{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:14:21Z","timestamp":1788984861880,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"am","delay-in-days":328,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","translationalres.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Translational Research"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.trsl.2020.02.003","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T08:43:30Z","timestamp":1581497010000},"page":"13-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-0902","authenticated-orcid":false,"given":"Shang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7322-3390","authenticated-orcid":false,"given":"Yanzhi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.trsl.2020.02.003_bib0001","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"key":"10.1016\/j.trsl.2020.02.003_bib0002","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/138161212799040457","article-title":"Phenotypes and enviromental factors: their influence in PCOS","volume":"18","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.trsl.2020.02.003_bib0003","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.fertnstert.2016.05.011","article-title":"Environmental determinants of polycystic ovary syndrome","volume":"106","author":"Merkin","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.trsl.2020.02.003_bib0004","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11427-019-1572-7","article-title":"Recent advances in mammalian reproductive biology","volume":"63","author":"Wen","year":"2020","journal-title":"Sci China Life Sci"},{"key":"10.1016\/j.trsl.2020.02.003_bib0005","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1080\/09513590.2017.1395841","article-title":"Treatment strategies for women with polycystic ovary syndrome","volume":"34","author":"Jin","year":"2018","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0006","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1111\/j.1365-2265.2008.03305.x","article-title":"Exercise training improves autonomic function and inflammatory pattern in women with polycystic ovary syndrome (PCOS)","volume":"69","author":"Giallauria","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.trsl.2020.02.003_bib0007","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/REP-14-0499","article-title":"Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause","volume":"150","author":"de Melo","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.trsl.2020.02.003_bib0008","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1196\/annals.1365.014","article-title":"Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age","volume":"1092","author":"Pasquali","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.trsl.2020.02.003_bib0009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ng1504","article-title":"System-level identification of transcriptional circuits underlying mammalian circadian clocks","volume":"37","author":"Ueda","year":"2005","journal-title":"Nat Genet"},{"key":"10.1016\/j.trsl.2020.02.003_bib0010","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/hep.26992","article-title":"CLOCK\/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1","volume":"59","author":"Zhou","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.trsl.2020.02.003_bib0011","doi-asserted-by":"crossref","first-page":"558","DOI":"10.3389\/fneur.2017.00558","article-title":"Circadian and metabolic effects of light: implications in weight homeostasis and health","volume":"8","author":"Plano","year":"2017","journal-title":"Front Neurol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0012","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1600-079X.2007.00473.x","article-title":"The dark side of light at night: physiological, epidemiological, and ecological consequences","volume":"43","author":"Navara","year":"2007","journal-title":"J Pineal Res"},{"key":"10.1016\/j.trsl.2020.02.003_bib0013","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature04368","article-title":"Constant darkness is a circadian metabolic signal in mammals","volume":"439","author":"Zhang","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.trsl.2020.02.003_bib0014","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1210\/en.2018-00691","article-title":"Integration of circadian and metabolic control of reproductive function","volume":"159","author":"Evans","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.trsl.2020.02.003_bib0015","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1210\/jc.2018-02385","article-title":"Morning circadian misalignment is associated with insulin resistance in girls with obesity and polycystic ovarian syndrome","volume":"104","author":"Simon","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.trsl.2020.02.003_bib0016","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humrep\/des463","article-title":"Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp","volume":"28","author":"Stepto","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.trsl.2020.02.003_bib0017","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","article-title":"Adverse metabolic and cardiovascular consequences of circadian misalignment","volume":"106","author":"Scheer","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2020.02.003_bib0018","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.2337\/db09-0699","article-title":"Sleep restriction for 1 week reduces insulin sensitivity in healthy men","volume":"59","author":"Buxton","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.trsl.2020.02.003_bib0019","doi-asserted-by":"crossref","first-page":"855","DOI":"10.18632\/aging.100092","article-title":"Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats","volume":"1","author":"Vinogradova","year":"2009","journal-title":"Aging"},{"key":"10.1016\/j.trsl.2020.02.003_bib0020","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.trsl.2020.02.003_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/943694","article-title":"Manifestation of hyperandrogenism in the continuous light exposure-induced PCOS rat