{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:00:40Z","timestamp":1789351240129,"version":"build-2803163510"},"reference-count":212,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplantation Reviews"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.trre.2010.01.002","type":"journal-article","created":{"date-parts":[[2010,2,12]],"date-time":"2010-02-12T09:45:03Z","timestamp":1265967903000},"page":"52-66","source":"Crossref","is-referenced-by-count":32,"title":["Regulatory T cells in transplantation: does extracellular adenosine triphosphate metabolism through CD39 play a crucial role?"],"prefix":"10.1016","volume":"24","author":[{"given":"Francisco","family":"Salcido-Ochoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Rotzschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trre.2010.01.002_bib1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1600-6143.2006.01272.x","article-title":"Kidney and pancreas transplantation in the United States, 1995-2004","volume":"6","author":"Cohen","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1600-6143.2004.00332.x","article-title":"Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era","volume":"4","author":"Meier-Kriesche","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib3","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1681\/ASN.2005050463","article-title":"Chronic renal allograft dysfunction","volume":"16","author":"Chapman","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trre.2010.01.002_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.med.58.061705.145143","article-title":"Why hasn't eliminating acute rejection improved graft survival?","volume":"58","author":"Tantravahi","year":"2007","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.trre.2010.01.002_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1126\/science.271.5246.173","article-title":"Immunology taught by viruses","volume":"271","author":"Zinkernagel","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.trre.2010.01.002_bib6","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.282.5392.1338","article-title":"Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking","volume":"282","author":"Alferink","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.trre.2010.01.002_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1084\/jem.188.2.409","article-title":"Major histocompatibility complex class I-restricted cross-presentation is biased towards high dose antigens and those released during cellular destruction","volume":"188","author":"Kurts","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.8303275","article-title":"Levels of peripheral T cell tolerance induced by different doses of tolerogen","volume":"263","author":"Ferber","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.trre.2010.01.002_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1084\/jem.186.2.239","article-title":"Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells","volume":"186","author":"Kurts","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0065-2776(08)60652-5","article-title":"Heterogeneity of cytokine secretion patterns and functions of helper T cells","volume":"46","author":"Mosmann","year":"1989","journal-title":"Adv Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib11","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.coi.2007.07.020","article-title":"Th17: the third member of the effector T cell trilogy","volume":"19","author":"Bettelli","year":"2007","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4049\/jimmunol.144.1.16","article-title":"Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody","volume":"144","author":"Jenkins","year":"1990","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/intimm\/9.7.935","article-title":"Immobilized anti-CD3 mAb induces anergy in murine naive and memory CD4+ T cells in vitro","volume":"9","author":"Chai","year":"1997","journal-title":"Int Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib14","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/(SICI)1521-4141(199902)29:02<686::AID-IMMU686>3.0.CO;2-N","article-title":"Anergic T cells act as suppressor cells in vitro and in vivo","volume":"29","author":"Chai","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib16","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.184.2.387","article-title":"Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation","volume":"184","author":"Asano","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib17","first-page":"723","article-title":"Cell interactions in the induction of tolerance: the role of thymic lymphocytes","volume":"18","author":"Gershon","year":"1970","journal-title":"Immunology"},{"key":"10.1016\/j.trre.2010.01.002_bib18","first-page":"903","article-title":"Infectious immunological tolerance","volume":"21","author":"Gershon","year":"1971","journal-title":"Immunology"},{"key":"10.1016\/j.trre.2010.01.002_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-3083.1988.tb02344.x","article-title":"Do suppressor T cells exist?","volume":"27","author":"Moller","year":"1988","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0167-5699(93)90180-S","article-title":"Saying the \u201cS\u201d word in public","volume":"14","author":"Green","year":"1993","journal-title":"Immunol Today"},{"key":"10.1016\/j.trre.2010.01.002_bib21","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.8094901","article-title":"\u201cInfectious\u201d transplantation tolerance","volume":"259","author":"Qin","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.trre.2010.01.002_bib22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/intimm\/10.6.775","article-title":"Specific suppression of T helper alloreactivity by allo-MHC class I-restricted CD8+","volume":"10","author":"Liu","year":"1998","journal-title":"Int Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0008-8749(90)90222-D","article-title":"In vitro and in vivo analysis of bone marrow-derived CD3+, CD4\u2212, CD8\u2212, NK1.1+ cell lines","volume":"129","author":"Sykes","year":"1990","journal-title":"Cell Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib24","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/77513","article-title":"Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression","volume":"6","author":"Zhang","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.trre.2010.01.002_bib25","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/90604","article-title":"The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells","volume":"2","author":"Weiner","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib26","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1084\/jem.20040395","article-title":"Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis","volume":"200","author":"Rifa'I","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.immunol.18.1.185","article-title":"The