{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:04:57Z","timestamp":1792047897157,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transplantation Reviews"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.trre.2024.100842","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T09:15:04Z","timestamp":1711098904000},"page":"100842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Tacrolimus intra-patient variability measures and its associations with allograft clinical outcomes in kidney transplantation"],"prefix":"10.1016","volume":"38","author":[{"given":"Wenmin","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaile","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trre.2024.100842_bb0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2016.1151037","article-title":"Clinical determinants of calcineurin inhibitor disposition: a mechanistic review","volume":"48","author":"Vanhove","year":"2016","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.trre.2024.100842_bb0010","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1177\/1060028020931806","article-title":"Exploratory analysis of the impact of an mHealth medication adherence intervention on tacrolimus trough concentration variability: post hoc results of a randomized controlled trial","volume":"54","author":"McGillicuddy","year":"2020","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.trre.2024.100842_bb0015","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2165\/00002018-200225100-00003","article-title":"Drug interactions with tacrolimus","volume":"25","author":"van Gelder","year":"2002","journal-title":"Drug Saf"},{"key":"10.1016\/j.trre.2024.100842_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.602764","article-title":"Tacrolimus intrapatient variability after switching from immediate or prolonged-release to extended-release formulation, after an organ transplantation","volume":"12","author":"Del Bello","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.trre.2024.100842_bb0025","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/cpt.1618","article-title":"Intrapatient variability of tacrolimus exposure in solid organ transplantation: a novel marker for clinical outcome","volume":"107","author":"Kuypers","year":"2020","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.trre.2024.100842_bb0030","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.2215\/CJN.16421221","article-title":"Patterns in tacrolimus variability and association with De Novo Donor-specific antibody formation in pediatric kidney transplant recipients","volume":"17","author":"Piburn","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.trre.2024.100842_bb0035","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1111\/ajt.16002","article-title":"A comprehensive review of the impact of tacrolimus intrapatient variability on clinical outcomes in kidney transplantation","volume":"20","author":"Gonzales","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0040","doi-asserted-by":"crossref","DOI":"10.1111\/petr.14036","article-title":"Impact of once-daily ER-tac on trough concentration variability in a stable AYA renal transplant recipient cohort","volume":"25","author":"Chandran","year":"2021","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0045","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1007\/s00467-016-3422-5","article-title":"Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence","volume":"31","author":"Pizzo","year":"2016","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.trre.2024.100842_bb0050","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1399-3046.2010.01409.x","article-title":"Variability in tacrolimus blood levels increases the risk of late rejection and graft loss after solid organ transplantation in older children","volume":"14","author":"Pollock-Barziv","year":"2010","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0055","first-page":"393","article-title":"Association of the combination of time-weighted variability of tacrolimus blood level and exposure to low drug levels with graft survival after kidney transplantation","volume":"32","author":"Rozen-Zvi","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1037566","article-title":"Combined impact of the inter and intra-patient variability of tacrolimus blood level on allograft outcomes in kidney transplantation","volume":"13","author":"Park","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.trre.2024.100842_bb0065","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.humimm.2018.03.004","article-title":"Correlations between donor-specific antibodies and non-adherence with chronic active antibody-mediated rejection phenotypes and their impact on kidney graft survival","volume":"79","author":"Malheiro","year":"2018","journal-title":"Hum Immunol"},{"key":"10.1016\/j.trre.2024.100842_bb0070","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/TP.0000000000001040","article-title":"Within-patient variability in tacrolimus blood levels predicts kidney graft loss and donor-specific antibody development","volume":"100","author":"Rodrigo","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2024.100842_bb0075","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1080\/1744666X.2020.1693263","article-title":"Impact of low tacrolimus exposure and high tacrolimus intra-patient variability on the development of de novo anti-HLA donor-specific antibodies in kidney transplant recipients","volume":"15","author":"Mendoza Rojas","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.trre.2024.100842_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.746013","article-title":"Intrapatient variability in tacrolimus trough levels over 2 years affects long-term allograft outcomes of kidney transplantation","volume":"12","author":"Park","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.trre.2024.100842_bb0085","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1111\/tri.12798","article-title":"A high intrapatient variability in tacrolimus exposure is associated with poor long-term outcome of kidney transplantation","volume":"29","author":"Shuker","year":"2016","journal-title":"Transpl Int"},{"key":"10.1016\/j.trre.2024.100842_bb0090","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/TP.0b013e31822dc34f","article-title":"Monitoring nonadherence and acute rejection with variation in blood immunosuppressant levels in pediatric renal transplantation","volume":"92","author":"Hsiau","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2024.100842_bb0095","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.trre.2015.01.002","article-title":"Intra-patient variability in tacrolimus exposure: causes, consequences for clinical management","volume":"29","author":"Shuker","year":"2015","journal-title":"Transplant