatibility of a bioceramic nanoparticulate cement in primary human mesenchymal cells","volume":"35","author":"De-Deus","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2591.2008.01506.x","article-title":"Cytotoxicity and genotoxicity of pulp capping materials in two cell lines","volume":"42","author":"Camargo","year":"2009","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2011.05.042_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.joen.2009.09.002","article-title":"Cytotoxicity of RealSeal on human osteoblast-like MG63 cells","volume":"36","author":"Xu","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib11","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.joen.2010.06.022","article-title":"Human periodontal ligament cell response to a newly developed calcium phosphate\u2013based root canal sealer","volume":"36","author":"Bae","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib12","first-page":"8","article-title":"Bioceramic technology\u2014a game changer in endodontic obturation","volume":"6","author":"Koch","year":"2009","journal-title":"NJAGD Wisdom"},{"key":"10.1016\/j.tripleo.2011.05.042_bib13","first-page":"42","article-title":"Ceramics-based sealers as new alternative to currently used endodontic sealers","volume":"1","author":"Kossev","year":"2009","journal-title":"Roots"},{"key":"10.1016\/j.tripleo.2011.05.042_bib14","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.tripleo.2011.05.042_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01404408","article-title":"A rapid and simple MTT-based spectrometric assay for determining drug sensitivity in monolayer cultures","volume":"11","author":"Edmondson","year":"1988","journal-title":"J Tissue Cult Methods"},{"key":"10.1016\/j.tripleo.2011.05.042_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-9657.2004.00284.x","article-title":"Apexification","volume":"21","author":"Rafter","year":"2005","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.tripleo.2011.05.042_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s007840050002","article-title":"Biological aspects of root canal filling materials\u2014histocompatibility, cytotoxicity, and mutagenicity","volume":"1","author":"Geurtsen","year":"1997","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.tripleo.2011.05.042_bib18","first-page":"174","article-title":"Experimental endodontics","author":"Spangberg","year":"1990"},{"key":"10.1016\/j.tripleo.2011.05.042_bib19","first-page":"123","article-title":"Biological effects of root canal filling materials","volume":"20","author":"Spangberg","year":"1969","journal-title":"Odontol Revy"},{"key":"10.1016\/j.tripleo.2011.05.042_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2591.1997.00056.x","article-title":"Multilayer and monolayer cell cultures in a cytotoxicity assay of root canal sealers","volume":"30","author":"Vajrabhaya","year":"1997","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2011.05.042_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00004770-200005000-00010","article-title":"Cytotoxicity of mineral trioxide aggregate using human periodontal ligament fibroblasts","volume":"26","author":"Keiser","year":"2000","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0142-9612(97)00137-3","article-title":"Biocompatibility of various light-curing and one conventional glass-ionomer cement","volume":"19","author":"Leyhausen","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.tripleo.2011.05.042_bib23","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.joen.2008.08.001","article-title":"The effects of six root-end filling materials and their leachable components on cell viability","volume":"34","author":"Al-Sa'eed","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib24","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1177\/026119299502300609","article-title":"Cytotoxicity of biomaterials basic mechanisms and in vitro test methods: a review","volume":"23","author":"Groth","year":"1995","journal-title":"Altern Laboratory Anim"},{"key":"10.1016\/j.tripleo.2011.05.042_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1365-2591.2002.00459.x","article-title":"Cytotoxicity of resin-, zinc oxide-eugenol-, and calcium hydroxide-based root canal sealers on human periodontal ligament cells and permanent V79 cells","volume":"35","author":"Huang","year":"2002","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2011.05.042_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00004770-200309000-00010","article-title":"Cytotoxicity testing of endodontic sealers: a new method","volume":"29","author":"Camps","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1741-2358.2006.00103.x","article-title":"In vitro biocompatibility of denture relining materials","volume":"23","author":"Dahl","year":"2006","journal-title":"Gerodontology"},{"key":"10.1016\/j.tripleo.2011.05.042_bib28","first-page":"255","article-title":"Cytotoxicity of AH plus and AH26 in vitro on Chinese hamster V79 fibroblasts","volume":"34","author":"Miletic","year":"2000","journal-title":"Acta Stomatol Croat"},{"key":"10.1016\/j.tripleo.2011.05.042_bib29","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1067\/moe.2003.20","article-title":"Cell and tissue reactions to mineral trioxide aggregate and Portland cement","volume":"95","author":"Saidon","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Radiol Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1365-2591.2005.00987.x","article-title":"Cytotoxicity of MTA and Portland cement on human ECV 304 endothelial cells","volume":"38","author":"De Deus","year":"2005","journal-title":"Int Endod J"},{"key":"10.1016\/j.tripleo.2011.05.042_bib31","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0099-2399(06)81964-3","article-title":"Periapical tissue response to two calcium hydroxide-containing endodontic sealers","volume":"16","author":"Soares","year":"1990","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib32","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0099-2399(98)80082-4","article-title":"In vivo comparison of the biocompatibility of two root canal sealers implanted into the subcutaneous connective tissue of rats","volume":"24","author":"Kolokouris","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.joen.2006.07.022","article-title":"Human pulp cells response to Portland cement in vitro","volume":"33","author":"Min","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib34","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0142-9612(00)00016-8","article-title":"Tissue responses of calcium phosphate cement: a study in dogs","volume":"21","author":"Yuan","year":"2000","journal-title":"Biomaterials"},{"key":"10.1016\/j.tripleo.2011.05.042_bib35","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.joen.2010.08.038","article-title":"Effects of iRoot SP on mineralization-related genes expression in MG63 cells","volume":"36","author":"Zhang","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.tripleo.2011.05.042_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.joen.2010.11.027","article-title":"Cytotoxicity comparison of mineral trioxide aggregates and endosequence bioceramic root repair materials","volume":"37","author":"Damas","year":"2011","journal-title":"J Endod"}],"container-title":["Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210411003714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079210411003714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T06:41:11Z","timestamp":1638427271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079210411003714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1079210411003714"],"URL":"https:\/\/doi.org\/10.1016\/j.tripleo.2011.05.042","relation":{},"ISSN":["1079-2104"],"issn-type":[{"value":"1079-2104","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}