{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:37:06Z","timestamp":1788953826102,"version":"build-2803163510"},"reference-count":125,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Reviews"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.trre.2020.100549","type":"journal-article","created":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T23:14:37Z","timestamp":1589152477000},"page":"100549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Implications of liver donor age on ischemia reperfusion injury and clinical outcomes"],"prefix":"10.1016","volume":"34","author":[{"given":"Kevin M.","family":"Dickson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo N.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trre.2020.100549_bb0005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1600-6143.2006.01242.x","article-title":"Characteristics associated with liver graft failure: the concept of a donor risk index","volume":"6","author":"Feng","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0010","author":"2019 Annual Report of the U.S. Organ Procurement and Transplantation Network and Scientific Registry of Transplant Recipients"},{"key":"10.1016\/j.trre.2020.100549_bb0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/00007890-198909000-00020","article-title":"Treatment of primary liver graft nonfunction with prostaglandin E1","volume":"48","author":"Greig","year":"1989","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0020","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/hep.1840200410","article-title":"Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation","volume":"20","author":"Strasberg","year":"1994","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0025","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.510240116","article-title":"Donor age and outcome of liver transplantation","volume":"24","author":"Hoofnagle","year":"1996","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/archsurg.140.3.273","article-title":"Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation","volume":"140","author":"Moore","year":"2005","journal-title":"Arch Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0035","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/lt.500050501","article-title":"Use of older donor livers is associated with more extensive ischemic damage on intraoperative biopsies during liver transplantation","volume":"5","author":"Desch\u00eanes","year":"1999","journal-title":"Liver Transpl Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0040","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1097\/01.sla.0000164077.77912.98","article-title":"Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience","volume":"241","author":"Busuttil","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0045","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1681\/ASN.V781106","article-title":"Aging and the kidney","volume":"7","author":"Epstein","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trre.2020.100549_bb0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cardiores.2004.12.020","article-title":"Protection in the aged heart: preventing the heart-break of old age?","volume":"66","author":"Juhaszova","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.trre.2020.100549_bb0055","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrneurol.2010.36","article-title":"Ischemic stroke in the elderly: an overview of evidence","volume":"6","author":"Chen","year":"2010","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.trre.2020.100549_bb0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/cvr\/cvp033","article-title":"Loss of cardioprotection with ageing","volume":"83","author":"Boengler","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.trre.2020.100549_bb0065","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1681\/ASN.2009010072","article-title":"Telomere shortening reduces regenerative capacity after acute kidney injury","volume":"21","author":"Westhoff","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trre.2020.100549_bb0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/oxfordjournals.bmb.a072387","article-title":"Hepatic drug metabolism and ageing","volume":"46","author":"Woodhouse","year":"1990","journal-title":"Br Med Bull"},{"key":"10.1016\/j.trre.2020.100549_bb0075","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0168-8278(86)80022-8","article-title":"Quantitative liver function in the elderly assessed by galactose elimination capacity, aminopyrine demethylation and caffeine clearance","volume":"3","author":"Schnegg","year":"1986","journal-title":"J Hepatol"},{"key":"10.1016\/j.trre.2020.100549_bb0080","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1172\/JCI107938","article-title":"The effects of age and liver disease on the disposition and elimination of diazepam in adult man","volume":"55","author":"Klotz","year":"1975","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trre.2020.100549_bb0085","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"Fausto","year":"2006","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0090","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000052829","article-title":"The aging liver","volume":"48","author":"Zeeh","year":"2002","journal-title":"Gerontology."},{"key":"10.1016\/j.trre.2020.100549_bb0095","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2165\/00003088-199834050-00003","article-title":"The aging liver. Drug clearance and an oxygen diffusion barrier hypothesis","volume":"34","author":"Le Couteur","year":"1998","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.trre.2020.100549_bb0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.1840090222","article-title":"The effect of age upon liver volume and apparent liver blood flow in healthy man","volume":"9","author":"Wynne","year":"1989","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0105","doi-asserted-by":"crossref","unstructured":"Woodhouse K, Wynne HA. Age-related changes in hepatic function. Implications for drug therapy. Drugs Aging. 