model","volume":"2015","author":"Kang","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.trsl.2020.02.003_bib0022","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2265.1993.tb01769.x","article-title":"Circadian variation in serum free and non-SHBG-bound testosterone in normal men: measurements, and simulation using a mass action model","volume":"39","author":"Cooke","year":"1993","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0023","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.sleep.2015.06.011","article-title":"Sleep interruption associated with house staff work schedules alters circadian gene expression","volume":"16","author":"Fang","year":"2015","journal-title":"Sleep Med"},{"key":"10.1016\/j.trsl.2020.02.003_bib0024","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.cr.7290234","article-title":"Apoptosis in granulosa cells during follicular atresia: relationship with steroids and insulin-like growth factors","volume":"14","author":"Yu","year":"2004","journal-title":"Cell Res"},{"key":"10.1016\/j.trsl.2020.02.003_bib0025","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1177\/1933719114549852","article-title":"High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1","volume":"22","author":"Ni","year":"2015","journal-title":"Reprod Sci"},{"key":"10.1016\/j.trsl.2020.02.003_bib0026","doi-asserted-by":"crossref","first-page":"64","DOI":"10.14715\/cmb\/2017.63.10.10","article-title":"Hyperandrogenism stimulates inflammation and promote apoptosis of cumulus cells","volume":"63","author":"Xu","year":"2017","journal-title":"Cell Mol Biol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0027","doi-asserted-by":"crossref","first-page":"9563","DOI":"10.1002\/jcp.26859","article-title":"BMAL1 and CLOCK proteins in regulating UVB-induced apoptosis and DNA damage responses in human keratinocytes","volume":"233","author":"Sun","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0028","first-page":"2668","article-title":"Effect of Period 2 on the proliferation, apoptosis and migration of osteosarcoma cells, and the corresponding mechanisms","volume":"16","author":"Qin","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.trsl.2020.02.003_bib0029","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1007\/s00394-017-1482-3","article-title":"Chronic treatment with prebiotics, probiotics and synbiotics attenuated cardiac dysfunction by improving cardiac mitochondrial dysfunction in male obese insulin-resistant rats","volume":"57","author":"Tunapong","year":"2018","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.trsl.2020.02.003_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.2912","article-title":"Comparative evaluation of probiotics effects on plasma glucose, lipid, and insulin levels in streptozotocin-induced diabetic rats","volume":"33","author":"Memarrast","year":"2017","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.trsl.2020.02.003_bib0031","doi-asserted-by":"crossref","first-page":"e12506","DOI":"10.1111\/jpi.12506","article-title":"Melatonin modulates dysregulated circadian clocks in mice with diethylnitrosamine-induced hepatocellular carcinoma","volume":"65","author":"Sanchez","year":"2018","journal-title":"J Pineal Res"},{"key":"10.1016\/j.trsl.2020.02.003_bib0032","doi-asserted-by":"crossref","first-page":"E1047","DOI":"10.1152\/ajpendo.00361.2004","article-title":"Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling","volume":"288","author":"Corbould","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.trsl.2020.02.003_bib0033","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biochi.2004.10.019","article-title":"Positive and negative regulation of insulin signaling through IRS-1 phosphorylation","volume":"87","author":"Gual","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.trsl.2020.02.003_bib0034","doi-asserted-by":"crossref","first-page":"E392","DOI":"10.1152\/ajpendo.2001.281.2.E392","article-title":"Defects in insulin receptor signaling in vivo in the polycystic ovary syndrome (PCOS)","volume":"281","author":"Dunaif","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.trsl.2020.02.003_bib0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mce.2011.08.008","article-title":"Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice","volume":"352","author":"De Gendt","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0036","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.2337\/db11-1136","article-title":"Deletion of the androgen receptor in adipose tissue in male mice elevates retinol binding protein 4 and reveals independent effects on visceral fat mass and on glucose homeostasis","volume":"61","author":"McInnes","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.trsl.2020.02.003_bib0037","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.1195027","article-title":"Circadian integration of metabolism and energetics","volume":"330","author":"Bass","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.trsl.2020.02.003_bib0038","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.180147","article-title":"Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression","volume":"8","author":"Sefried","year":"2018","journal-title":"Open Biol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0039","doi-asserted-by":"crossref","first-page":"50754","DOI":"10.1074\/jbc.M408388200","article-title":"The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells","volume":"279","author":"Revollo","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.trsl.2020.02.003_bib0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bbrc.2018.04.095","article-title":"Light exposure influences the diurnal oscillation of gut microbiota in mice","volume":"501","author":"Wu","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.trsl.2020.02.003_bib0041","doi-asserted-by":"crossref","first-page":"T139","DOI":"10.1530\/JME-18-0016","article-title":"Role of IGF-binding proteins in regulating IGF responses to changes in metabolism","volume":"61","author":"Clemmons","year":"2018","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0042","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/00001703-199206000-00006","article-title":"Hyperandrogenism: new insights