Rev"},{"key":"10.1016\/j.trre.2024.100842_bb0100","doi-asserted-by":"crossref","DOI":"10.1111\/petr.13388","article-title":"Intra-patient variability in tacrolimus exposure in pediatric liver transplant recipients: evolution, risk factors, and impact on patient outcomes","volume":"23","author":"Defrancq","year":"2019","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0105","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/FTD.0b013e3182731809","article-title":"Impact of tacrolimus intraindividual variability and CYP3A5 genetic polymorphism on acute rejection in kidney transplantation","volume":"34","author":"Ro","year":"2012","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.trre.2024.100842_bb0110","first-page":"697","article-title":"Tacrolimus variability score outperforms coefficient of variation in predicting clinical outcomes of living kidney transplantation","volume":"21","author":"Yin","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196552","article-title":"Tacrolimus intra-patient variability is not associated with chronic active antibody mediated rejection","volume":"13","author":"Sablik","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.trre.2024.100842_bb0120","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/TP.0000000000002913","article-title":"Tacrolimus intrapatient variability, time in therapeutic range, and risk of De Novo Donor-specific antibodies","volume":"104","author":"Davis","year":"2020","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2024.100842_bb0125","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000000899","article-title":"Association of intrapatient variability of tacrolimus concentration with early deterioration of chronic histologic lesions in kidney transplantation","volume":"5","author":"Mo","year":"2019","journal-title":"Transplant Direct"},{"key":"10.1016\/j.trre.2024.100842_bb0130","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1038\/ki.2013.465","article-title":"Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant failure","volume":"85","author":"Sapir-Pichhadze","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.trre.2024.100842_bb0135","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/FTD.0000000000000850","article-title":"High intrapatient variability in tacrolimus exposure calculated over a long period is associated with De novo donor-specific antibody development and\/or late rejection in Thai kidney transplant patients receiving concomitant CYP3A4\/5 inhibitors","volume":"43","author":"Larpparisuth","year":"2021","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.trre.2024.100842_bb0140","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1007\/s00467-022-05426-3","article-title":"Association of intraindividual tacrolimus variability with de novo donor-specific HLA antibody development and allograft rejection in pediatric kidney transplant recipients with low immunological risk","volume":"37","author":"Baghai Arassi","year":"2022","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.trre.2024.100842_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13424","article-title":"Tacrolimus trough and dose intra-patient variability and CYP3A5 genotype: effects on acute rejection and graft failure in European American and African American kidney transplant recipients","volume":"32","author":"Seibert","year":"2018","journal-title":"Clin Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0150","doi-asserted-by":"crossref","first-page":"910","DOI":"10.6002\/ect.2021.0231","article-title":"Tacrolimus trough intravariability in patients treated with the prolonged-release formulation is a risk factor for acute graft rejection","volume":"19","author":"Mira","year":"2021","journal-title":"Exp Clin Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-84868-5","article-title":"Association between medication adherence and intrapatient variability in tacrolimus concentration among stable kidney transplant recipients","volume":"11","author":"Ko","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.trre.2024.100842_bb0160","doi-asserted-by":"crossref","DOI":"10.1111\/petr.14297","article-title":"Effects of tacrolimus intrapatient variability and CYP3A5 polymorphism on the outcomes of pediatric kidney transplantation","volume":"26","author":"Choi","year":"2022","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0165","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1007\/s00467-019-04346-z","article-title":"Defining a threshold for tacrolimus intra-patient variability associated with late acute cellular rejection in paediatric kidney transplant recipients","volume":"34","author":"Abu Bakar","year":"2019","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.trre.2024.100842_bb0170","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/FTD.0000000000000955","article-title":"High tacrolimus intrapatient variability and subtherapeutic immunosuppression are associated with adverse kidney transplant outcomes","volume":"44","author":"Mendoza Rojas","year":"2022","journal-title":"Ther Drug Monit"},{"key":"10.1016\/j.trre.2024.100842_bb0175","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4103\/1319-2442.335446","article-title":"Tacrolimus intrapatient variability in BK virus nephropathy and chronic calcineurin toxicity in kidney transplantation","volume":"32","author":"Turgut","year":"2021","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"10.1016\/j.trre.2024.100842_bb0180","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","article-title":"Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence","volume":"12","author":"Sellar\u00e9s","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0185","doi-asserted-by":"crossref","first-page":"5935123","DOI":"10.1155\/2017\/5935123","article-title":"The humoral theory of transplantation","volume":"2017","author":"Ravindranath","year":"2017","journal-title":"J Immunol Res"},{"key":"10.1016\/j.trre.2024.100842_bb0190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/tri.12873","article-title":"Determining donor-specific antibody C1q-binding ability improves the prediction of antibody-mediated rejection in human leucocyte antigen-incompatible kidney transplantation","volume":"30","author":"Malheiro","year":"2017","journal-title":"Transpl Int"},{"key":"10.1016\/j.trre.2024.100842_bb0195","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.trim.2015.01.002","article-title":"Analysis of preformed donor-specific anti-HLA antibodies characteristics for prediction of antibody-mediated rejection in kidney transplantation","volume":"32","author":"Malheiro","year":"2015","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.trre.2024.100842_bb0200","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s13318-020-00644-2","article-title":"Combined effect of inter- and