{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:48:53Z","timestamp":1788922133618,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","translationalres.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.trsl.2016.03.015","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:17:40Z","timestamp":1459297060000},"page":"140-160.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["The role of acid-base imbalance in statin-induced myotoxicity"],"prefix":"10.1016","volume":"174","author":[{"given":"Dhiaa A.","family":"Taha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8776-0085","authenticated-orcid":false,"given":"Cornelia H.","family":"De Moor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Bong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj D.","family":"Gandhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Wei","family":"Hoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3136-0933","authenticated-orcid":false,"given":"Pavel","family":"Gershkovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2016.03.015_bib1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1007\/s11606-008-0636-7","article-title":"Prevalence of musculoskeletal pain and statin use","volume":"23","author":"Buettner","year":"2008","journal-title":"J Gen Intern Med"},{"key":"10.1016\/j.trsl.2016.03.015_bib2","first-page":"1","article-title":"Prescription cholesterol-lowering medication use in adults aged 40 and over: United States, 2003\u20132012","volume":"177","author":"Gu","year":"2014","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.trsl.2016.03.015_bib3","doi-asserted-by":"crossref","first-page":"d4350","DOI":"10.1136\/bmj.d4350","article-title":"Statin prescriptions in UK now total a million each week","volume":"343","author":"Trusler","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.trsl.2016.03.015_bib4","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1016\/j.jacc.2013.11.002","article-title":"2013 ACC\/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines","volume":"63","author":"Stone","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.trsl.2016.03.015_bib5","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.jacc.2013.11.005","article-title":"2013 ACC\/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology\/American Heart Association task force on practice guidelines","volume":"63","author":"Goff","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.trsl.2016.03.015_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1001\/jama.2013.284657","article-title":"More than a billion people taking statins?: potential implications of the new cardiovascular guidelines","volume":"311","author":"Ioannidis","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.trsl.2016.03.015_bib7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2165\/00002018-200225090-00004","article-title":"Effects of HMG-CoA reductase inhibitors on skeletal muscle","volume":"25","author":"Evans","year":"2002","journal-title":"Drug Saf"},{"key":"10.1016\/j.trsl.2016.03.015_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ejps.2007.12.009","article-title":"Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in\u00a0vitro","volume":"33","author":"Skottheim","year":"2008","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.trsl.2016.03.015_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0165-6147(97)01147-4","article-title":"Hydrophilicity\/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors","volume":"19","author":"Hamelin","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.trsl.2016.03.015_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.trsl.2014.01.013","article-title":"Translational insight into statin-induced muscle toxicity: from cell culture to clinical studies","volume":"164","author":"Taha","year":"2014","journal-title":"Transl Res"},{"key":"10.1016\/j.trsl.2016.03.015_bib11","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neuropharm.2011.01.003","article-title":"Acute lipophilicity-dependent effect of intravascular simvastatin in the early phase of focal cerebral ischemia","volume":"60","author":"Beretta","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.trsl.2016.03.015_bib12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.clpt.2006.02.014","article-title":"Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy","volume":"79","author":"Hermann","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.trsl.2016.03.015_bib13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2015.08.002","article-title":"Statin-induced myopathy is associated with mitochondrial complex III inhibition","volume":"22","author":"Schirris","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.trsl.2016.03.015_bib14","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s11095-005-6037-2","article-title":"Interconversion pharmacokinetics of simvastatin and its hydroxy acid in dogs: effects of gemfibrozil","volume":"22","author":"Prueksaritanont","year":"2005","journal-title":"Pharm Res"},{"key":"10.1016\/j.trsl.2016.03.015_bib15","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1023\/A:1018923325359","article-title":"The interconversion kinetics, equilibrium, and solubilities of the lactone and hydroxyacid forms of the HMG-CoA reductase inhibitor, CI-981","volume":"10","author":"Kearney","year":"1993","journal-title":"Pharm Res"},{"key":"10.1016\/j.trsl.2016.03.015_bib16","first-page":"1251","article-title":"\u03b2-Oxidation of simvastatin in mouse liver preparations","volume":"29","author":"Prueksaritanont","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.trsl.2016.03.015_bib17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1124\/dmd.30.5.505","article-title":"Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization","volume":"30","author":"Prueksaritanont","year":"2002","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.trsl.2016.03.015_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5152\/jaem.2014.27880","article-title":"Acid-base disorders in the emergency department: incidence, etiologies and outcomes","volume":"13","author":"K\u00f6se","year":"2014","journal-title":"JAEM"},{"key":"10.1016\/j.trsl.2016.03.015_bib19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/01.NPR.0000469255.98119.82","article-title":"Identifying acid-base and electrolyte imbalances","volume":"40","author":"Gooch","year":"2015","journal-title":"Nurse Pract"},{"key":"10.1016\/j.trsl.2016.03.015_bib20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/0972-5229.60175","article-title":"Extreme metabolic alkalosis in intensive