2(3):243\u2013255. https:\/\/doi.org\/10.2165\/00002512-199202030-00007","DOI":"10.2165\/00002512-199202030-00007"},{"key":"10.1016\/j.trre.2020.100549_bb0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/ageing\/28.1.29","article-title":"Total and functional hepatic blood flow decrease in parallel with ageing","volume":"28","author":"Zoli","year":"1999","journal-title":"Age Ageing"},{"key":"10.1016\/j.trre.2020.100549_bb0115","first-page":"E1023","article-title":"Age effect on fibrinogen and albumin synthesis in humans","volume":"275","author":"Fu","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trre.2020.100549_bb0120","doi-asserted-by":"crossref","unstructured":"Anantharaju A, Feller A, Chedid A. Aging liver: a review. Gerontology. 48(6):343\u2013353. doi:https:\/\/doi.org\/10.1159\/000065506","DOI":"10.1159\/000065506"},{"key":"10.1016\/j.trre.2020.100549_bb0125","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1002\/hep.25787","article-title":"Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver","volume":"56","author":"Verma","year":"2012","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0130","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1097\/TP.0b013e31817b00c2","article-title":"Toward \u201cno age limit\u201d for liver transplant donors","volume":"85","author":"Verzaro","year":"2008","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0135","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1600-6143.2004.00472.x","article-title":"Liver transplantation from donors aged 80 years and over: pushing the limit","volume":"4","author":"Nardo","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0140","unstructured":"Filipponi F, Romagnoli J, Urbani L, Catalano G, Costa A, Mosca F. Transplantation of a ninety-three-year-old donor liver. Case report. Hepatogastroenterology. 50(50):510\u2013511. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12749259."},{"key":"10.1016\/j.trre.2020.100549_bb0145","unstructured":"Mazziotti A, Cescon M, Grazi GL, et al. Successful liver transplantation using an 87 year-old donor. Hepatogastroenterology. 46(27):1819\u20131822. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10430352."},{"key":"10.1016\/j.trre.2020.100549_bb0150","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/lt.25580","article-title":"Nonagenarian grafts for liver transplantation","volume":"25","author":"Ghinolfi","year":"2019","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0155","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/lt.21100","article-title":"Increased ischemic injury in old mouse liver: an ATP-dependent mechanism","volume":"13","author":"Selzner","year":"2007","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0160","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0009-9236(97)90166-1","article-title":"Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions","volume":"61","author":"Sotaniemi","year":"1997","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.trre.2020.100549_bb0165","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(96)07642-8","article-title":"Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups","volume":"349","author":"Poynard","year":"1997","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.trre.2020.100549_bb0170","first-page":"G1260","article-title":"Partial hepatectomy-induced polyploidy attenuates hepatocyte replication and activates cell aging events","volume":"276","author":"Sigal","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trre.2020.100549_bb0175","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/jhep.2002.33993","article-title":"Contribution of donor age to the recent decrease in patient survival among HCV-infected liver transplant recipients","volume":"36","author":"Berenguer","year":"2002","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0180","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1600-6143.2004.00470.x","article-title":"Impact of donor age and year of transplant on graft survival in liver transplant recipients with chronic hepatitis C","volume":"4","author":"Russo","year":"2004","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0185","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jcp.1041180302","article-title":"Delayed and reduced cell replication and diminishing levels of DNA polymerase-alpha in regenerating liver of aging mice","volume":"118","author":"Fry","year":"1984","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.trre.2020.100549_bb0190","first-page":"509","article-title":"The influence of age upon the incorporation of THYMIDINE-2-C14 into the DNA of regenerating rat liver","volume":"24","author":"BUCHER","year":"1964","journal-title":"Cancer Res"},{"key":"10.1016\/j.trre.2020.100549_bb0195","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1093\/nar\/26.13.3293","article-title":"Regenerating livers of old rats contain high levels of C\/EBPalpha that correlate with altered expression of cell cycle associated proteins","volume":"26","author":"Timchenko","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.trre.2020.100549_bb0200","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(03)00318-0","article-title":"Aging reduces proliferative capacities of liver by switching pathways of C\/EBPalpha growth arrest","volume":"113","author":"Iakova","year":"2003","journal-title":"Cell."},{"key":"10.1016\/j.trre.2020.100549_bb0205","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nature03260","article-title":"Rejuvenation of aged progenitor cells by exposure to a young systemic environment","volume":"433","author":"Conboy","year":"2005","journal-title":"Nature."