{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:26:16Z","timestamp":1783477576134,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK091601"],"award-info":[{"award-number":["DK091601"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Translational Genomics Research Institute"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","translationalres.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.trsl.2015.04.014","type":"journal-article","created":{"date-parts":[[2015,5,4]],"date-time":"2015-05-04T21:40:58Z","timestamp":1430775658000},"page":"304-314","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease\u2013related fibrosis"],"prefix":"10.1016","volume":"166","author":[{"given":"Fatjon","family":"Leti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Malenica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meera","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Courtright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Van Keuren-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Legendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Still","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn S.","family":"Gerhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna K.","family":"DiStefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2015.04.014_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cld.2004.04.004","article-title":"The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease","volume":"8","author":"McCullough","year":"2004","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.trsl.2015.04.014_bib2","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/hep.25762","article-title":"The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association","volume":"55","author":"Chalasani","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2015.04.014_bib3","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0016-5085(99)70506-8","article-title":"Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity","volume":"116","author":"Matteoni","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.trsl.2015.04.014_bib4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cgh.2008.11.005","article-title":"Long-term follow-up of patients with nonalcoholic fatty liver","volume":"7","author":"Rafiq","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2015.04.014_bib5","doi-asserted-by":"crossref","first-page":"16230","DOI":"10.1073\/pnas.0808830105","article-title":"MicroRNA-directed transcriptional gene silencing in mammalian cells","volume":"105","author":"Kim","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2015.04.014_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/labinvest.2010.166","article-title":"Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease","volume":"91","author":"Alisi","year":"2011","journal-title":"Lab Invest"},{"key":"10.1016\/j.trsl.2015.04.014_bib7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1440-1746.2011.06864.x","article-title":"Transition from hepatic steatosis to steatohepatitis: unique microRNA patterns and potential downstream functions and pathways","volume":"27","author":"Jin","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.trsl.2015.04.014_bib8","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.bbrc.2011.09.120","article-title":"High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis","volume":"414","author":"Ahn","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2015.04.014_bib9","doi-asserted-by":"crossref","first-page":"e80774","DOI":"10.1371\/journal.pone.0080774","article-title":"Deep sequencing of small RNA repertoires in mice reveals metabolic disorders-associated hepatic miRNAs","volume":"8","author":"Liang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.04.014_bib10","doi-asserted-by":"crossref","first-page":"e72324","DOI":"10.1371\/journal.pone.0072324","article-title":"MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice","volume":"8","author":"Miller","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.04.014_bib11","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/labinvest.2010.113","article-title":"Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice","volume":"90","author":"Pogribny","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.trsl.2015.04.014_bib12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.bbrc.2013.11.109","article-title":"The effects of miR-467b on lipoprotein lipase (LPL) expression, pro-inflammatory cytokine, lipid levels and atherosclerotic lesions in apolipoprotein E knockout mice","volume":"443","author":"Tian","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2015.04.014_bib13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jbm.a.32602","article-title":"Collagen\/silk fibroin bi-template induced biomimetic bone-like substitutes","volume":"99","author":"Wang","year":"2011","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.trsl.2015.04.014_bib14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.diabres.2012.11.025","article-title":"Upregulation of miR-15b in NAFLD models and in the serum of patients with fatty liver disease","volume":"99","author":"Zhang","year":"2013","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.trsl.2015.04.014_bib15","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1002\/hep.22569","article-title":"Nonalcoholic steatohepatitis is associated with altered hepatic MicroRNA expression","volume":"48","author":"Cheung","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2015.04.014_bib16","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/gutjnl-2014-306996","article-title":"Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis","volume":"64","author":"Pirola","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.trsl.2015.04.014_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1472-6947-12-45","article-title":"An electronic health record-enabled obesity database","volume":"12","author":"Wood","year":"2012","journal-title":"BMC Med Inform Decis Mak"},{"key":"10.1016\/j.trsl.2015.04.014_bib18","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2015.04.014_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00592-014-0654-3","article-title":"Genome-wide analysis of hepatic lipid content in extreme