{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:44:02Z","timestamp":1781541842484,"version":"3.54.5"},"reference-count":118,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","translationalres.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.trsl.2015.12.012","type":"journal-article","created":{"date-parts":[[2015,12,28]],"date-time":"2015-12-28T18:21:29Z","timestamp":1451326889000},"page":"23-32.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Cardiovascular symptoms in patients with systemic mast cell activation disease"],"prefix":"10.1016","volume":"174","author":[{"given":"Ulrich W.","family":"Kolck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Haenisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard J.","family":"Molderings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2015.12.012_bib1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fimmu.2012.00120","article-title":"Mast cell: an emerging partner in immune interaction","volume":"3","author":"Gri","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib2","first-page":"1","article-title":"Mast cell function in physiology and pathophysiology","volume":"5","author":"Molderings","year":"2010","journal-title":"Biotrend Rev"},{"key":"10.1016\/j.trsl.2015.12.012_bib3","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s00018-010-0587-0","article-title":"Biological implications of preformed mast cell mediators","volume":"68","author":"Lundequist","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.trsl.2015.12.012_bib4","series-title":"\u201cMast cells\u201d in COPE: cytokines and cells online pathfinder encyclopaedia","author":"Ibelgaufts","year":"2015"},{"key":"10.1016\/j.trsl.2015.12.012_bib5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-065X.2007.00514.x","article-title":"Renin: at the heart of the mast cell","volume":"217","author":"Reid","year":"2007","journal-title":"Immunol Rev"},{"key":"10.1016\/j.trsl.2015.12.012_bib6","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJM198510313131807","article-title":"Increased adventitial mast cells in a patient with coronary spasm","volume":"313","author":"Forman","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib7","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1056\/NEJM198610093151515","article-title":"Mast-cell degranulation in human hearts","volume":"315","author":"Dvorak","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0162-3109(95)00037-3","article-title":"Immunological characterization and functional importance of human heart mast cells","volume":"31","author":"Marone","year":"1995","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.trsl.2015.12.012_bib9","doi-asserted-by":"crossref","first-page":"13607","DOI":"10.1073\/pnas.0403208101","article-title":"Mast cells: a unique source of renin","volume":"101","author":"Silver","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2015.12.012_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/jpet.110.172262","article-title":"Interaction between sensory C-fibers and cardiac mast cells in ischemia\/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction","volume":"335","author":"Morrey","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.trsl.2015.12.012_bib11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1172\/JCI25713","article-title":"Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia\/reperfusion","volume":"116","author":"Mackins","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2015.12.012_bib12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1161\/CIRCULATIONAHA.110.952481","article-title":"Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells","volume":"122","author":"Koda","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2015.12.012_bib13","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jaci.2006.04.017","article-title":"Mast cells: ontogeny, homing, and recruitment of a unique innate effector cell","volume":"117","author":"Gurish","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib14","doi-asserted-by":"crossref","first-page":"S450","DOI":"10.1016\/j.jaci.2005.11.016","article-title":"IgE, mast cells, basophils, and eosinophils","volume":"117","author":"Prussin","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0344-0338(11)80086-5","article-title":"Heterogeneity of mast cells at multiple body sites. Fluorescent determination of avidin binding and immunofluorescent determination of chymase, tryptase, and carboxypeptidase content","volume":"189","author":"Weidner","year":"1993","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.trsl.2015.12.012_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/01.RES.66.2.511","article-title":"Mast cells in the rat heart during normal growth and in cardiac hypertrophy","volume":"66","author":"Rakusan","year":"1990","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib17","first-page":"839","article-title":"Proteinase activities in bovine atrium and the possible role of mast cell tryptase in the processing of atrial natriuretic factor (ANF)","volume":"99","author":"Proctor","year":"1991","journal-title":"Comp Biochem Physiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1161\/01.CIR.98.7.699","article-title":"Resident cardiac mast cells degranulate and release preformed TNF-\u03b1, initiating the cytokine cascade in experimental canine myocardial