specific regulation of immune responses by CD8+ T cells restricted by the MHC class Ib molecule, Qa-1","volume":"18","author":"Jiang","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib28","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.4049\/jimmunol.167.7.3800","article-title":"Induction of TCR Vbeta-specific CD8+ CTLs by TCR Vbeta-derived peptides bound to HLA-E","volume":"167","author":"Li","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib29","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1182\/blood-2004-07-2583","article-title":"Isolation and characterization of human antigen-specific TCR alpha beta+ CD4(\u2212)CD8\u2212 double-negative regulatory T cells","volume":"105","author":"Fischer","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/ni760","article-title":"Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4","volume":"3","author":"Chang","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2337\/diabetes.54.1.92","article-title":"Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes","volume":"54","author":"Lindley","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.trre.2010.01.002_bib33","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4049\/jimmunol.174.1.164","article-title":"Dysfunctional blood and target tissue CD4+CD25high regulatory T cells in psoriasis: mechanism underlying unrestrained pathogenic effector T cell proliferation","volume":"174","author":"Sugiyama","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-11-3900","article-title":"Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis","volume":"105","author":"Balandina","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib35","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1084\/jem.20031579","article-title":"Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis","volume":"199","author":"Viglietta","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20061531","article-title":"Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta","volume":"204","author":"Nadkarni","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib37","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1084\/jem.193.11.1285","article-title":"Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood","volume":"193","author":"Jonuleit","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib38","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/eji.1830260822","article-title":"Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium","volume":"26","author":"Modigliani","year":"1996","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib39","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1084\/jem.194.4.427","article-title":"Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells","volume":"194","author":"Bensinger","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib40","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/intimm\/10.4.371","article-title":"Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency","volume":"10","author":"Papiernik","year":"1998","journal-title":"Int.Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1074-7613(02)00367-9","article-title":"CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2","volume":"17","author":"Malek","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib42","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/ni.1607","article-title":"A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells","volume":"9","author":"Liu","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib43","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ni1265","article-title":"Inducing and expanding regulatory T cell populations by foreign antigen","volume":"6","author":"Kretschmer","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib44","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1073\/pnas.0400810101","article-title":"TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes","volume":"101","author":"Peng","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trre.2010.01.002_bib45","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.4049\/jimmunol.178.7.4022","article-title":"Cutting Edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells","volume":"178","author":"Davidson","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib46","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.162.9.5317","article-title":"Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance","volume":"162","author":"Itoh","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib47","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.188.2.287","article-title":"CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production","volume":"188","author":"Thornton","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1074-7613(02)00280-7","article-title":"CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor","volume":"16","author":"McHugh","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib49","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni759","article-title":"Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance","volume":"3","author":"Shimizu","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib50","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2004.08.010","article-title":"Role of LAG-3 in regulatory T cells","volume":"21","author":"Huang","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib51","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/eji.200324799","article-title":"Neuropilin-1: a surface marker of regulatory T cells","volume":"34","author":"Bruder","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib52","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1182\/blood-2006-04-016451","article-title":"Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells","volume":"109","author":"Garin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib53","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1182\/blood-2007-01-069229","article-title":"Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function","volume":"110","author":"Kubach","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2007.04.017","article-title":"Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor","volume":"27","author":"Yamaguchi","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib55","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.20060468","article-title":"Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells","volume":"203","author":"Seddiki","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib56","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.192.2.295","article-title":"Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation","volume":"192","author":"Read","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib58","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib59","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1182\/blood-2006-12-064527","article-title":"Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression","volume":"110","author":"Borsellino","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib60","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.trre.2010.01.002_bib61","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib62","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4+CD25 