obesity","volume":"52","author":"DiStefano","year":"2014","journal-title":"Acta Diabetol"},{"key":"10.1016\/j.trsl.2015.04.014_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/nar\/gkr688","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades","volume":"40","author":"Friedlander","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.trsl.2015.04.014_bib21","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.trsl.2015.04.014_bib22","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","article-title":"MicroRNA targets in Drosophila","volume":"5","author":"Enright","year":"2003","journal-title":"Genome Biol"},{"key":"10.1016\/j.trsl.2015.04.014_bib23","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.trsl.2015.04.014_bib24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jbi.2011.05.002","article-title":"miRWalk\u2013database: prediction of possible miRNA binding sites by \u201cwalking\u201d the genes of three genomes","volume":"44","author":"Dweep","year":"2011","journal-title":"J Biomed Inform"},{"key":"10.1016\/j.trsl.2015.04.014_bib25","doi-asserted-by":"crossref","first-page":"D163","DOI":"10.1093\/nar\/gkq1107","article-title":"miRTarBase: a database curates experimentally validated microRNA-target interactions","volume":"39","author":"Hsu","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.trsl.2015.04.014_bib26","first-page":"17","article-title":"MiR-182 is up-regulated and targeting Cebpa in hepatocellular carcinoma","volume":"26","author":"Wang","year":"2014","journal-title":"Chin J Cancer Res"},{"key":"10.1016\/j.trsl.2015.04.014_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/1471-2407-12-227","article-title":"MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma","volume":"12","author":"Wang","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.trsl.2015.04.014_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gene.2013.06.006","article-title":"Meta-analysis of microRNA-183 family expression in human cancer studies comparing cancer tissues with noncancerous tissues","volume":"527","author":"Zhang","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.trsl.2015.04.014_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cmet.2013.06.010","article-title":"An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis","volume":"18","author":"Jeon","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.trsl.2015.04.014_bib30","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/en.2011-1527","article-title":"Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice","volume":"153","author":"Zhang","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.trsl.2015.04.014_bib31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2036.2010.04366.x","article-title":"Differential expression of miRNAs in the visceral adipose tissue of patients with non-alcoholic fatty liver disease","volume":"32","author":"Estep","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.trsl.2015.04.014_bib32","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/j.1530-0277.2009.01007.x","article-title":"MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice","volume":"33","author":"Dolganiuc","year":"2009","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.trsl.2015.04.014_bib33","doi-asserted-by":"crossref","first-page":"25053","DOI":"10.1074\/jbc.M700501200","article-title":"MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster","volume":"282","author":"Xu","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2015.04.014_bib34","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1002\/hep.27175","article-title":"Saturated free fatty acids induce cholangiocyte lipoapoptosis","volume":"60","author":"Natarajan","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2015.04.014_bib35","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.ajpath.2013.08.011","article-title":"Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity","volume":"183","author":"Ni","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.trsl.2015.04.014_bib36","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.ajpath.2013.08.013","article-title":"Hepatitis C and alcohol exacerbate liver injury by suppression of FOXO3","volume":"183","author":"Tumurbaatar","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.trsl.2015.04.014_bib37","doi-asserted-by":"crossref","first-page":"e74340","DOI":"10.1371\/journal.pone.0074340","article-title":"Deletion of hepatic FoxO1\/3\/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis","volume":"8","author":"Xiong","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.04.014_bib38","doi-asserted-by":"crossref","first-page":"C314","DOI":"10.1152\/ajpcell.00395.2013","article-title":"miR-182 attenuates atrophy-related gene expression by targeting FoxO3 in skeletal muscle","volume":"307","author":"Hudson","year":"2014","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.trsl.2015.04.014_bib39","doi-asserted-by":"crossref","first-page":"740","DOI":"10.18632\/oncotarget.1608","article-title":"Sp1-mediated microRNA-182 expression regulates lung cancer progression","volume":"5","author":"Yang","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.trsl.2015.04.014_bib40","doi-asserted-by":"crossref","first-page":"e23937","DOI":"10.1371\/journal.pone.0023937","article-title":"Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease","volume":"6","author":"Cermelli","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.04.014_bib41","doi-asserted-by":"crossref","first-page":"G697","DOI":"10.1152\/ajpgi.00426.2010","article-title":"Obesity, diabetes mellitus, and liver fibrosis","volume":"300","author":"Chiang","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524415001401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524415001401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T22:54:21Z","timestamp":1537656861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524415001401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1931524415001401"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2015.04.014","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease\u2013related fibrosis","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2015.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}