{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:22:23Z","timestamp":1758633743518},"reference-count":29,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.trsl.2010.12.007","type":"journal-article","created":{"date-parts":[[2011,1,14]],"date-time":"2011-01-14T12:20:59Z","timestamp":1295007659000},"page":"368-377","source":"Crossref","is-referenced-by-count":4,"title":["Deferasirox protects against iron-induced hepatic injury in Mongolian gerbil"],"prefix":"10.1016","volume":"157","author":[{"given":"Rabaa M.","family":"Al-Rousan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin M.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjaiah","family":"Katta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Laurino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaozong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Triest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Blough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2010.12.007_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.110.172668","article-title":"Iron-induced cardiac damage: role of apoptosis and deferasirox intervention","volume":"336","author":"Wang","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.trsl.2010.12.007_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1182\/asheducation-2001.1.47","article-title":"Secondary iron overload","author":"Kushner","year":"2001","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.trsl.2010.12.007_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJM199409013310902","article-title":"Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major","volume":"331","author":"Brittenham","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2010.12.007_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000125550","article-title":"Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial","volume":"119","author":"Vichinsky","year":"2008","journal-title":"Acta Haematol"},{"key":"10.1016\/j.trsl.2010.12.007_bib5","first-page":"873","article-title":"Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload","volume":"91","author":"Piga","year":"2006","journal-title":"Haematologica"},{"key":"10.1016\/j.trsl.2010.12.007_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12012-010-9068-9","article-title":"Deferasirox decreases age-associated iron accumulation in the aging F344XBN rat heart and liver","volume":"10","author":"Arvapalli","year":"2010","journal-title":"Cardiovasc Toxicol"},{"key":"10.1016\/j.trsl.2010.12.007_bib7","first-page":"217","article-title":"A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload","volume":"69","author":"Carthew","year":"1993","journal-title":"Lab Invest"},{"key":"10.1016\/j.trsl.2010.12.007_bib8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0022-2143(03)00135-5","article-title":"Deferoxamine prevents cardiac hypertrophy and failure in the gerbil model of iron-induced cardiomyopathy","volume":"142","author":"Yang","year":"2003","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.trsl.2010.12.007_bib9","doi-asserted-by":"crossref","first-page":"e6430","DOI":"10.1371\/journal.pone.0006430","article-title":"Aging-associated dysfunction of akt\/protein kinase B: s-nitrosylation and acetaminophen intervention","volume":"4","author":"Wu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2010.12.007_bib10","doi-asserted-by":"crossref","first-page":"E1002","DOI":"10.1152\/ajpendo.00518.2004","article-title":"Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors","volume":"288","author":"Woo","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.trsl.2010.12.007_bib11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/dmrr.932","article-title":"Acetaminophen prevents aging-associated hyperglycemia in aged rats: effect of aging-associated hyperactivation of p38-MAPK and ERK1\/2","volume":"25","author":"Wu","year":"2009","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.trsl.2010.12.007_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/gerona\/glp203","article-title":"Possible molecular mechanisms underlying age-related cardiomyocyte apoptosis in the F344XBN rat heart","volume":"65","author":"Kakarla","year":"2010","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.trsl.2010.12.007_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2174\/138955708783498087","article-title":"Importance of iron and iron metabolism in nonalcoholic fatty liver disease","volume":"8","author":"Baptista-Gonzalez","year":"2008","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.trsl.2010.12.007_bib14","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1161\/01.ATV.0000189303.45609.1f","article-title":"Iron chelation and vascular function: in search of the mechanisms","volume":"25","author":"Ferrara","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2010.12.007_bib15","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1074\/jbc.270.10.4983","article-title":"Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2","volume":"270","author":"Kim","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2010.12.007_bib16","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1016\/S0021-9258(19)37165-0","article-title":"Ferritin: a cytoprotective antioxidant strategem of endothelium","volume":"267","author":"Balla","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2010.12.007_bib17","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1161\/01.ATV.0000181763.57495.2b","article-title":"Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats","volume":"25","author":"Ishizaka","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2010.12.007_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/A:1013874804911","article-title":"Iron-induced oxidant stress in nonparenchymal liver cells: mitochondrial derangement and fibrosis in acutely iron-dosed gerbils and its prevention by silybin","volume":"34","author":"Pietrangelo","year":"2002","journal-title":"J Bioenerg Biomembr"},{"key":"10.1016\/j.trsl.2010.12.007_bib19","doi-asserted-by":"crossref","first-page":"34832","DOI":"10.1074\/jbc.274.49.34832","article-title":"Role of iron and superoxide for generation of hydroxyl radical, oxidative DNA lesions, and mutagenesis in Escherichia coli","volume":"274","author":"Nunoshiba","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2010.12.007_bib20","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1182\/blood-2006-05-020867","article-title":"Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences","volume":"108","author":"Glickstein","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2010.12.007_bib21","doi-asserted-by":"crossref","first-page":"9902","DOI":"10.1016\/S0021-9258(18)48019-2","article-title":"Protein damage and degradation by oxygen radicals. II. Modification of amino acids","volume":"262","author":"Davies","year":"1987","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2010.12.007_bib22","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1210\/en.2004-0392","article-title":"Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis","volume":"145","author":"Cooksey","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.trsl.2010.12.007_bib23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00395-010-0094-3","article-title":"Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat","volume":"105","author":"Kakarla","year":"2010","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.trsl.2010.12.007_bib24","doi-asserted-by":"crossref","first-page":"15540","DOI":"10.1074\/jbc.273.25.15540","article-title":"Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis","volume":"273","author":"Janicke","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2010.12.007_bib25","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1016\/j.lfs.2004.07.035","article-title":"Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate","volume":"76","author":"Yajun","year":"2005","journal-title":"Life Sci"},{"key":"10.1016\/j.trsl.2010.12.007_bib26","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1093\/ndt\/gfl341","article-title":"Apoptotic stress pathway activation mediated by iron on endothelial cells in vitro","volume":"21","author":"Carlini","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.trsl.2010.12.007_bib27","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2010.12.007_bib28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0092-8674(95)90411-5","article-title":"Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death","volume":"80","author":"Yang","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2010.12.007_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1089-3261(05)70116-1","article-title":"Iron-induced liver injury","volume":"4","author":"Bonkovsky","year":"2000","journal-title":"Clin Liver Dis"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524410003336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524410003336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T11:27:16Z","timestamp":1637148436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524410003336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S1931524410003336"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2010.12.007","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}