care","volume":"13","author":"Tripathy","year":"2009","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.trsl.2016.03.015_bib21","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s00101-009-1615-z","article-title":"Successful treatment of extreme metabolic acidosis and profound hypothermia","volume":"58","author":"Neuenfeldt","year":"2009","journal-title":"Der Anaesthesist"},{"key":"10.1016\/j.trsl.2016.03.015_bib22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/003693308603100408","article-title":"Survival from extreme lactic and keto-acidosis in diabetes mellitus","volume":"31","author":"Wathen","year":"1986","journal-title":"Scott Med J"},{"key":"10.1016\/j.trsl.2016.03.015_bib23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/pgmj.65.763.321","article-title":"Severe, self-limiting lactic acidosis and rhabdomyolysis accompanying convulsions","volume":"65","author":"Winocour","year":"1989","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.trsl.2016.03.015_bib24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1399-6576.1987.tb02620.x","article-title":"Extreme metabolic acidosis-case report","volume":"31","author":"Sjogren","year":"1987","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.trsl.2016.03.015_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bcr-2012-008315","article-title":"Survival from profound metabolic acidosis due to hypovolaemic shock. A world record?","author":"Di Rollo","year":"2013","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.trsl.2016.03.015_bib26","first-page":"1866","article-title":"Extreme metabolic acidosis after presumed intoxication with ethylene glycol","volume":"171","author":"Lundgaard","year":"2009","journal-title":"Ugeskr Laeger"},{"key":"10.1016\/j.trsl.2016.03.015_bib27","first-page":"518","article-title":"Is it possible to survive metabolic acidosis with pH measure below 6.8? A study of two cases of inedible alcohol intoxication","volume":"68","author":"Kostek","year":"2010","journal-title":"Przegl Lek"},{"key":"10.1016\/j.trsl.2016.03.015_bib28","first-page":"530","article-title":"Extremely severe metabolic acidosis and multi-organ complications in ethylene glycol intoxication: a case study","volume":"68","author":"Kujawa","year":"2010","journal-title":"Przegl Lek"},{"key":"10.1016\/j.trsl.2016.03.015_bib29","first-page":"332","article-title":"Effect of medium pH on the cytotoxicity of hydrophilic statins","volume":"10","author":"Kobayashi","year":"2007","journal-title":"J Pharm Pharm Sci"},{"key":"10.1016\/j.trsl.2016.03.015_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijpharm.2007.04.010","article-title":"Preventive effects of bicarbonate on cerivastatin-induced apoptosis","volume":"341","author":"Kobayashi","year":"2007","journal-title":"Int J Pharm"},{"key":"10.1016\/j.trsl.2016.03.015_bib31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1248\/yakushi.132.609","article-title":"Effects of acidification and alkalinization agents on statins-induced muscle toxicity","volume":"132","author":"Kobayashi","year":"2011","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.trsl.2016.03.015_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18433\/J33018","article-title":"Bicarbonate supplementation as a preventive way in statins-induced muscle damage","volume":"11","author":"Kobayashi","year":"2008","journal-title":"J Pharm Pharm Sci"},{"key":"10.1016\/j.trsl.2016.03.015_bib33","series-title":"Neuromuscular Imaging","first-page":"335","article-title":"Toxic and drug-induced myopathies","author":"Peters","year":"2013"},{"key":"10.1016\/j.trsl.2016.03.015_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jpba.2007.12.002","article-title":"pH adjustment of human blood plasma prior to bioanalytical sample preparation","volume":"47","author":"Hendriks","year":"2008","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.trsl.2016.03.015_bib35","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/01.STR.19.3.385","article-title":"Glial swelling during extracellular acidosis in\u00a0vitro","volume":"19","author":"Kempski","year":"1988","journal-title":"Stroke"},{"key":"10.1016\/j.trsl.2016.03.015_bib36","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.biomaterials.2011.10.048","article-title":"Control of cell attachment on pH-responsive chitosan surface by precise adjustment of medium pH","volume":"33","author":"Chen","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.trsl.2016.03.015_bib37","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12033-013-9712-2","article-title":"Assessment of reference genes for real-time quantitative PCR gene expression normalization during C2C12 and H9C2 skeletal muscle differentiation","volume":"56","author":"Masilamani","year":"2014","journal-title":"Mol Biotechnol"},{"key":"10.1016\/j.trsl.2016.03.015_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1073\/pnas.1009830108","article-title":"Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition","volume":"108","author":"Yang","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2016.03.015_bib39","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.trsl.2016.03.015_bib40","doi-asserted-by":"crossref","first-page":"E109","DOI":"10.1208\/aapsj0901011","article-title":"Key elements of bioanalytical method validation for small molecules","volume":"9","author":"Bansal","year":"2007","journal-title":"AAPS J"},{"key":"10.1016\/j.trsl.2016.03.015_bib41","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0378-4347(96)00088-6","article-title":"Validation of liquid chromatographic and gas chromatographic methods Applications to pharmacokinetics","volume":"686","author":"Bressolle","year":"1996","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1016\/j.trsl.2016.03.015_bib42","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0378-4347(96)00297-6","article-title":"Validation of chromatographic methods in biomedical analysis viewpoint and discussion","volume":"689","author":"Causon","year":"1997","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1016\/j.trsl.2016.03.015_bib43","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0731-7085(95)01644-9","article-title":"A strategy for validation of bioanalytical methods","volume":"14","author":"Braggio","year":"1996","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.trsl.2016.03.015_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.talanta.2011.11.055","article-title":"Development and validation of UHPLC-ESI-MS\/MS method for the determination of selected cardiovascular drugs, polyphenols and their metabolites in