{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:25:15Z","timestamp":1788870315559,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"departmental funds"}],"content-domain":{"domain":["translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.trsl.2014.05.009","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T12:20:21Z","timestamp":1400847621000},"page":"400-410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical relevance of urinary angiotensinogen and renin as potential biomarkers in patients with overt proteinuria"],"prefix":"10.1016","volume":"164","author":[{"given":"Hye Ryoun","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wooseong","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Young","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2014.05.009_bib1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1523-1755.2003.00065.x","article-title":"Precocious activation of genes of the renin-angiotensin system and the fibrogenic cascade in IgA glomerulonephritis","volume":"64","author":"Del Prete","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2014.05.009_bib2","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MAJ.0b013e3181b90c25","article-title":"Increased urinary angiotensinogen is precedent to increased urinary albumin in patients with type 1 diabetes","volume":"338","author":"Saito","year":"2009","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.trsl.2014.05.009_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1124\/pr.59.3.3","article-title":"The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease","volume":"59","author":"Kobori","year":"2007","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.trsl.2014.05.009_bib4","first-page":"F218","article-title":"Rat proximal tubule cell line transformed with origin-defective SV40 DNA: autocrine ANG II feedback","volume":"276","author":"Ingelfinger","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1523-1755.2002.00155.x","article-title":"Urinary excretion of angiotensinogen reflects intrarenal angiotensinogen production","volume":"61","author":"Kobori","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2014.05.009_bib6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3109\/07853890.2011.558518","article-title":"The origin and the clinical significance of urinary angiotensinogen in proteinuric IgA nephropathy patients","volume":"44","author":"Jang","year":"2012","journal-title":"Ann Med"},{"key":"10.1016\/j.trsl.2014.05.009_bib7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1161\/01.HYP.0000050102.90932.CF","article-title":"Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension","volume":"41","author":"Kobori","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib8","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/01.HYP.0000122875.91100.28","article-title":"AT1 receptor mediated augmentation of intrarenal angiotensinogen in angiotensin II-dependent hypertension","volume":"43","author":"Kobori","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib9","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1681\/ASN.2004080676","article-title":"Enhanced intrarenal angiotensinogen contributes to early renal injury in spontaneously hypertensive rats","volume":"16","author":"Kobori","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2014.05.009_bib10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jash.2008.04.008","article-title":"Urinary angiotensinogen as a potential biomarker of severity of chronic kidney diseases","volume":"2","author":"Kobori","year":"2008","journal-title":"J Am Soc Hypertens"},{"key":"10.1016\/j.trsl.2014.05.009_bib11","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1097\/HJH.0b013e32834bbcbf","article-title":"Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney","volume":"29","author":"van den Heuvel","year":"2011","journal-title":"J Hypertens"},{"key":"10.1016\/j.trsl.2014.05.009_bib12","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/HYPERTENSIONAHA.108.123042","article-title":"Aliskiren accumulates in renin secretory granules and binds plasma prorenin","volume":"52","author":"Krop","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib13","doi-asserted-by":"crossref","first-page":"R510","DOI":"10.1152\/ajpregu.00512.2011","article-title":"Intracardiac intracellular angiotensin system in diabetes","volume":"302","author":"Kumar","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib14","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.peptides.2011.06.018","article-title":"On the local cardiac renin angiotensin system. Basic and clinical implications","volume":"32","author":"De Mello","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.trsl.2014.05.009_bib15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pneurobio.2011.07.001","article-title":"Brain renin-angiotensin\u2014a new look at an old system","volume":"95","author":"Wright","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00109-008-0336-0","article-title":"Update on tissue renin-angiotensin systems","volume":"86","author":"Bader","year":"2008","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.trsl.2014.05.009_bib17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.RES.40.2.174","article-title":"Effect of intrarenal angiotensin II blockade on renal function in conscious dogs","volume":"40","author":"Kimbrough","year":"1977","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2014.05.009_bib18","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1172\/JCI112528","article-title":"Therapeutic advantage of\u00a0converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat","volume":"77","author":"Anderson","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2014.05.009_bib19","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1681\/ASN.2006040356","article-title":"Renin-angiotensin-aldosterone system and progression of renal disease","volume":"17","author":"Ruster","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2014.05.009_bib20","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.1016\/j.peptides.2006.05.006","article-title":"Quantification of human angiotensinogen by a novel sandwich ELISA","volume":"27","author":"Suzaki","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.trsl.2014.05.009_bib21","doi-asserted-by":"crossref","first-page":"F956","DOI":"10.1152\/ajprenal.00090.2007","article-title":"Novel sandwich ELISA for human