into etiology, diagnosis, and therapy","volume":"4","author":"Barbieri","year":"1992","journal-title":"Curr Opin Obstet Gynecol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0043","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.mce.2016.08.041","article-title":"Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro","volume":"437","author":"Laurent","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0044","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.trsl.2020.02.003_bib0045","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(01)00610-9","article-title":"Posttranslational mechanisms regulate the mammalian circadian clock","volume":"107","author":"Lee","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.trsl.2020.02.003_bib0046","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3109\/09513590.2012.760195","article-title":"The role of cytokines in polycystic ovarian syndrome","volume":"29","author":"Ebejer","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0047","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1210\/jcem-67-3-460","article-title":"Inhibition of sex hormone-binding globulin production in the human hepatoma (HepG2) cell line by insulin and prolactin","volume":"67","author":"Plymate","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.trsl.2020.02.003_bib0048","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.tem.2015.05.001","article-title":"Novel insights in SHBG regulation and clinical implications","volume":"26","author":"Simo","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.trsl.2020.02.003_bib0049","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1210\/en.2012-2066","article-title":"Excess androgen during puberty disrupts circadian organization in female rats","volume":"154","author":"Sellix","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.trsl.2020.02.003_bib0050","doi-asserted-by":"crossref","first-page":"T123","DOI":"10.1530\/ERC-16-0366","article-title":"Women in cancer thematic review: circadian rhythmicity and the influence of \u2018clock' genes on prostate cancer","volume":"23","author":"Kiss","year":"2016","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.trsl.2020.02.003_bib0051","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tem.2015.11.007","article-title":"Daily eating patterns and their impact on health and disease","volume":"27","author":"Zarrinpar","year":"2016","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.trsl.2020.02.003_bib0052","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3389\/fmicb.2016.00345","article-title":"Gut microbiota: the brain peacekeeper","volume":"7","author":"Mu","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.trsl.2020.02.003_bib0053","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tem.2019.08.013","article-title":"Intersection of the gut microbiome and circadian rhythms in metabolism","volume":"31","author":"Frazier","year":"2020","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.trsl.2020.02.003_bib0054","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1699-0463.1997.tb05066.x","article-title":"Prevention of onset in an insulin-dependent diabetes mellitus model, NOD mice, by oral feeding of Lactobacillus casei","volume":"105","author":"Matsuzaki","year":"1997","journal-title":"APMIS"},{"key":"10.1016\/j.trsl.2020.02.003_bib0055","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1271\/bbb.67.1421","article-title":"Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats","volume":"67","author":"Tabuchi","year":"2003","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.trsl.2020.02.003_bib0056","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.trsl.2020.02.003_bib0057","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1001\/jama.2013.2710","article-title":"Melatonin secretion and the incidence of type 2 diabetes","volume":"309","author":"McMullan","year":"2013","journal-title":"Jama"},{"key":"10.1016\/j.trsl.2020.02.003_bib0058","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1034\/j.1600-079X.2003.00083.x","article-title":"Effect of pinealectomy on plasma levels of insulin and leptin and on hepatic lipids in type 2 diabetic rats","volume":"35","author":"Nishida","year":"2003","journal-title":"J Pineal Res"},{"key":"10.1016\/j.trsl.2020.02.003_bib0059","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bj.2015.09.003","article-title":"Effects of long-term light, darkness and oral administration of melatonin on serum levels of melatonin","volume":"39","author":"Farhadi","year":"2016","journal-title":"Biomed J"},{"key":"10.1016\/j.trsl.2020.02.003_bib0060","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/molehr\/gav023","article-title":"Circadian clock regulation of melatonin MTNR1B receptor expression in human myometrial smooth muscle cells","volume":"21","author":"Beesley","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.trsl.2020.02.003_bib0061","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/jpi.12019","article-title":"Analysis of the daily changes of melatonin receptors in the rat liver","volume":"54","author":"Venegas","year":"2013","journal-title":"J Pineal Res"},{"key":"10.1016\/j.trsl.2020.02.003_bib0062","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.1073\/pnas.1722295115","article-title":"Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle","volume":"115","author":"Wefers","year":"2018","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Translational Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524420300323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1931524420300323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T12:40:16Z","timestamp":1761828016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1931524420300323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":62,"alternative-id":["S1931524420300323"],"URL":"https:\/\/doi.org\/10.1016\/j.trsl.2020.02.003","relation":{},"ISSN":["1931-5244"],"issn-type":[{"value":"1931-5244","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Translational Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.trsl.2020.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}