{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:17:47Z","timestamp":1758820667685,"version":"3.40.5"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","translationalres.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.trsl.2016.03.003","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T21:46:35Z","timestamp":1457559995000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A new era for an old cell: heightened appreciation of mast cell disease emerges"],"prefix":"10.1016","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-4244","authenticated-orcid":false,"given":"Lawrence B.","family":"Afrin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2016.03.003_bib1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1469-185X.2009.00105.x","article-title":"The mast cell: an evolutionary perspective","volume":"85","author":"Crivellato","year":"2010","journal-title":"Biol Rev Camb Philos Soc"},{"key":"10.1016\/j.trsl.2016.03.003_bib2","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2010.08.035","article-title":"Mast cell activation syndrome: proposed diagnostic criteria","volume":"126","author":"Akin","year":"2010","journal-title":"J Allergy Clin Immunol"},{"year":"2016","series-title":"\u201cMast Cells\u201d in COPE: Cytokines and Cells Online Pathfinder Encyclopaedia","author":"Ibelgaufts","key":"10.1016\/j.trsl.2016.03.003_bib3"},{"issue":"6 Suppl 1","key":"10.1016\/j.trsl.2016.03.003_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0090-4295(01)01129-3","article-title":"Mast cell involvement in interstitial cystitis: a review of human and experimental evidence","volume":"57","author":"Theoharides","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.trsl.2016.03.003_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11882-005-0086-9","article-title":"The re-emergence of the mast cell as a pivotal cell in asthma pathogenesis","volume":"5","author":"Brightling","year":"2005","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.trsl.2016.03.003_bib6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00535-011-0379-9","article-title":"Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review","volume":"46","author":"Ford","year":"2011","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.trsl.2016.03.003_bib7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.msard.2015.11.005","article-title":"Important role of mast cells in multiple sclerosis","volume":"5","author":"Conti","year":"2016","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.trsl.2016.03.003_bib8","doi-asserted-by":"crossref","first-page":"E1677","DOI":"10.1210\/jc.2012-1532","article-title":"Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes","volume":"97","author":"Divoux","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.trsl.2016.03.003_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fimmu.2012.00007","article-title":"Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans","volume":"3","author":"Shi","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.trsl.2016.03.003_bib10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbadis.2010.12.017","article-title":"Mast cell activation and autism","volume":"1822","author":"Theoharides","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.trsl.2016.03.003_bib11","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.bbi.2015.07.002","article-title":"Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases","volume":"50","author":"Afrin","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.trsl.2016.03.003_bib12","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.0906-6705.2003.0109a.x","article-title":"What is the physiological function of mast cells?","volume":"12","author":"Maurer","year":"2003","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.trsl.2016.03.003_bib13","first-page":"146","article-title":"The presentation, diagnosis and treatment of mast cell activation syndrome: review article","volume":"3","author":"Afrin","year":"2014","journal-title":"Curr Allergy Clin Immunol"},{"key":"10.1016\/j.trsl.2016.03.003_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.phr.2004.04.005","article-title":"The growing burden of chronic disease in America","volume":"119","author":"Anderson","year":"2004","journal-title":"Public Health Rep"},{"key":"10.1016\/j.trsl.2016.03.003_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","article-title":"Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study","volume":"380","author":"Barnett","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.trsl.2016.03.003_bib16","doi-asserted-by":"crossref","first-page":"e76241","DOI":"10.1371\/journal.pone.0076241","article-title":"Familial occurrence of systemic mast cell activation disease","volume":"8","author":"Molderings","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2016.03.003_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.trsl.2016.01.003","article-title":"Mast cell activation disease and the modern epidemic of chronic inflammatory disease","volume":"174","author":"Afrin","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.003_bib18","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.trsl.2016.02.011","article-title":"Emerging concepts: mast cell involvement in allergic diseases","volume":"174","author":"Modena","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.003_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.trsl.2016.01.005","article-title":"Mast cells and their activation in lung disease","volume":"174","author":"Virk","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.003_bib20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.trsl.2015.09.009","article-title":"Interaction between allergic asthma and atherosclerosis","volume":"174","author":"Liu","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.003_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.trsl.2015.12.012","article-title":"Cardiovascular symptoms in patients with systemic mast cell activation disease","volume":"174","author":"Kolck","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.003_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.trsl.2016.03.013","article-title":"Neuropsychiatric features in mastocytosis","author":"Georgin-Lavialle","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.003_bib23","doi-asserted-by":"crossref","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","article-title":"Case-control cohort study of patients' perceptions of disability in mastocytosis","volume":"3","author":"Hermine","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2016.03.003_bib24","doi-asserted-by":"crossref","first-page":"e39468","DOI":"10.1371\/journal.pone.0039468","article-title":"Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression","volume":"7","author":"Moura","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.trsl.2016.03.003_bib25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.trsl.2016.01.001","article-title":"Transgenerational transmission of systemic mast cell activation disease\u2014genetic and epigenetic features","volume":"174","author":"Molderings","year":"2016","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.003_bib26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.critrevonc.2014.09.001","article-title":"The genetic basis of mast cell activation disease\u2014looking through a glass darkly","volume":"93","author":"Molderings","year":"2015","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524416000724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524416000724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T08:30:36Z","timestamp":1536913836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524416000724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":26,"alternative-id":["S1931524416000724"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2016.03.003","relation":{},"ISSN":["1931-5244"],"issn-type":[{"type":"print","value":"1931-5244"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new era for an old cell: heightened appreciation of mast cell disease emerges","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2016.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}