},{"key":"10.1016\/j.trre.2020.100549_bb0210","first-page":"237","article-title":"Increasing age--an important adverse prognostic factor in hepatitis A virus infection","volume":"22","author":"Forbes","year":"1988","journal-title":"J R Coll Physicians Lond"},{"key":"10.1016\/j.trre.2020.100549_bb0215","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/lt.21050","article-title":"Early indicators of prognosis in fulminant hepatic failure: an assessment of the model for end-stage liver disease (MELD) and King\u2019s college hospital criteria","volume":"13","author":"Dhiman","year":"2007","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0220","first-page":"67","article-title":"Impact of donor and recipient age on allograft tolerance","volume":"7","author":"Martins","year":"2009","journal-title":"Exp Clin Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0225","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.sla.0000167848.96692.ad","article-title":"Effects of 10 minutes of ischemic preconditioning of the cadaveric liver on the graft\u2019s preservation and function: the ying and the yang","volume":"242","author":"Azoulay","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0230","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00007890-200209150-00001","article-title":"Inhibition of ischemia\/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1","volume":"74","author":"Tullius","year":"2002","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0235","article-title":"Ischaemic pre-conditioning for elective liver resections performed under vascular occlusion","volume":"1","author":"Gurusamy","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.trre.2020.100549_bb0240","article-title":"Pharmacological interventions for ischaemia reperfusion injury in liver resection surgery performed under vascular control","volume":"4","author":"Abu-Amara","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.trre.2020.100549_bb0245","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1016\/j.transproceed.2004.10.069","article-title":"Impact of ischemia\/reperfusion on transplanted livers procured from elderly cadaveric donors","volume":"36","author":"Santori","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100549_bb0250","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1600-6143.2007.02108.x","article-title":"Effect modification in liver allografts with prolonged cold ischemic time","volume":"8","author":"Segev","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0255","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/hh2001.097796","article-title":"Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide","volume":"89","author":"Hoffmann","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.trre.2020.100549_bb0260","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12660","article-title":"Does the danger model shed any light on central tolerance?: a response to Al-Yassin","volume":"88","author":"Fuchs","year":"2018","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.trre.2020.100549_bb0265","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1399-0012.2005.00384.x","article-title":"Influence of cumulative number of marginal donor criteria on primary organ dysfunction in liver recipients","volume":"19","author":"Pokorny","year":"2005","journal-title":"Clin Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0270","doi-asserted-by":"crossref","first-page":"388","DOI":"10.5114\/aoms.2018.73470","article-title":"Age-related differences in function and structure of rat livers subjected to ischemia\/reperfusion","volume":"14","author":"Trocha","year":"2018","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.trre.2020.100549_bb0275","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1096\/fj.201801234R","article-title":"Young plasma attenuates age-dependent liver ischemia reperfusion injury","volume":"33","author":"Liu","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.trre.2020.100549_bb0280","first-page":"1207","article-title":"Effect of aging process on liver function in extracorporeal rat liver perfusion","volume":"54","author":"Trocha","year":"2007","journal-title":"Hepatogastroenterology."},{"key":"10.1016\/j.trre.2020.100549_bb0285","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/gerona\/61.1.20","article-title":"Identification of valid housekeeping genes and antioxidant enzyme gene expression change in the aging rat liver","volume":"61","author":"Chen","year":"2006","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.trre.2020.100549_bb0290","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.3748\/wjg.v11.i24.3696","article-title":"Expression of tissue inhibitor of matrix metalloproteinases-1 during aging in rat liver","volume":"11","author":"Zhang","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.trre.2020.100549_bb0295","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jss.2006.08.013","article-title":"Ischemia-reperfusion injury is more severe in older versus young rat livers","volume":"137","author":"Park","year":"2007","journal-title":"J Surg Res"},{"key":"10.1016\/j.trre.2020.100549_bb0300","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1096\/fj.03-0139fje","article-title":"Heat-induced liver injury in old rats is associated with exaggerated oxidative stress and altered transcription factor activation","volume":"17","author":"Zhang","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.trre.2020.100549_bb0305","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/01.shk.0000181282.14050.11","article-title":"Age-dependent responses to hepatic ischemia\/reperfusion injury","volume":"24","author":"Okaya","year":"2005","journal-title":"Shock."},{"key":"10.1016\/j.trre.2020.100549_bb0310","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1080\/003655298750026831","article-title":"Ageing affects anoxia\/reoxygenation injury in rat hepatocytes","volume":"33","author":"Gasbarrini","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.trre.2020.100549_bb0315","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0022-3468(90)90404-W","article-title":"Susceptibility of hepatic microcirculation to reperfusion injury: a comparison of adult and suckling rats","volume":"25","author":"Yahanda","year":"1990","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0320","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00007890-199409150-00001","article-title":"The effects of aging and nutritional state on hypoxia-reoxygenation injury in the perfused rat liver","volume":"58","author":"Le Couteur","year":"1994","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0325","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0168-8278(05)80020-0","article-title":"Preservation-induced liver injury. Clinical aspects, mechanisms and therapeutic approaches","volume":"18","author":"Chazouill\u00e8res","year":"1993","journal-title":"J Hepatol"},{"key":"10.1016\/j.trre.2020.100549_bb0330","doi-asserted-by":"crossref","unstructured":"Nishimura T, Yoshida Y, Watanabe F, et al. Blood level of mitochondrial aspartate aminotransferase as an indicator of the extent of ischemic necrosis of the rat liver. Hepatology. 