{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:51:16Z","timestamp":1785873076452,"version":"3.56.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.trsl.2010.05.008","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T08:31:15Z","timestamp":1277281875000},"page":"229-234","source":"Crossref","is-referenced-by-count":62,"title":["Hyaluronic acid predicts hepatic fibrosis in children with nonalcoholic fatty liver disease"],"prefix":"10.1016","volume":"156","author":[{"given":"Valerio","family":"Nobili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Alisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"De Vito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pietrobattista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Morino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"De ville De Goyet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Bedogni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Pinzani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2010.05.008_bib1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jpeds.2009.06.014","article-title":"Pediatric nonalcoholic fatty liver disease in 2009","volume":"155","author":"Alisi","year":"2009","journal-title":"J Pediatr"},{"key":"10.1016\/j.trsl.2010.05.008_bib2","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1136\/gut.2009.184465","article-title":"Childhood NAFLD: a ticking time-bomb?","volume":"58","author":"Nobili","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2010.05.008_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11894-008-0011-1","article-title":"The obesity epidemic and nonalcoholic fatty liver disease in children","volume":"10","author":"Dunn","year":"2008","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.trsl.2010.05.008_bib4","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/hep.23119","article-title":"Advances in pediatric nonalcoholic fatty liver disease","volume":"50","author":"Loomba","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2010.05.008_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.SGA.0000316530.31366.6e","article-title":"Pediatric nonalcoholic fatty liver disease","volume":"31","author":"Lerret","year":"2008","journal-title":"Gastroenterol Nurs"},{"key":"10.1016\/j.trsl.2010.05.008_bib6","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1002\/hep.23133","article-title":"Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study","volume":"50","author":"Carter-Kent","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2010.05.008_bib7","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1136\/gut.2008.171280","article-title":"The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years","volume":"58","author":"Feldstein","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2010.05.008_bib8","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/hep.21262","article-title":"NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice","volume":"44","author":"Nobili","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2010.05.008_bib9","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.3748\/wjg.15.6017","article-title":"Pediatric non-alcoholic fatty liver disease: preventive and therapeutic value of lifestyle intervention","volume":"15","author":"Nobili","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.trsl.2010.05.008_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jhep.2009.03.019","article-title":"Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis","volume":"51","author":"Argo","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2010.05.008_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cld.2009.07.008","article-title":"Histopathology of non-alcoholic fatty liver disease","volume":"13","author":"Brunt","year":"2009","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.trsl.2010.05.008_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncpgasthep1025","article-title":"Technology Insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography","volume":"5","author":"Pinzani","year":"2008","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2010.05.008_bib13","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/S1262-3636(08)74603-2","article-title":"Non-invasive diagnosis of steatosis and fibrosis","volume":"34","author":"Castera","year":"2008","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.trsl.2010.05.008_bib14","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1136\/gut.2008.154435","article-title":"Are non-invasive tests accurate enough to predict hepatic fibrosis in non-alcoholic fatty liver disease (NAFLD)?","volume":"57","author":"Chavez-Tapia","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2010.05.008_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1741-7015-7-21","article-title":"The pediatric NAFLD fibrosis index: a predictor of liver fibrosis in children with non-alcoholic fatty liver disease","volume":"7","author":"Nobili","year":"2009","journal-title":"BMC Med"},{"key":"10.1016\/j.trsl.2010.05.008_bib16","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.jhep.2004.12.008","article-title":"Fibrosis in chronic liver diseases: diagnosis and management","volume":"42","author":"Pinzani","year":"2005","journal-title":"J Hepatol"},{"key":"10.1016\/j.trsl.2010.05.008_bib17","first-page":"149","article-title":"Noninvasive biochemical markers of liver fibrosis","volume":"15","author":"Grigorescu","year":"2006","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1016\/j.trsl.2010.05.008_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cca.2007.02.038","article-title":"Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests","volume":"381","author":"Gressner","year":"2007","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.trsl.2010.05.008_bib19","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1586\/14737159.4.5.715","article-title":"Noninvasive