high regulatory cells in human peripheral blood","volume":"167","author":"Baecher-Allan","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib63","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1182\/blood-2008-04-150524","article-title":"CD49d provides access to \u201cuntouched\u201d human Foxp3+ Treg free of contaminating effector cells","volume":"113","author":"Kleinewietfeld","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jim.2009.05.004","article-title":"Isolation of functional human regulatory T cells (Treg) from the peripheral blood based on the CD39 expression","volume":"346","author":"Mandapathil","year":"2009","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.trre.2010.01.002_bib65","doi-asserted-by":"crossref","first-page":"37672","DOI":"10.1074\/jbc.M104521200","article-title":"Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation","volume":"276","author":"Schubert","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trre.2010.01.002_bib66","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib67","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"A function for interleukin 2 in Foxp3-expressing regulatory T cells","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib68","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.immuni.2005.01.016","article-title":"Regulatory T cell lineage specification by the forkhead transcription factor foxp3","volume":"22","author":"Fontenot","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib69","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1084\/jem.20050784","article-title":"Developmental regulation of Foxp3 expression during ontogeny","volume":"202","author":"Fontenot","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib70","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ni1428","article-title":"Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice","volume":"8","author":"Kim","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib71","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1084\/jem.20061852","article-title":"Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease","volume":"204","author":"Lahl","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib72","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/83713","article-title":"The immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome (IPEX) is caused by mutations of FOXP3","volume":"27","author":"Bennett","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.trre.2010.01.002_bib73","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaci.2005.08.047","article-title":"Role of regulatory T cells in human diseases","volume":"116","author":"Chatila","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib74","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature05478","article-title":"Foxp3 occupancy and regulation of key target genes during T-cell stimulation","volume":"445","author":"Marson","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.trre.2010.01.002_bib75","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/nature05563","article-title":"Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells","volume":"445","author":"Zheng","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.trre.2010.01.002_bib76","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1073\/pnas.0501675102","article-title":"Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells","volume":"102","author":"Bettelli","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trre.2010.01.002_bib77","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2006.05.042","article-title":"FOXP3 controls regulatory T cell function through cooperation with NFAT","volume":"126","author":"Wu","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.trre.2010.01.002_bib78","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nature05673","article-title":"Foxp3 controls regulatory T-cell function by interacting with AML1\/Runx1","volume":"446","author":"Ono","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.trre.2010.01.002_bib79","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1196\/annals.1394.022","article-title":"Impaired T cell receptor signaling in Foxp3+ CD4 T cells","volume":"1103","author":"Carson","year":"2007","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.trre.2010.01.002_bib80","doi-asserted-by":"crossref","first-page":"7797","DOI":"10.1073\/pnas.0800928105","article-title":"T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR","volume":"105","author":"Sauer","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trre.2010.01.002_bib81","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.4049\/jimmunol.180.5.2757","article-title":"Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK","volume":"180","author":"Luo","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib82","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.4049\/jimmunol.173.8.4994","article-title":"Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene","volume":"173","author":"Su","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib83","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.4049\/jimmunol.172.9.5287","article-title":"Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells","volume":"172","author":"Bensinger","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib84","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1189\/jlb.0605344","article-title":"Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells","volume":"80","author":"Tsang","year":"2006","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.trre.2010.01.002_bib85","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.4049\/jimmunol.177.4.2186","article-title":"Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells","volume":"177","author":"Hickman","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib86","first-page":"2521","article-title":"PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs","volume":"116","author":"Walsh","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trre.2010.01.002_bib87","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4049\/jimmunol.164.1.183","article-title":"Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific","volume":"164","author":"Thornton","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib88","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.4049\/jimmunol.176.3.1582","article-title":"CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer","volume":"176","author":"Smyth","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib89","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.4049\/jimmunol.175.7.4180","article-title":"Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells","volume":"175","author":"Lim","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib90","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1182\/blood-2004-07-2505","article-title":"CCR6 