ischemia\/reperfusion","volume":"98","author":"Frangogiannis","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2015.12.012_bib19","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.pharmthera.2006.05.008","article-title":"Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models","volume":"112","author":"Moyazaki","year":"2006","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.trsl.2015.12.012_bib20","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI39345","article-title":"Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents","volume":"120","author":"Wei","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.trsl.2015.12.012_bib21","series-title":"Asthma and allergic diseases","first-page":"237","article-title":"Human cardiac mast cells and their role in severe allergic reactions","author":"Marone","year":"1998"},{"key":"10.1016\/j.trsl.2015.12.012_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.pharmthera.2013.01.001","article-title":"Mast cells and vascular diseases","volume":"138","author":"Kennedy","year":"2013","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.trsl.2015.12.012_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1210\/er.2011-0013","article-title":"Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases","volume":"33","author":"Xu","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1016\/j.trsl.2015.12.012_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4939-1568-2_7","article-title":"Mast cells in human health and disease","volume":"1220","author":"DeBruin","year":"2015","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.trsl.2015.12.012_bib25","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.cardiores.2003.08.016","article-title":"Release of TNF-\u03b1 during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers","volume":"60","author":"Gilles","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.yjmcc.2008.08.009","article-title":"Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure","volume":"45","author":"Palaniyandi","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/cvr\/cvq272","article-title":"Cardiac mast cells: the centrepiece in adverse myocardial remodelling","volume":"89","author":"Levick","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib28","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1093\/cvr\/cvr244","article-title":"Substance P induces adverse myocardial remodelling via a mechanism involving cardiac mast cells","volume":"92","author":"Mel\u00e9ndez","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib29","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/CIRCULATIONAHA.107.741595","article-title":"Mast cells play a critical role in the pathogenesis of viral myocarditis","volume":"118","author":"Higuchi","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2015.12.012_bib30","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cardfail.2005.05.005","article-title":"Pharmacologic inhibition of mast cell degranulation prevents left ventricular remodeling induced by chronic volume overload in rats","volume":"11","author":"Brower","year":"2005","journal-title":"J Card Fail"},{"key":"10.1016\/j.trsl.2015.12.012_bib31","doi-asserted-by":"crossref","first-page":"e60827","DOI":"10.1371\/journal.pone.0060827","article-title":"Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation","volume":"8","author":"Huang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.12.012_bib32","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/00007890-199205000-00015","article-title":"The relationship of mast cells and their secreted products to the volume of fibrosis in post transplant hearts","volume":"53","author":"Li","year":"1992","journal-title":"Transplantation"},{"key":"10.1016\/j.trsl.2015.12.012_bib33","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1097\/00007890-200206150-00004","article-title":"Mast cells in ongoing acute rejection: increase in number and expression of a different phenotype in rat heart transplants","volume":"73","author":"Zweifel","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.trsl.2015.12.012_bib34","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1248\/bpb.28.2128","article-title":"Involvement of mast cells in the development of fibrosis in rats with postmyocarditis dilated cardiomyopathy","volume":"28","author":"Palaniyandi Selvaraj","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.trsl.2015.12.012_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1084\/jem.20002036","article-title":"Evidence for a role of mast cells in the evolution to congestive heart failure","volume":"195","author":"Hara","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib36","doi-asserted-by":"crossref","first-page":"H679","DOI":"10.1152\/ajpheart.00145.2003","article-title":"Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats","volume":"285","author":"Joseph","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib37","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1097\/00004872-200310000-00022","article-title":"A role for cardiac mast cells in the pathogenesis of hypertensive heart disease","volume":"21","author":"Shiota","year":"2003","journal-title":"J Hypertens"},{"key":"10.1016\/j.trsl.2015.12.012_bib38","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.healun.2006.04.012","article-title":"Increased expression of the renin-angiotensin system and mast cell density but not of angiotensin-converting enzyme II in late stages of human heart failure","volume":"25","author":"Batlle","year":"2006","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.trsl.2015.12.012_bib39","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jacc.2006.05.069","article-title":"Impact of blockade of histamine H2 receptors on chronic heart failure revealed by retrospective and prospective randomized studies","volume":"48","author":"Kim","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1742-7843.2007.00147.x","article-title":"Resident cardiac mast cells: