{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:56:12Z","timestamp":1778799372195,"version":"3.51.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"PIRCHE"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Reviews"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.trre.2020.100533","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T11:37:37Z","timestamp":1579261057000},"page":"100533","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Critical evaluation of a possible role of HLA epitope matching in kidney transplantation"],"prefix":"10.1016","volume":"34","author":[{"given":"Gizem","family":"Kumru Sahin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Unterrainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caner","family":"S\u00fcsal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.trre.2020.100533_bb0005","series-title":"Cellular and Molecular Immunology","author":"Abbas","year":"2018"},{"key":"10.1016\/j.trre.2020.100533_bb0010","author":"Anthony Nolan Research Institute"},{"key":"10.1016\/j.trre.2020.100533_bb0015","series-title":"Eurotransplant Manual Chapter 4 Kidney (ETKAS and ESP, version 7)","author":"Eurotransplant International Foundation","year":"2018"},{"key":"10.1016\/j.trre.2020.100533_bb0020","doi-asserted-by":"crossref","first-page":"E428","DOI":"10.1111\/j.1399-0012.2012.01654.x","article-title":"Human leukocyte antigen mismatches associated with increased risk of rejection, graft failure, and death independent of initial immunosupression in renal transplant recipients","volume":"26","author":"Lim","year":"2012","journal-title":"Clin Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0025","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/MOT.0b013e3283636ddf","article-title":"Current role of human leukocyte antigen matching in kidney transplantation","volume":"18","author":"S\u00fcsal","year":"2013","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0030","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/TP.0000000000001115","article-title":"The risk of transplant failure with HLA mismatch in first adult kidney allografts from deceased donors","volume":"100","author":"Williams","year":"2016","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0035","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/TP.0b013e3181c69855","article-title":"Impact of HLA mismatching on incidence of posttransplant non-hodgkin lymphoma after kidney transplantation","volume":"89","author":"Opelz","year":"2010","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0040","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1111\/j.1600-6143.2012.04226.x","article-title":"Association of HLA mismatch with death with a functioning graft after kidney transplantation: a collaborative transplant study report","volume":"12","author":"Opelz","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0045","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1600-6143.2012.04013.x","article-title":"Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant","volume":"12","author":"Wiebe","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/TP.0b013e3181a9ec89","article-title":"A lifetime versus a graft life approach redefines the importance of HLA matching in kidney transplant patients","volume":"88","author":"Meier-Kriesche","year":"2009","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0055","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/TP.0b013e31817c90f5","article-title":"Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patients","volume":"86","author":"Fuggle","year":"2008","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0060","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5619402","article-title":"Clinical relevance of HLA antibodies in kidney transplantation: recent data from the Heidelberg transplant center and the collaborative transplant study","volume":"2017","author":"S\u00fcsal","year":"2017","journal-title":"J Immunol Res"},{"key":"10.1016\/j.trre.2020.100533_bb0065","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.humimm.2006.08.001","article-title":"A structurally based approach to determine HLA compatibility at the humoral immune level","volume":"67","author":"Duquesnoy","year":"2006","journal-title":"Hum Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0070","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0198-8859(02)00382-8","article-title":"HLA matchmaker: a molecularly based algorithm for histocompatibility determination. I. Description of the algorithm","volume":"63","author":"Duquesnoy","year":"2002","journal-title":"Hum Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0075","author":"HLA Epitope Registry"},{"key":"10.1016\/j.trre.2020.100533_bb0080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.humimm.2006.11.006","article-title":"HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens","volume":"68","author":"El-Awar","year":"2007","journal-title":"Hum Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1399-0039.2009.01271.x","article-title":"Correlations between Terasaki's HLA class I epitopes and HLA matchmaker-defined eplets on HLA-A, -B and -C antigens","volume":"74","author":"Duquesnoy","year":"2009","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.trre.2020.100533_bb0090","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1399-0039.2009.01272.x","article-title":"Correlations between Terasaki's HLA class II epitopes and HLA matchmaker-defined eplets on HLA-DR and -DQ antigens","volume":"74","author":"Marrari","year":"2009","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.trre.2020.100533_bb0095","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1097\/TP.0000000000001667","article-title":"Are