expression defines regulatory effector\/memory-like cells within the CD25(+)CD4+ T-cell subset","volume":"105","author":"Kleinewietfeld","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib91","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1084\/jem.20020190","article-title":"Interleukin 2 signaling is required for CD4(+) regulatory T cell function","volume":"196","author":"Furtado","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib92","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.4049\/jimmunol.172.11.6519","article-title":"Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function","volume":"172","author":"Thornton","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib93","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/ni1572","article-title":"The Foxp3+ regulatory T cell: a jack of all trades, master of regulation","volume":"9","author":"Tang","year":"2008","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib94","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.4049\/jimmunol.167.8.4271","article-title":"CD4(+)CD25(+) T cells facilitate the induction of T cell anergy","volume":"167","author":"Ermann","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib95","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1084\/jem.194.5.629","article-title":"Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta","volume":"194","author":"Nakamura","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib96","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1002\/eji.200323966","article-title":"Human CD4+CD25+ regulatory cells have marked and sustained effects on CD8+ T cell activation","volume":"33","author":"Camara","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib97","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1084\/jem.20081811","article-title":"CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance","volume":"206","author":"Friedline","year":"2009","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib98","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.immuni.2004.09.002","article-title":"Human T regulatory cells can use the perforin pathway to cause autologous target cell death","volume":"21","author":"Grossman","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib99","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.4049\/jimmunol.174.4.1783","article-title":"Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism","volume":"174","author":"Gondek","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib100","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/1521-4141(200006)30:6<1538::AID-IMMU1538>3.0.CO;2-X","article-title":"CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells","volume":"30","author":"Cederbom","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib101","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.4049\/jimmunol.172.8.4676","article-title":"Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells","volume":"172","author":"Misra","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib102","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.4049\/jimmunol.176.10.6202","article-title":"Modulation of dendritic cell function by naive and regulatory CD4+ T cells","volume":"176","author":"Veldhoen","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib103","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1016\/S0041-1345(02)03533-9","article-title":"Dendritic cells prohibited by anergic T cells acquire tolerogenic properties","volume":"34","author":"Salcido-Ochoa","year":"2002","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2010.01.002_bib104","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.4049\/jimmunol.181.8.5396","article-title":"The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation","volume":"181","author":"Chen","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ni1289","article-title":"Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice","volume":"7","author":"Tang","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib106","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1084\/jem.20050783","article-title":"Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo","volume":"203","author":"Tadokoro","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib107","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ni1536","article-title":"CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells","volume":"8","author":"Pandiyan","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib108","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1084\/jem.20020394","article-title":"Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells","volume":"196","author":"Jonuleit","year":"2002","journal-title":"J Exp.Med"},{"key":"10.1016\/j.trre.2010.01.002_bib109","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2567.2007.02544.x","article-title":"CD4+ CD25+ [corrected] regulatory T cells render naive CD4+","volume":"120","author":"Qiao","year":"2007","journal-title":"Immunology"},{"key":"10.1016\/j.trre.2010.01.002_bib110","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.4049\/jimmunol.173.8.5008","article-title":"Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells","volume":"173","author":"Stephens","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib111","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.22.012703.104731","article-title":"Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors","volume":"22","author":"Sitkovsky","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib112","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nri1685","article-title":"Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors","volume":"5","author":"Sitkovsky","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib113","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0074-7696(04)40002-3","article-title":"Cellular distribution and functions of P2 receptor subtypes in different systems","volume":"240","author":"Burnstock","year":"2004","journal-title":"Int Rev