are they the major culprit in the pathogenesis of cardiac hypertrophy?","volume":"102","author":"Balakumar","year":"2008","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.trsl.2015.12.012_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijcard.2012.07.023","article-title":"Takotsubo cardiomyopathy, mental stress and the Kounis syndrome","volume":"161","author":"Cheng","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ejheart.2006.05.011","article-title":"Tako-Tsubo-like syndrome during anaphylactic reaction","volume":"9","author":"Vultaggio","year":"2007","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.trsl.2015.12.012_bib43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.anndiagpath.2012.04.007","article-title":"Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases","volume":"17","author":"Ramalho","year":"2013","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.trsl.2015.12.012_bib44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/ATVBAHA.114.303570","article-title":"Mast cells as effectors in atherosclerosis","volume":"35","author":"Bot","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.trsl.2015.12.012_bib45","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/CIRCULATIONAHA.105.553735","article-title":"Histamine induces tissue factor expression","volume":"112","author":"Steffel","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.trsl.2015.12.012_bib46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijcard.2004.10.023","article-title":"Serum tryptase levels in acute coronary syndromes","volume":"104","author":"Kervinen","year":"2005","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib47","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.atherosclerosis.2004.09.008","article-title":"Mast cell tryptase: a new biomarker in patients with stable coronary artery disease","volume":"178","author":"Deliargyris","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.trsl.2015.12.012_bib48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tcm.2012.07.012","article-title":"Mast cell chymase and tryptase in abdominal aortic aneurysm formation","volume":"22","author":"Wang","year":"2012","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib49","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1161\/CIRCRESAHA.111.243758","article-title":"Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation","volume":"108","author":"Zhang","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib50","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2010.08.035","article-title":"Mast cell activation syndrome: proposed diagnostic criteria","volume":"126","author":"Akin","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib51","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2362.2007.01807.x","article-title":"Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria","volume":"37","author":"Valent","year":"2007","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.trsl.2015.12.012_bib52","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1756-8722-4-10","article-title":"Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options","volume":"4","author":"Molderings","year":"2011","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.trsl.2015.12.012_bib53","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jaci.2011.04.037","article-title":"Mast cell activation syndrome: a newly recognized disorder with systemic clinical manifestations","volume":"128","author":"Hamilton","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib54","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000328760","article-title":"Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal","volume":"157","author":"Valent","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib55","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.critrevonc.2014.09.001","article-title":"The genetic basis of mast cell activation disease\u2014looking through a glass darkly","volume":"93","author":"Molderings","year":"2015","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.trsl.2015.12.012_bib56","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1182\/blood-2004-07-2639","article-title":"Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen","volume":"105","author":"Kohno","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2015.12.012_bib57","doi-asserted-by":"crossref","first-page":"5342","DOI":"10.1182\/blood-2008-08-175190","article-title":"Identification of proapoptotic Bim as a tumor suppressor in neoplastic mast cells: role of KIT D816V and effects of various targeted drugs","volume":"114","author":"Aichberger","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.trsl.2015.12.012_bib58","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1038\/cddis.2010.20","article-title":"Pro-apoptotic Bax is the major and Bak an auxiliary effector in cytokine deprivation-induced mast cell apoptosis","volume":"1","author":"Karlberg","year":"2010","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.trsl.2015.12.012_bib59","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0145-2126(01)00038-8","article-title":"Diagnostic criteria and classification of mastocytosis: a consensus proposal","volume":"25","author":"Valent","year":"2001","journal-title":"Leuk Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib60","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00251-014-0768-3","article-title":"Evidence for contribution of epigenetic mechanisms in the pathogenesis of systemic mast cell activation disease","volume":"66","author":"Haenisch","year":"2014","journal-title":"Immunogenetics"},{"key":"10.1016\/j.trsl.2015.12.012_bib61","article-title":"Concurrent