6(4):701\u2013707. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2426171.","DOI":"10.1002\/hep.1840060427"},{"key":"10.1016\/j.trre.2020.100549_bb0335","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.trre.2020.100549_bb0340","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1432-2277.2009.00947.x","article-title":"Incidence of and risk factors for ischemic-type biliary lesions following orthotopic liver transplantation","volume":"23","author":"Heidenhain","year":"2010","journal-title":"Transpl Int"},{"key":"10.1016\/j.trre.2020.100549_bb0345","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1600-6143.2009.02560.x","article-title":"Liver transplantation using donation after cardiac death donors: long-term follow-up from a single center","volume":"9","author":"de Vera","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0350","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/j.1600-6143.2010.03293.x","article-title":"Donation after cardiac death liver transplantation: predictors of outcome","volume":"10","author":"Mathur","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0355","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/hep.510250134","article-title":"Predictive value of intraoperative biopsies and liver function tests for preservation injury in orthotopic liver transplantation","volume":"25","author":"Gaffey","year":"1997","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0360","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1600-6143.2006.01702.x","article-title":"Primary nonfunction (PNF) in the MELD era: an SRTR database analysis","volume":"7","author":"Johnson","year":"2007","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0365","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/00007890-199304000-00024","article-title":"Risk factors for primary dysfunction after liver transplantation--a multivariate analysis","volume":"55","author":"Ploeg","year":"1993","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0370","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/lt.500010507","article-title":"Influence of donor age on graft survival after liver transplantation--united network for organ sharing registry","volume":"1","author":"Detre","year":"1995","journal-title":"Liver Transpl Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0375","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/01.TP.0000146258.79425.04","article-title":"Age and immune response in organ transplantation","volume":"79","author":"Martins","year":"2005","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0380","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00007890-199001000-00023","article-title":"The influence of preservation injury on rejection in the hepatic transplant recipient","volume":"49","author":"Howard","year":"1990","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0385","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/lt.500020107","article-title":"Hepatic allograft rejection: regulation of the immunogenicity of human intrahepatic biliary epithelial cells","volume":"2","author":"Leon","year":"1996","journal-title":"Liver Transpl Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0390","first-page":"1558","article-title":"Impaired initial function in liver grafts from donors > 50 years of age","volume":"25","author":"Buckel","year":"1993","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100549_bb0395","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00007890-199101000-00021","article-title":"The use of \u201cmarginal\u201d donors for organ transplantation. The influence of donor age on outcome","volume":"51","author":"Alexander","year":"1991","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0400","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/00007890-200109270-00023","article-title":"Preoperative factors associated with outcome and their impact on resource use in 1148 consecutive primary liver transplants","volume":"72","author":"Markmann","year":"2001","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0405","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/lt.20992","article-title":"Liver retransplantation for primary nonfunction: analysis of a 20-year single-center experience","volume":"13","author":"Uemura","year":"2007","journal-title":"Liver Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0410","first-page":"297","article-title":"Expanded liver donor age over 60 years for hepatic transplantation","author":"Grande","year":"1998","journal-title":"Clin Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0415","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1015-9584(09)60323-7","article-title":"Use of elderly donors (> 60 years) for liver transplantation","volume":"27","author":"Zhao","year":"2004","journal-title":"Asian J Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0420","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1016\/j.transproceed.2005.10.040","article-title":"Donors older than 70 years in liver transplantation","volume":"37","author":"Gastaca","year":"2005","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100549_bb0425","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.transproceed.2004.11.056","article-title":"Does the liver ever age? Results of liver transplantation with donors above 80 years of age","volume":"37","author":"Zapletal","year":"2005","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100549_bb0430","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/hep.21888","article-title":"Minimizing risk associated with elderly liver donors by matching to preferred recipients","volume":"46","author":"Segev","year":"2007","journal-title":"Hepatology."