{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:21:08Z","timestamp":1789665668950,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.trsl.2010.01.004","type":"journal-article","created":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T04:12:19Z","timestamp":1266811939000},"page":"238-246","source":"Crossref","is-referenced-by-count":97,"title":["Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease\u2014KOZANI STUDY"],"prefix":"10.1016","volume":"155","author":[{"given":"Nikolaos P.E.","family":"Kadoglou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stilianos","family":"Lampropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkistis","family":"Kapelouzou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argirios","family":"Gkontopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios K.","family":"Theofilogiannakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigorios","family":"Fotiadis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kottas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2010.01.004_bib1","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.amjmed.2008.06.012","article-title":"Evidence of systemic inflammation and estimation of coronary artery disease risk: a population perspective","volume":"121","author":"Wilson","year":"2008","journal-title":"Am J Med"},{"key":"10.1016\/j.trsl.2010.01.004_bib2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/0148607108325251","article-title":"Adipose inflammation, insulin resistance, and cardiovascular disease","volume":"32","author":"Shah","year":"2008","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"10.1016\/j.trsl.2010.01.004_bib3","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/bbrc.1998.9489","article-title":"Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor","volume":"251","author":"Tatemoto","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2010.01.004_bib4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pharmthera.2005.04.001","article-title":"Emerging roles of apelin in biology and medicine","volume":"107","author":"Kleinz","year":"2005","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.trsl.2010.01.004_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.regpep.2004.10.019","article-title":"Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells","volume":"126","author":"Kleinz","year":"2005","journal-title":"Regul Pept"},{"key":"10.1016\/j.trsl.2010.01.004_bib6","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1096\/fj.06-7294com","article-title":"Hypoxia inducible factor regulates the cardiac expression and secretion of apelin","volume":"21","author":"Ronkainen","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.trsl.2010.01.004_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2478\/v10039-008-0024-x","article-title":"Visfatin and apelin, new adipokines, and their relation to endothelial function in patients with chronic renal failure","volume":"53","author":"Malyszko","year":"2008","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.trsl.2010.01.004_bib8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bbrc.2007.04.017","article-title":"Direct effects of apelin on cardiomyocyte contractility and electrophysiology","volume":"357","author":"Farkasfalvi","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2010.01.004_bib9","doi-asserted-by":"crossref","first-page":"H1329","DOI":"10.1152\/ajpheart.01341.2008","article-title":"Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation","volume":"296","author":"Leeper","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.trsl.2010.01.004_bib10","first-page":"3343","article-title":"Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis","volume":"118","author":"Chun","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2010.01.004_bib11","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.2353\/ajpath.2007.070471","article-title":"Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis","volume":"171","author":"Hashimoto","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.trsl.2010.01.004_bib12","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.2169\/internalmedicine.47.1287","article-title":"Reduced apelin levels in stable angina","volume":"47","author":"Li","year":"2008","journal-title":"Intern Med"},{"key":"10.1016\/j.trsl.2010.01.004_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/157016309787581048","article-title":"Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect","volume":"6","author":"Cordido","year":"2009","journal-title":"Curr Drug Discov Technol"},{"key":"10.1016\/j.trsl.2010.01.004_bib14","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.metabol.2009.05.009","article-title":"Ghrelin and obestatin modulate early atherogenic processes on cells: enhancement of monocyte adhesion and oxidized low-density lipoprotein binding","volume":"58","author":"Kellokoski","year":"2009","journal-title":"Metabolism"},{"key":"10.1016\/j.trsl.2010.01.004_bib15","first-page":"661","article-title":"Novel markers of carotid atherosclerosis in patients with type 2 diabetes","volume":"35","author":"Kadoglou","year":"2008","journal-title":"Exp Clin Endocrin Diab"},{"key":"10.1016\/j.trsl.2010.01.004_bib16","doi-asserted-by":"crossref","first-page":"15S","DOI":"10.1016\/S0002-9343(98)00206-X","article-title":"The new diagnostic criteria for diabetes: the impact on management of diabetes and macrovascular risk factors","volume":"105","author":"Peters","year":"1998","journal-title":"Am J Med"},{"key":"10.1016\/j.trsl.2010.01.004_bib17","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0002-9149(83)80105-2","article-title":"A more meaningful scoring system for determining the severity of coronary heart disease","volume":"51","author":"Gensini","year":"1983","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.trsl.2010.01.004_bib18","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ejheart.2008.06.002","article-title":"The role of apelin in cardiovascular function and heart failure","volume":"10","author":"Chandrasekaran","year":"2008","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.trsl.2010.01.004_bib19","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1096\/fj.06-7294com","article-title":"Hypoxia inducible factor