angiotensinogen","volume":"293","author":"Katsurada","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib22","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1681\/ASN.2006060554","article-title":"Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease","volume":"18","author":"Yamamoto","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2014.05.009_bib23","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1161\/HYPERTENSIONAHA.108.123802","article-title":"Urinary angiotensinogen as a novel biomarker of the intrarenal renin-angiotensin system status in hypertensive patients","volume":"53","author":"Kobori","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib24","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ndt\/gfq371","article-title":"Urinary angiotensinogen reflects the activity of intrarenal renin-angiotensin system in patients with IgA nephropathy","volume":"26","author":"Nishiyama","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.trsl.2014.05.009_bib25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000286037","article-title":"Urinary angiotensinogen accurately reflects intrarenal renin-angiotensin system activity","volume":"31","author":"Urushihara","year":"2010","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.trsl.2014.05.009_bib26","first-page":"H1818","article-title":"Active renin and angiotensinogen in cardiac interstitial fluid after myocardial infarction","volume":"276","author":"Hirsch","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00583388","article-title":"In situ hybridization and immunohistochemistry of renal angiotensinogen in neonatal and adult rat kidneys","volume":"281","author":"Darby","year":"1995","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.trsl.2014.05.009_bib28","doi-asserted-by":"crossref","first-page":"28142","DOI":"10.1074\/jbc.272.44.28142","article-title":"The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice","volume":"272","author":"Ding","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2014.05.009_bib29","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1161\/01.HYP.34.6.1265","article-title":"Elements of a paracrine tubular renin-angiotensin system along the entire nephron","volume":"34","author":"Rohrwasser","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib30","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/01.HYP.0000016177.20565.A0","article-title":"Effects of dietary sodium and genetic background on angiotensinogen and renin in mouse","volume":"39","author":"Lantelme","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000060154","article-title":"Intrarenal formation of angiotensin II","volume":"135","author":"Navar","year":"2001","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.trsl.2014.05.009_bib32","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1681\/ASN.2011121159","article-title":"Liver angiotensinogen is the primary source of renal angiotensin II","volume":"23","author":"Matsusaka","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2014.05.009_bib33","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1681\/ASN.2012010078","article-title":"Multiphoton imaging of the glomerular permeability of angiotensinogen","volume":"23","author":"Nakano","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.trsl.2014.05.009_bib34","first-page":"F405","article-title":"Angiotensin I-converting enzyme activity in tubular fluid along the rat nephron","volume":"272","author":"Casarini","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib35","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/01.HYP.0000121462.27393.f6","article-title":"Depletion of tissue angiotensin-converting enzyme differentially influences the intrarenal and urinary expression of angiotensin peptides","volume":"43","author":"Modrall","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib36","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev-physiol-012110-142238","article-title":"Renin release: sites, mechanisms, and control","volume":"73","author":"Kurtz","year":"2011","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib37","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1161\/HYPERTENSIONAHA.107.107268","article-title":"The collecting duct is the major source of prorenin in diabetes","volume":"51","author":"Kang","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/HYPERTENSIONAHA.110.167957","article-title":"Soluble form of the (pro)renin receptor is augmented in the collecting duct and urine of chronic angiotensin II-dependent hypertensive rats","volume":"57","author":"Gonzalez","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib39","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/HYPERTENSIONAHA.110.165902","article-title":"Angiotensin II stimulates renin in inner medullary collecting duct cells via protein kinase C and independent of epithelial sodium channel and mineralocorticoid receptor activity","volume":"57","author":"Gonzalez","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2014.05.009_bib40","doi-asserted-by":"crossref","first-page":"F1195","DOI":"10.1152\/ajprenal.00339.2011","article-title":"Increased renin excretion is associated with augmented urinary angiotensin II levels in chronic angiotensin II-infused hypertensive rats","volume":"301","author":"Liu","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.trsl.2014.05.009_bib41","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1136\/postgradmedj-2011-130441","article-title":"Potential role of urinary angiotensinogen in predicting antiproteinuric effects of angiotensin receptor blocker in non-diabetic chronic kidney disease patients: a preliminary report","volume":"88","author":"Jang","year":"2012","journal-title":"Postgrad Med J"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524414001960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524414001960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T20:29:51Z","timestamp":1538598591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524414001960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S1931524414001960"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2014.05.009","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical relevance of urinary angiotensinogen and renin as potential biomarkers in patients with overt proteinuria","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2014.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}