{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:03:31Z","timestamp":1791191011966,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.trsl.2007.03.006","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T11:11:00Z","timestamp":1180177860000},"page":"81-92","source":"Crossref","is-referenced-by-count":38,"title":["Calcium-Diacylglycerol Guanine Nucleotide Exchange Factor I gene mutations associated with loss of function in canine platelets"],"prefix":"10.1016","volume":"150","author":[{"given":"Mary K.","family":"Boudreaux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Catalfamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Klok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2007.03.006_bib1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2007.03.006_bib2","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1182\/blood-2004-04-1257","article-title":"Integrins: dynamic scaffolds for adhesion and signaling in platelets","volume":"104","author":"Shattil","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2007.03.006_bib3","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1093\/emboj\/17.23.6776","article-title":"All in the family?","volume":"17","author":"Bos","year":"1998","journal-title":"EMBO J"},{"key":"10.1016\/j.trsl.2007.03.006_bib4","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1073\/pnas.86.9.3131","article-title":"A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets","volume":"86","author":"Lapetina","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2007.03.006_bib5","doi-asserted-by":"crossref","first-page":"19405","DOI":"10.1016\/S0021-9258(17)45385-3","article-title":"Rap1B, a cAMP-dependent protein kinase substrate, associates with the platelet cytoskeleton","volume":"265","author":"Fischer","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2007.03.006_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/emboj\/16.2.252","article-title":"Rapid calcium mediated activation of Rap1 in human platelets","volume":"16","author":"Franke","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.trsl.2007.03.006_bib7","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1073\/pnas.89.16.7796","article-title":"Role of rap1B and p21ras GTPase-activating protein in the regulation of phospholipase C-gamma 1 in human platelets","volume":"89","author":"Torti","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2007.03.006_bib8","doi-asserted-by":"crossref","first-page":"12009","DOI":"10.1074\/jbc.M111803200","article-title":"A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets","volume":"277","author":"Lova","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2007.03.006_bib9","doi-asserted-by":"crossref","first-page":"23382","DOI":"10.1074\/jbc.M202212200","article-title":"Activation of Rap1B by Gi family members in platelets","volume":"277","author":"Woulfe","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2007.03.006_bib10","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1182\/blood-2005-07-3023","article-title":"The small GTPase Rap1b regulates the cross talk between platelet integrin \u03b12\u03b21and integrin \u03b1IIb\u03b23","volume":"107","author":"Bernardi","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2007.03.006_bib11","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1172\/JCI22973","article-title":"Rap1b is required for normal platelet function and hemostasis in mice","volume":"115","author":"Chrzanowska-Wodnicka","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2007.03.006_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/28548","article-title":"The structural basis of the activation of Ras by Sos","volume":"394","author":"Boriack-Sjodin","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2007.03.006_bib13","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nm1098","article-title":"CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation","volume":"10","author":"Crittenden","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.trsl.2007.03.006_bib14","doi-asserted-by":"crossref","first-page":"25715","DOI":"10.1074\/jbc.M202791200","article-title":"Relationship between Rap1b, affinity modulation of integrin \u03b1IIb\u03b23, and the actin cytoskeleton","volume":"277","author":"Bertoni","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2007.03.006_bib15","first-page":"211","article-title":"An inherited platelet function defect in basset hounds","volume":"20","author":"Johnstone","year":"1979","journal-title":"Can Vet J"},{"key":"10.1016\/j.trsl.2007.03.006_bib16","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1182\/blood.V67.6.1568.1568","article-title":"Defective platelet-fibrinogen interaction in hereditary canine thrombopathia","volume":"67","author":"Catalfamo","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2007.03.006_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1939-1676.1994.tb03204.x","article-title":"Identification of an intrinsic platelet function defect in Spitz dogs","volume":"8","author":"Boudreaux","year":"1994","journal-title":"J Vet Int Med"},{"key":"10.1016\/j.trsl.2007.03.006_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/030098589603300408","article-title":"A platelet activation-specific monoclonal antibody that recognizes a receptor-induced binding site on canine fibrinogen","volume":"33","author":"Boudreaux","year":"1996","journal-title":"Vet Pathol"},{"key":"10.1016\/j.trsl.2007.03.006_bib19","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1182\/blood.V99.7.2434","article-title":"A hereditary bleeding disorder of dogs caused by lack of platelet procoagulant activity","volume":"99","author":"Brooks","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2007.03.006_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1042\/bj2420011","article-title":"Thrombin-induced phosphoinositide hydrolysis in platelets","volume":"242","author":"Huang","year":"1987","journal-title":"Biochem