we ready for epitope-based HLA matching in clinical organ transplantation?","volume":"101","author":"Duquesnoy","year":"2017","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0100","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/TP.0b013e3181ffff99","article-title":"Predicting HLA class II alloantigen immunogenicity from the number and physiochemical properties of amino acid polymorphisms","volume":"91","author":"Kosmoliaptsis","year":"2011","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0105","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1111\/ajt.13707","article-title":"Alloantibody responses after renal transplant failure can be better predicted by donor\u2013recipient HLA amino acid sequence and physicochemical disparities than conventional HLA matching","volume":"16","author":"Kosmoliaptsis","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/159479","article-title":"Predicting alloreactivity in transplantation","volume":"2014","author":"Geneugelijk","year":"2014","journal-title":"J Immunol Res"},{"key":"10.1016\/j.trre.2020.100533_bb0115","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.humimm.2012.12.004","article-title":"Predicted indirectly recognizable HLA epitopes presented by HLA-DR correlate with the de novo development of donor-specific HLA IgG antibodies after kidney transplantation","volume":"74","author":"Otten","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0120","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1111\/ajt.13508","article-title":"Predicted indirectly recognizable HLA epitopes presented by HLA-DRB1 are related to HLA antibody formation during pregnancy","volume":"15","author":"Geneugelijk","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0125","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/TP.0b013e318224c14e","article-title":"Deleterious impact of mismatching for human leukocyte antigen-C in presensitized recipients of kidney transplants","volume":"92","author":"Tran","year":"2011","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0130","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1111\/ajt.12478","article-title":"Class II HLA epitope matching - a strategy to minimize de novo donor-specific antibody development and improve outcomes","volume":"13","author":"Wiebe","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.02010","article-title":"HLA-epitope matching or eplet risk stratification: the devil is in the details","volume":"9","author":"Tambur","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0140","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1097\/01.TP.0000055101.20821.AC","article-title":"HLA matchmaker: a molecularly based algorithm for histocompatibility determination. III. Effect of matching at the HLA-A,B amino acid triplet level on kidney transplant survival","volume":"75","author":"Duquesnoy","year":"2003","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0145","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1097\/01.TP.0000114595.59168.3B","article-title":"Critical evaluation of the amino acid triplet-epitope matching concept in cadaver kidney transplantation","volume":"77","author":"Laux","year":"2004","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0150","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1097\/01.TP.0000061759.57702.8A","article-title":"A new epitope-based HLA-DPB matching approach for cadaver kidney retransplants","volume":"75","author":"Laux","year":"2003","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0155","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.transproceed.2009.12.047","article-title":"Evaluation of HLA matchmaker compatibility as predictor of graft survival and presence of anti-HLA antibodies","volume":"42","author":"Silva","year":"2010","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100533_bb0160","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1097\/TXD.0000000000000632","article-title":"The association between broad antigen HLA mismatches, eplet HLA mismatches and acute rejectiona after kidney transplantation","volume":"2","author":"Do Nguyen","year":"2016","journal-title":"Transplant Direct"},{"key":"10.1016\/j.trre.2020.100533_bb0165","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/ajt.12968","article-title":"HLA-DR and -DQ eplet mismatches and transplant glomerulopathy: a nested case-control study","volume":"15","author":"Sapir-Pichhadze","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0170","article-title":"HLA-DR\/DQ molecular mismatch: a prognostic biomarker for primary alloimmunity","author":"Wiebe","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0175","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1111\/ajt.13341","article-title":"The synergistic effect of class II HLA epitope-mismatch and nonadherence on acute rejection and graft survival","volume":"15","author":"Wiebe","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0180","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1681\/ASN.2017030287","article-title":"Class II eplet mismatch modulates tacrolimus trough levels required to prevent donor-specific antibody development","volume":"28","author":"Wiebe","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trre.2020.100533_bb0185","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/TP.0000000000002117","article-title":"A comparison of HLA molecular mismatch methods to determine HLA immunogenicity","volume":"102","author":"Wiebe","year":"2018","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/TP.0000000000001887","article-title":"Terasaki epitope mismatch burden