{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:18:09Z","timestamp":1790191089011,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.trsl.2011.04.003","type":"journal-article","created":{"date-parts":[[2011,5,22]],"date-time":"2011-05-22T12:23:00Z","timestamp":1306066980000},"page":"146-154","source":"Crossref","is-referenced-by-count":21,"title":["Cellular localization of NKCC2 and its possible role in the Cl\u2212 absorption in the rat and human distal colonic epithelia"],"prefix":"10.1016","volume":"158","author":[{"given":"Jin-Xia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuo","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2011.04.003_bib1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0005-2736(02)00586-2","article-title":"Regulation of Na+\u2013K+\u2013Cl\u2212 cotransport by phosphorylation and protein\u2013protein interactions","volume":"1566","author":"Flatman","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.trsl.2011.04.003_bib2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.physiol.62.1.515","article-title":"The Na-K-Cl cotransporter of secretory epithelia","volume":"62","author":"Haas","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.trsl.2011.04.003_bib3","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1152\/physrev.00011.2004","article-title":"Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters","volume":"85","author":"Gamba","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.trsl.2011.04.003_bib4","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1172\/JCI1042","article-title":"Na+\u2013K+\u2013Cl\u2212 cotransporter gene expression and function during enterocyte differentiation","volume":"101","author":"Matthews","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2011.04.003_bib5","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/s00268-002-4059-z","article-title":"Molecular regulation of Na+\u2013K+\u20132Cl\u2212 cotransporter (NKCC1) and epithelial chloride secretion","volume":"26","author":"Matthews","year":"2002","journal-title":"World J Surg"},{"key":"10.1016\/j.trsl.2011.04.003_bib6","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1172\/JCI118834","article-title":"Expression of the Na+\u2013K+\u20132Cl\u2212 cotransporter by macula densa and thick ascending limb cells of rat and rabbit","volume":"98","author":"Oberm\u00fcller","year":"1996","journal-title":"Nephron J Clin Invest"},{"key":"10.1016\/j.trsl.2011.04.003_bib7","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1365-2982.2009.01334.x","article-title":"Expression of NKCC2 in the rat gastrointestinal tract","volume":"21","author":"Xue","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.trsl.2011.04.003_bib8","first-page":"79","article-title":"Absorption and secretion of fluid and electrolytes by the rectum","volume":"93","author":"Edmonds","year":"1984","journal-title":"Scand J Gastroenterol Suppl"},{"key":"10.1016\/j.trsl.2011.04.003_bib9","doi-asserted-by":"crossref","first-page":"G7","DOI":"10.1152\/ajpgi.00079.2004","article-title":"Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation","volume":"287","author":"Itzkowitz","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.trsl.2011.04.003_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00581960","article-title":"Segmental heterogeneity of epithelial transport in rat large intestine","volume":"378","author":"Fromm","year":"1978","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.trsl.2011.04.003_bib11","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1023\/A:1011971117097","article-title":"Mechanism(s) of chloride transport in human distal colonic apical membrane vesicles","volume":"46","author":"Alrefai","year":"2001","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.trsl.2011.04.003_bib12","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2007.05.038","article-title":"Dopamine stimulates Cl\u2212 absorption coupled with HCO3\u2212 secretion in rat late distal colon","volume":"570","author":"Zhang","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.trsl.2011.04.003_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00441-003-0713-5","article-title":"Differential expression pattern of chloride transporters NCC, NKCC2, KCC1, KCC3, KCC4, and AE3 in the developing rat auditory","volume":"312","author":"Becker","year":"2003","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.trsl.2011.04.003_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00026.2001","article-title":"Electrolyte transport in the mammalian colon: mechanisms and implications for disease","volume":"82","author":"Kunzelmann","year":"2002","journal-title":"Physiol Rev"},{"key":"10.1016\/j.trsl.2011.04.003_bib15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1146\/annurev.physiol.67.031103.153004","article-title":"Molecular physiology of intestinal Na+\/H+ exchange","volume":"67","author":"Zachos","year":"2005","journal-title":"Ann Rev Physiol"},{"key":"10.1016\/j.trsl.2011.04.003_bib16","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1172\/JCI110760","article-title":"Evaluation of chloride\/bicarbonate. Exchange in the human colon in\u00a0vivo","volume":"71","author":"Davis","year":"1983","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.trsl.2011.04.003_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.ph.53.030191.001541","article-title":"Ion channels and colonic salt transport","volume":"53","author":"Dawson","year":"1991","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.trsl.2011.04.003_bib18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1748-1716.2010.02099.x","article-title":"Localization and functional characterization of the human NKCC2 isoforms","volume":"199","author":"Carota","year":"2010","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.trsl.2011.04.003_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00424-008-0607-1","article-title":"Thick ascending limb: the Na+: K+:2Cl\u2212 co-transporter, NKCC2, and the calcium-sensing receptor, CaSR","volume":"458","author":"Gamba","year":"2009","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.trsl.2011.04.003_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/jez.a.10310","article-title":"Cl\u2212 absorption in European eel intestine and its regulation","volume":"300","author":"Schettino","year":"2003","journal-title":"J Exp Zoolog Comp Exp Biol"},{"key":"10.1016\/j.trsl.2011.04.003_bib21","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1172\/JCI107039","article-title":"Localization of the action of cholera toxin on adenyl cyclase in mucosal epithelial cells of rabbit intestine","volume":"51","author":"Parkinson","year":"1972","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2011.04.003_bib22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0016-5085(19)32590-9","article-title":"Adenylate and guanylate cyclase activities and cellular differentiation in rat small intestine","volume":"69","author":"Quill","year":"1975","journal-title":"Gastroenterol"},{"key":"10.1016\/j.trsl.2011.04.003_bib23","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.84.20.6965","article-title":"Intestinal brush border membranes contain regulatory subunits of adenylyl cyclase","volume":"84","author":"Pedro","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2011.04.003_bib24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s004240050953","article-title":"Regulation of the Na+2Cl\u2212K+ cotransporter in isolated rat colon crypts","volume":"439","author":"Dirk","year":"2000","journal-title":"Pfl\u00fcgers Arch"},{"key":"10.1016\/j.trsl.2011.04.003_bib25","doi-asserted-by":"crossref","first-page":"24965","DOI":"10.1074\/jbc.M109.037135","article-title":"cAMP stimulates apical exocytosis of the renal Na-K-2Cl cotransporter NKCC2 in the thick ascending limb","volume":"284","author":"Paulo","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2011.04.003_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1469-7793.1999.0251o.x","article-title":"Basolateral K+ channel involvement in forskolin-activated chloride secretion in human colon","volume":"519","author":"O\u2019Sullivan","year":"1999","journal-title":"J Physiol"},{"key":"10.1016\/j.trsl.2011.04.003_bib27","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF00374861","article-title":"Isolated perfused rabbit colon crypts: stimulation of Cl\u2212 secretion by forskolin","volume":"425","author":"Lohrmann","year":"1993","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.trsl.2011.04.003_bib28","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1248\/bpb.30.1407","article-title":"Appearance of segmental discrepancy of anion transport in rat distal colon","volume":"30","author":"Xue","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.trsl.2011.04.003_bib29","doi-asserted-by":"crossref","first-page":"C912","DOI":"10.1152\/ajpcell.00396.2002","article-title":"Characterization of Cl-HCO3 exchange in basolateral membrane of rat distal colon","volume":"285","author":"Ikuma","year":"2003","journal-title":"Am J Physiol Cell Physiol"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193152441100154X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193152441100154X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T19:44:49Z","timestamp":1712432689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193152441100154X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S193152441100154X"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2011.04.003","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}