Cytol"},{"key":"10.1016\/j.trre.2010.01.002_bib114","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1189\/jlb.0802418","article-title":"Alerting and tuning the immune response by extracellular nucleotides","volume":"73","author":"la Sala","year":"2003","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.trre.2010.01.002_bib115","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1006\/bbrc.2000.2410","article-title":"CD39 modulates IL-1 release from activated endothelial cells","volume":"270","author":"Imai","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trre.2010.01.002_bib116","doi-asserted-by":"crossref","first-page":"26051","DOI":"10.1074\/jbc.M102568200","article-title":"P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide","volume":"276","author":"Warny","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trre.2010.01.002_bib117","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.4049\/jimmunol.166.3.1611","article-title":"Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses","volume":"166","author":"la Sala","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib118","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nri1997","article-title":"Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation","volume":"7","author":"Mariathasan","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib119","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.molmed.2007.07.005","article-title":"From inflammasomes to fevers, crystals and hypertension: how basic research explains inflammatory diseases","volume":"13","author":"McDermott","year":"2007","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.trre.2010.01.002_bib120","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nm1617","article-title":"Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells","volume":"13","author":"Idzko","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.trre.2010.01.002_bib121","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1042\/bj2980099","article-title":"Inhibition of cancer growth and selective glutathione depletion in Ehrlich tumour cells in vivo by extracellular ATP","volume":"298","author":"Lasso de la Vega","year":"1994","journal-title":"Biochem J"},{"key":"10.1016\/j.trre.2010.01.002_bib122","doi-asserted-by":"crossref","first-page":"33116","DOI":"10.1074\/jbc.271.51.33116","article-title":"Identification and characterization of CD39\/vascular ATP diphosphohydrolase","volume":"271","author":"Kaczmarek","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trre.2010.01.002_bib123","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11302-006-9003-5","article-title":"The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance","volume":"2","author":"Robson","year":"2006","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.trre.2010.01.002_bib124","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1600-065X.1998.tb01574.x","article-title":"Ecto-enzyme and signaling functions of lymphocyte CD73","volume":"161","author":"Resta","year":"1998","journal-title":"Immunol Rev"},{"key":"10.1016\/j.trre.2010.01.002_bib125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1182\/blood-2005-06-2599","article-title":"Adenosine A2a receptors induce heterologous desensitization of chemokine receptors","volume":"108","author":"Zhang","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib126","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1182\/blood-2004-04-1407","article-title":"Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo","volume":"105","author":"Erdmann","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib127","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.it.2008.12.002","article-title":"T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response","volume":"30","author":"Sitkovsky","year":"2009","journal-title":"Trends Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib128","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1055\/s-0037-1614868","article-title":"Analysis of CD39\/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes","volume":"82","author":"Koziak","year":"1999","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trre.2010.01.002_bib129","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1074\/jbc.275.3.2057","article-title":"Palmitoylation targets CD39\/endothelial ATP diphosphohydrolase to caveolae","volume":"275","author":"Koziak","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trre.2010.01.002_bib130","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.4049\/jimmunol.175.5.3075","article-title":"High sensitivity of CD4+CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors","volume":"175","author":"Aswad","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib131","doi-asserted-by":"crossref","first-page":"6780","DOI":"10.4049\/jimmunol.177.10.6780","article-title":"T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5\u2032-adenosine monophosphate to adenosine","volume":"177","author":"Kobie","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib132","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1146\/annurev.pharmtox.41.1.775","article-title":"Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection","volume":"41","author":"Linden","year":"2001","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.trre.2010.01.002_bib133","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/ncpneph0238","article-title":"Blocking the immune response in ischemic acute kidney injury: the role of adenosine 2A agonists","volume":"2","author":"Li","year":"2006","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1016\/j.trre.2010.01.002_bib134","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1084\/jem.20062129","article-title":"Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression","volume":"204","author":"Bopp","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib135","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1189\/jlb.0706474","article-title":"Regulatory T cell-mediated suppression: potential role of ICER","volume":"81","author":"Bodor","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.trre.2010.01.002_bib136","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/eji.200636510","article-title":"ICER\/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells","volume":"37","author":"Bodor","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib137","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11302-006-9050-y","article-title":"CD39 and control of cellular immune responses","volume":"3","author":"Dwyer","year":"2007","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.trre.2010.01.002_bib138","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1084\/jem.20031562","article-title":"Developmental stage, phenotype, and migration distinguish naive- and