regulates the cardiac expression and secretion of apelin","volume":"21","author":"Ronkainen","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.trsl.2010.01.004_bib20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/eurjhf\/hfp043","article-title":"Plasma apelin concentration is depressed following acute myocardial infarction in man","volume":"11","author":"Weir","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.trsl.2010.01.004_bib21","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/01.CIR.0000091235.94914.75","article-title":"Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction","volume":"108","author":"Chen","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2010.01.004_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pcad.2008.09.001","article-title":"Atherosclerotic plaque stability\u2014what determines the fate of a plaque?","volume":"51","author":"Halvorsen","year":"2008","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.trsl.2010.01.004_bib23","first-page":"495","article-title":"Reducing morbidity and mortality in high risk patients with statins","volume":"5","author":"Singh","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.trsl.2010.01.004_bib24","article-title":"Effects of rosiglitazone and metformin treatment on apelin, visfatin, and ghrelin levels in patients with type 2 diabetes mellitus","author":"Kadoglou","year":"2009","journal-title":"Metabolism"},{"key":"10.1016\/j.trsl.2010.01.004_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/157016106775203135","article-title":"The effects of obesity-related peptides on the vasculature","volume":"4","author":"Skilton","year":"2006","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1016\/j.trsl.2010.01.004_bib26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3109\/08860220903151419","article-title":"Plasma ghrelin levels are associated with coronary microvascular and endothelial dysfunction in peritoneal dialysis patients","volume":"31","author":"Caliskan","year":"2009","journal-title":"Ren Fail"},{"key":"10.1016\/j.trsl.2010.01.004_bib27","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.atherosclerosis.2008.10.013","article-title":"Plasma des-acyl ghrelin, but not plasma HMW adiponectin, is a useful cardiometabolic marker for predicting atherosclerosis in elderly hypertensive patients","volume":"204","author":"Yano","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.trsl.2010.01.004_bib28","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1097\/01.tp.0000287456.82676.01","article-title":"Ghrelin, glucose homeostasis, and carotid intima media thickness in kidney transplantation","volume":"84","author":"Gen\u00eds","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.trsl.2010.01.004_bib29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.coph.2005.10.006","article-title":"Ghrelin and cardiovascular health","volume":"6","author":"Garc\u00eda","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.trsl.2010.01.004_bib30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.cardiores.2005.09.001","article-title":"Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man","volume":"69","author":"Kleinz","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.trsl.2010.01.004_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/sj.bjp.0704228","article-title":"[125I-His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissue: up-regulation of receptors with athersclerosis","volume":"134","author":"Katugampola","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.trsl.2010.01.004_bib32","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1440-1681.2005.04274.x","article-title":"Pathophysiological levels of the obesity related peptides resistin and ghrelin increase adhesion molecule expression on human vascular endothelial cells","volume":"32","author":"Skilton","year":"2005","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.trsl.2010.01.004_bib33","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.peptides.2009.09.008","article-title":"Ghrelin vaccination decreases plasma MCP-1 level in LDLR(-\/-)-mice","volume":"30","author":"Kellokoski","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.trsl.2010.01.004_bib34","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1161\/01.CIR.0000127956.43874.F2","article-title":"Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells","volume":"109","author":"Li","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2010.01.004_bib35","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/me.2006-0146","article-title":"A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome proliferator-activated receptor gamma-dependent pathway","volume":"20","author":"Avallone","year":"2006","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.trsl.2010.01.004_bib36","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.atherosclerosis.2008.08.030","article-title":"LDL-cholesterol lowering increases plasma apelin in isolated hypercholesterolemia","volume":"204","author":"Tasci","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.trsl.2010.01.004_bib37","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00592-007-0244-8","article-title":"Short-term therapy with atorvastatin or fenofibrate does not affect plasma ghrelin, resistin or adiponectin levels in type 2 diabetic patients with mixed hyperlipoproteinaemia","volume":"44","author":"Otto","year":"2007","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.trsl.2010.01.004_bib38","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ejvs.2007.12.011","article-title":"Intensive lipid-lowering therapy ameliorates novel calcification markers and GSM score in patients with carotid stenosis","volume":"35","author":"Kadoglou","year":"2008","journal-title":"Eur J Vasc Endovasc Surg"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524410000290?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524410000290?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T01:02:53Z","timestamp":1558832573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524410000290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S1931524410000290"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2010.01.004","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}