activating KIT mutations in systemic mastocytosis","author":"Lasho","year":"2015","journal-title":"Br J Haematol"},{"key":"10.1016\/j.trsl.2015.12.012_bib62","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/00365520701245744","article-title":"Multiple novel alterations in Kit tyrosine kinase in patients with gastrointestinally pronounced systemic mast cell activation disorder","volume":"42","author":"Molderings","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.trsl.2015.12.012_bib63","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00251-010-0474-8","article-title":"Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects","volume":"62","author":"Molderings","year":"2010","journal-title":"Immunogenetics"},{"key":"10.1016\/j.trsl.2015.12.012_bib64","doi-asserted-by":"crossref","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","article-title":"Case-control cohort study of patients' perceptions of disability in mastocytosis","volume":"3","author":"Hermine","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.12.012_bib65","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2567.2012.03627.x","article-title":"Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics","volume":"137","author":"Haenisch","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.trsl.2015.12.012_bib66","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/bjh.12916","article-title":"Epidemiology of systemic mastocytosis in Denmark","volume":"166","author":"Cohen","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.trsl.2015.12.012_bib67","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jaci.2012.10.015","article-title":"Prevalence of indolent systemic mastocytosis in a Dutch region","volume":"131","author":"van Doormaal","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib68","doi-asserted-by":"crossref","first-page":"e76241","DOI":"10.1371\/journal.pone.0076241","article-title":"Familial occurrence of systemic mast cell activation disease","volume":"8","author":"Molderings","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2015.12.012_bib69","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jaci.2010.02.019","article-title":"Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms","volume":"125","author":"Alvarez-Twose","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"3 suppl","key":"10.1016\/j.trsl.2015.12.012_bib70","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1111\/1523-1747.ep12468899","article-title":"Systemic mastocytosis: retrospective review of a decade's clinical experience at the Brigham and Women's Hospital","volume":"96","author":"Horan","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.trsl.2015.12.012_bib71","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijcard.2012.06.041","article-title":"Mast cell-related disorders presenting with Kounis syndrome","volume":"161","author":"Gonz\u00e1lez-de-Olano","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib72","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/j.1398-9995.2005.00592.x","article-title":"Systemic mastocytosis associated with recurrent paroxysmal atrial fibrillation","volume":"60","author":"Ricciardi","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.trsl.2015.12.012_bib73","first-page":"311","article-title":"Clinical variability in two cases of systemic mastocytosis","volume":"105","author":"Bazan-Socha","year":"2001","journal-title":"Pol Arch Med Wewn"},{"key":"10.1016\/j.trsl.2015.12.012_bib74","first-page":"1","article-title":"Systemic mastocytosis: management of an unusual case with histamine (H1 and H2) antagonists and cyclooxygenase inhibition","volume":"10","author":"Crawhall","year":"1987","journal-title":"Clin Invest Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib75","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.annemergmed.2005.02.002","article-title":"Shortness of breath, syncope, and cardiac arrest caused by systemic mastocytosis","volume":"45","author":"Rohr","year":"2005","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib76","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/01.HYP.0000158259.68614.40","article-title":"Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders","volume":"45","author":"Shibao","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2015.12.012_bib77","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s11739-013-1012-0","article-title":"Mastocytosis presenting as cardiac emergency","volume":"8","author":"Ridolo","year":"2013","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib78","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0005-2744(78)90089-X","article-title":"Isorenin, pseudorenin, cathepsin D and renin. A comparative enzymatic study of angiotensin-forming enzymes","volume":"522","author":"Hackenthal","year":"1978","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.trsl.2015.12.012_bib79","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/BF00173392","article-title":"Facilitatory presynaptic angiotensin receptors on the sympathetic nerves of the human saphenous vein and pulmonary artery. Potential involvement in \u03b2-adrenoceptor-mediated facilitation of noradrenaline release","volume":"338","author":"Molderings","year":"1988","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.trsl.2015.12.012_bib80","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.hrthm.2008.02.025","article-title":"The renin-angiotensin-aldosterone system (RAAS) and cardiac arrhythmias","volume":"5","author":"Iravanian","year":"2008","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.trsl.2015.12.012_bib81","first-page":"141","article-title":"The role of histamine in the