intrapatient variability in tacrolimus exposure on graft impairment within a 3-year period following kidney transplantation: a single-center experience","volume":"45","author":"Stefanovi\u0107","year":"2020","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"10.1016\/j.trre.2024.100842_bb0205","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.transproceed.2016.02.081","article-title":"Higher variability of tacrolimus trough level increases risk of acute rejection in kidney transplant recipients","volume":"48","author":"Huang","year":"2016","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trre.2024.100842_bb0210","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00467-019-04377-6","article-title":"Tacrolimus variability is associated with de novo donor-specific antibody development in pediatric renal transplant recipients","volume":"35","author":"Solomon","year":"2020","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.trre.2024.100842_bb0215","doi-asserted-by":"crossref","first-page":"12114","DOI":"10.1038\/s41598-021-91630-4","article-title":"Clinical significance of tacrolimus intra-patient variability on kidney transplant outcomes according to pre-transplant immunological risk","volume":"11","author":"Kim","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.trre.2024.100842_bb0220","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1093\/ndt\/gfq096","article-title":"High within-patient variability in the clearance of tacrolimus is a risk factor for poor long-term outcome after kidney transplantation","volume":"25","author":"Borra","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0225","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1111\/ajt.15346","article-title":"Late intra-patient tacrolimus trough level variability as a major problem in kidney transplantation: a collaborative transplant study report","volume":"19","author":"S\u00fcsal","year":"2019","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0230","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1399-3046.2012.01727.x","article-title":"Intra-patient variability in tacrolimus trough concentrations and renal function decline in pediatric renal transplant recipients","volume":"16","author":"Prytula","year":"2012","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0235","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/15269248221145044","article-title":"Tacrolimus formulation, exposure variability, and outcomes in kidney transplant recipients","volume":"33","author":"Lai","year":"2023","journal-title":"Prog Transp (Aliso Viejo, Calif)"},{"key":"10.1016\/j.trre.2024.100842_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.973564","article-title":"Comparison of different methods to assess tacrolimus concentration intra-patient variability as potential marker of medication non-adherence","volume":"13","author":"Kostalova","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.trre.2024.100842_bb0245","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1111\/ajt.13803","article-title":"High intrapatient variability of tacrolimus concentrations predicts accelerated progression of chronic histologic lesions in renal recipients","volume":"16","author":"Vanhove","year":"2016","journal-title":"Am J Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0250","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.clinbiochem.2006.06.011","article-title":"Application of the EMIT 2000 tacrolimus assay on the Abbott architect c8000 high volume clinical chemistry analyzer","volume":"39","author":"Boer","year":"2006","journal-title":"Clin Biochem"},{"key":"10.1016\/j.trre.2024.100842_bb0255","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.clinbiochem.2008.02.015","article-title":"Quantification of cyclosporine and tacrolimus in whole blood. Comparison of liquid chromatography-electrospray mass spectrometry with the enzyme multiplied immunoassay technique","volume":"41","author":"Ansermot","year":"2008","journal-title":"Clin Biochem"},{"key":"10.1016\/j.trre.2024.100842_bb0260","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cca.2019.07.026","article-title":"A high-throughput LC-MS\/MS method for the quantification of four immunosu- ppressants drugs in whole blood","volume":"498","author":"Gong","year":"2019","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.trre.2024.100842_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14020379","article-title":"The role of intra-patient variability of tacrolimus drug concentrations in solid organ transplantation: a focus on liver, heart, lung and pancreas","volume":"14","author":"Coste","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.trre.2024.100842_bb0270","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/cts.13276","article-title":"High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation","volume":"15","author":"Dopazo","year":"2022","journal-title":"Cts-Clin Translat Sci"},{"key":"10.1016\/j.trre.2024.100842_bb0275","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1097\/TP.0000000000001840","article-title":"Tacrolimus trough concentration variability and disparities in African American kidney transplantation","volume":"101","author":"Taber","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.trre.2024.100842_bb0280","first-page":"326","article-title":"Intrapatient variability in tacrolimus exposure does not predict the development of cardiac allograft vasculopathy after heart transplant","volume":"16","author":"Shuker","year":"2018","journal-title":"Exp Clin Transplant"},{"key":"10.1016\/j.trre.2024.100842_bb0285","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/TP.0000000000001129","article-title":"High intrapatient tacrolimus variability is associated with worse outcomes in renal transplantation using a low-dose tacrolimus immunosuppressive regime","volume":"101","author":"Whalen","year":"2017","journal-title":"Transplantation"}],"container-title":["Transplantation Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X24000259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0955470X24000259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T07:29:52Z","timestamp":1718177392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0955470X24000259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0955470X24000259"],"URL":"https:\/\/doi.org\/10.1016\/j.trre.2024.100842","relation":{},"ISSN":["0955-470X"],"issn-type":[{"value":"0955-470X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tacrolimus intra-patient variability measures and its associations with allograft clinical outcomes in kidney transplantation","name":"articletitle","label":"Article Title"},{"value":"Transplantation Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trre.2024.100842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100842"}}