predicts the development of de novo DQ donor-specific antibodies and are associated with adverse allograft outcomes","volume":"102","author":"Willicombe","year":"2018","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0195","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1111\/ajt.14393","article-title":"Donor\u2013recipient matching based on predicted indirectly recognizable HLA epitopes independently predicts the incidence of de novo donor-specific HLA antibodies following renal transplantation","volume":"17","author":"Lachmann","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2018.00321","article-title":"PIRCHE-II is related to graft failure after kidney transplantation","volume":"9","author":"Geneugelijk","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2018.06.006","article-title":"The clinical significance of epitope mismatch load in kidney transplantation: a multicentre study","author":"Dani\u00ebls","year":"2018","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0210","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/petr.12815","article-title":"Application of an epitope-based allocation system in pediatric kidney transplantation","volume":"20","author":"Kausman","year":"2016","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0215","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/ajt.14041","article-title":"Optimizing outcomes in pediatric renal transplantation through the Australian paired kidney exchange program","volume":"17","author":"Sypek","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0220","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1097\/TP.0000000000001196","article-title":"Providing better-matched donors for HLA mismatched compatible pairs through kidney paired donation","volume":"101","author":"Ferrari","year":"2017","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0225","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/petr.12762","article-title":"Donor selection in pediatric kidney transplantation using DR and DQ eplet mismatching: a new histocompatibility paradigm","volume":"20","author":"Bryan","year":"2016","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0230","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/iji.12359","article-title":"Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes","volume":"45","author":"Geneugelijk","year":"2018","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.trre.2020.100533_bb0235","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/TP.0b013e3181b04a5f","article-title":"Enhanced kidney allocation to highly sensitized patients by the acceptable mismatch program","volume":"88","author":"Claas","year":"2009","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0240","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.trim.2015.08.006","article-title":"The 25th anniversary of the eurotransplant acceptable mismatch program for highly sensitized patients","volume":"33","author":"Heidt","year":"2015","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.trre.2020.100533_bb0245","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.kint.2017.07.018","article-title":"Kidney allocation based on proven acceptable antigens results in superior graft survival in highly sensitized patients","volume":"93","author":"Heidt","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.trre.2020.100533_bb0250","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/01.TP.0000438639.36838.ac","article-title":"Modeling the benefits and costs of integrating an acceptable HLA mismatch allocation model for highly sensitized patients","volume":"97","author":"Do","year":"2014","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0255","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/TP.0000000000000355","article-title":"Differences in immunogenicity of HLA antigens and the impact of cross-reactivity on the humoral response","volume":"99","author":"Lucas","year":"2015","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0260","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1111\/ajt.13918","article-title":"Hiding in plain sight\u2014a new look at HLA epitopes: a case report","volume":"16","author":"Tambur","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0265","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1097\/01.TP.0000120385.03278.28","article-title":"The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens","volume":"77","author":"Dankers","year":"2004","journal-title":"Transplant"},{"key":"10.1016\/j.trre.2020.100533_bb0270","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/ctr.12663","article-title":"Sensitization trends after renal allograft failure: the role of DQ eplet mismatches in becoming highly sensitized","volume":"30","author":"Singh","year":"2016","journal-title":"Clin Transplant"}],"container-title":["Transplantation Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X20300069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X20300069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:05:14Z","timestamp":1760630714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955470X20300069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0955470X20300069"],"URL":"https:\/\/doi.org\/10.1016\/j.trre.2020.100533","relation":{},"ISSN":["0955-470X"],"issn-type":[{"value":"0955-470X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Critical evaluation of a possible role of HLA epitope matching in kidney transplantation","name":"articletitle","label":"Article Title"},{"value":"Transplantation Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trre.2020.100533","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100533"}}