diagnosis of fibrosis in chronic liver disease","volume":"4","author":"Lichtinghagen","year":"2004","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.trsl.2010.05.008_bib20","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/hep.21984","article-title":"Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European liver fibrosis panel and exploring simple markers","volume":"47","author":"Guha","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2010.05.008_bib21","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1046\/j.1440-1746.2000.02233.x","article-title":"Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: validating the European liver fibrosis panel and exploring simple markers","volume":"15","author":"McHutchison","year":"2000","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2010.05.008_bib22","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1111\/j.1572-0241.2007.01761.x","article-title":"Diagnostic accuracy of serum hyaluronic acid, Fibrospect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C","volume":"103","author":"Mehta","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.trsl.2010.05.008_bib23","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/lt.21508","article-title":"Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C","volume":"14","author":"Pungpapong","year":"2008","journal-title":"Liver Transpl"},{"key":"10.1016\/j.trsl.2010.05.008_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/01.mpg.0000228121.44606.9f","article-title":"Hyaluronic acid predicts hepatic fibrosis in children with hepatic disease","volume":"43","author":"Hartley","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.trsl.2010.05.008_bib25","first-page":"1","article-title":"CDC growth charts: United States","volume":"8","author":"Kuczmarski","year":"2000","journal-title":"Adv Data"},{"key":"10.1016\/j.trsl.2010.05.008_bib26","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.dld.2009.02.048","article-title":"Elevated serum ALT in children presenting to the emergency unit: relationship with NAFLD","volume":"41","author":"Nobili","year":"2009","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.trsl.2010.05.008_bib27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s00247-003-1044-0","article-title":"Blind and ultrasound-guided percutaneous liver biopsy in children","volume":"33","author":"Nobili","year":"2003","journal-title":"Pediatr Radiol"},{"key":"10.1016\/j.trsl.2010.05.008_bib28","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2010.05.008_bib29","series-title":"Nonparametric statistics for the behavioral sciences","author":"Siegel","year":"1988"},{"key":"10.1016\/j.trsl.2010.05.008_bib30","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/ije\/26.6.1323","article-title":"Regression models for ordinal responses: a review of methods and applications","volume":"26","author":"Ananth","year":"1997","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.trsl.2010.05.008_bib31","series-title":"Logistic regression models","author":"Hilbe","year":"2009"},{"key":"10.1016\/j.trsl.2010.05.008_bib32","series-title":"Regression models for categorical dependent variables using Stata","author":"Long","year":"2006"},{"key":"10.1016\/j.trsl.2010.05.008_bib33","first-page":"27","article-title":"Measures to summarize and compare the predictive capacity of markers","volume":"5","author":"Goo","year":"2009","journal-title":"Int J Biostat"},{"key":"10.1016\/j.trsl.2010.05.008_bib34","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mam.2007.09.002","article-title":"Myofibroblast - like cells and liver fibrogenesis: emerging concepts in a rapidly moving scenario","volume":"29","author":"Parola","year":"2008","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.trsl.2010.05.008_bib35","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1136\/gut.2009.187039","article-title":"Paediatric non-alcoholic fatty liver disease","volume":"59","author":"Nobili","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2010.05.008_bib36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.gastro.2008.09.013","article-title":"Performance of ELF serum markers in predicting fibrosis stage in pediatric non-alcoholic fatty liver disease","volume":"136","author":"Nobili","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trsl.2010.05.008_bib37","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/hep.22376","article-title":"Accuracy and reproducibility of transient elastography for the diagnosis of fibrosis in pediatric nonalcoholic steatohepatitis","volume":"48","author":"Nobili","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2010.05.008_bib38","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1478-3231.2005.01064.x","article-title":"Hyaluronic acid, an accurate serum marker for severe hepatic fibrosis in patients with non-alcoholic fatty liver disease","volume":"25","author":"Suzuki","year":"2005","journal-title":"Liver Int"},{"key":"10.1016\/j.trsl.2010.05.008_bib39","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.trsl.2009.06.007","article-title":"Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease","volume":"154","author":"Miele","year":"2009","journal-title":"Transl Res"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524410001015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524410001015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T06:27:09Z","timestamp":1544423229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524410001015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S1931524410001015"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2010.05.008","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}