effector\/memory-like CD4+ regulatory T cells","volume":"199","author":"Huehn","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib139","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/01.TP.0000155179.61445.78","article-title":"Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression","volume":"79","author":"Benghiat","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib140","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1600-065X.2003.00089.x","article-title":"The balance of deletion and regulation in allograft tolerance","volume":"196","author":"Zheng","year":"2003","journal-title":"Immunol Rev"},{"key":"10.1016\/j.trre.2010.01.002_bib141","doi-asserted-by":"crossref","first-page":"3789","DOI":"10.4049\/jimmunol.166.6.3789","article-title":"IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo","volume":"166","author":"Hara","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib142","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.4049\/jimmunol.168.3.1080","article-title":"CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses","volume":"168","author":"Kingsley","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib143","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nri1027","article-title":"Regulatory T cells in transplantation tolerance","volume":"3","author":"Wood","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib144","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nri1002","article-title":"The complementary roles of deletion and regulation in transplantation tolerance","volume":"3","author":"Lechler","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib145","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/01.TP.0000159147.56408.9C","article-title":"Regulatory T cells, derived from naive CD4+","volume":"79","author":"Chai","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib146","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.4049\/jimmunol.174.6.3290","article-title":"The generation of CD25+ CD4+ regulatory T cells that prevent allograft rejection does not compromise immunity to a viral pathogen","volume":"174","author":"Bushell","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib147","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.smim.2003.12.007","article-title":"Regulatory T cells and organ transplantation","volume":"16","author":"Waldmann","year":"2004","journal-title":"Semin Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib148","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/lt.20612","article-title":"Low circulating regulatory T-cell levels after acute rejection in liver transplantation","volume":"12","author":"Demirkiran","year":"2006","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2010.01.002_bib149","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1097\/01.ASN.0000057540.98231.C1","article-title":"Regulatory CD25+ T cells in human kidney transplant recipients","volume":"14","author":"Salama","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trre.2010.01.002_bib150","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1073\/pnas.0705834104","article-title":"Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance","volume":"104","author":"Brouard","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trre.2010.01.002_bib151","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/01.tp.0000203166.44968.86","article-title":"Contrasting CD25hiCD4+T cells\/FOXP3 patterns in chronic rejection and operational drug-free tolerance","volume":"81","author":"Louis","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib152","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.21.120601.141122","article-title":"Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses","volume":"22","author":"Sakaguchi","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib153","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/intimm\/10.12.1969","article-title":"Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic\/suppressive state","volume":"10","author":"Takahashi","year":"1998","journal-title":"Int Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib154","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1084\/jem.20030422","article-title":"Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells","volume":"198","author":"Yamazaki","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib155","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1182\/blood.V99.10.3493","article-title":"The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality","volume":"99","author":"Taylor","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib156","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1084\/jem.193.11.1295","article-title":"Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function","volume":"193","author":"Levings","year":"2001","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib157","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1182\/blood-2004-01-0151","article-title":"In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures","volume":"104","author":"Godfrey","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib158","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1182\/blood-2004-01-0086","article-title":"Large-scale in vitro expansion of polyclonal human CD4(+)CD25 high regulatory T cells","volume":"104","author":"Hoffmann","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib159","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/nm915","article-title":"CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation","volume":"9","author":"Edinger","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.trre.2010.01.002_bib160","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1172\/JCI17702","article-title":"Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia","volume":"112","author":"Trenado","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trre.2010.01.002_bib161","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.4049\/jimmunol.170.8.3939","article-title":"Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells","volume":"170","author":"Mottet","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib162","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/nm1312","article-title":"Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells","volume":"11","author":"Zhang","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.trre.2010.01.002_bib163","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.4049\/jimmunol.176.2.1266","article-title":"Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation\/differentiation of pathogenic T