cardiovascular system","volume":"14","author":"Cabani\u00e9","year":"1988","journal-title":"Drugs Exp Clin Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib82","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/01.RES.77.1.206","article-title":"Functional identification of histamine H3-receptors in the human heart","volume":"77","author":"Imamura","year":"1995","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2015.12.012_bib83","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1517\/13543784.9.11.2537","article-title":"Therapeutic potential of H3-receptor agonists in myocardial infarction","volume":"9","author":"Mackins","year":"2000","journal-title":"Exp Opin Invest Drugs"},{"key":"10.1016\/j.trsl.2015.12.012_bib84","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2465","article-title":"The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines","volume":"7","author":"Thurmond","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.trsl.2015.12.012_bib85","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0090-6980(84)90033-9","article-title":"Effects of intravenous infusions of prostaglandin D2 in man","volume":"28","author":"Heavey","year":"1984","journal-title":"Prostaglandins"},{"key":"10.1016\/j.trsl.2015.12.012_bib86","first-page":"1523","article-title":"Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options","volume":"139","author":"Molderings","year":"2014","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.trsl.2015.12.012_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.20028593","article-title":"Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine","volume":"120","author":"Bucchi","year":"2002","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib88","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2125.2005.02544.x","article-title":"Comparative effects of ivabradine, a selective heart rate-lowering agent, and propranolol on systemic and cardiac haemodynamics at rest and during exercise","volume":"61","author":"Joannides","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.trsl.2015.12.012_bib89","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00210-010-0565-y","article-title":"Ivabradine in patients with inappropriate sinus tachycardia","volume":"382","author":"Zellerhoff","year":"2010","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.trsl.2015.12.012_bib90","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1385\/CRIAI:31:2:131","article-title":"Regulation of mast cells by beta-agonists","volume":"31","author":"Peachell","year":"2006","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib91","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1440-1681.2006.04435.x","article-title":"Beta-adrenoceptor-mediated inhibition of mediator release from human peripheral blood-derived mast cells","volume":"33","author":"Wang","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib92","first-page":"621","article-title":"Diagnostics and therapy of systemic mastocytosis","volume":"58","author":"Alfter","year":"2007","journal-title":"Med Welt"},{"key":"10.1016\/j.trsl.2015.12.012_bib93","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jaci.2014.09.004","article-title":"Ramipril and metoprolol intake aggravate human and murine anaphylaxis: evidence for direct mast cell priming","volume":"135","author":"Nassiri","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib94","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00005792-198811000-00001","article-title":"Systemic mast cell disease. Analysis of 58 cases and literature review","volume":"67","author":"Travis","year":"1988","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.trsl.2015.12.012_bib95","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/014107680009300309","article-title":"Unexplained loss of consciousness: systemic mastocytosis","volume":"93","author":"Valabhji","year":"2000","journal-title":"J R Soc Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib96","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.prostaglandins.2009.01.001","article-title":"Survey of aspirin administration in systemic mastocytosis","volume":"88","author":"Butterfield","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.trsl.2015.12.012_bib97","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-2222.2008.03104.x","article-title":"Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis","volume":"39","author":"Ono","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.trsl.2015.12.012_bib98","first-page":"437","article-title":"Cardiovascular risk associated with celecoxib or etoricoxib: a meta-analysis of randomized controlled trials which adopted comparison with placebo or naproxen","volume":"62","author":"De Vecchis","year":"2014","journal-title":"Minerva Cardioangiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib99","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/j.jaci.2007.03.032","article-title":"Omalizumab for the treatment of unprovoked anaphylaxis in patients with systemic mastocytosis","volume":"119","author":"Carter","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib100","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.anai.2010.04.011","article-title":"Omalizumab monotherapy for bee sting and unprovoked \u201canaphylaxis\u201d in a patient with systemic mastocytosis and undetectable specific IgE","volume":"104","author":"Kontou-Fili","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib101","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.anai.2012.02.021","article-title":"Prevention of anaphylaxis related to mast cell activation syndrome with