},{"key":"10.1016\/j.trre.2020.100549_bb0435","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/01.sla.0000219669.84192.b3","article-title":"Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants","volume":"243","author":"Cameron","year":"2006","journal-title":"Ann Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0440","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/lt.21359","article-title":"Critical use of extended criteria donor liver grafts in adult-to-adult whole liver transplantation: a single-center experience","volume":"14","author":"Gruttadauria","year":"2008","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0445","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1432-2277.2004.tb00464.x","article-title":"Liver transplantation using organs from donors older than 60 years","volume":"17","author":"Neipp","year":"2004","journal-title":"Transpl Int"},{"key":"10.1016\/j.trre.2020.100549_bb0450","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jamcollsurg.2008.08.009","article-title":"Advanced donor age alone does not affect patient or graft survival after liver transplantation","volume":"207","author":"Anderson","year":"2008","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0455","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/lt.21433","article-title":"Improving the outcome of liver transplantation with very old donors with updated selection and management criteria","volume":"14","author":"Cescon","year":"2008","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0460","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1477-2574.2010.00275.x","article-title":"Liver grafts from selected older donors do not have significantly more ischaemia reperfusion injury","volume":"13","author":"Martins","year":"2011","journal-title":"HPB."},{"key":"10.1016\/j.trre.2020.100549_bb0465","first-page":"196","article-title":"Orthotopic liver transplant using allografts from geriatric population in the United States: is there any age limit?","volume":"8","author":"Singhal","year":"2010","journal-title":"Exp Clin Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0470","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.trre.2019.06.004","article-title":"Grafts from selected deceased donors over 80 years old can safely expand the number of liver transplants: a systematic review and meta-analysis","volume":"33","author":"Domagala","year":"2019","journal-title":"Transplant Rev (Orlando)"},{"key":"10.1016\/j.trre.2020.100549_bb0475","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1097\/TP.0b013e3181722f75","article-title":"Donor age and cold ischemia interact to produce inferior 90-day liver allograft survival","volume":"85","author":"Reese","year":"2008","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0480","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/lt.21726","article-title":"No difference in clinical transplant outcomes for local and imported liver allografts","volume":"15","author":"Mangus","year":"2009","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0485","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.transproceed.2006.11.012","article-title":"Long-term analysis of primary nonfunction in liver transplant recipients","volume":"39","author":"Kemmer","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100549_bb0490","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002468","article-title":"Consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation: a meta-analysis","volume":"3","author":"Stahl","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.trre.2020.100549_bb0495","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/01.TP.0000110318.70879.20","article-title":"A simple scoring system to evaluate the effects of cold ischemia on marginal liver donors","volume":"77","author":"Tekin","year":"2004","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0500","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jss.2008.03.018","article-title":"The cumulative effects of cold ischemic time and older donor age on liver graft survival","volume":"148","author":"Cassuto","year":"2008","journal-title":"J Surg Res"},{"key":"10.1016\/j.trre.2020.100549_bb0505","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/lt.20583","article-title":"Recurrent hepatitis C posttransplant: early preservation injury may predict poor outcome","volume":"12","author":"Watt","year":"2006","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0510","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/lt.21617","article-title":"Risk of extended criteria donors in hepatitis C virus-positive recipients","volume":"14","author":"Berenguer","year":"2008","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0515","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.18632\/aging.101511","article-title":"Aging aggravates hepatic ischemia-reperfusion injury in mice by impairing mitophagy with the involvement of the EIF2\u03b1-parkin pathway","volume":"10","author":"Li","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.trre.2020.100549_bb0520","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12761","article-title":"Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia\/reperfusion injury in aged livers","volume":"17","author":"Chun","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.trre.2020.100549_bb0525","doi-asserted-by":"crossref","first-page":"105711","DOI":"10.1016\/j.intimp.2019.105711","article-title":"Combined ischemic and rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice","volume":"74","author":"Jiang","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.trre.2020.100549_bb0530","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.molimm.2018.10.004","article-title":"Age-dependent loss of induced regulatory T cell function exacerbates liver ischemia-reperfusion injury","volume":"103","author":"Liu","year":"2018","journal-title":"Mol Immunol"},{"key":"10.1016\/j.trre.2020.100549_bb0535","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/SLA.0000000000001765","article-title":"Remote ischemic preconditioning: a novel strategy in rescuing older livers from ischemia-reperfusion injury in a rodent