J"},{"key":"10.1016\/j.trsl.2007.03.006_bib21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1042\/bj2450933","article-title":"Extraction and recovery of inositol phosphates from tissues","volume":"245","author":"Wreggett","year":"1987","journal-title":"Biochem J"},{"key":"10.1016\/j.trsl.2007.03.006_bib22","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1042\/bj2450655","article-title":"A rapid separation method for inositol phosphates and their isomers","volume":"245","author":"Wreggett","year":"1987","journal-title":"Biochem J"},{"key":"10.1016\/j.trsl.2007.03.006_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/030098589603300504","article-title":"Type I Glanzmann\u2019s thrombasthenia in a Great Pyrenees dog","volume":"33","author":"Boudreaux","year":"1996","journal-title":"Vet Pathol"},{"key":"10.1016\/j.trsl.2007.03.006_bib24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0079-6603(02)71047-7","article-title":"A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases","volume":"71","author":"Quilliam","year":"2002","journal-title":"Prog Nuc Acid Res Mol Biol"},{"key":"10.1016\/j.trsl.2007.03.006_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-0038-1642749","article-title":"Impairment of phosphatidylinositol metabolism in a patient with a bleeding disorder associated with defects in initial platelet responses","volume":"59","author":"Lages","year":"1988","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2007.03.006_bib26","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/0006-291X(86)90772-2","article-title":"Evidence for regulatory control of canine platelet phosphodiesterase","volume":"140","author":"Boudreaux","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2007.03.006_bib27","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0006-291X(86)90773-4","article-title":"Impaired cAMP metabolism associated with abnormal function of thrombopathic canine platelets","volume":"140","author":"Boudreaux","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2007.03.006_bib28","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1083\/jcb.147.7.1419","article-title":"Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling","volume":"147","author":"Shiraga","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.trsl.2007.03.006_bib29","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1073\/pnas.95.22.13278","article-title":"A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia","volume":"95","author":"Kawasaki","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2007.03.006_bib30","doi-asserted-by":"crossref","first-page":"12819","DOI":"10.1073\/pnas.202380099","article-title":"Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling","volume":"99","author":"Eto","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2007.03.006_bib31","first-page":"1195","article-title":"Thrombin receptor-activating peptides unlike thrombin are insufficient for platelet activation in most species","volume":"69","author":"Catalfamo","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2007.03.006_bib32","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0049-3848(95)00084-5","article-title":"Species differences in platelet responses to thrombin and SFLLRN","volume":"78","author":"Derian","year":"1995","journal-title":"Thromb Res"},{"key":"10.1016\/j.trsl.2007.03.006_bib33","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/0953710042000199848","article-title":"Differential activation and inhibition of human platelet thrombin receptors by structurally distinct alpha, beta- and gamma-thrombin","volume":"15","author":"Soslau","year":"2004","journal-title":"Platelets"},{"key":"10.1016\/j.trsl.2007.03.006_bib34","doi-asserted-by":"crossref","first-page":"5458","DOI":"10.1021\/bi9927078","article-title":"Biphasic kinetics of activation and signaling for PAR1 and PAR4 thrombin receptors in platelets","volume":"39","author":"Covic","year":"2000","journal-title":"Biochem"},{"key":"10.1016\/j.trsl.2007.03.006_bib35","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1128\/MCB.20.3.779-785.2000","article-title":"Sequential regulation of the small GTPase Rap1 in human platelets","volume":"20","author":"Franke","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.trsl.2007.03.006_bib36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/09537109509013265","article-title":"Circumvention of the Basset hound hereditary thrombopathy by platelet activation with phorbol myristate acetate","volume":"6","author":"McConnell","year":"1995","journal-title":"Platelets"},{"key":"10.1016\/j.trsl.2007.03.006_bib37","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1055\/s-0038-1651044","article-title":"Absent platelet aggregation with normal fibrinogen binding in Basset hound hereditary thrombopathy","volume":"62","author":"Patterson","year":"1989","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.trsl.2007.03.006_bib38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ejcb.2006.01.007","article-title":"The mAKAP signaling complex: Integration of cAMP, calcium, and MAP kinase signaling pathways","volume":"85","author":"Dodge-Kafka","year":"2006","journal-title":"European J Cell Biol"},{"key":"10.1016\/j.trsl.2007.03.006_bib39","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/01.ATV.20.2.285","article-title":"Congenital disorders of platelet signal transduction","volume":"20","author":"Rao","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524407000928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524407000928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T07:35:23Z","timestamp":1628926523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524407000928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S1931524407000928"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2007.03.006","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}