cells","volume":"176","author":"Trenado","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib164","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1074-7613(02)00279-0","article-title":"Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals","volume":"16","author":"Green","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib165","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.4049\/jimmunol.175.7.4283","article-title":"Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta","volume":"175","author":"Huang","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib166","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.20040139","article-title":"In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes","volume":"199","author":"Tang","year":"2004","journal-title":"J Exp Med"},{"issue":"Suppl 2","key":"10.1016\/j.trre.2010.01.002_bib167","doi-asserted-by":"crossref","first-page":"14622","DOI":"10.1073\/pnas.0405234101","article-title":"Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells","volume":"101","author":"Bluestone","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trre.2010.01.002_bib168","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1182\/blood-2003-04-1164","article-title":"Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo","volume":"102","author":"Jiang","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib169","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1097\/01.tp.0000244932.29542.9e","article-title":"Generation and expansion of human CD4+ CD25+ regulatory T cells with indirect allospecificity: potential reagents to promote donor-specific transplantation tolerance","volume":"82","author":"Jiang","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib170","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1182\/blood-2006-05-025460","article-title":"In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance","volume":"109","author":"Golshayan","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib171","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.intimp.2006.07.032","article-title":"In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity","volume":"6","author":"Tsang","year":"2006","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.trre.2010.01.002_bib172","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.20040180","article-title":"CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes","volume":"199","author":"Tarbell","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib173","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.175.5.3053","article-title":"Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice","volume":"175","author":"Masteller","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib174","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.20012097","article-title":"Identification of regulatory T cells in tolerated allografts","volume":"195","author":"Graca","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.trre.2010.01.002_bib175","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1098\/rstb.2001.0845","article-title":"The role of peripheral T-cell deletion in transplantation tolerance","volume":"356","author":"Wells","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.trre.2010.01.002_bib176","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1172\/JCI33185","article-title":"Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice","volume":"118","author":"Tsang","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trre.2010.01.002_bib177","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1034\/j.1600-6143.2001.10201.x","article-title":"Allorecognition","volume":"1","author":"Rogers","year":"2001","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib178","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1432-2277.2007.00470.x","article-title":"Influence of direct and indirect allorecognition pathways on CD4(+)CD25(+) regulatory T-cell function in transplantation","volume":"20","author":"Sanchez-Fueyo","year":"2007","journal-title":"Transpl Int"},{"key":"10.1016\/j.trre.2010.01.002_bib179","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.4049\/jimmunol.161.11.5813","article-title":"Linked suppression of skin graft rejection can operate through indirect recognition","volume":"161","author":"Wise","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib180","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nm1688","article-title":"Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes","volume":"14","author":"Joffre","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.trre.2010.01.002_bib181","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nri2137","article-title":"What does the future holds for cell-based tolerogenic therapy?","volume":"7","author":"Bluestone","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib182","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ni.1774","article-title":"Instability of the transcription factor Forp3 leads to the generation of pathogenic memory T cells in vivo","volume":"10","author":"Zhou","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib183","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.immuni.2008.03.018","article-title":"Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery","volume":"28","author":"Ito","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib184","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1073\/pnas.0811556106","article-title":"Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity","volume":"106","author":"Komatsu","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trre.2010.01.002_bib185","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1128\/MCB.13.8.4760","article-title":"Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location","volume":"13","author":"Bram","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.trre.2010.01.002_bib186","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1182\/blood-2002-10-3014","article-title":"The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade","volume":"101","author":"Blaha","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib187","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00007890-200008150-00005","article-title":"Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance induction","volume":"70","author":"Smiley","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib188","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1097\/00007890-199811270-00021","article-title":"Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment","volume":"66","author":"Li","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib189","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.4049\/jimmunol.176.6.3593","article-title":"Molecular mechanisms underlying FOXP3 induction in human T