model","volume":"264","author":"Limani","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0540","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2011.08.005","article-title":"Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice","volume":"141","author":"Wang","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trre.2020.100549_bb0545","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1002\/lt.21864","article-title":"Exaggerated up-regulation of tumor necrosis factor alpha-dependent apoptosis in the older mouse liver following reperfusion injury: targeting liver protective strategies to patient age","volume":"15","author":"Selzner","year":"2009","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0550","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jss.2008.01.007","article-title":"Intermittent ischemia but not ischemic preconditioning is effective in restoring bile flow after ischemia reperfusion injury in the livers of aged rats","volume":"152","author":"Schiesser","year":"2009","journal-title":"J Surg Res"},{"key":"10.1016\/j.trre.2020.100549_bb0555","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1016\/j.transproceed.2004.10.066","article-title":"Alleviating ischemia-reperfusion injury in aged rat liver by induction of heme oxygenase-1","volume":"36","author":"Wang","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100549_bb0560","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/TP.0000000000001999","article-title":"Ischemia-reperfusion injury in aged livers-the energy metabolism, inflammatory response, and autophagy","volume":"102","author":"Kan","year":"2018","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0565","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.18632\/aging.101527","article-title":"Remote ischemic conditioning: a promising therapeutic intervention for multi-organ protection","volume":"10","author":"Zhou","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.trre.2020.100549_bb0570","series-title":"Fundamentals of pathology","author":"Sattar","year":"2018"},{"key":"10.1016\/j.trre.2020.100549_bb0575","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3748\/wjg.v11.i5.690","article-title":"Heme oxygenase-1 alleviates ischemia\/reperfusion injury in aged liver","volume":"11","author":"Wang","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.trre.2020.100549_bb0580","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1097\/01.TP.0000063408.97289.89","article-title":"Short-term immunosuppressive treatment of the donor ameliorates consequences of ischemia\/ reperfusion injury and long-term graft function in renal allografts from older donors","volume":"75","author":"Reutzel-Selke","year":"2003","journal-title":"Transplantation."},{"key":"10.1016\/j.trre.2020.100549_bb0585","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1600-6143.2010.03100.x","article-title":"Donor intervention and organ preservation: where is the science and what are the obstacles?","volume":"10","author":"Feng","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0590","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0002-9440(10)63365-2","article-title":"Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse","volume":"165","author":"Kapturczak","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.trre.2020.100549_bb0595","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/SLA.0b013e318221ff49","article-title":"Clinical translation of remote ischemic preconditioning of the liver","volume":"254","author":"Martins","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.trre.2020.100549_bb0600","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1600-6143.2007.02091.x","article-title":"Ischemic preconditioning: promises from the laboratory to patients--sustained or disillusioned?","volume":"8","author":"DeOliveira","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2020.100549_bb0605","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/lt.25362","article-title":"Pilot, open, randomized, prospective trial for Normothermic machine perfusion evaluation in liver transplantation from older donors","volume":"25","author":"Ghinolfi","year":"2019","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trre.2020.100549_bb0610","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-019-0374-x","article-title":"An integrated perfusion machine preserves injured human livers for 1 week","author":"Eshmuminov","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.trre.2020.100549_bb0615","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.transproceed.2017.02.014","article-title":"Salvage of an octogenarian liver graft using Normothermic perfusion: a case report","volume":"49","author":"Pezzati","year":"2017","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2020.100549_bb0620","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1053\/j.gastro.2018.12.037","article-title":"Evolving trends in machine perfusion for liver transplantation","volume":"156","author":"Dutkowski","year":"2019","journal-title":"Gastroenterology."},{"key":"10.1016\/j.trre.2020.100549_bb0625","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/tri.13441","article-title":"The future of organ perfusion and re-conditioning","volume":"32","author":"Weissenbacher","year":"2019","journal-title":"Transpl Int"}],"container-title":["Transplantation Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X20300227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X20300227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T16:04:53Z","timestamp":1760630693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955470X20300227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":125,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0955470X20300227"],"URL":"https:\/\/doi.org\/10.1016\/j.trre.2020.100549","relation":{},"ISSN":["0955-470X"],"issn-type":[{"value":"0955-470X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implications of liver donor age on ischemia reperfusion injury and clinical outcomes","name":"articletitle","label":"Article Title"},{"value":"Transplantation Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trre.2020.100549","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100549"}}