{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:57:11Z","timestamp":1789642631522,"version":"4.0.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"crossref","award":["P30-CA23074"],"award-info":[{"award-number":["P30-CA23074"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","translationalres.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.trsl.2015.05.002","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T06:35:04Z","timestamp":1431498904000},"page":"440-450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss"],"prefix":"10.1016","volume":"166","author":[{"given":"Maki","family":"Niihori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Platto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzu","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audriana","family":"Hurbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison M.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phi","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan A.","family":"Mudery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin J.","family":"Slepian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2015.05.002_bib1","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.2010.1501","article-title":"Newborn hearing screening vs later hearing screening and developmental outcomes in children with permanent childhood hearing impairment","volume":"304","author":"Korver","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.trsl.2015.05.002_bib2","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/oxfordjournals.aje.a009713","article-title":"Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study","volume":"148","author":"Cruickshanks","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.trsl.2015.05.002_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00003446-199008000-00001","article-title":"Hearing in the elderly: the Framingham cohort, 1983-1985. Part I. Basic audiometric test results","volume":"11","author":"Gates","year":"1990","journal-title":"Ear Hear"},{"key":"10.1016\/j.trsl.2015.05.002_bib4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00003446-198507000-00003","article-title":"Hearing loss in the elderly: an epidemiologic study of the Framingham Heart Study Cohort","volume":"6","author":"Moscicki","year":"1985","journal-title":"Ear Hear"},{"key":"10.1016\/j.trsl.2015.05.002_bib5","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1001\/archinternmed.2011.506","article-title":"Hearing loss prevalence in the United States","volume":"171","author":"Lin","year":"2011","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.trsl.2015.05.002_bib6","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1001\/archinte.168.14.1522","article-title":"Prevalence of hearing loss and differences by demographic characteristics among US adults\u2014Data from the National Health and Nutrition Examination Survey, 1999-2004","volume":"168","author":"Agrawal","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.trsl.2015.05.002_bib7","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1097\/00005537-199911000-00016","article-title":"Ototoxic impact of cisplatin in pediatric oncology patients","volume":"109","author":"Berg","year":"1999","journal-title":"Laryngoscope"},{"key":"10.1016\/j.trsl.2015.05.002_bib8","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1288\/00005537-199007000-00008","article-title":"High-dose cisplatin treatment\u2014hearing-loss and plasma-concentrations","volume":"100","author":"Laurell","year":"1990","journal-title":"Laryngoscope"},{"key":"10.1016\/j.trsl.2015.05.002_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.heares.2006.09.015","article-title":"Mechanisms of cisplatin-induced ototoxicity and prevention","volume":"226","author":"Rybak","year":"2007","journal-title":"Hear Res"},{"key":"10.1016\/j.trsl.2015.05.002_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"Henderson","year":"2006","journal-title":"Ear Hear"},{"key":"10.1016\/j.trsl.2015.05.002_bib11","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/sj.ki.5002434","article-title":"Ototoxicity","volume":"72","author":"Rybak","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.trsl.2015.05.002_bib12","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbrc.2011.10.019","article-title":"Protective role of Nrf2 in age-related hearing loss and gentamicin ototoxicity","volume":"415","author":"Hoshino","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2015.05.002_bib13","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1200\/JCO.2006.08.9821","article-title":"New waves of discovery: modeling cancer in zebrafish","volume":"25","author":"Goessling","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.trsl.2015.05.002_bib14","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0091-679X(04)76026-4","article-title":"Discovery and use of small molecules for probing biological processes in zebrafish","volume":"76","author":"Peterson","year":"2004","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.trsl.2015.05.002_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/zeb.2009.0639","article-title":"Chemical screening for hair cell loss and protection in the zebrafish lateral line","volume":"7","author":"Coffin","year":"2010","journal-title":"Zebrafish"},{"key":"10.1016\/j.trsl.2015.05.002_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.drudis.2010.01.001","article-title":"Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevents and cause hearing loss","volume":"15","author":"Ou","year":"2010","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.trsl.2015.05.002_bib17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.heares.2011.12.001","article-title":"Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish","volume":"284","author":"Buck","year":"2012","journal-title":"Hear Res"},{"key":"10.1016\/j.trsl.2015.05.002_bib18","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.heares.2007.07.003","article-title":"Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line","volume":"233","author":"Ou","year":"2007","journal-title":"Hear Res"},{"key":"10.1016\/j.trsl.2015.05.002_bib19","doi-asserted-by":"crossref","first-page":"e29727","DOI":"10.1371\/journal.pone.0029727","article-title":"Rheotaxis in larval zebrafish is mediated by lateral line mechanosensory hair cells","volume":"7","author":"Suli","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.05.002_bib20","series-title":"The zebrafish book. a guide for the laboratory use of zebrafish (Danio rerio)","first-page":"3.1","author":"Westerfeld","year":"2007"},{"key":"10.1016\/j.trsl.2015.05.002_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.heares.2005.12.009","article-title":"Lateral line hair cell maturation is a determinant of aminoglycoside susceptibility in zebrafish (Danio rerio)","volume":"213","author":"Santos","year":"2006","journal-title":"Hear Res"},{"key":"10.1016\/j.trsl.2015.05.002_bib22","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1177\/0194599814524894","article-title":"Prevention of cispltin-induced hearing loss by intratympanic dexamethasone: a randomized controlled study","volume":"150","author":"Marshak","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.trsl.2015.05.002_bib23","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/MAO.0b013e31818599d5","article-title":"Cisplatin-induced ototoxicity: effect of intrartympanic dexamethasone injections","volume":"29","author":"Hill","year":"2008","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.trsl.2015.05.002_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10162-002-3022-x","article-title":"Neomycin-induced hair cell death and rapid regeneration in the lateral line of zebrafish (Danio rerio)","volume":"4","author":"Harris","year":"2003","journal-title":"J Assoc Res Otolaryngol"},{"key":"10.1016\/j.trsl.2015.05.002_bib25","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1523\/JNEUROSCI.3905-11.2012","article-title":"Identification of modulators of hair cell regeneration in the zebrafish lateral line","volume":"32","author":"Namdaran","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.trsl.2015.05.002_bib26","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1001\/jama.2011.679","article-title":"Oral vs intratympanic corticisteroid therapy for idiopathic sudden sensorineural hearing loss a randomized trial","volume":"305","author":"Rauch","year":"2011","journal-title":"JAMA"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524415001449?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524415001449?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T16:59:37Z","timestamp":1537635577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524415001449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S1931524415001449"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2015.05.002","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2015.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}