human urine","volume":"89","author":"Magiera","year":"2012","journal-title":"Talanta"},{"key":"10.1016\/j.trsl.2016.03.015_bib45","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/bmc.1690","article-title":"Simultaneous determination of simvastatin, lovastatin and niacin in human plasma by LC MS\/MS and its application to a human pharmacokinetic study","volume":"26","author":"Rao Pilli","year":"2012","journal-title":"Biomed Chromatogr"},{"key":"10.1016\/j.trsl.2016.03.015_bib46","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/bjp.2008.192","article-title":"Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres","volume":"154","author":"Sakamoto","year":"2008","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.trsl.2016.03.015_bib47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/dmd.113.054783","article-title":"Utility of Oatp1a\/1b-knockout and OATP1B1\/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein","volume":"42","author":"Higgins","year":"2014","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.trsl.2016.03.015_bib48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/CIRCRESAHA.109.203596","article-title":"Human skeletal muscle drug transporters determine local exposure and toxicity of statins","volume":"106","author":"Knauer","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.trsl.2016.03.015_bib49","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.lfs.2008.02.019","article-title":"Association between risk of myopathy and cholesterol-lowering effect: a comparison of all statins","volume":"82","author":"Kobayashi","year":"2008","journal-title":"Life Sci"},{"key":"10.1016\/j.trsl.2016.03.015_bib50","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/j.bcp.2003.08.011","article-title":"Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors\u00a0in human myocytes","volume":"66","author":"Nishimoto","year":"2003","journal-title":"Biochem pharmacol"},{"key":"10.1016\/j.trsl.2016.03.015_bib51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/taap.1995.1058","article-title":"In\u00a0vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes","volume":"131","author":"Masters","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.trsl.2016.03.015_bib52","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s00018-006-6235-z","article-title":"Toxicity of statins on rat skeletal muscle mitochondria","volume":"63","author":"Kaufmann","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.trsl.2016.03.015_bib53","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.bbrc.2005.10.108","article-title":"Simvastatin induces impairment in skeletal muscle while heart is protected","volume":"338","author":"Sirvent","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2016.03.015_bib54","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.3390\/toxins6092612","article-title":"Uremic toxins enhance statin-induced cytotoxicity in differentiated human rhabdomyosarcoma cells","volume":"6","author":"Uchiyama","year":"2014","journal-title":"Toxins"},{"key":"10.1016\/j.trsl.2016.03.015_bib55","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2165\/00003088-200847070-00003","article-title":"Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin","volume":"47","author":"Neuvonen","year":"2008","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.trsl.2016.03.015_bib56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00280-006-0340-4","article-title":"Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin","volume":"60","author":"Prijovich","year":"2007","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.trsl.2016.03.015_bib57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/abio.1993.1325","article-title":"Preferential binding of the carboxylate form of camptothecin by human serum albumin","volume":"212","author":"Burke","year":"1993","journal-title":"Anal Biochem"},{"key":"10.1016\/j.trsl.2016.03.015_bib58","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0090-9556(24)15082-9","article-title":"Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters","volume":"28","author":"Billecke","year":"2000","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.trsl.2016.03.015_bib59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.apsb.2011.08.001","article-title":"Enzyme-mediated hydrolytic activation of prodrugs","volume":"1","author":"Yang","year":"2011","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"10.1016\/j.trsl.2016.03.015_bib60","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0090-9556(25)08543-5","article-title":"In\u00a0vitro and in\u00a0vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase","volume":"18","author":"Vickers","year":"1990","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.trsl.2016.03.015_bib61","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1083\/jcb.132.4.657","article-title":"Myogenin expression, cell cycle withdrawal, and phenotypic differentiation are temporally separable events that precede cell fusion upon myogenesis","volume":"132","author":"Andres","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.trsl.2016.03.015_bib62","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2165\/11319380-000000000-00000","article-title":"Risk factors and drug interactions predisposing to statin-induced myopathy: implications for risk assessment, prevention and treatment","volume":"33","author":"Chatzizisis","year":"2010","journal-title":"Drug Saf"},{"key":"10.1016\/j.trsl.2016.03.015_bib63","first-page":"961","article-title":"Influence of acid-base balance on efficacy and toxicity of drugs","volume":"58","author":"Milne","year":"1965","journal-title":"Proc R Soc Med"},{"key":"10.1016\/j.trsl.2016.03.015_bib64","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1021\/mp200103h","article-title":"pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1","volume":"8","author":"Varma","year":"2011","journal-title":"Mol Pharm"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524416001079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524416001079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T01:07:52Z","timestamp":1748826472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524416001079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":64,"alternative-id":["S1931524416001079"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2016.03.015","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of acid-base imbalance in statin-induced myotoxicity","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2016.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}