omalizumab","volume":"108","author":"Bell","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib102","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2340\/00015555-1687","article-title":"Omalizumab induced remission of idiopathic anaphylaxis in a patient suffering from indolent systemic mastocytosis","volume":"94","author":"Kibsgaard","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.trsl.2015.12.012_bib103","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.anai.2014.05.001","article-title":"Omalizumab effectively prevents recurrent refractory anaphylaxis in a patient with monoclonal mast cell activation syndrome","volume":"113","author":"Jagdis","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3 suppl","key":"10.1016\/j.trsl.2015.12.012_bib104","doi-asserted-by":"crossref","first-page":"19S","DOI":"10.1111\/1523-1747.ep12468945","article-title":"Biochemical diagnosis of systemic mast cell disorders","volume":"96","author":"Roberts","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.trsl.2015.12.012_bib105","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaip.2013.09.004","article-title":"The mastocytosis society survey on mast cell disorders: patient experiences and perceptions","volume":"2","author":"Jennings","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.trsl.2015.12.012_bib106","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJM198012113032405","article-title":"Increased production of prostaglandin D2 in patients with systemic mastocytosis","volume":"303","author":"Roberts","year":"1980","journal-title":"N Engl J Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib107","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s12967-014-0213-2","article-title":"Prostaglandin D2-supplemented \u201cfunctional eicosanoid testing and typing\u201d assay with peripheral blood leukocytes as a new tool in the diagnosis of systemic mast cell activation disease: an explorative diagnostic study","volume":"12","author":"Sch\u00e4fer","year":"2014","journal-title":"J Transl Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib108","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0025-6196(11)63618-5","article-title":"Systemic mast cell disease associated with the hypereosinophilic syndrome","volume":"73","author":"McElroy","year":"1998","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.trsl.2015.12.012_bib109","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s002920050215","article-title":"Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma","volume":"18","author":"Sotlar","year":"1997","journal-title":"Pathologe"},{"issue":"suppl 2","key":"10.1016\/j.trsl.2015.12.012_bib110","article-title":"Anaphylaxis in a patient with mastocytosis [abstract]","volume":"7","author":"Clarke","year":"2012","journal-title":"J Hospital Med"},{"key":"10.1016\/j.trsl.2015.12.012_bib111","unstructured":"Kolck UW. Investigations on the pathogenesis of the systemic mast cell activation syndrome and its impact on heart function. Bonn: University, medical thesis, 2009; [in German]; URN:nbn:de:hbz:5N-19064. Available at: http:\/\/hss.ulb.uni-bonn.de\/2009\/1906\/1906.htm. Accessed December 2015."},{"key":"10.1016\/j.trsl.2015.12.012_bib112","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jacc.2006.12.018","article-title":"Cardiac mast cells: implications for heart failure","volume":"49","author":"Kolck","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.trsl.2015.12.012_bib113","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.echo.2008.11.023","article-title":"Recommendations for the evaluation of left ventricular diastolic function by echocardiography","volume":"22","author":"Nagueh","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.trsl.2015.12.012_bib114","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/j.transproceed.2007.06.047","article-title":"Correlation between mast cell density and myocardial fibrosis in congestive heart failure patients","volume":"39","author":"Batlle","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.trsl.2015.12.012_bib115","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/HYPERTENSIONAHA.108.123158","article-title":"Cardiac mast cells mediate left ventricular fibrosis in the hypertensive rat heart","volume":"53","author":"Levick","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.trsl.2015.12.012_bib116","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/eurheartj\/ehs104","volume":"33","author":"McMurray","year":"2012","journal-title":"Eur Heart J"},{"issue":"suppl 2","key":"10.1016\/j.trsl.2015.12.012_bib117","first-page":"AB188","article-title":"Systemic mastocytosis presenting as Prinzmetal (variant) angina","volume":"127","author":"Ward","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2015.12.012_bib118","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11739-012-0754-4","article-title":"Kounis syndrome (allergic acute coronary syndrome): different views in allergologic and cardiologic literature","volume":"7","author":"Fassio","year":"2012","journal-title":"Intern Emerg Med"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524415004545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524415004545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T12:04:54Z","timestamp":1718280294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524415004545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":118,"alternative-id":["S1931524415004545"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2015.12.012","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular symptoms in patients with systemic mast cell activation disease","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2015.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}