cells","volume":"176","author":"Mantel","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib190","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1182\/blood-2006-01-0329","article-title":"Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production","volume":"108","author":"Zeiser","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib191","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.tp.0000229473.95202.50","article-title":"Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients","volume":"82","author":"Segundo","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib192","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0009-9120(98)00045-9","article-title":"Rapamune (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression","volume":"31","author":"Sehgal","year":"1998","journal-title":"Clin Biochem"},{"key":"10.1016\/j.trre.2010.01.002_bib193","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/01.TP.0000158023.21233.DE","article-title":"Effects of immunosuppressants on induction of regulatory cells after intratracheal delivery of alloantigen","volume":"79","author":"Shibutani","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib194","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.4049\/jimmunol.167.4.1945","article-title":"Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance","volume":"167","author":"Gregori","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib195","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1111\/j.1600-6143.2007.01829.x","article-title":"CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects","volume":"7","author":"Kang","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib196","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S1074-7613(03)00259-0","article-title":"Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance","volume":"19","author":"Zheng","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.trre.2010.01.002_bib197","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jgm.1220","article-title":"Clinical-grade preparation of human natural regulatory T-cells encoding the thymidine kinase suicide gene as a safety gene","volume":"10","author":"Guillot-Delost","year":"2008","journal-title":"J Gene Med"},{"key":"10.1016\/j.trre.2010.01.002_bib198","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4049\/jimmunol.178.1.320","article-title":"Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin","volume":"178","author":"Strauss","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib199","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.2337\/db08-0138","article-title":"Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells","volume":"57","author":"Monti","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.trre.2010.01.002_bib200","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/nm931","article-title":"Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade","volume":"9","author":"Monk","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.trre.2010.01.002_bib201","doi-asserted-by":"crossref","first-page":"944","DOI":"10.4049\/jimmunol.177.2.944","article-title":"Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells","volume":"177","author":"Valmori","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib202","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/01.tp.0000194860.21533.b9","article-title":"Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells","volume":"81","author":"Nikolaeva","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib203","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1182\/blood-2004-10-3932","article-title":"Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells","volume":"105","author":"Battaglia","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.trre.2010.01.002_bib204","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/00007890-200010150-00020","article-title":"Rapamycin induces transforming growth factor-beta production by lymphocytes","volume":"70","author":"Dodge","year":"2000","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2010.01.002_bib205","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1111\/j.1600-6143.2007.01842.x","article-title":"Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells","volume":"7","author":"Gao","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib206","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1600-6143.2005.00749.x","article-title":"Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties","volume":"5","author":"Larsen","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib207","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.trim.2007.01.005","article-title":"Absence of CD4CD25 regulatory T cell expansion in renal transplanted patients treated in vivo with belatacept mediated CD28-CD80\/86 blockade","volume":"17","author":"Chavez","year":"2007","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib208","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1600-6143.2006.01604.x","article-title":"Following anti-CD25 treatment, a functional CD4+CD25+ regulatory T-cell pool is present in renal transplant recipients","volume":"7","author":"Kreijveld","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib209","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.trim.2007.03.001","article-title":"Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation","volume":"18","author":"Vlad","year":"2007","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.trre.2010.01.002_bib210","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1016\/j.transproceed.2008.03.066","article-title":"Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cells","volume":"40","author":"Morales","year":"2008","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2010.01.002_bib211","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1600-6143.2007.02134.x","article-title":"CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H","volume":"8","author":"Bloom","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2010.01.002_bib212","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1182\/blood-2008-01-130146","article-title":"Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro","volume":"111","author":"Feng","year":"2008","journal-title":"Blood"}],"container-title":["Transplantation Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X10000030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X10000030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T06:35:06Z","timestamp":1685428506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955470X10000030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":212,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0955470X10000030"],"URL":"https:\/\/doi.org\/10.1016\/j.trre.2010.01.002","relation":{},"ISSN":["0955-470X"],"issn-type":[{"value":"0955-470X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}